Plecanatide ni iki: Ibikoresho, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Plecanatide ni umuti wandikirwa na muganga ufasha kuvura imyitwarire idahinduka yo kwituma no kurwara indwara y'amara yitwa irritable bowel syndrome hamwe no kwituma bigoranye (IBS-C). Ubu buvuzi bworoheje ariko bufite akamaro bukora butera amara yawe gukora amazi menshi, ibyo bikoroha imyanda yo mu nda kandi bigatuma kwituma byoroha kandi bikaba byiza.

Plecanatide ni iki?

Plecanatide ni umuti w'imiterere ya peptide ikora nk'imisemburo karemano mu mubiri wawe yitwa guanylin. Iherereye mu cyiciro cy'imiti yitwa guanylate cyclase-C agonists, ibyo byumvikana bigoye ariko bisobanura ko bifasha amara yawe gukora neza.

Uyu muti uza mu buryo bw'ikagari gato ufata mu kanwa rimwe ku munsi. Bitandukanye n'imiti imwe ikaze yo kwituma ishobora gutera kuribwa cyangwa kwihutisha, plecanatide ikora buhoro hamwe n'inzira karemano y'umubiri wawe kugira ngo isubizeho imikorere isanzwe y'amara.

FDA yemeje plecanatide mu 2017 nyuma y'ubushakashatsi bwakozwe mu bitaro bwerekanye ko bushobora kunoza cyane ubwinshi bwo kwituma no kugabanya guhatiriza mu bantu bafite imyitwarire idahinduka yo kwituma.

Plecanatide ikoreshwa mu iki?

Plecanatide ivura ibibazo bibiri by'ingenzi bigira ingaruka ku bantu babarirwa muri za miliyoni ku isi yose. Muganga wawe ashobora kukwandikira uyu muti niba urwana n'ibibazo byo mu gihe kirekire bigira ingaruka ku buzima bwawe bwa buri munsi.

Uburyo bw'ibanze bukoreshwa ni ukurwanya imyitwarire idahinduka yo kwituma, bivuze kwituma bigoranye mu gihe kirekire nta mpamvu igaragara. Iyi ndwara irimo kugira kwituma guke kuruta gatatu mu cyumweru, hamwe n'ibimenyetso nk'uko guhatiriza, imyanda yo mu nda ikomeye, cyangwa kumva ko udashobora gushyira imyanda yose hanze.

Plecanatide kandi ivura indwara y'amara yitwa irritable bowel syndrome hamwe no kwituma bigoranye (IBS-C). Iyi ndwara ihuriza hamwe ibimenyetso byo kwituma bigoranye byavuzwe haruguru hamwe n'ububabare bwo mu nda, kubyimba, no guhinduka kw'imyitwarire y'amara byamaze byibura amezi atatu.

Plecanatide ikora ite?

Plecanatide ikora mugukoresha imitsi yihariye mumara yawe yitwa guanylate cyclase-C receptors. Iyo izo receptors zikoreshejwe, zitera urukurikirane rwibikorwa byongera umwuka mumara yawe.

Uyu mwuka wiyongereye ufasha koroshya imyanda yawe kandi ugashishikariza imyanya yawe isanzwe. Tekereza nk'ukora mumara yawe kwibuka uburyo bakora neza aho kubahatira gukora muburyo butari busanzwe.

Uyu muti ufatwa nkukomeye cyane ugereranije nibintu bisanzwe nkibyongera imitsi, ariko byoroshye kuruta imiti ikoreshwa mugutanga imyanya. Abantu benshi babona impinduka muminsi ya mbere yubuvuzi, nubwo bamwe bashobora gukenera ibyumweru bibiri kugirango babone inyungu zose.

Bitandukanye nimiti itera imyanya ishobora gutakaza imbaraga uko igihe kigenda, plecanatide ikomeza inyungu zayo mugukoresha bikomeje kandi ntibisanzwe bitera kwishingikiriza.

Nkwiriye Gufata Plecanatide Nte?

Fata plecanatide nkuko muganga wawe abitegeka, mubisanzwe urupapuro rumwe rwa 3-mg rimwe kumunsi. Urashobora kubifata hamwe cyangwa utabifatanije n'ibiryo, ariko kubifata kumwanya umwe buri munsi bifasha gukomeza urwego rumwe mumubiri wawe.

Mimina urupapuro rwose n'ikirahure cyuzuye cy'amazi. Ntukore, ntukore, cyangwa ucagagure urupapuro, kuko ibi bishobora kugira ingaruka kuburyo umuti ukora mumubiri wawe.

Niba ufite ikibazo cyo kumira ibinini, urashobora gukanda urupapuro ukaruvanga numubare muto wa applesauce cyangwa amazi. Koresha uru ruvange ako kanya kandi ntukabike nyuma.

Guma neza muminsi yose mugihe ufata plecanatide. Kunywa amazi menshi bifasha umuti gukora neza kandi bigabanya ibyago byingaruka.

Nkwiriye Gufata Plecanatide Igihe Kingana Gite?

Igihe cyo kuvura plecanatide gitandukanye bitewe nimiterere yawe bwite n'uburyo wakiriye umuti. Abantu benshi bafite imyanya idahoraho bakeneye kuvurwa igihe kirekire kugirango bakomeze imikorere isanzwe yimyanya.

Muganga wawe ashobora gutangira akoresha imiti mu gihe cy'ibyumweru byinshi kugira ngo arebe uko umuti ukora kuri wowe. Niba ubonye ibimenyetso by'uburwayi bwawe bigabanuka cyane, ashobora kugusaba gukomeza kuvurwa.

Abantu bamwe barwaye IBS-C bashobora gukenera gukomeza kuvurwa kugira ngo bafate neza uburwayi bwabo. Abandi bashobora kugabanya urugero rw'umuti bafata cyangwa bakawuhagarika igihe gito igihe ibimenyetso byabo byoroheje.

Ntuzigere uhagarika gufata plecanatide ako kanya utabanje kubaza muganga wawe, kuko ibimenyetso byawe byo guhura n'inkorora bishobora kugaruka. Umuganga wawe azagufasha kumenya gahunda nziza yo kuvurwa igihe kirekire ikwiriye uko urwaye.

Ni izihe ngaruka ziterwa na Plecanatide?

Kimwe n'indi miti yose, plecanatide ishobora gutera ingaruka, nubwo abantu benshi bayihanganira neza. Kumenya ibyo witegura bishobora kugufasha kumva ufite icyizere cyinshi ku buvuzi bwawe.

Ingaruka zikunze kugaragara muri rusange zoroheje kandi zijyanye n'uburyo umuti ukora. Dore ingaruka ushobora guhura nazo:

• Impiswi (zifata hafi 5% by'abantu)
• Urubavu rubabaza cyangwa kutumva neza
• Umwuka mubi (gaze)
• Urubavu rurabyimba
• Isesemi
• Umutwe

Izi ngaruka zisanzwe zikunze gukira igihe umubiri wawe wimenyereza umuti, akenshi mu minsi mike ya mbere yo kuvurwa.

Ingaruka zikomeye ariko zitagaragara cyane zisaba ubufasha bwihuse bw'abaganga. Nubwo bitamenyerewe, ugomba guhamagara muganga wawe ako kanya niba uhuye n'ibi bikurikira:

• Impiswi zikomeye cyangwa zihoraho zitagabanuka
• Ibimenyetso byo kumuka amazi (kuribwa, umunwa wumye, kugabanuka kw'inkari)
• Urubavu rubabaza cyane bitandukanye n'ibimenyetso byawe bisanzwe
• Amara mu musarani wawe
• Isesemi ikabije cyangwa kuruka

Abantu benshi basanga gutangira bafata amazi ahagije no gufata umuti buri gihe bifasha kugabanya ingaruka.

Ninde utagomba gufata Plecanatide?

Plecanatide ntibereye buri wese, kandi ibibazo by'ubuzima cyangwa ibihe runaka bituma bidatekanye gukoresha. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kugushyiriraho uyu muti.

Ntabwo ukwiye gufata plecanatide niba uri munsi y'imyaka 18, kuko umutekano n'imikorere byayo bitarashyirwaho ku bana n'urubyiruko. Uyu muti ntusabwa kandi niba utwite cyangwa wonka, keretse inyungu ziruta cyane ibyago.

Ibibazo by'ubuzima byihariye bituma plecanatide itakwemerwa birimo:

• Kuziba kw'amara bizwi cyangwa gukekwa
• Indwara ikomeye yo mu mara (indwara ya Crohn cyangwa ulcerative colitis)
• Indwara ikomeye y'impyiko
• Amateka y'impiswi ikomeye cyangwa ibibazo by'impiswi bihoraho
• Allergie kuri plecanatide cyangwa ibice byayo byose

Bwira muganga wawe ibibazo byawe byose by'ubuzima, cyane cyane niba ufite amateka y'ibibazo by'impyiko, ibibazo byo mu mara, cyangwa ufata indi miti ishobora guhura na plecanatide.

Amazina y'ubwoko bwa Plecanatide

Plecanatide iboneka munsi y'izina ry'ubwoko rya Trulance muri Leta Zunze Ubumwe z'Amerika. Ubu nicyo gusa izina ry'ubwoko ririho, nubwo ubwoko bwa generic bushobora kuboneka mu gihe kizaza.

Trulance ikorwa na Bausch Health Companies kandi iza mu mapirisi ya 3-mg. Uyu muti ubusanzwe ugurwa na gahunda nyinshi z'ubwishingizi, nubwo ubwishingizi bushobora gutandukana bitewe na gahunda yawe yihariye n'ubuzima bwawe.

Niba ikiguzi kibangamiye, baza muganga wawe kuri gahunda zo gufasha abarwayi cyangwa gahunda zo kugabanya imiti ishobora kugufasha kugabanya amafaranga utanga.

Uburyo bwa Plecanatide

Imiti itandukanye ishobora kuvura guhagarara kw'amara bihoraho na IBS-C niba plecanatide itagukwiriye. Muganga wawe ashobora gusuzuma izi nzira zindi zishingiye ku bimenyetso byawe byihariye n'amateka yawe y'ubuzima.

Imiti yindi yandikwa mu cyiciro kimwe irimo linaclotide (Linzess) na lubiprostone (Amitiza). Iyi miti ikora hakoreshejwe uburyo butandukanye gato ariko ifite ingaruka zisa ku mikorere y'amara.

Uburyo bwo kuvura butagomba kwandikwa na muganga bushobora gukoreshwa na muganga wawe burimo:

• Polyethylene glycol (MiraLAX)
• Ibiyobyabwenge bya psyllium fiber
• Docusate sodium (Colace)
• Bisacodyl (Dulcolax)

Umuvuzi wawe azagufasha kumenya uburyo bwo kuvura bukwiye cyane kubera uburwayi bwawe bwihariye n'ibimenyetso.

Ese Plecanatide iruta Linaclotide?

Plecanatide na linaclotide ni imiti ikora neza mu kuvura imvune zidakira n'indwara ya IBS-C, ariko ifite itandukaniro rishobora gutuma imwe ikwiriye kurusha iyindi.

Plecanatide ishobora gutera impiswi idakabije ugereranije na linaclotide, bigatuma iba nziza ku bantu bafite ubwumvikane kuri iyi ngaruka. Ubushakashatsi bwa kliniki bwerekana ko plecanatide ifite impiswi nke zibuza kuvurwa.

Ku rundi ruhande, linaclotide imaze igihe kinini iboneka kandi ifite amakuru menshi ya kliniki ashyigikira imikoreshereze yayo. Iraboneka kandi mu bipimo byinshi, bituma habaho uburyo bwo gupima buhinduka.

Guhitamo hagati yiyi miti akenshi biterwa n'uburyo umuntu yabyakiriye, kwihanganira ingaruka, n'ibitekerezo by'ikiguzi. Muganga wawe azagufasha kumenya uburyo bukwiye cyane kubera uko wifashe.

Ibikunze Kubazwa Kuri Plecanatide

Ese Plecanatide irakwiriye ku bantu barwaye diyabete?

Yego, plecanatide muri rusange irakwiriye ku bantu barwaye diyabete. Uyu muti ntugira ingaruka ku isukari yo mu maraso, kandi ubushakashatsi ntibwerekanye ubufatanye ubwo aribwo bwose buteye impungenge hagati ya plecanatide n'imiti isanzwe ya diyabete.

Ariko, niba ugize impiswi nk'ingaruka, ibi bishobora kugira ingaruka ku kugenzura isukari mu maraso yawe cyangwa imitsi y'imiti. Genzura isukari yawe mu maraso cyane iyo utangiye gufata plecanatide kandi uvugishe muganga wawe niba ubonye impinduka idasanzwe.

Nkwiriye gukora iki niba mfashe plecanatide nyinshi ku buryo butunguranye?

Niba ufata plecanatide nyinshi ku buryo butunguranye kuruta urugero rwanditswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya. Gufata nyinshi bishobora kongera ibyago byo kugira impiswi ikabije no kumuka amazi mu mubiri.

Reba ibimenyetso byo kumuka amazi mu mubiri nko kuribwa umutwe, umunwa wumye, kugabanya kunyara, cyangwa kumva uribwa. Nywa amazi menshi kandi usabe ubufasha bw'ubuvuzi niba ugize impiswi ikabije cyangwa ihoraho.

Ntugerageze "gukosora" urugero rurenzeho urukinguruzo rukurikira. Subiza gahunda yawe isanzwe yo gufata imiti nk'uko byategetswe n'umuganga wawe.

Nkwiriye gukora iki niba nciwe urugero rwa plecanatide?

Niba ucikanwe urugero rwa plecanatide, ifate ako kanya wibuka, keretse igihe kigeze cyo gufata urugero rukurikira. Muri icyo gihe, reka urugero rucikanwe ukomeze gahunda yawe isanzwe yo gufata imiti.

Ntufate urugero rwa kabiri icyarimwe kugirango ukosore urugero rucikanwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka. Niba ukunda kwibagirwa urugero, tekereza gushyiraho umwanya wo kwibutsa buri munsi cyangwa gufata umuti icyarimwe buri munsi.

Gucikanwa n'urugero rimwe na rimwe ntibizakugiraho ingaruka, ariko gerageza gufata plecanatide buri gihe kugirango ubone ibisubizo byiza mu kugenzura ibimenyetso byawe byo guhagarara kw'amara.

Nshobora guhagarika ryari gufata plecanatide?

Ushobora guhagarika gufata plecanatide iyo muganga wawe yemeje ko bikwiye, akenshi iyo ibimenyetso byawe byo guhagarara kw'amara byateye imbere cyane kandi bihoraho. Ariko, abantu benshi bafite guhagarara kw'amara guhoraho bakeneye kuvurwa buri gihe kugirango bagumane imikorere isanzwe y'amara.

Ntugahagarike gufata plecanatide utabanje kubiganiraho na muganga wawe, kuko ibimenyetso byawe bishobora kugaruka. Umuganga wawe ashobora kugusaba kugabanya buhoro buhoro umuti cyangwa agashaka impinduka mu mibereho yawe kugira ngo bifashe mu kugumana imikorere yawe myiza.

Niba ushaka kuganira ku birebana no guhagarika umuti, ganira na muganga wawe ku mpungenge zawe kandi mukorane kugira ngo mukore gahunda izagufasha kugumana ubuzima bwiza mu igogora.

Nshobora gufata Plecanatide hamwe n'ibindi byongera imyanda?

Muri rusange, ntugomba gufata plecanatide hamwe n'ibindi byongera imyanda keretse muganga wawe abikugiriyeho inama by'umwihariko. Kuvanga imiti yongera imyanda bishobora kongera ibyago byo kuribwa, kumuka kw'amazi, no kutagira ibinyampeke bihagije mu mubiri.

Niba uri gufata indi miti ivura kubura imyanda, ganira na muganga wawe uko wakwimukira kuri plecanatide mu buryo bwizewe. Bashobora kugusaba guhagarika indi miti yongera imyanda mbere yo gutangira plecanatide cyangwa bagashaka gahunda yihariye yo kuyifata.

Buri gihe menyesha umuganga wawe imiti yose n'ibyongera imbaraga ufata kugira ngo wirinde guhura n'ibibazo bishobora kugira ingaruka mbi.