Quizartinib ni iki: Ibikoresho, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Quizartinib ni umuti w'indwara ya kanseri ugamije kuvura neza ubwoko bwihariye bwa kanseri y'amaraso yitwa acute myeloid leukemia (AML). Uyu muti unyobwa mu kanwa ukora ubugenzuzi bwo guhagarika poroteyine zidasanzwe zifasha selile za kanseri gukura no kwiyongera mu magufa yawe.

Niba wowe cyangwa umuntu ukunda yarandikiwe quizartinib, birashoboka ko urimo guhangana no gusuzuma kanseri igoye. Nubwo ibi bishobora kumera nk'ibigoye, gusobanukirwa uko uyu muti ukora birashobora kugufasha kumva witeguye kandi ufite icyizere mu rugendo rwawe rw'ubuvuzi.

Quizartinib ni iki?

Quizartinib ni umuti wa kanseri wandikirwa na muganga kandi ukaba mu cyiciro cy'imiti yitwa kinase inhibitors. Igamije by'umwihariko guhagarika poroteyine yitwa FLT3, ishobora gukabya mu bwoko bumwe bwa kanseri y'amaraso.

Uyu muti uza mu buryo bw'ibinini binyobwa mu kanwa, bivuze ko ushobora kuwufata mu kanwa iwawe aho gukenera kuvurirwa mu bitaro. Uyu muti watejwe imbere by'umwihariko ku bantu bafite kanseri y'amaraso ya acute myeloid leukemia ifite ihinduka ryihariye ry'imikorere y'uturemangingo twitwa FLT3-ITD.

Muganga wawe azaba yaragenzuye selile za kanseri yawe kugirango yemeze ko ufite iri hinduka ryihariye mbere yo kugushyiriraho quizartinib. Ubu buryo bwihariye bufasha kumenya neza ko umuti uzagira akamaro kanini ku bwoko bwawe bwihariye bwa kanseri y'amaraso.

Quizartinib ikoreshwa mu kuvura iki?

Quizartinib ikoreshwa mu kuvura abantu bakuru bafite kanseri y'amaraso ya acute myeloid leukemia (AML) ifite ihinduka ryihariye ry'imikorere y'uturemangingo twitwa FLT3-ITD. Uyu muti akenshi wandikwa iyo kanseri yawe yagarutse nyuma yo kuvurwa mbere cyangwa itarasubiza neza ku bundi buvuzi.

AML ni ubwoko bwa kanseri y'amaraso igira ingaruka ku magufa yawe, aho umubiri wawe ukora selile z'amaraso. Iyo ufite iyi ndwara, amagufa yawe akora selile nyinshi zidasanzwe z'amaraso yera zitagira akamaro, zikabuza selile z'amaraso nziza gukora neza.

Impinduka ya FLT3-ITD ituma selile za kanseri zikura kandi zikagwira cyane. Abantu bagera kuri 25-30% barwaye AML bafite iyi mpinduka yihariye, ni yo mpamvu gupima imiterere ya jeni ari ngombwa cyane mbere yo gutangira kuvurwa.

Muganga wawe w’inzobere mu kuvura kanseri ashobora no gutekereza quizartinib niba utujuje ibisabwa byo gukoresha imiti ikaze yo kuvura kanseri bitewe n’imyaka yawe cyangwa izindi ngorane z’ubuzima. Uyu muti utanga uburyo bwihariye bushobora kuba bworoheje ku mubiri wawe mugihe ugihangana na kanseri neza.

Quizartinib ikora ite?

Quizartinib ikora ibuza poroteyine yihariye yitwa FLT3 ikora nk'“agahinduragurika ko gukura” kuri selile za kanseri. Iyo iyi poroteyine yahindutse, iguma yaka igihe cyose, ibwira selile za kanseri gukomeza gukura no kwigabanya vuba.

Bitekereze nk'imodoka ifite pedali yo kwihutisha yafashwe. Impinduka ya FLT3 ikomeza “gukanda” pedali, ituma selile za kanseri zigwira hanze y’ubushobozi. Quizartinib ikora nk'uko ushyiraho feri, ihagarika iyi nzira yo gukura idashoboka.

Uyu muti ufata nk'ubuvuzi bukomeye kandi bwiza bwihariye. Bitandukanye na shimi yo kuvura kanseri gakondo igira ingaruka ku selile zose zigabanyuka vuba, quizartinib yihariye igamije poroteyine yahindutse muri selile zawe za kanseri, bishobora kuvuga ingaruka nke ku selile nzima.

Umaze gufata umuti, ujya mu maraso yawe ukagera mu bworo aho selile za leukemia zikurira. Mu kubuza poroteyine ya FLT3, bishobora gufasha kugabanya umubare wa selile za kanseri kandi bigatuma ubworo bwawe butangira kongera gukora selile z’amaraso nziza.

Nkwiriye gufata Quizartinib nte?

Ukwiye gufata quizartinib nk'uko muganga wawe abitegeka, akenshi rimwe ku munsi ku gihe kimwe buri munsi. Uyu muti uza mu buryo bw'ibinini ushira byose hamwe n'ikirahure cyuzuye cy'amazi.

Ushobora gufata quizartinib urya cyangwa utarya, ariko gerageza kubigira akamenyero. Niba usanzwe uyifata mu gitondo, komeza ubigenza utyo mu gihe cyose uvurwa. Ibi bifasha kugumana urugero rwa imiti mu mubiri wawe.

Ntugasenye, ntukore cyangwa umene ibinini, kuko ibi bishobora kugira ingaruka ku buryo umuti winjizwa mu mubiri. Niba ugira ikibazo cyo kumira ibinini, ganira n'ikipe yawe y'ubuzima ku buryo bwagufasha, ariko ntuzigere uhindura ibinini ubwabyo.

Ni ngombwa gufata quizartinib hafi y'igihe kimwe buri munsi kugira ngo ugumane urugero rwawo mu maraso yawe. Gushyiraho alarme ya buri munsi cyangwa kubihuza n'igikorwa gisanzwe nk'ukoza amenyo birashobora kugufasha kwibuka.

Bika imiti yawe ahantu hashyushye, kure y'ubushuhe n'ubushyuhe. Uyibike mu gikoresho cyayo cy'umwimerere kandi kure y'abana n'amatungo.

Nzamara Igihe Kingana Gite Ndafata Quizartinib?

Igihe cyo kuvurwa na quizartinib gitandukana cyane ku muntu ku muntu kandi biterwa n'uburyo umubiri wawe wakira neza imiti. Muganga wawe azakurikiza uko urimo utera imbere binyuze mu bipimo by'amaraso bisanzwe na biopsies z'umushongi w'amagufa kugira ngo amenye igihe gikwiye cyo gukoresha imiti.

Abantu benshi bakomeza gufata quizartinib mu mezi menshi kugeza ku myaka myinshi, igihe cyose bigikora neza mu kurwanya kanseri yabo kandi ingaruka zikaba zigikoreshwa. Abarwayi bamwe bashobora kuyifata igihe cyose nk'uburyo bwo gukomeza kuvurwa kugira ngo bagumane kanseri yabo mu gihe cyo gukira.

Umuhanga wawe mu by'indwara ya kanseri azagenzura buri gihe niba imiti ikora neza binyuze mu kugenzura imibare y'uturemangingo tw'amaraso yawe no gushakisha uturemangingo twa kanseri mu mushongi w'amagufa yawe. Niba kanseri yawe yitwara neza, birashoboka ko uzakomeza kuvurwa igihe kirekire.

Ntuzigere uhagarika gufata quizartinib mu buryo butunguranye cyangwa guhindura gahunda yawe yo gufata imiti utabanje kubaza ikipe yawe y'ubuzima. N'iyo wumva umeze neza, imiti iracyashobora kurwanya uturemangingo twa kanseri tutarimo gutera ibimenyetso.

Ni Ibihe Bikorwa Bigaragara Byatewe na Quizartinib?

Kimwe n'imiti yose ivura kanseri, quizartinib ishobora gutera ibikorwa bigaragara, nubwo atari buri wese ubyumva. Ibikorwa bigaragara byinshi birashobora guhangana nabyo hakoreshejwe uburyo bukwiye bwo gukurikirana no gufashwa n'ikipe yawe y'ubuzima.

Dore ibikorwa bigaragara bisanzwe ushobora guhura nabyo mugihe ufata quizartinib:

• Kuruka no kuruka
• Impiswi cyangwa guhagarara kw'amara
• Kunanirwa no gucika intege
• Kugabanya ubushake bwo kurya
• Urubavu n'ububabare bwo mu ngingo
• Umutwe
• Urugero
• Impinduka z'uburyohe

Ibi bikorwa bigaragara bisanzwe akenshi biragenda bikemuka umubiri wawe umaze kumenyera umuti. Ikipe yawe y'ubuzima irashobora gutanga ingamba n'imiti yo gufasha guhangana n'ibi bimenyetso neza.

Ibikorwa bigaragara bikomeye birashobora kubaho, nubwo bitamenyerewe. Ni ngombwa kumenya ibi kugirango ushobore gushaka ubufasha bw'ubuvuzi vuba niba bibaye ngombwa:

• Ibibazo by'umutima (QT yongera)
• Indwara zikomeye ziterwa n'umubare muto w'uturemangingo twera tw'amaraso
• Gushirira cyangwa gukomeretsa bitewe n'umubare muto w'uturemangingo tw'amaraso
• Ibibazo by'umwijima
• Kuguma kw'amazi no kubyimba
• Kugorana guhumeka
• Ibikorwa bikomeye byo ku ruhu

Muganga wawe azagukurikirana hafi akoresheje ibizamini by'amaraso bisanzwe no gukurikirana umutima kugirango afate ibikorwa bigaragara bikomeye hakiri kare. Abantu benshi barashobora gukomeza kuvurwa neza hamwe n'ubuyobozi bw'ubuvuzi bukwiye.

Ibikorwa bigaragara bidakunze ariko bikomeye birashobora kwishingikiriza ku bibazo bikomeye by'umutima, indwara ziteje ubuzima bw'akaga, cyangwa syndrome ya tumor lysis (igihe selile za kanseri zisenyuka vuba cyane). Nubwo izi ngorane zitamenyerewe, ikipe yawe y'ubuvuzi izareba ibimenyetso byo gutanga umuburo hakiri kare kandi ikore vuba niba bibaye.

Ninde Utagomba Gufata Quizartinib?

Quizartinib ntibereye buri wese, kandi muganga wawe azagenzura neza niba ari wo mwanzuro ukwiriye kuri wowe. Abantu bafite indwara zimwe na zimwe z'umutima ntibashobora kuba bakwiriye guhabwa uyu muti bitewe n'ingaruka ushobora kugira ku mutima.

Ntabwo ukwiriye gufata quizartinib niba ufite allergie izwi kuri uyu muti cyangwa ibikoresho byawo. Muganga wawe azitonda kandi mu kuwugusabira niba ufite ibibazo bikomeye by'umwijima cyangwa impyiko, kuko izi ngingo zifasha mu gutunganya umuti.

Abantu bafite uburwayi bumwe na bumwe bwo gutera kw'umutima, cyane cyane abafite indwara ya long QT syndrome, ntibashobora gufata quizartinib mu buryo bwizewe. Muganga wawe ashobora gukora electrocardiogram (ECG) mbere yo gutangira kuvurwa kugira ngo arebe uko umutima wawe utera.

Kugira inda no konsa ni ibintu by'ingenzi byo kwitaho. Quizartinib ishobora gukomeretsa umwana utaravuka, bityo gukoresha uburyo bwiza bwo kuboneza urubyaro ni ngombwa mugihe uvurwa no mu gihe runaka nyuma yo guhagarika umuti. Niba uri konsa, uzakenera kuganira n'ikipe yawe y'ubuvuzi ku buryo bwo kugaburira umwana.

Muganga wawe azatekereza kandi ku buzima bwawe muri rusange, imiti yindi urimo gufata, n'amateka y'indwara zikomeye mbere yo kugusabira quizartinib. Iyi suzuma ryitondewe rifasha kumenya niba umuti ufite umutekano kandi ukwiriye kubera uko ubuzima bwawe bumeze.

Izina ry'ubucuruzi rya Quizartinib

Quizartinib iboneka ku izina ry'ubucuruzi rya Vanflyta muri Leta Zunze Ubumwe z'Amerika n'ibindi bihugu. Iri ni ryo zina ry'ubucuruzi uzabona ku icupa ry'umuti wawe no ku gipaki cy'umuti.

Uyu muti watejwe imbere na Daiichi Sankyo kandi wemerejwe na FDA mu kuvura FLT3-ITD positive AML. Muganga wawe nakwandikira quizartinib, farumasi izawugusohereza nka Vanflyta keretse niba babisobanuye ukundi.

Imiti ya rusange ya quizartinib ntiraboneka, kuko uyu muti ukiri mushya kandi ukaba ukirinzwe na patenti. Ibi bivuze ko Vanflyta ariyo miti ya quizartinib yonyine iboneka yo kwandikirwa.

Izindi miti isimbura Quizartinib

Hari imiti myinshi isimbura iboneka yo kuvura indwara ya FLT3-positive AML, buri imwe ifite uburyo bwo gukora butandukanye n'ingaruka zayo. Muganga wawe w'inzobere mu kuvura kanseri azagufasha kumenya uburyo bwiza bwakubera mu bihe byawe byihariye.

Midostaurin (Rydapt) ni undi muti uhagarika FLT3 ukunze gukoreshwa hamwe na chimiothérapie mu kuvura indwara ya FLT3-positive AML yamenyekanye vuba. Ikora kimwe na quizartinib ariko ikunze gukoreshwa hakiri kare mu kuvura.

Gilteritinib (Xospata) ni undi muti ugamije kuvura indwara ya FLT3-positive AML ukoreshwa iyo indwara yagarutse cyangwa idakira ku bundi buvuzi. Ikomereza proteyine nyinshi zifite uruhare mu mikurire y'uturemangingo twa kanseri.

Uburyo bwa kera bwo kuvura na chimiothérapie bukomeje kuba uburyo bw'ingenzi bwo kuvura, cyane cyane ku bantu bafite ubuzima bwiza buhagije bwo kwihanganira ubuvuzi bukomeye. Ibi bishobora kuba birimo guhuza cytarabine na anthracyclines.

Guterwa uturemangingo tw'imitsi ishobora kuzitwa ku barwayi bamwe, cyane cyane urubyiruko rufite ubuzima bwiza muri rusange. Ubu buvuzi bukomeye bushobora gukiza indwara ya AML ariko bisaba guhitamo abarwayi neza no kubategura.

Muganga wawe azatekereza ku bintu nk'imyaka yawe, ubuzima muri rusange, ubuvuzi bwakozwe mbere, n'imiterere yihariye ya genetike ya leukemia yawe igihe asaba izindi miti isimbura quizartinib.

Ese Quizartinib iruta Midostaurin?

Quizartinib na midostaurin ni imiti ihagarika FLT3 ikora neza, ariko akenshi ikoreshwa mu bihe bitandukanye aho guhuzwa. Guhitamo

Midostaurin ikoreshwa cyane nk'igice cy'imiti y'ibanze yo kuvura abarwayi bashya bafite indwara ya FLT3-positive AML, akenshi ivanze n'imiti isanzwe ya kanseri. Byagaragaye ko ituma abarwayi baramba iyo yongerewe ku miti isanzwe.

Quizartinib, ku rundi ruhande, ikoreshwa cyane cyane mu kuvura abarwayi basubiye mu burwayi cyangwa batitabira imiti ya FLT3-positive AML. Yagenewe gukoreshwa mu gihe kanseri yagarutse nyuma yo kuvurwa cyangwa ititabiriye neza izindi miti.

Mu bijyanye n'ubushobozi, imiti yombi yagaragaje ibyiza bikomeye mu igeragezwa ryo kwa muganga. Quizartinib yagaragaje imbaraga zikomeye cyane ku mpinduka zimwe na zimwe za FLT3 kandi ishobora kugira imbaraga kurushaho mu bushakashatsi bumwe na bumwe bwo mu laboratori.

Uburyo imiti yombi igira ingaruka zitandukanye. Nubwo zombi zishobora gutera ingaruka zimwe na zimwe zisanzwe nk'isuka no kunanirwa, zishobora kugira ibyago bitandukanye byo guteza ibibazo bikomeye nk'ibibazo by'umutima cyangwa indwara zandura.

Umuvuzi wawe w'indwara ya kanseri azatekereza ku mateka yawe y'imiti, uko ubuzima bwawe buhagaze ubu, n'imiterere yihariye ya kanseri yawe mu guhitamo hagati y'iyi miti. Icyemezo ntigishingiye ku cyemezo cy'uko ni iyihe

Abantu bafite uburwayi bw'umutima butandukanye bashobora kutaba abakandida ba quizartinib, ariko abafite indwara z'umutima zigenzurwa neza bashobora gukomeza kuyifata neza hamwe no gukurikiranwa neza.

Nkwiriye gukora iki niba mfashe quizartinib nyinshi ku buryo butunguranye?

Niba ufata quizartinib nyinshi ku buryo butunguranye kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Ntukegere ngo urebe niba ibimenyetso bigaragara, kuko kwitabwaho kwa muganga vuba ni ingenzi.

Kufata quizartinib nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane ibibazo by'umutima. Itsinda ryawe ry'abaganga rishobora kwifuza kugukurikirana neza kandi rishobora gukora ibizamini byinshi nk'ikizamini cy'umutima.

Kugirango wirinde gufata imiti myinshi ku buryo butunguranye, bika imiti yawe mu gikoresho cyayo cy'umwimerere hamwe n'inyandiko zisobanutse, kandi ushobora gukoresha igikoresho cyo gutegura imiti niba ufata imiti myinshi. Ntukigere wongera doze niba wibagiwe imwe.

Nkwiriye gukora iki niba nibagiwe gufata doze ya quizartinib?

Niba wibagiwe doze ya quizartinib, yifate ako kanya wibuka, keretse igihe cyegereye doze yawe itaha iteganyijwe. Muricyo gihe, reka doze wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata doze ebyiri icyarimwe kugirango usimbuze doze wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka. Niba utazi neza igihe, vugana n'umuganga wawe kugirango akuyobore.

Gushyiraho ibyibutso bya buri munsi kuri terefone yawe cyangwa guhuza imiti yawe n'igikorwa gisanzwe birashobora kugufasha kwibuka gufata quizartinib buri gihe. Gufata imiti buri gihe ni ingenzi kugirango ugumane urwego ruzima mu mubiri wawe.

Nshobora kureka gufata quizartinib ryari?

Wagombye kureka gufata quizartinib gusa mugihe umuganga wawe w'indwara z'umutima abona ko bikwiye kubikora. Iyi myanzuro izashingira ku buryo imiti igenzura neza leukemia yawe niba urimo guhura n'ingaruka zicungwa.

Abantu bamwe bashobora gukenera gufata quizartinib mu mezi cyangwa imyaka, mu gihe abandi bashobora kwimukira ku zindi miti cyangwa bakagera ku gukira mu gihe kirekire. Muganga wawe azakoresha ibizamini by'amaraso bisanzwe no gusuzuma umushongi w'amagufa kugira ngo agufashe gufata izo myanzuro.

Ntuzigere uhagarika gufata quizartinib ku bushake bwawe, n'iyo wumva umeze neza. Umuti ushobora kuba ugihanganye n'uturemangingo twa kanseri, kandi guhagarara mu buryo butunguranye byatuma leukemia yawe igaruka cyangwa ikiyongera.

Nshobora gufata indi miti nkanwa quizartinib?

Imiti myinshi ishobora gukururana na quizartinib, bityo ni ngombwa kubwira umuganga wawe ibijyanye n'imiti yose, ibyongerera imbaraga, n'ibicuruzwa by'ibyatsi urimo gufata. Gukururana kumwe bishobora kugira ingaruka ku buryo quizartinib ikora neza cyangwa bikongera ibyago byo kugira ingaruka ziterwa n'iyo miti.

Imiti imwe na rimwe igira ingaruka ku mutima ikwiye gukoreshwa witonze cyane cyangwa ikirindwa rwose mugihe ufata quizartinib. Muganga wawe azasuzuma urutonde rw'imiti yawe neza kandi ashobora gukenera guhindura cyangwa gusimbuza imiti imwe.

Buri gihe banuza umuganga wawe mbere yo gutangira imiti mishya, harimo imiti itangwa nta tegeko rya muganga n'ibyongerera imbaraga. Bashobora kugufasha gusobanukirwa n'uburyo bishobora gukururana no kumenya neza ko imiti yawe ikomeza kuba myiza kandi ikora neza.