Safinamide ni iki: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Safinamide ni umuti wandikirwa na muganga ufasha mu gucunga ibimenyetso bya indwara ya Parkinson iyo ukoreshejwe hamwe n'izindi nshuti. Ujya mu cyiciro cy'imiti yitwa MAO-B inhibitors, ikora ibyo ikingira enzyme isenya dopamine mu bwonko bwawe. Ibi bifasha mu gukomeza urwego rwa dopamine ruri hejuru, ibi bishobora kunoza ibibazo byo kugenda no kugabanya ibihe bya "off" igihe umuti wawe wa Parkinson utagikora neza.

Safinamide ni iki?

Safinamide ni umuti mushya wagenewe gufasha abantu barwaye indwara ya Parkinson. Ikora nk'ubuvuzi bwongerwa, bivuze ko uzayifata hamwe n'imiti yawe ya Parkinson isanzwe aho kuyisimbuza. Uyu muti ufite imikorere yihariye - ntabwo gusa ukingira enzyme ya MAO-B ahubwo unagira ingaruka ku bikorwa bya glutamate mu bwonko bwawe, bishobora gutanga inyungu zinyongera ku kugenzura imigendekere.

Uyu muti ufatwa nk'ubuvuzi bufite imbaraga ziringaniye mu bikoresho bya Parkinson. Ntabwo ifite imbaraga nka levodopa, ariko ishobora gutanga impinduka zifatika mu mikorere ya buri munsi no mu mibereho myiza. Abaganga benshi barayandika iyo abarwayi batangira guhura n'ibihe bya "off" kenshi cyangwa iyo imiti yabo isanzwe ikeneye kongerwa imbaraga.

Safinamide ikoreshwa mu iki?

Safinamide ikoreshwa cyane cyane mu kuvura indwara ya Parkinson nk'ubuvuzi bwongerwa kuri levodopa/carbidopa. Muganga wawe ashobora kuyigushyiriraho niba uhura n'imihindagurikire ya moteri, ari byo bihe umuti wawe nyamukuru ugenda ukavaho ibimenyetso byawe bigaruka. Ibi bihe bya "off" bishobora kurambya kandi bigira ingaruka ku bikorwa byawe bya buri munsi.

Uyu muti ufasha cyane abantu bari mu byiciro byo hagati n'ibya nyuma by'indwara ya Parkinson. Ushobora gufasha kunoza imikorere y'ibimenyetso by'indwara umunsi wose. Abandi barwayi basanga bifasha kugabanya dyskinesia, ari zo ngendo zitunguranye zishobora kubaho nk'ingaruka yo gukoresha levodopa igihe kirekire.

Safinamide ikora ite?

Safinamide ikora ibuza enzyme yitwa MAO-B, isanzwe isenya dopamine mu bwonko bwawe. Mu kubuza iyi enzyme, dopamine nyinshi iguma kuboneka kugira ngo selile z'ubwonko bwawe zikoreshe. Ibi ni ingenzi cyane mu ndwara ya Parkinson, aho selile zikora dopamine zigenda zitakara buhoro buhoro.

Igituma safinamide idasanzwe ni uburyo bwa kabiri ikoramo. Inabuzwa imiyoboro ya sodium kandi igabanya irekurwa rya glutamate, rishobora gufasha kurengera selile z'ubwonko no kunoza imikorere y'ingendo. Ubu buryo bubiri bushobora gusobanura impamvu abarwayi bamwe babona inyungu zirenze izo babona mu bindi bice bya MAO-B.

Uyu muti ufatwa nk'ukomeye ku rugero rwo hagati ugereranije n'izindi nshuti za Parkinson. Ntabwo ikomeye nka levodopa, ariko ishobora gutanga impinduka zikomeye iyo ikoreshejwe neza. Abantu benshi barwaye babona impinduka buhoro buhoro mu byumweru byinshi aho guhinduka cyane ako kanya.

Nkwiriye gufata safinamide nte?

Fata safinamide nk'uko muganga wawe abitegeka, akenshi rimwe ku munsi hamwe n'ibiryo cyangwa nta biryo. Uyu muti uza mu buryo bw'ibinini kandi ugomba kumezwa wose hamwe n'amazi. Ntabwo ukeneye kuwufata n'amata cyangwa ibiryo byihariye, ibyo bituma byoroha kubishyira mu murimo wawe wa buri munsi.

Abaganga benshi batangira abarwayi ku gipimo gito hanyuma bakagikuriza buhoro buhoro bitewe n'uko ubasha kwakira no kwihanganira uyu muti. Fata ku gihe kimwe buri munsi kugira ngo ugumane urwego ruhamye mu mubiri wawe. Niba uwufata mu gitondo, komereza ku gipimo cyo mu gitondo mu gihe cyose uvurwa.

Ushobora gufata safinamide urya cyangwa utarya, ariko gerageza kubigira akamenyero. Abantu bamwe basanga kuyifata barya bibafasha kwirinda kuribwa mu nda, mu gihe abandi bakunda kuyifata batariye. Nta mbogamizi zihariye zirebana n'imirire, ariko kugira imirire yuzuye bishobora gufasha gahunda yawe y'ubuvuzi.

Nzamara Mfata Safinamide Igihe Kingana Gite?

Safinamide akenshi ni umuti ufashwa igihe kirekire uzakomeza gufata igihe cyose ugufitiye akamaro kandi ukawihanganira neza. Abantu benshi barwaye indwara ya Parkinson bakeneye gufata imiti yabo igihe cyose, kuko iyi ndwara ikomeza kandi ni ihoraho. Muganga wawe azagenzura uko ubyitwaramo kandi ahindure gahunda yawe y'ubuvuzi uko igihe kigenda gihita.

Akamaro kose ka safinamide gashobora gutwara ibyumweru byinshi kugira ngo bigaragarire. Abarwayi bamwe babona impinduka mu kwezi kwa mbere, mu gihe abandi bashobora gukenera amezi atatu kugira ngo bumve ingaruka zose. Ibi bigenda buhoro ni ibisanzwe kandi ntibisobanura ko umuti utari gukora.

Muganga wawe azajya agenzura buri gihe niba safinamide ikomeje kugufasha mu bihe byawe byihariye. Niba ibimenyetso bya Parkinson bihinduka cyangwa niba uhuye n'ingaruka ziteye ikibazo, bashobora guhindura urugero rwawe cyangwa bagatekereza ku zindi miti. Ntukigere uhagarika gufata safinamide mu buryo butunguranye utabanje kubaza umuganga wawe, kuko ibi bishobora gutuma ibimenyetso byawe birushaho kuba bibi.

Ni Iyihe Ngaruka Ziterwa na Safinamide?

Kimwe n'indi miti yose, safinamide ishobora gutera ingaruka, nubwo abantu benshi bayihanganira neza. Ingaruka zisanzwe ni nto kandi akenshi zirushaho gukira uko umubiri wawe umenyera umuti. Kumenya icyo witegura bishobora kugufasha kumva witeguye kandi ufite icyizere ku buvuzi bwawe.

Dore ingaruka zivugwa cyane abarwayi bahura nazo:

• Uburwayi bwo kuruka no kuribwa mu nda
• Kuribwa umutwe cyangwa kumva uruhuka
• Umutwe
• Kugorana gusinzira cyangwa kurota inzozi zigaragara
• Kuzamuka kw'imitsi idashaka (dyskinesia)
• Kunanirwa cyangwa kumva unaniwe
• Ukwima kw'ifumbire
• Umunwa wumye

Ibi bimenyetso rusange byo ku ruhande mubisanzwe birashoboka kandi bishobora kugabanuka uko igihe kigenda. Guha umuti hamwe n'ibiryo birashobora gufasha kugabanya kuruka, kandi kuguma ufite amazi ahagije birashobora gufasha umunwa wumye no kwima ifumbire.

Ibyo bitagaragara cyane ariko bikomeye byo ku ruhande bisaba ubufasha bwihuse bw'abaganga. Nubwo ibi bibaho ku gice gito cy'abarwayi, ni ngombwa kubimenya:

• Umubyibuho ukabije w'amaraso, cyane cyane niba urya ibiryo birimo tyramine nyinshi
• Igihe gito cyo gusinzira mu gihe cy'imirimo ya buri munsi
• Kurota cyangwa kuvurungana
• Impinduka zikomeye z'imitekerereze cyangwa agahinda gakabije
• Uburibwe mu gituza cyangwa ibibazo by'umutima
• Ibimenyetso bikomeye byo ku ruhu cyangwa ibibara
• Ibimenyetso by'ibibazo by'umwijima nk'uruhu cyangwa amaso y'umuhondo

Vugana n'umuganga wawe ako kanya niba ubonye kimwe muri ibi bimenyetso bikomeye byo ku ruhande. Barashobora gufasha kumenya niba umuti ukeneye guhindurwa cyangwa guhagarikwa.

Ninde utagomba gufata Safinamide?

Safinamide ntabwo ari nziza kuri buri wese, kandi umuganga wawe azasuzuma neza amateka yawe mbere yo kuyandika. Indwara zimwe na zimwe n'imiti birashobora guhura nabi na safinamide, bityo ni ngombwa gutanga amakuru yuzuye yerekeye ubuzima bwawe.

Abantu bafite ibi bibazo mubisanzwe bagomba kwirinda safinamide cyangwa bakayikoresha bitonze cyane:

• Indwara ikomeye y'umwijima cyangwa kunanirwa kw'umwijima
• Amateka y'ibibazo by'amaso cyangwa macular degeneration
• Indwara ikomeye y'impyiko
• Amateka ya psychose cyangwa ibibazo bikomeye by'ubuzima bwo mu mutwe
• Umubyibuho w'amaraso utagenzurwa
• Amateka ya stroke cyangwa indwara zikomeye z'umutima n'imitsi

Muganga wawe azakenera kumenya imiti yose urimo gufata, kuko safinamide ishobora gukururana n'imiti myinshi. Ibi bikubiyemo imiti yandikwa na muganga, imiti igurishwa itagombye uruhushya, n'imiti ikomoka ku bimera.

Gutwita no konsa bisaba kwitonderwa by'umwihariko. Nubwo hari amakuru make ku mikoreshereze ya safinamide mu gihe cyo gutwita, muganga wawe azagereranya inyungu zishoboka n'ibishobora kuba byatera. Niba uteganya gutwita cyangwa uri konsa, ganira na muganga wawe mbere yo gutangira kuvurwa.

Amazina ya Safinamide y'ubwoko

Safinamide iboneka ku izina ry'ubwoko rya Xadago muri Leta Zunze Ubumwe z'Amerika no mu bindi bihugu byinshi. Iyi ni yo miti ikoreshwa cyane kandi ushobora guhura nayo muri farumasi yawe. Uyu muti ukorwa n'amasosiyete menshi y'imiti hashingiwe ku masezerano yo gutanga uruhushya.

Mu turere tumwe na tumwe, safinamide ishobora kuboneka ku mazina y'ubwoko atandukanye cyangwa nk'ubwoko bwa rusange. Umufarumasiti wawe ashobora kugufasha kumenya uburyo bwihariye urimo guhabwa kandi akemeza ko urimo guhabwa umuti ukwiye. Buri gihe jya ureba na muganga wawe niba ubonye impinduka iyo ari yo yose ku isura cyangwa ku ipaki y'umuti wawe.

Uburyo bwo gusimbuza Safinamide

Niba safinamide itagukwiriye cyangwa itatanga inyungu zihagije, imiti myinshi isimbura ishobora gufasha mu gucunga ibimenyetso bya indwara ya Parkinson. Muganga wawe ashobora gutekereza ku bindi bice bya MAO-B, imiti ikora kuri dopamine, cyangwa ibice bya COMT bitewe n'ibyo ukeneye byihariye n'amateka yawe y'ubuvuzi.

Ibindi bice bya MAO-B birimo selegiline na rasagiline, bikora kimwe na safinamide ariko bifite ingaruka zitandukanye. Imiti ikora kuri dopamine nka pramipexole na ropinirole itera mu buryo butaziguye imyakura ya dopamine kandi ishobora kuba imiti yongerwa. Ibice bya COMT nka entacapone bifasha kongera ingaruka za levodopa mu kubuza ko isenyuka.

Uburyo bwo guhitamo bujyana n'ibimenyetso byawe, imiti yindi urimo gufata, n'uburyo wihanganira ingaruka zitandukanye. Muganga wawe azakorana nawe kugirango abone uburyo buzafasha cyane mu kuvura ibibazo byawe byihariye.

Ese Safinamide iruta Rasagiline?

Safinamide na rasagiline zombi ni MAO-B inhibitors zikoreshwa mu kuvura indwara ya Parkinson, ariko zifite itandukaniro rikomeye. Safinamide ni nshya kandi ifite uburyo bubiri bwo gukora, ikabuza MAO-B kandi ikagira ingaruka ku nzira ya glutamate. Rasagiline ikora cyane cyane binyuze muri MAO-B inhibition kandi imaze igihe ikoreshwa, bituma abaganga bagira uburambe bwinshi ku ngaruka zayo.

Ubushakashatsi bwerekana ko safinamide ishobora gufasha cyane mu kugabanya igihe cyo

Niba ufite indwara y'umutima yoroheje kandi igenzurwa neza, safinamide iracyashobora kuba igisubizo hamwe no gukurikiranwa neza. Muganga wawe ashobora gushaka kugenzura umuvuduko w'amaraso yawe buri gihe kandi ashobora kugusaba kwirinda ibiryo birimo tyramine nyinshi, bishobora gutera umuvuduko w'amaraso mwinshi iyo bivanzwe n'ibiyobyabwenge bya MAO-B.

Nkwiriye gukora iki niba nanyweye safinamide nyinshi bitunguranye?

Niba unyweye safinamide nyinshi bitunguranye kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya, kabone n'iyo wumva umeze neza. Kunywa safinamide nyinshi bishobora gutera ingaruka zikomeye zirimo umuvuduko w'amaraso mwinshi cyane, isesemi ikabije, urujijo, n'ibibazo by'umutima.

Ntugategereze kureba niba ibimenyetso bigaragara - gufata ingamba hakiri kare ni ngombwa iyo umuntu yarengeje urugero rw'imiti. Bika icupa ry'umuti hamwe nawe igihe ushaka ubufasha kugirango abaganga bamenye neza icyo wanyoye n'urugero wanyoye. Niba urimo guhura n'ibimenyetso bikomeye nk'ububabare mu gituza, guhumeka bigoranye, cyangwa urujijo, hamagara serivisi zihutirwa ako kanya.

Nkwiriye gukora iki niba nirengagije urugero rwa safinamide?

Niba wibagiwe urugero rwa safinamide, unywe ako kanya wibuka, keretse igihe cyegereje cyo gufata urugero rwawe ruteganyijwe. Muri icyo gihe, reka urugero wibagiwe ukomeze gahunda yawe isanzwe yo kunywa imiti. Ntukigere unywa urugero ebyiri icyarimwe kugirango wuzuze urugero wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti.

Gerageza kunywa safinamide ku gihe kimwe buri munsi kugirango ugumane urugero ruri hejuru mu mubiri wawe. Gushyiraho alarme ya buri munsi cyangwa gukoresha umuteguro w'ibipimo birashobora kugufasha kwibuka urugero rwawe. Niba ukunda kwibagirwa urugero, vugana na muganga wawe kuri gahunda zo kunoza imikoreshereze y'imiti.

Nshobora kureka kunywa safinamide ryari?

Ugomba guhagarika gufata safinamide gusa ukurikije ubuyobozi bwa muganga wawe. Guhagarika ako kanya birashobora gutuma ibimenyetso bya Parkinson yawe birushaho kwiyongera vuba, ibyo bikaba bishobora guteza akaga kandi bikagira ingaruka zikomeye ku mibereho yawe. Muganga wawe akenshi azagusaba kugabanya urugero rwa dose buhoro buhoro aho guhagarika ako kanya.

Hariho impamvu nyinshi zituma muganga wawe ashobora kugusaba guhagarika safinamide, harimo ingaruka zikomeye, kutagira akamaro, cyangwa gukenera guhindura imiti itandukanye. Bazakorana nawe kugirango bakore gahunda itekanye yo kuva ku muti mu gihe bakomeza kugenzura ibimenyetso bikwiye hamwe n'ubundi buvuzi.

Nshobora kunywa inzoga niba mfata Safinamide?

Inzoga irashobora gukorana na safinamide kandi irashobora gushimangira ingaruka zimwe na zimwe nk'izuru, gusinzira, no kuyoba. Nubwo inzoga ntoya zishobora kwemerwa kubantu bamwe, ni ngombwa kuganira ku kunywa inzoga na muganga wawe mbere yo kunywa inzoga mugihe ufata safinamide.

Inzoga irashobora kandi kugira ingaruka ku bimenyetso bya Parkinson yawe kandi irashobora kubangamira imikorere yimiti yawe. Abantu bamwe basanga inzoga ituma umutwaro wabo urushaho kuba mubi cyangwa bigira ingaruka ku gipimo cyabo no guhuza. Muganga wawe ashobora kugufasha gusobanukirwa uburyo inzoga yagira ingaruka ku gahunda yawe yihariye yo kuvura no ku buzima bwawe muri rusange.