Inkingo ya Polymyxin B: Ibyo ikora, Uburyo bwo kuyikoresha, Ingaruka zayo, n'ibindi

Inkingo ya Polymyxin B ni umuti ukomeye wa antibiyotike abaganga bakoresha mu kuvura indwara ziterwa na mikorobe zikomeye iyo izindi antibiyotike zitagize icyo zikora. Uyu muti ubarirwa mu itsinda ryitwa polymyxin antibiotics, kandi wagenewe kurwanya ubwoko runaka bwa mikorobe zishobora gutera indwara zikomeye ziteye ubuzima akaga. Nubwo ufatwa nk'umuti ukomeye ufite ingaruka zishobora kugaragara, ufite akamaro gakomeye mu kuvura iyo urwaye indwara zikomeye zitavurwa n'izindi miti.

Polymyxin B ni iki?

Polymyxin B ni antibiyotike ikora yica urukuta rw'inyuma rwa mikorobe zimwe na zimwe, mu by'ukuri ikazisenya zivuye hanze. Ni icyo abaganga bita antibiyotike ya

Ubwoko bw’indwara zishobora gukenera polymyxin B harimo umusonga, sepsis (indwara yo mu maraso), na infections zo mu nzira y'inkari ziterwa na mikorobe zimwe na zimwe nka Pseudomonas aeruginosa, Acinetobacter, cyangwa ubwoko bumwe na bumwe bwa E. coli. Izi mikorobe zateje ubudahangarwa ku miti myinshi isanzwe ikoreshwa, bigatuma polymyxin B iba umuti w'ingenzi wo kuvura.

Mu bindi bihe, abaganga bakoresha kandi polymyxin B ku ndwara zo mu nda cyangwa indwara zigaragara nyuma yo kubagwa. Umwanzuro wo gukoresha uyu muti uza buri gihe nyuma yo gusuzuma neza indwara yawe yihariye n'ibisubizo bya mikorobe.

Polymyxin B ikora ite?

Polymyxin B ikora igamije urukuta rw'inyuma rwa mikorobe, cyane cyane mikorobe ya gram-negative. Ifatana n'ibice biri mu rukuta rw'uturemangingo twa mikorobe byitwa lipopolysaccharides, bituma urukuta rw'uturemangingo rusenyuka rugatoboka. Iyi nzira iheruka kwica mikorobe itera indwara yawe.

Uyu muti ufata nk'ukomeye cyane mu isi y'imiti yica mikorobe. Mugihe iyi mbaraga ituma ikora neza ku mikorobe idahangarwa, bisobanura kandi ko ishobora kugira ingaruka ku turemangingo twawe ku rugero runaka, niyo mpamvu abaganga bakugenzura neza mugihe uvurwa. Uyu muti ukora vuba mugihe ugeze aho indwara iri binyuze mu maraso yawe.

Kubera ko polymyxin B ikomeye cyane, abaganga bakoresha gusa mugihe bibaye ngombwa. Ntabwo ari umuti wa mbere uhitwamo, ahubwo ni igikoresho gikomeye giteganyirijwe ibihe aho imiti yoroheje itagize icyo igeraho.

Nkwiriye gufata polymyxin B nte?

Polymyxin B y'urushinge ihabwa buri gihe n'abashinzwe ubuzima mu bitaro cyangwa ahantu hakorerwa ibizamini. Ntabwo uzajyana uyu muti mu rugo kuko bisaba kugenzura neza no gutanga neza. Uyu muti ubusanzwe utangwa binyuze muri IV (intravenous) umurongo w'umutsi w'umutsi, ukemerera kuzenguruka mu mubiri wawe vuba.

Itsinda ry'abaganga bakuvura bazaguha urushinge buhoro buhoro mu gihe cy'isaha imwe cyangwa ebyiri. Iyi mikoreshereze buhoro ifasha kugabanya ibyago byo kugira ingaruka mbi kandi ikemerera umubiri wawe gukoresha neza imiti. Igihe nyacyo n'uburyo bishobora gutandukana bitewe n'uburwayi bwawe bwihariye n'uko umubiri wawe witwara ku buvuzi.

Mugihe cy'ubuvuzi, ntugomba guhangayika kubijyanye no kubuzwa kurya cyangwa gufata imiti hamwe n'amafunguro kuko itangwa mu maraso yawe. Ariko, kuguma ufite amazi ahagije ni ingenzi, bityo itsinda ry'abaganga bakuvura rishobora kugushishikariza kunywa amazi menshi keretse hari impamvu ya muganga yo kuyagabanya.

Itsinda ryawe ry'abaganga rizakurikirana imikorere y'impyiko zawe, kumva, n'uburyo rusange umubiri wawe witwara ku miti mugihe cyose uvurwa. Bazahindura urugero rwa dose cyangwa igihe niba bibaye ngombwa bitewe n'uko umubiri wawe ukoresha umuti.

Nzamara Igihe Kingana Iki Ndafata Polymyxin B?

Igihe uvurwa na polymyxin B giterwa n'ubwoko n'uburemere bw'indwara yawe, kimwe n'uko umubiri wawe witwara vuba ku miti. Uburyo bwinshi bwo kuvura bumara hagati y'iminsi 7 kugeza kuri 14, ariko ibi birashobora gutandukana cyane bitewe n'uko ubuzima bwawe bumeze.

Muganga wawe azakurikirana ibimenyetso by'indwara yawe binyuze mu bizami by'amaraso n'izindi nzira zo kumenya igihe byemewe guhagarika imiti. Bazashaka ibimenyetso byerekana ko bagiteri zirimo ziravanwaho kandi ko umubiri wawe urimo gukira neza. Ubwandu bumwe bushobora gusaba uburyo bugufi bw'iminsi 5-7, mugihe ubwandu bukomeye cyangwa bugoye bushobora gukenera ibihe birebire byo kuvurwa.

Ni ngombwa kurangiza uburyo bwose bwo kuvura, kabone niyo watangira kumva umeze neza mbere yuko birangira. Guhagarika kare cyane birashobora korohereza bagiteri kubaho no gushobora guteza imbere kurwanya antibiyotike. Itsinda ry'abaganga bakuvura rizafata icyemezo icyo aricyo cyose cyo guhindura cyangwa guhagarika ubuvuzi bwawe hashingiwe ku iterambere ryawe n'ibisubizo by'ibizamini.

Ni Ibihe Bikorwa Bigaragara Biterwa na Polymyxin B?

Kimwe n'imiti myinshi ikomeye, polymyxin B ishobora gutera ibikorwa bigaragara, nubwo atari buri wese ubyumva. Ibikorwa bigaragara cyane birashobora gucungwa kandi bikunze gukira igihe umubiri wawe umaze kumenyera umuti cyangwa nyuma yo kurangiza kuvurwa.

Dore ibikorwa bigaragara ushobora guhura nabyo, kandi ni ngombwa kwibuka ko ikipe yawe y'ubuzima ikugenzura cyane kugirango ifate kandi ivure ibibazo byose hakiri kare:

Ibyo bikorwa bisanzwe bigaragara birimo:

• Urubavu, umutuku, cyangwa kubyimba ahantu umuti watewe
• Isesemi cyangwa kuribwa mu nda
• Umuzungero cyangwa kumva uruhuka
• Umutwe
• Uruhu ruruka cyangwa kuribwa
• Umunaniro w'imitsi cyangwa kunanirwa

Ibyo bikorwa bikomeye bisaba ubufasha bwihuse bw'abaganga birimo:

• Ibibazo by'impyiko (imihindukire yo kunyara, kubyimba amaguru cyangwa ibirenge)
• Imyitwarire yo kumva cyangwa guhinda mu matwi
• Urugero rukomeye rwo kwanga umuti (kubura umwuka, uruhu rukomeye, kubyimba mu maso cyangwa mu muhogo)
• Ibimenyetso bya neurologique (urujijo, gufatwa, umuzungero ukomeye)
• Umunaniro ukomeye w'imitsi cyangwa guhagarara kw'imitsi

Ikipe yawe y'ubuzima ikugenzura cyane kubera ibi bikorwa bikomeye, cyane cyane imikorere y'impyiko n'imihindukire yo kumva, aribyo bikorwa bigaragara bishobora guhangayikisha cyane. Bazagenzura buri gihe imikorere y'amaraso yawe kandi bakubaze ibimenyetso byose urimo guhura nabyo.

Ibyo bikorwa bigaragara byinshi ni iby'agateganyo kandi bikemuka nyuma yo kurangiza kuvurwa. Ariko, mu bihe bidasanzwe, ibikorwa bimwe na bimwe ku kumva cyangwa imikorere y'impyiko birashobora kuramba, niyo mpamvu abaganga bakoresha uyu muti gusa igihe bibaye ngombwa.

Ninde Utagomba Gufata Polymyxin B?

Abantu bamwe ntibagomba guhabwa inshinge ya polymyxin B, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Ikintu cy'ingenzi ni ukumenya niba warigeze kugira allergie kuri polymyxin B cyangwa imiti y'antibiotike isa nayo mu bihe byashize.

Muganga wawe azitondera cyane mu kwandika polymyxin B niba ufite ibibazo by'impyiko, kuko uyu muti ushobora gutuma imikorere y'impyiko irushaho kuba mibi. Bazatekereza kandi neza ibyago niba ufite ibibazo byo kumva cyangwa amateka y'indwara zo gucika intege kw'imitsi nka myasthenia gravis.

Niba utwite cyangwa wonka, muganga wawe azagereranya inyungu n'ibyago bishoboka neza cyane. Nubwo polymyxin B ishobora kuba ngombwa ku ndwara zikomeye, bazagukurikiranira hafi na umwana wawe niba ubuvuzi bukenewe.

Abantu bafata indi miti imwe, cyane cyane iyo ishobora kugira ingaruka ku mikorere y'impyiko cyangwa kumva, bashobora gukenera gukurikiranwa by'umwihariko cyangwa guhindurirwa urugero rw'umuti. Itsinda ryawe ry'ubuzima rizasuzuma imiti yawe yose kugirango ryemeze ubuvuzi bwizewe.

Amazina y'ubwoko bwa Polymyxin B

Izina risanzwe rya polymyxin B injection ni Poly-Rx. Ariko, uyu muti uboneka kandi nk'umuti rusange, bivuze ko ushobora kuwuhabwa ku izina rusange

Mugihe polymyxin B ikunze gukoreshwa mu kurwanya indwara zananiranye, hariho rimwe na rimwe imiti yindi ishobora gukora neza mu bihe byihariye byawe. Iyi miti ishingira ku bwoko bwa mikorobe itera uburwayi bwawe n'uburyo zihanganira imiti.

Imiti yindi abaganga bashobora gutekereza harimo colistin (isa cyane na polymyxin B), imiti mishya ya beta-lactam, cyangwa uburyo bwo kuvura hakoreshejwe imiti myinshi icyarimwe. Mu bihe bimwe na bimwe, tigecycline cyangwa imiti mishya nka ceftazidime-avibactam bishobora kuba amahitamo.

Ihitamo ry'umuti rishingira buri gihe ku ngaruka z'isuzuma ry'imikorobe yawe n'ibizamini byo kureba uko yihanganira imiti. Muganga wawe azahitamo umuti ukwiriye cyane ushingiye ku kintu gishobora gukora neza kurwanya indwara yawe yihariye mugihe gitera ingaruka nke.

Rimwe na rimwe, uburyo bwo kuvura hakoreshejwe polymyxin B hamwe n'indi miti burushaho gukora neza kurusha gukoresha umuti umwe gusa. Itsinda ryawe ry'ubuvuzi rizagena uburyo bwiza bushingiye ku miterere yawe bwite.

Ese Polymyxin B iruta Colistin?

Polymyxin B na colistin ni imiti isa cyane ikomoka mu muryango umwe kandi ikora mu buryo busa. Byombi bifatwa nk'ibikorera kimwe kurwanya mikorobe zinaniranye za gram-negative, kandi guhitamo hagati yazo akenshi biterwa n'uko ziboneka n'icyo muganga wawe akunda.

Ubushakashatsi bumwe buvuga ko polymyxin B ishobora kuba yoroshye ku mpyiko ugereranije na colistin, ariko imiti yombi ifite ibyago bisa kandi bisaba gukurikiranwa neza. Itandukaniro riri mu ngaruka ziterwa n'imiti ni rito, kandi imiti yombi ifatwa nk'amahitamo akwiriye ku ndwara zananiranye.

Umuti wawe wa muganga hagati y'izi antibiyotike ebyiri ushobora guterwa n'ibintu nk'imikorere y'impyiko zawe, ibisubizo by'umuco wa bagiteri, cyangwa umuti urimo kuboneka vuba mu kigo cy'ubuvuzi. Byombi ni imiti ikora neza mu kuvura indwara zikomeye zirwanya imiti.

Mu bihe bimwe na bimwe, muganga wawe ashobora guhindura umuti umwe akawushyira ku wundi bitewe n'uko urimo kwitwara ku miti cyangwa niba ibimenyetso bigaragara. Ikintu cy'ingenzi ni uko urimo guhabwa ubuvuzi bukwiye bw'indwara yawe, hatitawe kuri antibiyotike ya polymyxin ikoreshwa.

Ibikunze Kubazwa Kuri Polymyxin B

Q1. Ese Polymyxin B irakwiriye ku bantu barwaye indwara z'impyiko?

Polymyxin B isaba kwitonda cyane ku bantu barwaye indwara z'impyiko kuko bishobora gutuma imikorere y'impyiko irushaho kuba mibi. Ariko, abaganga rimwe na rimwe baracyayandika ku ndwara zikomeye iyo inyungu ziruta ibyago. Niba ufite ibibazo by'impyiko, muganga wawe ashobora guhindura urugero rw'umuti wawe kandi akagenzura imikorere y'impyiko zawe cyane mu gihe cy'ubuvuzi.

Itsinda ryawe ry'ubuvuzi rizasuzuma imikorere y'amaraso yawe kenshi kugirango barebe niba impyiko zawe zikoresha umuti neza. Bashobora kandi kureba niba ufite amazi ahagije kandi wirinda indi miti ishobora gushyira igitutu ku mpyiko zawe mu gihe cy'ubuvuzi.

Q2. Nkwiriye gukora iki niba mbonye polymyxin B nyinshi mu buryo butunganye?

Kubera ko polymyxin B itangwa gusa n'abakora mu buvuzi mu bigo by'ubuvuzi, kwiyongera kw'umuti mu buryo butunganye ni gake cyane. Niba ufite impungenge ku rugero rw'umuti wawe cyangwa ufite ibimenyetso bidasanzwe mu gihe cy'ubuvuzi, menyesha itsinda ryawe ry'ubuvuzi ako kanya. Bashobora gusuzuma uko bimeze kandi bagatanga ubuvuzi bukwiye niba bibaye ngombwa.

Itsinda ryawe ry'ubuvuzi rigenzura urugero rw'umuti wawe neza kandi rigahindura bitewe n'uburemere bwawe, imikorere y'impyiko zawe, n'uburyo witwara ku miti. Batojwe kumenya ibimenyetso by'ingaruka z'imiti kandi bazafata ingamba zikwiye niba hari ikibazo kigaragaye.

Q3. Ninkora iki ninsubiza urugero rwa Polymyxin B?

Kubera ko polymyxin B itangwa n'abantu b'inzobere mu by'ubuzima mu bitaro cyangwa ahantu hakorerwa ibizamini, ntuzaba ufite inshingano yo gushyiraho igihe cyo gufata imiti yawe. Itsinda ryawe ry'ubuzima rigenga gahunda yawe y'imiti kandi rikareba ko ubona imiti ku gihe.

Niba hariho gutinda mu rugero rwawe rwashyizweho kubera ibikorwa by'ubuvuzi cyangwa izindi mpamvu, itsinda ryawe ry'ubuzima rizagena gahunda yawe yo kuvura uko bikwiye. Bazareba ko ubona imiti yose ukeneye kugira ngo uvurwe neza indwara yawe.

Q4. Ni ryari nshobora kureka gufata Polymyxin B?

Ntabwo ukwiye kureka kuvurwa na polymyxin B wenyine, n'iyo wumva umeze neza. Umwanzuro wo kureka kuvurwa ufatwa n'itsinda ryawe ry'ubuzima rishingiye ku bimenyetso by'indwara yawe, imikorere yawe mu buzima, no kurangiza imiti yose yagutanzwe.

Muganga wawe azakurikiza uko urimo uragenda binyuze mu bizamini by'amaraso no kugusuzuma mu buryo bw'umubiri kugira ngo amenye igihe byemewe kureka imiti. Kureka kare cyane byatuma bagiteri zikomeza kubaho kandi zishobora kwigirira ubushobozi bwo kurwanya imiti, bigatuma indwara zo mu gihe kizaza zitorohera kuvurwa.

Q5. Nshobora guteza imbere ubushobozi bwo kurwanya Polymyxin B?

Nubwo ubushobozi bwa bagiteri bwo kurwanya polymyxin B bushobora gutezwa imbere, biracyari bike ugereranije no kurwanya izindi antibiyotike. Ariko, iyi ni imwe mu mpamvu zituma abaganga bafata iyi miti ku ndwara zikomeye kandi bakareba ko urangiza imiti yose yagutanzwe.

Gufata imiti nk'uko yategetswe kandi kurangiza imiti yose bifasha kwirinda guteza imbere ubushobozi bwo kurwanya imiti. Itsinda ryawe ry'ubuzima rikoresha polymyxin B mu buryo bw'ubwitonzi kugira ngo rikomeze imikorere yayo ku barwayi bo mu gihe kizaza bashobora kuyikeneye ku ndwara ziteje ubuzima bwabo akaga.