Rasagiline ni iki: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Rasagiline ni umuti wandikirwa na muganga ufasha mu gucunga ibimenyetso bya indwara ya Parkinson, binyuze mu kubuza imyunyu ngugu yangiza dopamine mu bwonko bwawe. Uyu muti woroshye ariko ukora neza ukora mu buryo butagaragara kugira ngo ufashishe kubungabunga dopamine ubwonko bwawe bukeneye kugira ngo bigende neza kandi bihuzagurike.

Niba wowe cyangwa umuntu witaho yarandikiwe rasagiline, birashoboka ko uri gushaka amakuru asobanutse kandi y'ukuri ku byo witegura. Reka tunyure mu bintu byose ukeneye kumenya kuri uyu muti mu buryo bumvikana kandi butanga icyizere.

Rasagiline ni iki?

Rasagiline ni mu cyiciro cy'imiti yitwa MAO-B inhibitors, bivuze ko ibuza imyunyu ngugu yihariye mu bwonko bwawe yitwa monoamine oxidase type B. Uyu munyu ngugu usanzwe wangiza dopamine, ubutumwa bwa kemikali bufasha kugenzura imigendekere n'imikoranire.

Mu kubuza uyu munyu ngugu mu buryo bworoheje, rasagiline ifasha kugumisha dopamine nyinshi mu bwonko bwawe. Tekereza nk'ifasha ubwonko bwawe gufata dopamine bugikora, aho kubuhatira gukora nyinshi.

Uyu muti ufatwa nk'ubuvuzi bufite imbaraga ziringaniye. Ntabwo ikomeye nka levodopa, ariko itanga ubufasha buhoraho kandi buhamye abantu benshi basanga bifasha mu gucunga ibimenyetso byabo.

Rasagiline ikoreshwa mu iki?

Rasagiline ikoreshwa cyane cyane mu kuvura indwara ya Parkinson, haba nk'ubuvuzi bwonyine mu ntangiriro ndetse no nk'ubuvuzi bwongerwa iyo ikoreshejwe hamwe n'indi miti. Muganga wawe ashobora kuyigushyiriraho niba urimo guhura n'ingorane zo kugenda, umubiri ugoye cyangwa guhinda umushyitsi bifitanye isano n'indwara ya Parkinson.

Mu ntangiriro ya indwara ya Parkinson, rasagiline irashobora gufasha gutinda gukenera imiti ikomeye mugihe itanga ubufasha ku bimenyetso. Iyo Parkinson igenda ikura, akenshi ivangwa na levodopa kugira ngo ifashe kunoza ibibazo bishobora kubaho hamwe n'uwo muti.

Abaganga bamwe na bo bandika rasagiline ku buryo butemewe n'amategeko ku zindi ndwara zifitanye isano na dopamine, nubwo ibyo bidakunze kubaho. Umuganga wawe azemeza niba uyu muti ukwiriye imiterere yawe yihariye.

Rasagiline ikora ite?

Rasagiline ikora ibuza mu buryo bwihariye enzyme ya MAO-B mu bwonko bwawe, ikaba ishinzwe gusenya dopamine. Iyo iyi enzyme yabuze, urwego rwa dopamine ruguma rumeze neza umunsi wose.

Ubu buryo bubaho buhoro buhoro kandi buke. Ntabwo uzumva umuvuduko wihuse cyangwa impinduka zikomeye nkuko byagenda ku yindi miti. Ahubwo, rasagiline itanga ubufasha buhoro buhoro bwubaka uko igihe kigenda.

Uyu muti kandi ushobora kugira ingaruka zo kurinda ku ngingo z'imitsi, nubwo abashakashatsi bakiri gukora ubushakashatsi kuri iyi nyungu ishoboka. Icyo tuzi neza ni uko bifasha gukomeza urwego rwa dopamine mu buryo bufasha imyitozo myiza no guhuza ibikorwa.

Nkwiriye gufata rasagiline nte?

Rasagiline ikunze gufatwa rimwe ku munsi, akenshi mu gitondo hamwe n'ibiryo cyangwa nta biryo. Urutonde rusanzwe rutangirirwaho ni 0.5 mg, umuganga wawe ashobora kongera kuri 1 mg ku munsi bitewe n'uburyo ubyakira n'ibyo ukeneye.

Ushobora gufata uyu muti n'amazi, kandi ntacyo bitwaye niba umaze kurya. Ariko, abantu bamwe basanga byoroshye kwibuka igihe bawufatiye hamwe n'ifunguro rya mu gitondo cyangwa izindi gahunda zisanzwe zo mu gitondo.

Gerageza gufata rasagiline ku gihe kimwe buri munsi kugirango ugumane urwego rumeze neza mu mubiri wawe. Niba uyifata hamwe n'indi miti ya Parkinson, umuganga wawe azatanga amabwiriza yihariye yo gukoresha neza uko bakorana.

Jya umira urupapuro rwose aho kurukata cyangwa kurumata. Ibi bituma umuti usohoka neza mu mubiri wawe.

Nkwiriye gufata rasagiline igihe kingana iki?

Rasagiline akenshi ni umuti umara igihe kirekire uzakomeza gufata igihe cyose ukiri ingirakamaro ku bimenyetso byawe. Abantu benshi barwaye indwara ya Parkinson bayifata amezi cyangwa imyaka, kuko yagenewe gutanga ubufasha buhoraho aho gukemura ikibazo vuba.

Muganga wawe azagenzura uko umuti ukora neza kuri wowe mugihe cyo kugenzura buri gihe. Bazareba uko ibimenyetso byawe byitwara niba urimo guhura n'ingaruka zose zirenga inyungu.

Abantu bamwe bafata rasagiline imyaka myinshi bafite ibisubizo byiza, mugihe abandi bashobora gukenera guhindura gahunda yabo yo kuvurwa uko ubuzima bwabo buhinduka. Ikintu cyingenzi nukugirana imikoranire myiza n'ikipe yawe y'ubuzima kubijyanye nuko wumva.

Ni izihe ngaruka ziterwa na Rasagiline?

Kimwe n'imiti yose, rasagiline irashobora gutera ingaruka, nubwo abantu benshi bayihanganira neza. Kumva icyo witegura birashobora kugufasha kumva witeguye kandi ufite icyizere kubijyanye n'ubuvuzi bwawe.

Ingaruka zisanzwe ni zoroshye kandi akenshi zinozwa mugihe umubiri wawe wimenyereza umuti:

• Umutwe
• Urubavu cyangwa umubyimba w'ingingo
• Kutagira igogora cyangwa kurwara inda
• Ibimenyetso bisa na grip
• Kugira agahinda gakabije cyangwa guhinduka kw'amarangamutima
• Urugero
• Umunwa wumye

Izi ngaruka zisanzwe za buri munsi akenshi ntizisaba guhagarika umuti, ariko ugomba kubiganiraho na muganga wawe niba bibaye bibangamiye cyangwa bihoraho.

Ingaruka zitagaragara cyane ariko zikomeye zirashobora kubaho, nubwo zikora ku bantu bake:

• Igihe cyo gusinzira gitunguranye mugihe cy'imirimo ya buri munsi
• Kugira ibitekerezo cyangwa urujijo
• Uruhu rukabije cyangwa ibibara
• Ibyifuzo bidasanzwe cyangwa imyitwarire (gukina urusimbi, kugura, kurya)
• Guhinduka gukomeye kw'umuvuduko w'amaraso
• Urubavu mu gituza cyangwa umutima utagira gahunda

Niba wumva ibi bimenyetso bikomeye, vugana n'umuganga wawe ako kanya. Ashobora kugufasha kumenya niba umuti ugomba guhindurwa cyangwa guhagarikwa.

Mu buryo butavugwa cyane, rasagiline ishobora gukorana n'ibiryo bimwe na bimwe birimo tyramine nyinshi (nk'amakeke ashaje cyangwa inyama zitunganyirijwe) cyangwa indi miti kugira ngo itere umuvuduko mwinshi w'amaraso. Muganga wawe azatanga amabwiriza yihariye y'imirire niba bibaye ngombwa.

Ninde utagomba gufata Rasagiline?

Rasagiline ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Indwara zimwe na zimwe n'imiti bishobora gutuma rasagiline idatekanye cyangwa idakora neza.

Ntabwo ugomba gufata rasagiline niba ukoresha imiti imwe na rimwe yo kurwanya depression, cyane cyane MAOIs, SSRIs, cyangwa SNRIs. Ubu buryo bushobora gutera imikoranire iteye akaga igira ingaruka ku mitsi yawe y'amaraso n'ubwonko.

Abantu barwaye indwara zikomeye z'umwijima bagomba kwirinda rasagiline kuko umwijima utunganya uyu muti. Muganga wawe ashobora gutegeka ibizamini by'imikorere y'umwijima mbere yo gutangira kuvurwa kugira ngo yemeze ko bitekanye kuri wowe.

Iindi miti idakora neza na rasagiline irimo:

• Meperidine (pethidine) n'indi miti yo kurwanya ububabare ya opioid
• Dextromethorphan (iboneka mu miti yo gukingira inkorora)
• St. John's wort
• Tramadol
• Antibiyotike zimwe na zimwe nka linezolid

Buri gihe bwire muganga wawe ku miti yose, ibyongerera imbaraga, n'ibicuruzwa by'ibyatsi ukoresha. Ibi birimo imiti igurishwa idakeneye uruhushya rwa muganga ishobora kugaragara nk'itari mbi ariko ishobora gukorana na rasagiline.

Amazina y'ubwoko bwa Rasagiline

Rasagiline iboneka munsi y'izina ry'ubwoko bwa Azilect, ryo rikaba ari ryo rikoreshwa cyane. Ubwoko bwa rasagiline bwa generic buraboneka kandi bukora kimwe neza nk'umuti w'izina ry'ubwoko.

Isositeri yawe ishobora kugira izina ry'ubwoko cyangwa verisiyo rusange, bitewe n'ubwishingizi bwawe n'ibyo ukunda. Zombi zirimo ibintu bikora kimwe kandi bikora kimwe.

Niba uhindura hagati y'ubwoko n'ubwoko rusange, cyangwa hagati y'abakora ibicuruzwa bitandukanye, bimenyeshe muganga wawe. Nubwo bidasanzwe, abantu bamwe babona itandukaniro rito mu buryo bumva, kandi muganga wawe ashobora gufasha gukurikirana uko witwara.

Izindi nzira zishobora gusimbura Rasagiline

Imiti myinshi ishobora kuvura indwara ya Parkinson niba rasagiline itagukwiriye cyangwa ikareka gukora neza. Muganga wawe ashobora gutekereza izi nzira zishobora gusimbura bitewe n'ibimenyetso byawe byihariye n'amateka yawe y'ubuvuzi.

Izindi MAO-B inhibitors zirimo selegiline, ikora kimwe na rasagiline ariko ifatwa kabiri ku munsi. Abantu bamwe babaho neza hamwe n'imwe kurusha iyindi, akenshi bitewe n'ingaruka ziterwa cyangwa ibyo bakunda.

Dopamine agonists nka pramipexole, ropinirole, cyangwa rotigotine (iboneka nka patch) bikora mu buryo butandukanye binyuze mu gushishikariza imiterere ya dopamine. Izi zirashobora kuba izindi nzira zishobora gukora neza, cyane cyane mu ntangiriro ya indwara ya Parkinson.

Kubimenyetso byateye imbere cyane, levodopa ikomeza kuba umuti wa zahabu. Akenshi ihuzwa na carbidopa kugirango igabanye ingaruka ziterwa no kunoza imikorere. Muganga wawe ashobora kubikugiraho inama niba rasagiline yonyine itatanga uburyo bwo kugenzura ibimenyetso bihagije.

Ese Rasagiline iruta Selegiline?

Rasagiline na selegiline ni MAO-B inhibitors zikora kimwe, ariko zifite itandukaniro rikomeye rishobora gutuma imwe ikwemerera kurusha iyindi.

Rasagiline ifatwa rimwe ku munsi, mugihe selegiline ikunze gufatwa kabiri ku munsi. Ibi birashobora gutuma rasagiline yoroha kubantu benshi, cyane cyane abamaze gukoresha imiti myinshi.

Ubushakashatsi bumwe buvuga ko rasagiline ishobora kugirana imikoranire micye n'ibiryo birimo tyramine, nubwo imiti yombi muri rusange isaba kumenya ibyo kurya. Rasagiline kandi ikunda kugira ingaruka zizwi neza ku bantu benshi.

Selegiline imaze igihe kinini iboneka kandi ifite amakuru menshi yerekeye umutekano mu gihe kirekire, ibyo abaganga bamwe bakunda. Ariko, rasagiline akenshi itera imbogamizi nkeya zo gusinzira kuko itavungurwa ikavamo ibintu bisa na amphetamine.

Umuvuzi wawe azatekereza ku murimo wawe wa buri munsi, imiti yindi ukoresha, n'ibyo ukunda mu guhitamo hagati y'izi mpuzanzira. Nta na rimwe riruta irindi - biterwa n'icyo gikora neza ku miterere yawe bwite.

Ibikunze Kubazwa Kuri Rasagiline

Ese Rasagiline irakwiriye ku bantu barwaye indwara z'umutima?

Rasagiline irashobora gukoreshwa neza ku bantu benshi bafite indwara z'umutima, ariko bisaba gukurikiranwa neza. Uyu muti rimwe na rimwe ushobora kugira ingaruka ku mitsi y'amaraso n'umuvuduko w'umutima, bityo umuganga wawe azashaka gusuzuma amateka yawe y'umutima neza.

Niba ufite indwara y'umutima ifashwe neza, rasagiline irashobora kuba igisubizo hamwe n'ubuvuzi bukwiriye. Umuvuzi wawe ashobora gushimangira ko ukora ibizamini kenshi cyangwa gukurikiranwa kw'umutima mugihe utangiye uyu muti.

Abantu bafite umuvuduko w'amaraso mwinshi udakontroliwe cyangwa bagize ibitero by'umutima vuba aha bashobora gukenera kwirinda rasagiline cyangwa kuyikoresha bitonze cyane. Buri gihe ganira ku mateka yawe yose y'umutima n'umuganga wawe mbere yo gutangira umuti mushya uwo ari wo wose.

Nkwiriye gukora iki niba mfunguye rasagiline ku buryo butunguranye?

Niba ufata rasagiline nyinshi kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe gukumira uburozi ako kanya. Guhura na nyinshi bishobora gutera impinduka ziteje akaga ku mitsi y'amaraso, kubabara umutwe cyane, cyangwa ibindi bimenyetso bikomeye.

Ntugategereze kureba niba ibimenyetso bizagaragara – shakisha inama z'abaganga ako kanya. Kugira urupapuro rw'imiti hamwe nawe birashobora gufasha abaganga kumenya neza urugero wanyoye no gutanga ubuvuzi bukwiye.

Kugirango wirinde kunywa imiti irenze urugero, tekereza gukoresha agasanduku k'imiti cyangwa gushyiraho ibyibutsa kuri terefone. Niba urera umuntu ufite ibibazo byo kwibuka, mufashe gushyiraho gahunda y'imiti itekanye.

Nkwiriye gukora iki niba nciwe urugero rwa Rasagiline?

Niba wibagiwe urugero rwa rasagiline, yifate uko wibuka, keretse igihe cyegereje urugero rwawe ruteganyijwe. Muri urwo rubanza, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero ebyiri icyarimwe kugirango usubize urugero wibagiwe. Ibi birashobora kongera ibyago byo kugira ingaruka zidakurikije, bitagize icyo byongera ku nyungu.

Niba ukunda kwibagirwa urugero, gerageza guhuza imiti yawe n'akazi ka buri munsi nko kumesa amenyo cyangwa kurya ifunguro rya mu gitondo. Guhora bikomeza urugero rwa imiti mu mubiri wawe.

Nshobora guhagarika ryari gufata Rasagiline?

Wagombye guhagarika gufata rasagiline gusa ukurikije ubuyobozi bw'umuganga wawe. Guhagarika ako kanya ntizatera ibimenyetso byo gukurwaho biteye akaga, ariko ibimenyetso byawe bya Parkinson bishobora kugaruka cyangwa bikiyongera bitagize ubufasha bw'imiti.

Umuganga wawe ashobora kugusaba guhagarika rasagiline niba ufite ingaruka zikomeye, niba itagifasha ibimenyetso byawe, cyangwa niba uhinduye uburyo bwo kuvura.

Abantu bamwe bashobora kugabanya buhoro buhoro urugero rwabo mbere yo guhagarika burundu, mu gihe abandi bashobora guhagarara ako kanya hashingiwe ku nama z'umuganga wabo. Ikintu cy'ingenzi ni ukugira gahunda yo gucunga ibimenyetso byawe mugihe cy'inzibacyuho.

Nshobora kunywa inzoga niba mfata Rasagiline?

Kunywa inzoga mu rugero ruciriritse muri rusange birakwemerwa mugihe ufata rasagiline, ariko ugomba kubiganiraho na muganga wawe mbere na mbere. Inzoga irashobora gukurikiranwa n'imiti ndetse n'ibimenyetso bya indwara ya Parkinson muburyo butandukanye ku muntu kumuntu.

Abantu bamwe basanga inzoga ituma ibimenyetso byabo byo kwimuka birushaho cyangwa bikongera isereri mugihe bivanzwe na rasagiline. Abandi bashobora kubona ko kwihanganira inzoga bisanzwe byahindutse kuva batangira imiti.

Niba muganga wawe yemeye gukoresha inzoga rimwe na rimwe, tangira n'utuntu duto kugirango urebe uko umubiri wawe witwara. Uhora ushyira imbere umutekano wawe kandi wirinda inzoga niba ubonye uburyo ubwo aribwo bwose buteye impungenge cyangwa ibimenyetso byiyongereye.