Sarilumab ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Sarilumab ni umuti wandikirwa na muganga ufasha kugabanya umubyimbirwe mu bantu barwaye indwara ya rheumatoid arthritis n'izindi ndwara ziterwa n'umubiri w'umuntu wanga ibiwugize. Uyu muti utangwa mu nshinge munsi y'uruhu, kimwe n'uko abantu barwaye diyabete biha inshinge za insuline.

Uyu muti ubarirwa mu itsinda ryitwa IL-6 inhibitors, ikora ibikorwa byo guhagarika ibimenyetso byihariye mu mikorere y'umubiri wawe bitera kubabara no kubyimba mu ngingo. Bitekereze nk'aho ugabanya urusaku rw'umubiri wawe urimo gukora cyane.

Sarilumab ni iki?

Sarilumab ni umuti wa biyoloji ukoreshwa mu kurwanya interleukin-6 (IL-6), poroteyine itera umubyimbirwe mu mubiri wawe. Iyo urwaye rheumatoid arthritis, umubiri wawe ukora IL-6 nyinshi cyane, bigatuma ingingo zirwara, zigahumeka.

Uyu muti uza mu buryo bw'ikaramu cyangwa urushinge byuzuye mbere, ukabyinjiza munsi y'uruhu buri byumweru bibiri. Ukorwa hakoreshejwe ikoranabuhanga rigezweho rya biyoloji, bivuze ko ukorwa mu turemangingo tuzima aho gukoresha imiti gakondo.

Muganga wawe akenshi azandika sarilumab iyo indi miti ivura indwara ya arthritis itatanze umusaruro uhagije. Ifatwa nk'ubuvuzi bwihariye kuko bwibanda ku gice kimwe cy'umubiri w'umuntu aho guhagarika imikorere yose y'umubiri wawe.

Sarilumab ikoreshwa mu kuvura iki?

Sarilumab ikoreshwa cyane cyane mu kuvura indwara ya rheumatoid arthritis ikaze cyangwa yoroheje mu bantu bakuru. Ifasha kugabanya kubabara mu ngingo, kuzigama, no kubyimba bishobora gutuma ibikorwa bya buri munsi bigorana.

Muganga wawe ashobora kugusaba sarilumab niba utaragaragaje impinduka nziza ku miti ya methotrexate cyangwa indi miti ivura indwara ya antirheumatic (DMARDs). Irashobora gukoreshwa yonyine cyangwa igashyirwa hamwe na methotrexate kugira ngo habeho umusaruro mwiza.

Uyu muti urimo no kwigwaho ku bindi bibazo by’uburwayi butera umubiri kubyimba, nubwo indwara ya rheumatoid arthritis ikiri yo ikoreshwa cyane. Muganga wawe azagena niba sarilumab ikwiriye kuri wowe bitewe n’ibimenyetso byawe n’amateka yawe y’ubuzima.

Sarilumab ikora ite?

Sarilumab ikora ibuza imyakura ya interleukin-6 mu mubiri wawe. IL-6 isa nk'umutumwa ubwira umubiri wawe w’ubudahangarwa gukora kubyimba, kabone niyo bitakenewe.

Iyo sarilumab yifatanyije n'iyi myakura, ibuza IL-6 kohereza ibimenyetso byo kubyimba. Ibi bifasha kugabanya kwangirika kw’ingingo, kubabara, no kubyimba bifitanye isano na rheumatoid arthritis.

Uyu muti ufatwa nk'ukomeye ku rugero ruciriritse mu miti ikoreshwa mu buvuzi. Ugenewe kurwanya indwara runaka kurusha imiti ya steroid ariko iracyakomeye bihagije kugira ingaruka zikomeye ku mubiri wawe w’ubudahangarwa. Abantu benshi batangira kubona impinduka mu byumweru 2-4 nyuma yo gutangira kuvurwa.

Nkwiriye gufata sarilumab nte?

Sarilumab itangwa nk'urushinge rwo mu nsi y’uruhu, bivuze ko uyitera mu gice cy’ibinure munsi y’uruhu rwawe. Urutonde rusanzwe ni 200mg buri byumweru bibiri, nubwo muganga wawe ashobora gutangira na 150mg niba ufite ibibazo by’ubuzima runaka.

Ushobora kwitera sarilumab mu itako ryawe, ukuboko kwawe kw’igice cyo hejuru, cyangwa mu nda. Hinduranya aho utera urushinge buri gihe kugirango wirinde kurakara kw’uruhu. Uyu muti ugomba kuba ufite ubushyuhe busanzwe igihe uwitera, bityo uwukure muri firigo mbere y’iminota 30-60.

Ntabwo ukeneye gufata sarilumab hamwe n’ibiryo kuko iterwa mu rushinge aho kumira. Ariko, ni ngombwa kuyitera ku munsi umwe buri byumweru bibiri kugirango ugumane urwego ruzigama mu mubiri wawe.

Umuvuzi wawe cyangwa umuforomo bazakwigisha uko wifata urushinge. Abantu benshi babisanga byoroshye kurusha uko babyibazaga, kandi amapeni yuzuzwa mbere y’igihe akora inzira yoroshye.

Nkwiriye gufata sarilumab igihe kingana iki?

Sarilumab ikoreshwa akenshi mu kuvura indwara ya rheumatoid arthritis mu gihe kirekire. Abantu benshi bakomeza kuyifata igihe cyose ifasha ibimenyetso byabo kandi itateje ingaruka zikomeye.

Muganga wawe azagenzura uko ubuzima bwawe buhagaze mu mezi make ya mbere kugira ngo arebe niba umuti ukora neza. Niba urimo kugira iterambere rirambye, birashoboka ko uzakomeza gufata inshinge zisanzwe.

Abantu bamwe bashobora gukenera gufata sarilumab imyaka myinshi kugira ngo bagumane kugenzura ibimenyetso byabo. Ariko, umuganga wawe azagenzura imiti yawe buri gihe kugira ngo arebe niba ikigikwiye kuri wowe.

Ntuzigere uhagarika gufata sarilumab ako kanya utabanje kuvugana na muganga wawe. Ibimenyetso byawe bishobora kugaruka niba uhagaritse umuti ako kanya.

Ni izihe ngaruka ziterwa na Sarilumab?

Kimwe n'indi miti yose, sarilumab ishobora gutera ingaruka, nubwo atari buri wese uzagira izo ngaruka. Kumva icyo ugomba kwitaho bishobora kugufasha kumva ufite icyizere cyinshi ku miti yawe.

Dore ingaruka zisanzwe ushobora kugira:

• Uko umubiri wabyakiriye ahaterwa inshinge nk'uburibwe, kubyimba, cyangwa kubabara gake
• Uburwayi bwo mu myanya yo hejuru y'ubuhumekero nka grip cyangwa indwara z'amazuru
• Umutwe uba woroshye cyangwa ugereranije
• Ukwiyongera kw'urugero rwa cholesterol, muganga wawe azagenzura
• Enzymes zizamuka mu mwijima, zigaragazwa n'ibizamini by'amaraso

Izi ngaruka zisanzwe zikunze gucungwa kandi akenshi zigenda zikemuka uko umubiri wawe wimenyereza umuti.

Abantu bamwe bashobora kugira ingaruka zikomeye ariko zitabaho cyane zisaba ubufasha bwihutirwa bw'abaganga:

• Indwara zikomeye zishobora gutera urupfu
• Uko umubiri wabyakiriye bikabije bifite ingorane zo guhumeka cyangwa kubyimba
• Igabanuka rikomeye ry'umubare w'uturemangingo twera tw'amaraso cyangwa platelet
• Ibibazo by'umwijima bitera umuhondo w'uruhu cyangwa amaso
• Ukwangirika kw'amara, nubwo ibi bidakunze kubaho

Nubwo izi ngaruka zikomeye zitaba kenshi, ni ngombwa guhamagara umuganga wawe ako kanya niba wumva ibimenyetso bibangamye.

Ninde utagomba gufata Sarilumab?

Sarilumab ntabwo ikwiriye buri wese, kandi muganga wawe azasuzuma neza amateka yawe mbere yo kuyandika. Ibyiciro runaka cyangwa ibihe bituma uyu muti ushobora kuba mubi.

Ntugomba gufata sarilumab niba ufite kimwe muri ibi bikurikira:

• Indwara zikomeye, harimo igituntu cyangwa hepatite B
• Indwara ikomeye y'umwijima cyangwa imyunyunguro y'umwijima yazamutse cyane
• Umubare muto cyane w'uturemangingo tw'amaraso twera cyangwa twa platelet
• Allergies zizwi kuri sarilumab cyangwa ibindi byose bigize yo
• Inkingo zizima zateganyijwe mu byumweru bike biri imbere

Muganga wawe azakoresha kandi ubushishozi bwihariye niba ufite amateka y'indwara zikomeza kugaruka, kubagwa vuba, cyangwa izindi ndwara z'ubudahangarwa.

Gusama no konsa bisaba kwitonderwa byihariye. Nubwo sarilumab itarigishwa cyane ku bagore batwite, muganga wawe azagereranya inyungu n'ibishobora kuba bibi niba uteganya gusama cyangwa umaze gutwita.

Amazina y'ubwoko bwa Sarilumab

Sarilumab icururizwa ku izina rya Kevzara muri Leta Zunze Ubumwe z'Amerika no mu bindi bihugu byinshi. Iri niryo zina ry'ubwoko ririmo kuboneka kuri uyu muti.

Kevzara ikorwa na Sanofi na Regeneron Pharmaceuticals. Uyu muti uza mu bikoresho byuzuzwa mbere y'igihe no mu nshinge kugirango byorohereze kwikingiza iwawe mu rugo.

Bitandukanye n'indi miti, ntirimo verisiyo rusange ya sarilumab iraboneka. Ibi bivuze ko Kevzara ariyo yonyine ihari niba muganga wawe yanditse sarilumab.

Uburyo bwo gusimbuza Sarilumab

Niba sarilumab itagukwiriye, indi miti myinshi ya biyolojiya ishobora kuvura neza indwara ya rheumatoid arthritis. Muganga wawe ashobora gutekereza izi nzira zindi zishingiye ku byo ukeneye byihariye n'amateka yawe y'ubuvuzi.

Izindi nzitizi za IL-6 zirimo tocilizumab (Actemra), ikora kimwe na sarilumab ariko itangwa nk'urushinge cyangwa inshinge. Inzitizi za TNF nka adalimumab (Humira) cyangwa etanercept (Enbrel) zerekeza inzira zitandukanye z'uburwayi.

Inzitizi za JAK nka tofacitinib (Xeljanz) cyangwa baricitinib (Olumiant) ni imiti yo kunywa ishobora korohereza abantu bamwe kuyifata. DMARDs gakondo nka methotrexate cyangwa sulfasalazine zigumana ingirakamaro zo kuvura, cyane cyane kubantu bagitangira kuvurwa indwara ya arthritis.

Umuvuzi wawe azagufasha guhitamo uburyo bwiza bushingiye ku bimenyetso byawe, izindi ndwara, n'uburyo ukunda kuvurwa.

Ese Sarilumab iruta Tocilizumab?

Sarilumab na tocilizumab zombi ni inzitizi za IL-6, bivuze ko zikora mu buryo busa cyane kugirango zigabanye ububyimbirwe. Kuzigereranya mu buryo butaziguye birashobora kugorana kuko zitageragejwe mu bushakashatsi bunini.

Imiti yombi ifite akamaro kanini mu kuvura indwara ya rheumatoid arthritis, kandi abantu benshi babaho neza hamwe n'uburyo ubwo aribwo bwose. Guhitamo akenshi biterwa n'ibintu bifatika nk'uko umuti utangwa n'ibyo ukunda ku giti cyawe.

Sarilumab iboneka gusa nk'urushinge rwikorera buri byumweru bibiri, mugihe tocilizumab ishobora gutangwa nk'urushinge buri byumweru bine cyangwa urushinge rwa buri cyumweru. Abantu bamwe bakunda koroherezwa n'urushinge rwikorera, mugihe abandi bakunda gutanga imiti idakunze.

Umuvuzi wawe azatekereza ku miterere yawe yihariye, harimo n'indi miti urimo gufata n'ingaruka zose wigeze kugira, kugirango afashe kumenya uburyo bushobora kugukorera neza.

Ibikunze Kubazwa Kuri Sarilumab

Ese Sarilumab irakwiriye kubantu barwaye indwara y'umutima?

Sarilumab irashobora gukoreshwa kubantu barwaye indwara y'umutima, ariko bisaba gukurikiranwa neza. Uyu muti ushobora kongera urugero rwa cholesterol, rushobora kugira ingaruka ku byago byawe by'umutima.

Muganga wawe azagenzura urwego rw'umubiri rwawe rwa kolesteroli buri gihe kandi ashobora kukwandikira imiti igabanya kolesteroli niba bibaye ngombwa. Bazagenzura kandi ubuzima bw'umutima wawe muri rusange mu gihe cyose uvurwa.

Niba ufite umutima udakora neza cyane cyangwa ibibazo by'umutima bya vuba, umuganga wawe azagereranya inyungu za sarilumab n'ibishobora guteza akaga. Kuganira neza n'umuganga wawe w'umutima n'umuganga w'amagufi ni ibintu by'ingenzi.

Nkwiriye gukora iki niba nifashishije sarilumab nyinshi bitunguranye?

Niba witereye sarilumab nyinshi bitunguranye kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Ntukegere ngo urebe niba ibimenyetso bigaragara.

Kunywa sarilumab nyinshi bishobora kongera ibyago byo kurwara indwara zikomeye cyangwa izindi ngaruka. Muganga wawe ashobora kwifuza kugukurikiranira hafi cyangwa guhindura gahunda yawe yo kuvurwa.

Kugira ngo wirinde kunywa imiti myinshi bitunguranye, buri gihe genzura inkingo yawe mbere yo kuyitera kandi ntuzigere ufata inkingo zinyongera kugira ngo "ukosore" niba warabuze imwe.

Nkwiriye gukora iki niba nciwe inkingo ya sarilumab?

Niba wibagiwe guterwa urukingo rwa sarilumab rwatanzwe, ruterwe ako kanya wibukije, hanyuma usubire kuri gahunda yawe isanzwe. Ntukongere inkingo cyangwa ngo utere inkingo ebyiri zegeranye.

Niba hashize iminsi irenga mike utaraterwa urukingo wibagiwe, vugana n'umuganga wawe kugira ngo akugire inama. Bashobora kugusaba guhindura gahunda yawe cyangwa kugukurikiranira hafi.

Gushyiraho ibyibutso kuri terefone yawe cyangwa kalendari birashobora kugufasha kwibuka gahunda yawe yo guterwa inkingo. Abantu bamwe basanga bifasha guterwa urukingo ku munsi umwe mu cyumweru buri byumweru bibiri.

Nshobora kureka kunywa sarilumab ryari?

Ugomba kureka kunywa sarilumab gusa uyobowe na muganga wawe. Guhagarika imiti mu buryo butunguranye bishobora gutuma ibimenyetso byawe bya artrite bisubira, rimwe na rimwe bikaba bibi kurusha mbere.

Umuvuzi wawe ashobora kugusaba guhagarika sarilumab niba ugize ingaruka zikomeye, indwara zandura, cyangwa niba uburwayi bwawe bujya mu gihe kirekire cyo gukira. Bazakora gahunda yo kugukurikirana neza mugihe cyose cyo guhindura imiti.

Abantu bamwe bashobora kugabanya urugero rw'imiti bafata cyangwa bakongera igihe hagati yo guterwa inshinge aho guhagarika burundu. Muganga wawe azakorana nawe kugirango abone uburyo buzafasha kugenzura ibimenyetso byawe hamwe numuti muto ushoboka.

Nshobora guhabwa inkingo niba mfata Sarilumab?

Ushobora guhabwa inkingo nyinshi niba ufata sarilumab, ariko inkingo zikora zikwiye kwirindwa kuko zishobora gutera indwara kubantu bafite ubudahangarwa bw'umubiri butameze neza.

Muganga wawe azagusaba guhabwa inkingo zingenzi nka inkingo z'ibicurane, inkingo za pneumoniya, na inkingo za COVID-19 mbere yo gutangira sarilumab. Izi nkingo zikora neza iyo ubudahangarwa bwawe butameze neza.

Buri gihe bwire umuvuzi wese uguha inkingo ko ufata sarilumab. Bazareba neza ko inkingo zifite umutekano kandi zikwiriye kubera uko ubuzima bwawe bumeze.