Icyo Quinupristin na Dalfopristin ari cyo: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Quinupristin na dalfopristin ni uruvange rw'imiti ikomeye yica mikorobe abaganga bakoresha mu kuvura indwara ziterwa na mikorobe zikomeye iyo izindi miti zitagikora. Uyu muti ubarirwa mu cyiciro cyitwa streptogramins, kandi utangwa unyuze mu muyoboro wa IV (intravenous) unyuzwa mu maraso yawe.

Uru ruvange rw'imiti yica mikorobe akenshi rubikwa ku ndwara zikomeye, cyane cyane iziterwa na mikorobe zitarinda imiti. Muganga wawe azatekereza neza kuri ubu buryo bwo kuvura igihe afite indwara zikomeye ziterwa na mikorobe zikeneye kwitabwaho ako kanya.

Quinupristin na Dalfopristin ni iki?

Quinupristin na dalfopristin ni uruvange rw'imiti ibiri yica mikorobe ikorera hamwe nk'ikipe kugira ngo irwanye indwara ziterwa na mikorobe. Bitekereze nk'uruvange rwo kurwanya mikorobe zangiza zagaragaje ko zitakira izindi miti.

Uyu muti uza mu ifu abakozi bo mu bitaro bavanga n'amazi atagira mikorobe mbere yo kuyiguha unyuze muri IV. Uru ruvange rukora neza cyane ku mikorobe ya gram-positive, ni ukuvuga ubwoko bwa mikorobe butera indwara nyinshi zikomeye.

Uyu muti wica mikorobe ufatwa nk'umuti ukomeye, bivuze ko akenshi ukoreshwa iyo izindi miti yoroheje itagikora. Itsinda ryawe ry'ubuvuzi rizakugenzura neza mu gihe uri guhabwa uyu muti.

Quinupristin na Dalfopristin bikoreshwa mu kuvura iki?

Uru ruvange rw'imiti yica mikorobe ruvura indwara zikomeye z'uruhu n'imitsi yoroshye ziterwa na mikorobe zimwe na zimwe. Muganga wawe ashobora kukwandikira uyu muti igihe ufite indwara zikomeye zitakira izindi miti.

Uyu muti ukora neza cyane ku bwoko bumwe na bumwe bwa mikorobe zishobora gutera indwara ziteje ubuzima akaga. Dore indwara zikomeye uvura:

• Uburwayi bukomeye bw'uruhu n'imyubakire yarwo
• Uburwayi buterwa na Enterococcus faecium (ubwoko bwa mikorobe idakira na vancomycin)
• Uburwayi buterwa na Staphylococcus aureus (harimo n'ubwoko bumwe na bumwe budakira na methicillin)
• Uburwayi buterwa na Streptococcus pyogenes

Umuvuzi wawe azagena niba uyu muti ukwiriye uburwayi bwawe bwihariye hashingiwe ku bizamini byo muri laboratori no ku mateka yawe y'ubuvuzi. Ibi bituma wakira ubuvuzi bukwiye cyane uburwayi bwawe.

Quinupristin na Dalfopristin bikora gute?

Uyu muti wica mikorobe ukora mu guhagarika mikorobe gukora poroteyine zikeneye kugira ngo zibaho kandi zigwize. Iyo mikorobe itashoboye gukora izi poroteyine zingenzi, amaherezo irapfa, bigatuma umubiri wawe wikingira ukiza uburwayi.

Ibi bice byombi bikorera hamwe mu buryo bwa sinergistic, bivuze ko bikora neza cyane iyo bikorera hamwe kuruta uko byakorera umwe umwe. Quinupristin na dalfopristin byifatanya n'ibice bitandukanye by'imashini ikora poroteyine ya mikorobe, bigakora inzitizi ebyiri mikorobe zigorwa cyane no kurenga.

Ibi bifatwa nk'umuti ukomeye wica mikorobe kuko ushobora kwinjira mu buryo bwo kwirinda bwa mikorobe bwateje ubudahangarwa ku yindi miti. Ariko, uku gukomera nanone bisobanura ko bisaba gukurikiranwa neza mugihe cy'ubuvuzi.

Nkwiriye gufata Quinupristin na Dalfopristin nte?

Uyu muti uzawuhabwa gusa mu bitaro cyangwa ahantu hakorerwa ibizamini binyuze mu muyoboro wa IV. Itsinda ry'ubuvuzi rizawutegura kandi rikawuguhereza, bityo ntugomba guhangayika kuwufata wenyine.

Umuti ubusanzwe utangwa buri masaha 8 cyangwa 12, bitewe n'uburwayi bwawe bwihariye n'uko umubiri wawe witwara. Inshinge imwe ikunze kumara iminota 60, muri icyo gihe uzaba ukurikiranwa niba hari icyo wumva.

Ntabwo bisaba kwirinda kurya cyangwa kunywa ibyo kurya n'ibinyobwa mugihe ukoresha uyu muti, nubwo ikipe yawe y'ubuvuzi ishobora kugira inama zihariye zishingiye ku buryo uvurwa muri rusange. Umurongo wa IV wemerera umuti kujya mu maraso yawe ako kanya, ukarenga rwose sisitemu yawe yo mu gifu.

Nzamara Igihe Kingana Gite Nkoresha Quinupristin na Dalfopristin?

Ubusanzwe, igihe cyo kuvurwa kiva ku minsi 7 kugeza kuri 14, bitewe n'uburemere bw'ubwandu bwawe n'uburyo wumva umuti. Muganga wawe azakurikiza uko urimo urivurwa kandi ahindure igihe cyo kuvurwa uko bikwiye.

Ubwandu bumwe na bumwe bushobora gusaba igihe gito cyo kuvurwa, mugihe ubwandu bukomeye cyangwa bugoye bushobora gukenera igihe kirekire cyo kuvurwa. Ikipe yawe y'ubuvuzi izakoresha ibizamini byo muri laboratwari n'imikorere yawe ya kliniki kugirango imenye igihe gikwiye kuri wowe.

Ni ngombwa kurangiza igihe cyose cyo kuvurwa, nubwo watangira kumva umeze neza mbere yuko kirangira. Guhagarika imiti yica mikorobe kare cyane birashobora korohereza bagiteri kugaruka kandi bishobora guteza imbere ubudahangarwa bw'umuti.

Ni Iyihe Miterere Ibaho Mugihe Ukoresha Quinupristin na Dalfopristin?

Kimwe n'indi miti yose, quinupristin na dalfopristin bishobora gutera ingaruka, nubwo atari buri wese uzagira izo ngaruka. Ingaruka nyinshi zishobora kugenzurwa, kandi ikipe yawe y'ubuvuzi izagukurikiranira hafi mugihe cyose uvurwa.

Dore ingaruka zisanzwe ushobora guhura nazo:

• Urubavu, uburibwe, cyangwa kubyimba ahantu hashyirwa IV
• Uburibwe bw'imitsi n'uburibwe bw'ingingo
• Isesemi no kuruka
• Impiswi
• Umutwe
• Urugohe cyangwa ibimenyetso byo ku ruhu

Abantu bamwe bashobora guhura n'ingaruka zikomeye ariko zitabaho kenshi. Ikipe yawe y'ubuvuzi izareba ibimenyetso byabyo kandi ifate ingamba zikwiye nibibaye:

• Urugero rukomeye rwo kwivumbura ku miti
• Impinduka z'imikorere y'umwijima
• Impinduka z'umuvuduko w'umutima
• Uburibwe bukomeye bw'imitsi cyangwa intege nke
• Kugorwa no guhumeka

Niba ubonye ibimenyetso bidasanzwe cyangwa wumva uhangayitse ku buryo umubiri wawe witwara ku muti, ntugatinye kubibwira ikipe yawe y'ubuvuzi ako kanya. Bariho kugira ngo bagenzure umutekano wawe n'imibereho yawe myiza mu gihe cyose cy'ubuvuzi.

Ninde Utagomba Gufata Quinupristin na Dalfopristin?

Uyu muti ntukwiriye buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuwugena. Ibyiciro runaka cyangwa ibihe bishobora gutuma uyu muti wica mikorobe utakwiriye imiterere yawe.

Ntugomba guhabwa uyu muti niba ufite allergie izwi kuri quinupristin, dalfopristin, cyangwa igice icyo aricyo cyose cy'umuti. Ikipe yawe y'ubuvuzi izakubaza ibyerekeye allergie wigeze kugira ku miti yica mikorobe mbere yo gutangira ubuvuzi.

Abantu bafite indwara zimwe na zimwe bashobora gukenera ingamba zidasanzwe cyangwa ubuvuzi busimburwa. Muganga wawe azatekereza ibi bintu neza:

• Indwara y'umwijima cyangwa ibibazo byo gukora kw'umwijima
• Indwara zo mu mutima zituma umutima utera nabi
• Indwara z'imitsi cyangwa ibibazo by'imitsi byatewe n'imiti
• Gusama cyangwa konsa (bisaba isuzuma ryitonda ry'inyungu n'ibibazo)
• Indwara y'impyiko (bishobora gusaba guhindura urugero rwa dose)

Umutanga serivisi z'ubuzima nawe azasuzuma imiti yose urimo gufata, kuko imiti imwe ishobora guhura na quinupristin na dalfopristin. Iri suzuma ryuzuye ririnda umutekano wawe mu gihe cyose cy'ubuvuzi.

Amazina y'ubwoko bwa Quinupristin na Dalfopristin

Izina ry'ubwoko bw'uyu muti uhuza ni Synercid. Iri ni ryo zina ushobora kubona ku nyandiko z'ibitaro no ku byapa by'imiti mu gihe cy'ubuvuzi bwawe.

Abatanga serivisi z'ubuzima bakunda gukoresha izina rusange (quinupristin na dalfopristin) n'izina ry'ubwoko (Synercid) mu buryo busimburana. Byombi byerekeza ku muti umwe uhuza, bityo ntugahungabane niba wumva amazina atandukanye akoreshwa.

Uburyo busimburwa bwa Quinupristin na Dalfopristin

Izindi antibiyotike nyinshi zishobora kwitabwaho nk'izindi, bitewe n'ubwandu bwawe bwihariye n'ubuzima bwawe. Muganga wawe azahitamo bitewe n'ubwoko bwa bagiteri butera ubwandu bwawe n'ibintu by'ubuzima bwawe bwite.

Zimwe muri antibiyotike zindi zishobora kwitabwaho zirimo:

• Linezolid (kubera ubwandu burwanya gram-positive)
• Daptomycin (kubera ubwandu bumwe bw'uruhu n'imitsi yoroshye)
• Tigecycline (kubera ubwandu bugoye)
• Vancomycin (kubera ubwoko bumwe bwa bagiteri zirwanya)
• Clindamycin (kubera ubwandu bwihariye bw'uruhu)

Gu hitamo izindi bitewe n'ibintu byinshi, harimo bagiteri zihariye zirebwa, amateka yawe y'ubuzima, n'uburyo wabyitwayemo neza ku zindi nshuti. Itsinda ryawe ry'ubuzima rizagena uburyo bukwiye kuri wowe.

Ese Quinupristin na Dalfopristin biruta Vancomycin?

Niba quinupristin na dalfopristin biruta vancomycin biterwa rwose n'ubwandu bwawe bwihariye na bagiteri ibitera. Zombi ni antibiyotike zikomeye zikoreshwa kubera ubwandu bukomeye, ariko zikora mu buryo butandukanye kandi ku bwoko butandukanye bwa bagiteri.

Quinupristin na dalfopristin birashobora gukundwa mugihe havurwa vancomycin-resistant enterococci (VRE), ubwoko bwa bagiteri butitabira vancomycin. Muri ibyo bihe, iyi mvange itanga uburyo bwo kuvura neza mugihe vancomycin yananiwe.

Ariko, vancomycin irashobora kuba uburyo bwiza kubera ubundi bwoko bwinshi bw'ubwandu, cyane cyane buterwa na bagiteri zihanganye nayo. Muganga wawe azakoresha ibizamini byo muri laboratori kugirango amenye bagiteri zitera ubwandu bwawe n'antibiyotike zizaba zikora neza kuri zo.

Ibikunze Kubazwa Kuri Quinupristin na Dalfopristin

Ese Quinupristin na Dalfopristin birakwiriye kubantu barwaye indwara z'umutima?

Uyu muti ukeneye gukurikiranwa neza ku bantu barwaye indwara z'umutima, cyane cyane abafite ibibazo by'umuvuduko w'umutima. Uyu muti ushobora kugira ingaruka ku muvuduko w'umutima, bityo itsinda ry'abaganga rizagenzura neza imikorere y'umutima wawe mugihe uvurwa.

Niba warigeze kugira ibibazo by'umutima, muganga wawe azagereranya akamaro ko kuvura icyorezo ufite n'ibishobora kuzagirira umutima wawe. Bashobora gukoresha ibikoresho byongera kugenzura no guhindura gahunda yawe yo kuvurwa kugira ngo bagukingire.

Nkwiriye gukora iki niba ngize ububabare bukomeye mu mikaya mugihe mvurwa?

Ububabare bukomeye mu mikaya bushobora kuba ingaruka ikomeye ikeneye ubufasha bwihuse bw'abaganga. Niba ugize ububabare bukomeye mu mikaya, intege nke, cyangwa ububabare busa nkaho budasanzwe cyangwa bukomeye, menyesha itsinda ry'abaganga bawe ako kanya.

Itsinda ryawe ry'abaganga rishobora gukenera guhindura uburyo uvurwa cyangwa gutanga imiti yongera kugenzura ibi bimenyetso. Ntukagerageze kwihanganira ububabare bukomeye mu mikaya, kuko ibi bishobora kugaragaza ko hari ikindi kibazo gikomeye gikeneye kwitabwaho vuba.

Bikunda gute niba nciwe urugero rwa Quinupristin na Dalfopristin?

Kubera ko uzahabwa uyu muti mu bitaro cyangwa ahantu ho kuvurirwa, itsinda ryawe ry'abaganga ni ryo rigena igihe imiti yose izahabwa. Bafiteho uburyo bwo kureba ko uhabwa imiti yawe ku gihe.

Niba hari impamvu urugero rwatinze kubera uburyo bwo kuvura cyangwa izindi mpamvu, itsinda ryawe ry'abaganga rizahindura igihe bikwiye. Ntugomba guhangayika ku bijyanye no gucikanwa n'imiti kuko abantu babihuguriwe bari gucunga gahunda yawe yo kuvurwa.

Nshobora kureka gufata Quinupristin na Dalfopristin ryari?

Ntugomba na rimwe kureka uyu muti ku giti cyawe, kabone niyo wumva umeze neza cyane. Muganga wawe niwe uzafata icyemezo cyo kureka uyu muti bitewe n'uko urimo urushaho kumererwa neza ndetse n'ibisubizo by'ibizamini byo mu laboratori.

Kureka gufata imiti yica mikorobe kare bishobora gutuma bagaruka kandi bikaba byatera ko itongera gukora kuri iyo miti. Itsinda ryawe ry'ubuvuzi rizakurikirana uko urimo urwanya indwara, rikumenyeshe igihe urangirije umuti wose ukenewe kugira ngo ukire.

Nshobora guhabwa indi miti nkanwa Quinupristin na Dalfopristin?

Imiti myinshi ishobora gufatwa neza hamwe na quinupristin na dalfopristin, ariko hari imiti imwe isaba kwitonda cyangwa guhindura igihe ifatirwa. Itsinda ryawe ry'ubuvuzi rizasuzuma imiti yose ufata kugira ngo birinde ingaruka mbi.

Imiti imwe igira ingaruka ku mutima cyangwa imikorere y'umwijima ishobora gukenera gukurikiranwa by'umwihariko cyangwa guhindurirwa urugero rwa yo. Itsinda ryawe ry'abaganga rizakorana imiti yose ufata kugira ngo barebe ko ikora neza kandi neza kugira ngo ukire.