Icyo Secretin (inzira yo mu nshinge) ari cyo: Ibyo ikoreshwa, urugero rwo kuyifata, ingaruka zayo n'ibindi

Secretin ni umuti wa hormone ukorwa mu buryo bwa gihanga utangwa unyuze mu muyoboro w'amaraso, ufasha abaganga kumenya ibibazo biri mu gice cy'umubiri cy'impyiko n'urwagashya. Umubiri wawe ukora secretin mu buryo bwa kamere mu mara mato, ariko uwo mu buvuzi ukorwa mu buryo bwihariye kugira ngo utume urwagashya rwawe rurekura amazi afasha mu igogora kugira ngo abaganga babone uko ibyo bice by'umubiri bikora neza.

Uyu muti ukoreshwa cyane cyane mu bizami by'ubuvuzi byihariye, ntabwo ari nk'umuti usanzwe wafata uri mu rugo. Utekereze nk'igikoresho cyo gupima gifasha ikipe y'abaganga kukubona neza uko igogora ryawe rikora.

Secretin ikoreshwa mu iki?

Secretin ikoreshwa nk'igikoresho cyo gupima gifasha abaganga gusuzuma uko urwagashya rwawe n'urwagashya bikora neza. Intego nyamukuru ni ugushishikariza urwagashya rwawe gukora no kurekura enzymes zifasha mu igogora n'amazi akungahaye kuri bicarbonate.

Abaganga bakoresha cyane secretin mu gihe cy'uburyo bwo gupima bita secretin-enhanced magnetic resonance cholangiopancreatography (MRCP). Iri zina rishya risobanura isesengura ryihariye rya MRI rifata amashusho arambuye y'inzira ya bile n'inzira ya pancreatic. Iyo secretin itanzwe muri iki kizamini, bituma ibi bice bigaragara neza ku mashusho, bifasha abaganga kumenya ibibazo byo guhagarara, kubyimbirwa, cyangwa ibindi bibazo.

Abaganga kandi bakoresha secretin mu gupima indwara yitwa Zollinger-Ellison syndrome. Iyi ndwara idakunze kuboneka itera ibibyimba mu rwagashe cyangwa mu mara mato bikora aside nyinshi mu gifu. Ikizamini cya secretin gishobora gufasha kwemeza iyi diagnosis mugupima uburyo umubiri wawe witwara kuri hormone.

Secretin ikora ite?

Secretin ikora yigana hormone ya kamere y'umubiri wawe ibwira urwagashya rwawe gukora cyane. Iyo urya, amara yawe mato asanzwe arekura secretin kugira ngo yerekane urwagashya rwawe gukora amazi afasha mu igogora afasha gusenya ibiryo.

Ubwoko bwa gihanga bukorera akazi kamwe ariko mu buryo bugenzurwa, mu rwego rw'ubuvuzi. Mu minota mike nyuma yo guhabwa urushinge rwa IV, urugingo rwawe rwo mu nda rutangira kurekura amazi asobanutse, afite alkali akungahaye kuri bicarbonate. Aya mazi afasha mu gukuraho aside yo mu gifu kandi akubiyemo enzymes zishonga amavuta, poroteyine, na karubohidrate.

Uyu muti ufatwa nk'umuti wo gupima ufite imbaraga ziringaniye. Ntabwo woroshye nk'amwe mu mabara akoreshwa mu gupima, ariko ntabwo ari nawo ufite imbaraga nyinshi nka imiti ya chimiothérapie. Ingaruka zikunda kuba iz'igihe gito kandi zigashira mu masaha make igihe umubiri wawe ukora kandi ugakuraho hormone ya gihanga.

Nkwiriye Gufata Secretin Nte?

Secretin itangwa gusa n'abakora mu rwego rw'ubuzima mu kigo cy'ubuvuzi binyuze mu murongo wa intravenous (IV). Ntabwo uzanywa uyu muti uri mu rugo cyangwa ngo wihe.

Mbere yo gukora icyo kizamini, muganga wawe ashobora kukubwira ko ugomba kwirinda kurya cyangwa kunywa mu masaha 8 kugeza kuri 12. Ibi bivuze ko utarya cyangwa ngo unywe ikindi kintu cyose uretse amazi make. Kugira igifu cyuzuye bifasha mu kumenya neza ibisubizo by'ibizamini kandi bigabanya ibyago byo kuruka mu gihe cy'icyo kizamini.

Mugihe cy'ikizamini, umuforomo cyangwa umukanishi azashyira catheter ntoya ya IV mu urugingo rwawe rwo mu kuboko. Secretin ikoreshwa buhoro buhoro binyuze muri uyu murongo wa IV. Uzaba ukeneye kuryama utuje mu gihe cyo gupima, ibyo bikunda gufata iminota 30 kugeza kuri 60.

Nyuma yo guhabwa secretin, ushobora kumva ushyushye cyangwa ukagira umubiri utukura. Ibi ni ibisanzwe kandi bikunda gushira vuba. Itsinda ryawe ry'ubuzima rizakurikirana mu gihe cyose cy'icyo kizamini kugirango barebe ko wumva umeze neza kandi ko ukira neza kubera uwo muti.

Nkwiriye Gufata Secretin Igihe Kingana Gite?

Secretin ikoreshwa rimwe gusa kuri buri kizamini cyo gupima, ntabwo ari nk'ubuvuzi bukomeza. Uwo muti utangwa nk'urushinge rumwe rukora mu gihe cyose cy'ikizamini cyawe.

Ingaruka za secretin zisanzwe zimara amasaha 2 kugeza kuri 4 nyuma yo guterwa urushinge. Muri iki gihe, urugingo rwawe ruzakomeza gukora amazi afasha mu igogora afasha abaganga kureba neza imiterere y'imbere mu isuzuma ry'amashusho.

Niba ukeneye gusubiramo isuzuma mu gihe kizaza, muganga wawe ashobora gutegeka ikindi gikorwa cyongerewe na secretin. Ariko, akenshi ntibisaba doze nyinshi mugihe cyo gukora isuzuma rimwe keretse niba byategetswe na muganga wawe.

Ni Iyihe Mbereho ya Secretin?

Abantu benshi bakira neza secretin, ariko nk'umuti uwo ariwo wose, ushobora gutera ingaruka. Inkuru nziza ni uko ibisubizo bikomeye bidakunze kubaho, kandi ingaruka nyinshi ziba zoroshye kandi z'igihe gito.

Dore ingaruka zisanzwe ushobora guhura nazo mugihe cyangwa nyuma yo guterwa secretin:

• Uburwayi bworoshye cyangwa kutumva neza mu nda
• Kumva ushyushye cyangwa umubiri utukura mu maso no mu ijosi
• Guhungabana gato cyangwa kumva uruhuka
• Kuzamuka by'agateganyo kw'umuvuduko w'umutima
• Kugurumana guto mu nda yawe

Izi ngaruka zikunze gutangira mumunota muto nyuma yo guterwa urushinge kandi zikunze gushira mumaminuta 30 kugeza kuri 60. Itsinda ryawe ry'ubuvuzi rizakurikirana neza kandi rishobora gutanga ubufasha niba bibaye ngombwa.

Ingaruka zitakunze kubaho ariko zikomeye zirimo ibisubizo bikomeye by'uburwayi, nubwo ibi bidakunze kubaho. Ibimenyetso by'uburwayi bukomeye birimo guhumeka nabi, kubyimba cyane mu maso cyangwa mu muhogo, uruhu rwakwiriye hose, cyangwa guhungabana cyane. Niba kimwe muri ibi bibaye, itsinda ryawe ry'ubuvuzi rizasubiza ako kanya hamwe n'imiti ikwiye.

Abantu bamwe bashobora kugira umuvuduko w'amaraso muke nyuma yo guterwa secretin, bishobora gutera kumva intege nke cyangwa guta umutwe. Iyi niyo mpamvu uzakurikiranwa mugihe cyose cyo gukora isuzuma no mumwanya muto nyuma yaho.

Ninde Utagomba Gufata Secretin?

Secretin ntabwo ari nziza kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kugusaba iki kizamini. Abantu bafite indwara zimwe na zimwe cyangwa allergie bagomba kwirinda secretin cyangwa bakayikoresha bafite ubwitonzi bwinshi.

Ntabwo ukwiye guhabwa secretin niba ufite allergie kuri secretin ubwayo cyangwa ibiyigize byose. Niba waragize icyo wakoreye iyi miti mbere, gerageza kubwira umuganga wawe mbere y'igikorwa icyo aricyo cyose.

Abantu bafite indwara zikomeye z'umutima, umuvuduko w'amaraso udagenzurwa, cyangwa umutima watewe n'umutima vuba aha ntibashobora kuba abakandida beza bo gupimwa secretin. Uyu muti ushobora guhindura by'agateganyo umuvuduko w'umutima wawe n'umuvuduko w'amaraso, ibyo bishobora kuba byateza akaga niba ufite ibibazo by'umutima byihishe.

Niba utwite cyangwa wonka, ganira ku ngaruka n'inyungu n'umuganga wawe. N'ubwo secretin itaragaragazwa ko yangiza abana bakiri bato, akenshi ikoreshwa gusa iyo amakuru yo gupima ari ngombwa ku buzima bwawe.

Abarwayi bafite indwara zikomeye z'impyiko cyangwa umwijima bashobora gukenera guhindura urugero rw'imiti cyangwa uburyo bwo gupima bundi. Izi ngingo zifasha gutunganya no gukuraho imiti mu mubiri wawe, bityo ibibazo by'imikorere y'impyiko cyangwa umwijima bishobora kugira ingaruka ku buryo secretin ikora cyangwa igihe kimara mu mubiri wawe.

Amazina ya Secretin

Secretin iboneka munsi y'izina rya ChiRhoStim muri Leta Zunze Ubumwe z'Amerika. Iyi ni uburyo bukoreshwa cyane bwa secretin ya sintetike yo gupima.

ChiRhoStim ikorwa byihariye kugirango ikoreshwe mu buvuzi kandi iza mu ifu ivangwa n'amazi atari amaraso mbere yo guterwa inshinge. Uyu muti uboneka gusa binyuze mu baganga kandi ntushobora kugurwa ngo ukoreshwe mu rugo.

Ibikorwa bimwe by'ubuvuzi bishobora kwita kuri iki gikorwa amazina atandukanye, nka "secretin-enhanced MRCP" cyangwa "secretin stimulation test," ariko ibi byose bikoresha umuti umwe.

Uburyo bwo gusimbuza Secretin

Ibizamini bitandukanye bishobora gukoreshwa mu gusuzuma imikorere ya pankereya, nubwo buri kimwe gifite inyungu zacyo n'intege nke zacyo. Muganga wawe azahitamo uburyo bwiza bushingiye ku bimenyetso byawe byihariye n'amateka yawe y'ubuvuzi.

Utrasound ya endosikopike (EUS) itanga amashusho arambuye ya pankereya yawe hatabayeho gushishikariza imisemburo. Iyi nzira ikoresha urushinge ruto, rworoshye rufite probe ya ultrasound kugirango isuzume pankereya yawe kuva imbere mu nzira yawe yo mu gifu.

Ibyemezo bisanzwe bya MRI cyangwa CT birashobora kandi kugaragaza ibitagenda neza bya pankereya, nubwo bishobora kutatanga ibisobanuro byinshi kubyerekeye imikorere nkuko byakozwe mu bushakashatsi bwa secretin. Ibi bizamini bikoreshwa akenshi iyo secretin idakwiriye cyangwa itaboneka.

Ibizamini by'amaraso bipima imisemburo ya pankereya nka lipase na amylase birashobora kugaragaza ibibazo bya pankereya, ariko ntibitanga ibisobanuro birambuye byubaka nkuko ibizamini byerekana bitanga. Ibi bikoreshwa akenshi nk'ibikoresho byo gusuzuma byambere.

Kubantu bakekwa ko bafite syndrome ya Zollinger-Ellison, abaganga bashobora gukoresha ibindi bizamini byo gushishikariza imisemburo cyangwa gupima ibimenyetso byihariye by'amaraso aho gukoresha ibizamini bya secretin.

Ese Secretin iruta ibindi bizamini byo gusuzuma imikorere ya pankereya?

Ibyemezo byongerewe na Secretin bitanga inyungu zidasanzwe zituma ariyo nzira ikunda gukoreshwa mubibazo bimwe byo gupima. Inyungu nyamukuru nuko itanga amakuru yubaka kandi akora kubyerekeye pankereya yawe mumizamini rimwe.

Bitandukanye nibizamini bisanzwe byerekana, gushishikariza secretin byerekana uburyo pankereya yawe ikora neza, ntabwo gusa uko isa. Aya makuru akora ni ngombwa mugusuzuma indwara nka pankreatite idakira, aho pankereya ishobora kugaragara nkisanzwe ariko ntikore neza.

Ugereranije n'inzira zikomeye nka endoscopic retrograde cholangiopancreatography (ERCP), secretin-enhanced MRCP ifite ibyago bike. ERCP ikubiyemo gushyira scope mumunwa wawe mukibazo cyawe cyo mu gifu, gifite ibyago byinshi byo kugira ingaruka nka pankreatite cyangwa kuva amaraso.

Ariko, gupima secretin ntibisanzwe kuba uburyo bwiza. Kubera ibibazo bimwe na bimwe, ibizamini by'amaraso byoroshye cyangwa ishusho isanzwe bishobora gutanga amakuru ahagije. Muganga wawe azatekereza ku bimenyetso byawe, amateka yawe y'ubuvuzi, n'amakuru yihariye akenewe kugira ngo akore isuzuma ryiza.

Ibibazo Bikunze Kubazwa Kuri Secretin

Ese Secretin iratekanye ku bantu barwaye diyabete?

Secretin muri rusange iratekanye ku bantu barwaye diyabete, ariko urugero rw'isukari mu maraso yawe ruzakenera gukurikiranwa by'umwihariko mu gihe cy'igikorwa no nyuma yacyo. Umuti urashobora guhindura by'igihe gito uburyo umubiri wawe utunganya glucose.

Niba ufata imiti ya diyabete, muganga wawe ashobora guhindura gahunda yawe yo gufata imiti ku munsi wo gupima, cyane cyane ko uzaba ukeneye kwiyiriza mbere. Kora neza kuganira gahunda yawe yo gucunga diyabete n'ikipe yawe y'ubuzima mbere y'igikorwa.

Abantu bafite diyabete icungwa neza basanzwe bafata secretin nta bibazo. Ariko, niba isukari yo mu maraso yawe itajegajega vuba aha, muganga wawe ashobora gushaka gusubika ikizamini kugeza igihe diyabete yawe icungwa neza.

Nigira iki niba mbonye secretin nyinshi bitunguranye?

Kurenza urugero rwa secretin ni gake cyane kuko umuti utangwa gusa n'abakozi b'ubuzima bafite imyitozo mu bigo by'ubuvuzi bicungwa. Uburyo bwo gutanga buharurwa neza hashingiwe ku gipimo cy'umubiri wawe n'ikizamini cyihariye gikorerwa.

Niba secretin nyinshi yatanzwe bitunguranye, ushobora guhura n'ingaruka zikomeye nk'isuka ikabije, impinduka zikomeye ku gipimo cy'amaraso, cyangwa kuribwa mu nda igihe kirekire. Ikipe yawe y'ubuvuzi yahita itanga ubufasha kandi ikagukurikiranira hafi.

Inkuru nziza ni uko secretin itunganywa kandi ikavanwa mu mubiri wawe vuba, bityo niba hariho kurenza urugero, ingaruka zizaba iz'igihe gito. Abaganga bawe bafite imiti n'imiti ivura ihari yo gucunga ibikorwa byose bikomeye.

Nigira iki niba nciwe urugero rwa secretin?

Iki kibazo ntikireba secretin kuko atari umuti ufata buri gihe uri mu rugo. Secretin itangwa rimwe gusa mu gihe cyo gukora ibizamini byihariye byo kumenya indwara mu bigo by'ubuvuzi.

Niba wareretswe umwanya wo gukorerwa ikizamini cya secretin, hamagara ibiro bya muganga wawe kugira ngo usubizweho. Nta kaga kari mu gutinda ikizamini iminsi mike cyangwa ibyumweru, keretse niba ufite ibimenyetso bikomeye bisaba gusuzumwa ako kanya.

Muganga wawe azakumenyesha igihe ikizamini kigomba gukorerwa hashingiwe ku buzima bwawe bwihariye. Mu bihe byinshi, gusubiza ikizamini ntizigira ingaruka ku kuri kw'ibisubizo cyangwa gahunda yawe yo kuvurwa.

Nshobora Kureka Gufata Secretin Ryari?

Ntabwo ugomba guhangayika ku birebana no kureka secretin kuko atari umuti ukomeza gufatwa. Ingaruka zizimira mu masaha make nyuma yo guterwa urushinge rumwe mu gihe cyo gukora ikizamini cyawe.

Umubiri wawe uzakuraho hormone ya sintetike unyuze mu mpyiko zawe n'umwijima, nk'uko ubigenza ku yindi miti. Nta gukabya cyangwa kugabanya buhoro buhoro bikenewe.

Niba ukeneye gukora ibindi bizamini mu gihe kizaza, buri gikorwa cya secretin gifatwa nk'ikintu kimwe, rimwe gusa. Nta ngaruka ziterana cyangwa gukenera kuzirikana doze zabanjirijeho mu gihe cyo gutegura ibizamini bizaza.

Nshobora Gutwara Imodoka Nyuma yo Guterwa Secretin?

Abantu benshi bashobora gutwara imodoka nyuma yo guterwa secretin, ariko ugomba gutegereza kugeza igihe icyo aricyo cyose cyo kuruka cyangwa kumva umutwe bishize burundu. Uyu muti ushobora guhindura by'agateganyo umuvuduko w'amaraso yawe n'umuvuduko w'umutima, bishobora gutuma wumva udashikamye.

Teganya kuguma mu kigo cy'ubuvuzi byibura iminota 30 nyuma y'igikorwa cyawe kugira ngo abakozi bashobore kureba niba wumva ushikamye kandi witeguye. Niba wumva uruka, isesemi, cyangwa intege nke, teganya ko undi muntu akugeza mu rugo.

Abantu bamwe barumva bananiwe nyuma y'igikorwa, cyane cyane niba bari barabwiwe kwiyiriza mbere yaho cyangwa niba ikizamini cyari giteye ubwoba. Umenye kumva umubiri wawe kandi ntugatinye gusaba ubufasha mu gutwara niba utumva umeze neza rwose.