Saxagliptin ni iki: Ibikoreshwa, Uburyo bwo Gukoresha, Ingaruka Ziterwa n'Uko Bikora n'ibindi

Saxagliptin ni umuti wandikirwa na muganga ufasha abantu barwaye diyabete yo mu bwoko bwa 2 kugenzura urugero rw'isukari mu maraso yabo. Uyu muti ubarirwa mu cyiciro cy'imiti yitwa DPP-4 inhibitors, ikora ifasha umubiri wawe gukora insulin nyinshi iyo isukari yo mu maraso yawe iri hejuru kandi igabanya urugero rw'isukari umwijima wawe ukora.

Uyu muti akenshi wandikirwa iyo imirire n'imyitozo ngororamubiri gusa bidahagije ngo bigenzure isukari yo mu maraso, cyangwa iyo indi miti ivura diyabete ikeneye ubufasha bwiyongera. Abantu benshi basanga saxagliptin ari umuti woroshye ariko ufite akamaro mu buryo bwo gucunga diyabete yabo.

Saxagliptin ni iki?

Saxagliptin ni umuti uvurwa mu kanwa uvura diyabete ufata unywa, akenshi rimwe ku munsi. Ugenewe gukorana n'uburyo umubiri wawe ukoresha mu gukora insulin aho guhatira impinduka zikomeye ku rugero rw'isukari yo mu maraso yawe.

Tekereza saxagliptin nk'umufasha w'ingirakamaro ku rwungano rwawe rw'amaraso. Iyo isukari yo mu maraso yawe izamutse nyuma yo kurya, itegeka urwungano rwawe rw'amaraso kurekura insulin nyinshi. Muri icyo gihe, ibwira umwijima wawe kugabanya umuvuduko wo gukora isukari, bigatuma habaho uburyo bwo kugenzura isukari yo mu maraso buri ku rugero ruringaniye.

Uyu muti ufatwa nk'umuti uvura diyabete ufite imbaraga ziringaniye. Ntabwo ari nk'inshinge za insulin, ariko ni wo ugamije kurusha impinduka zoroheje z'imibereho gusa. Abantu benshi barawihanganira neza kuko ukorana buhoro n'uburyo umubiri wawe usanzwe ukoresha.

Saxagliptin ikoreshwa mu kuvura iki?

Saxagliptin ikoreshwa cyane cyane mu kuvura diyabete yo mu bwoko bwa 2 mu bantu bakuru. Muganga wawe ashobora kukwandikira uyu muti iyo gahunda yawe yo gucunga diyabete ikeneye ubufasha bwiyongera kugira ngo ugereranye urugero rw'isukari yo mu maraso yawe.

Dore ibintu by'ingenzi aho saxagliptin ifasha:

• Iyo imirire n'imyitozo ngororamubiri byonyine bitagikontorora isukari mu maraso yawe neza
• Nk'inyongera kuri metformin iyo metformin yonyine idahagije
• Hamwe n'izindi miti ya diyabete nka insuline cyangwa sulfonylureas
• Iyo ukeneye umuti utazatera kongera ibiro byinshi
• Niba ushaka umuti ufata rimwe ku munsi woroshye gushyira mu murongo wawe

Umuvuzi wawe azagena niba saxagliptin ikwiriye kuri wowe. Bazareba urwego rw'isukari yawe mu maraso, imiti urimo gufata, n'ubuzima bwawe muri rusange.

Saxagliptin ikora ite?

Saxagliptin ikora ibuza enzyme yitwa DPP-4 mu gihe cy'igogora. Iyi enzyme isanzwe isenya imisemburo ifasha kugenzura isukari mu maraso, bityo rero, kuyibuza, saxagliptin ituma iyi misemburo kamere ikora igihe kirekire kandi neza.

Iyo urya, amara yawe arekura imisemburo yitwa incretins itegeka pancreas yawe gukora insuline. Saxagliptin ifasha iyi misemburo kuguma ikora igihe kirekire, bivuze ko umubiri wawe ushobora gusubiza neza ku rwego rw'isukari mu maraso ruzamuka.

Uyu muti ufatwa nk'umuti wa diyabete ufite imbaraga ziringaniye. Uruta insuline cyangwa sulfonylureas kuko ukora gusa iyo isukari yawe mu maraso yazamutse. Iyo isukari yawe mu maraso isanzwe, saxagliptin ntigira ingaruka nyinshi, ibi bikagabanya ibyago byo kugira isukari nkeya mu maraso.

Icyiza cy'iyi nzira ni uko ikorana n'umuvuduko w'umubiri wawe. Nturimo guhatira pancreas yawe gukora cyane buri gihe, ahubwo uyihaye ibikoresho byiza byo gukora akazi kayo igihe bibaye ngombwa.

Nkwiriye gufata saxagliptin nte?

Saxagliptin isanzwe ifatwa rimwe ku munsi, hamwe n'ibiryo cyangwa nta biryo. Abantu benshi babona ko byoroshye kuyifata ku gihe kimwe buri munsi kugira ngo bagumane urwego ruringaniye mu mubiri wabo.

Ushobora gufata saxagliptin hamwe n'amazi, amata, cyangwa umutobe. Bitandukanye n'imiti imwe, ntisaba igihe cyihariye cyo gufatana n'ibiryo. Ariko, kuyifata hamwe n'ibiryo bishobora gufasha niba wumva umubiri utameze neza, nubwo ibyo bidakunze kubaho.

Ibi nibyo bikora neza kubantu benshi:

• Hitamo igihe gihamye buri munsi, nko ku ifunguro rya mugitondo cyangwa rya nimugoroba
• Mimina ikinini cyose hamwe n'ikirahure cyuzuye cy'amazi
• Ntugasye cyangwa urume ikinini
• Niba uyifata hamwe n'ibiryo, ifunguro iryo ariryo ryose risanzwe rirakwiriye
• Komeza kuyifata nubwo wumva umeze neza, kuko gucunga diyabete bikomeza

Muganga wawe azagutangiza urugero rukwiye rishingiye ku mikorere y'impyiko zawe n'izindi mpamvu z'ubuzima. Abantu benshi batangirana na 2.5 mg cyangwa 5 mg rimwe ku munsi, kandi ibi akenshi bikomeza kuba urugero rwa igihe kirekire.

Nzagomba Gufata Saxagliptin Igihe Kingana Gite?

Saxagliptin akenshi ni umuti wa igihe kirekire uzakomeza gufata igihe cyose ifasha gucunga diyabete yawe neza. Diyabete yo mu bwoko bwa 2 ni indwara idakira isaba gucungwa buri gihe, bityo abantu benshi baguma ku miti yabo ya diyabete iteganyijwe.

Muganga wawe azagenzura urugero rw'isukari mu maraso yawe n'ubuzima bwawe muri rusange buri gihe kugirango yemeze ko saxagliptin ikomeza kuba amahitamo akwiriye kuri wewe. Akenshi bazagenzura urugero rwawe rwa A1C buri mezi atatu cyangwa atandatu kugirango barebe uko gahunda yawe yo gucunga diyabete ikora neza.

Abantu bamwe bashobora gukenera guhindura imiti yabo ya diyabete uko igihe kigenda. Ibi ntibisobanura ko saxagliptin yahagaritse gukora, ahubwo diyabete irashobora guhinduka no kwaguka. Itsinda ryawe ry'ubuzima rizakorana nawe kugirango ukore impinduka zose zikenewe kugirango isukari yawe mu maraso igume mu rugero rwiza.

Ntuzigere uhagarika gufata saxagliptin ako kanya utabanje kuvugana na muganga wawe. Nubwo wumva umeze neza, isukari yawe mu maraso irashobora kuzamuka ikagera ku rwego ruteje akaga udafite imiti ikwiye.

Ni Iyihe Mbereko ya Saxagliptin?

Abantu benshi bacyura neza saxagliptin, ariko nk'imiti yose, irashobora gutera ingaruka. Inkuru nziza ni uko ingaruka zikomeye zitaba kenshi, kandi abantu benshi ntibagira ingaruka na gato.

Dore ingaruka zisanzwe abantu bamwe bagira:

• Umutwe
• Indwara zifata mu myanya y'ubuhumekero (nka ibicurane)
• Indwara zifata mu nzira y'inkari
• Urubu mu nda cyangwa kutumva neza
• Isesemi

Izi ngaruka zisanzwe akenshi ziba nto kandi zikagenda zikira uko umubiri wawe ukimenyera umuti. Niba zikomeje cyangwa zikaba zikubangamiye, bimenyeshe umuganga wawe.

Hariho ingaruka zimwe na zimwe zitaba kenshi ariko zikomeye zisaba ubufasha bwihuse bw'abaganga:

• Urubu rukabije mu ngingo rutagira icyo ruhinduka
• Ibimenyetso bya pankreatite (ububabare bukomeye mu nda bushobora kwerekeza mu mugongo)
• Urugero rw'umubiri (ibibara, kurigata, kubyimba, guhumeka bigoranye)
• Ibimenyetso byo kunanirwa k'umutima (kubyimba amaguru, guhumeka bigoranye, umunaniro udasanzwe)
• Urugero rukabije rw'uruhu cyangwa kubora

Nubwo izi ngaruka zikomeye zitaba kenshi, ni ngombwa kuzimenya kandi wahamagara umuganga wawe ako kanya niba wumva kimwe muri ibi bimenyetso.

Ninde utagomba gufata Saxagliptin?

Saxagliptin ntabwo ikwiriye kuri buri wese, kandi umuganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Hariho ibihe byihariye uyu muti ugomba kwirindwa cyangwa ugakoreshwa witonze cyane.

Ntabwo ugomba gufata saxagliptin niba ufite:

• Ubwoko bwa 1 bwa diyabete (yemerewe gusa kubwoko bwa 2)
• Amateka y'uburwayi bukomeye bwo kurwara saxagliptin cyangwa imiti isa nayo
• Diabetic ketoacidosis (ikibazo gikomeye cya diyabete)
• Indwara ikomeye y'impyiko (umuganga wawe ashobora gukenera guhindura urugero cyangwa agahitamo undi muti)

Umuganga wawe azakoresha saxagliptin yitonze cyane niba ufite:

• Amateka y'umutima udakora neza
• Ibibazo by'impyiko (n'ubwo biba bito bishobora gusaba guhindura urugero rwa imiti)
• Amateka ya pankreatite
• Urubavu cyangwa ibibazo bya nyungwe
• Amateka y'ibibazo bikomeye by'ingingo

Buri gihe bwire umuganga wawe ibijyanye n'uburwayi bwose ufite n'imiti yose ufata mbere yo gutangira gufata saxagliptin. Ibi bibafasha kumenya niba ari wo muti mwiza kandi ukora neza mu kuvura diyabete yawe.

Izina ry'ubwoko bwa Saxagliptin

Saxagliptin iboneka ku izina ry'ubwoko rya Onglyza. Ushobora no kuyisanga ivanze n'indi miti ivura diyabete ku mazina y'ubwoko atandukanye.

Urugero rwa saxagliptin ivanze na metformin igurishwa nka Kombiglyze XR. Iyi miti ivanze ishobora korohereza abantu bayikeneye yombi, kuko igabanya umubare w'ibinini ukeneye gufata buri munsi.

Uramutse ufata izina ry'ubwoko cyangwa urugero rusanzwe, ibikoresho bikora n'ubushobozi birasa. Gahunda yawe y'ubwishingizi na farumasi bishobora kugira uruhare mu guhitamo urugero ufata, ariko zombi zikora neza mu kugenzura isukari mu maraso.

Uundi muti ushobora gusimbura Saxagliptin

Niba saxagliptin atagukwiriye, hariyo indi miti ivura diyabete ikora mu buryo busa cyangwa butandukanye. Umuganga wawe ashobora kugufasha gushakisha izi nzira bitewe n'ibyo ukeneye n'ubuzima bwawe.

Izindi miti ya DPP-4 ikora kimwe na saxagliptin zirimo:

• Sitagliptin (Januvia)
• Linagliptin (Tradjenta)
• Alogliptin (Nesina)

Ubwoko butandukanye bw'imiti ivura diyabete umuganga wawe ashobora gutekereza harimo:

• Metformin (akenshi ni umuti wa mbere)
• GLP-1 receptor agonists (nka semaglutide cyangwa liraglutide)
• SGLT-2 inhibitors (nka empagliflozin cyangwa canagliflozin)
• Sulfonylureas (nka glipizide cyangwa glyburide)
• Insulin (mu kuvura diyabete ikomeye)

Uburyo bwiza biterwa n'ubuzima bwawe bwite, imiti yindi urimo gufata, n'intego zawe zo gucunga diyabete. Muganga wawe azakorana nawe kugirango abone umuti ukora neza kandi wihanganirwa.

Ese Saxagliptin iruta Sitagliptin?

Zose saxagliptin na sitagliptin ni ibiyobyabwenge bya DPP-4 bikora kimwe kugirango bacunge diyabete yo mu bwoko bwa 2. Nta muti n'umwe uruta undi, kuko byombi ni uburyo bukora neza bufite inyungu zingana n'ingaruka zimwe.

Itandukaniro rikuru hagati yiyi miti ni rito. Sitagliptin imaze igihe kinini iboneka kandi ifite amakuru menshi y'ubushakashatsi. Saxagliptin ishobora kugira ingaruka zitandukanye, hamwe n'ubushakashatsi bumwe buvuga ingaruka zitandukanye ku buzima bw'umutima, nubwo byombi muri rusange bifatwa nkibitekanye.

Icyemezo cya muganga wawe hagati yiyi miti akenshi giterwa na:

• Imikorere y'impyiko zawe (gukosora imiti birashobora gutandukana)
• Imiti yindi urimo gufata
• Ubwishingizi bwawe n'ibiciro by'imiti
• Uburwayi bwawe bwihariye n'ibintu bigushyira mu kaga
• Uburyo wakiriye neza imiti yindi ya diyabete

Imiti yombi ifatwa rimwe ku munsi kandi ikora neza hamwe n'ubundi buvuzi bwa diyabete. Uburyo "bwiza" ni ubukora neza kubuzima bwawe bwite kandi bugufasha kugera ku ntego zawe z'isukari mu maraso hamwe n'ingaruka nke.

Ibikunze Kubazwa Kuri Saxagliptin

Ese Saxagliptin iratekanye ku bantu barwaye indwara z'umutima?

Saxagliptin isaba ko uzirikana cyane niba urwaye indwara z'umutima, cyane cyane umutima wananiwe. Ubushakashatsi bumwe bwerekanye izamuka rito ry'abantu barwaye umutima bananiwe bari mu bitaro hagati y'abantu bafata saxagliptin, cyane cyane abafite ibibazo by'umutima.

Ariko, ibyo ntibisobanura ko saxagliptin ihita itekanye ku bantu barwaye indwara z'umutima. Muganga wawe azagereranya inyungu zo kugenzura isukari mu maraso n'ibibazo bishobora guteza umutima. Bazagukurikiranira hafi kandi bashobora kugusaba gukora isuzuma ry'imikorere y'umutima buri gihe niba ufite impungenge z'umutima.

Niba urwaye indwara y'umutima, gerageza kubiganiraho neza n'umuganga wawe. Bashobora guhitamo umuti wa diyabete utandukanye cyangwa gufata ingamba zidasanzwe zo gukurikirana ubuzima bw'umutima wawe mugihe ukoresha saxagliptin.

Nkwiriye gukora iki niba nanyweye saxagliptin nyinshi ku buryo butunguranye?

Niba unyweye saxagliptin nyinshi ku buryo butunguranye, ntugire ubwoba. Kunywa doze ebyiri rimwe na rimwe ntibishobora guteza ibibazo bikomeye, ariko ugomba guhamagara muganga wawe cyangwa ikigo gishinzwe ubumara kugirango baguhe ubujyanama.

Wikurikirane ibimenyetso nk'isuka, kuruka, kuribwa mu nda, cyangwa umunaniro udasanzwe. Nubwo saxagliptin itagira akamaro mu kugabanya isukari mu maraso, kunywa nyinshi bishobora gutera ibyo bimenyetso, cyane cyane niba unywa indi miti ya diyabete.

Hamagara muganga wawe, umufarumasiti, cyangwa ikigo gishinzwe ubumara (1-800-222-1222 muri Amerika) niba ufite impungenge zo kunywa nyinshi. Bashobora gutanga ubujyanama bwihariye bushingiye ku bwinshi wanyoye n'ubuzima bwawe bwihariye. Ntugerageze "kwishyura" doze yinyongera wirinda kunywa doze yawe iteganyijwe.

Nkwiriye gukora iki niba nirengagije kunywa doze ya saxagliptin?

Niba wibagiwe kunywa doze ya saxagliptin, yinywe vuba na bwangu wibuka, keretse igihe cyo kunywa doze yawe iteganyijwe kigeze. Muricyo gihe, irengagize doze wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere unywa doze ebyiri icyarimwe kugirango wishyure doze wibagiwe. Ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'iyo miti utagize inyungu zinyongera zo kugenzura isukari mu maraso yawe.

Kutafata umuti rimwe na rimwe ntibigira ingaruka, ariko gerageza kuwufata buri gihe kugira ngo urwaze rwa diyabete rugende neza. Tekereza gushyiraho umwanya wo kwibutswa buri munsi kuri terefone yawe cyangwa ukoreshe agasanduku kabugenewe kugufasha kwibuka gahunda yo gufata imiti yawe.

Ni ryari nshobora kureka gufata Saxagliptin?

Ugomba kureka gufata saxagliptin uyobowe na muganga wawe. N'iyo isukari yo mu maraso yawe yaba yaragabanutse cyane, ibi bishoboka cyane ko ari uko umuti ukora, atari uko utawukeneye.

Muganga wawe ashobora gutekereza kugabanya cyangwa kureka saxagliptin niba waragize impinduka zikomeye mu mibereho yawe zatumye urwaza rwa diyabete rugabanuka, niba urimo guhura n'ingaruka zikomeye, cyangwa niba bashaka kugerageza uburyo butandukanye bwo kuvura.

Abantu bamwe bashobora kugabanya imiti yabo ya diyabete binyuze mu kugabanya ibiro byinshi, kurya neza, no gukora imyitozo ngororamubiri buri gihe. Ariko, iki cyemezo kigomba gufatwa buri gihe hamwe n'ikipe yawe y'ubuvuzi, hamwe no gukurikiranira hafi urugero rw'isukari yo mu maraso yawe mu gihe cy'impinduka zose z'imiti.

Nshobora kunywa inzoga nkanwa saxagliptin?

Kunywa inzoga mu rugero ruto muri rusange birakwiriye mugihe ufata saxagliptin, ariko ugomba kubiganiraho na muganga wawe. Inzoga irashobora kugira ingaruka ku rugero rw'isukari yo mu maraso, kandi gufatanya n'imiti ya diyabete bisaba kwitonda.

Niba uhisemo kunywa inzoga, bikore mu rugero ruto kandi buri gihe ufite ibiryo. Inzoga irashobora kugabanya urugero rw'isukari yo mu maraso, cyane cyane iyo ihujwe n'imiti ya diyabete, bityo ukagenzura isukari yo mu maraso yawe witonze kurushaho ku minsi unywa.

Menya ko inzoga ishobora guhisha ibimenyetso by'isukari yo mu maraso iri hasi, bigatuma bigorana kumenya niba isukari yo mu maraso yawe imanuka cyane. Niba ufata indi miti ya diyabete hamwe na saxagliptin, ibyago byo kugira isukari yo mu maraso iri hasi hamwe n'inzoga birashobora kuba byinshi.