Icyo Selegiline ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'iyo miti n'ibindi

Selegiline ni umuti wandikirwa na muganga ufasha mu gucunga ibimenyetso bya indwara ya Parkinson mu kurinda dopamine mu bwonko bwawe. Uyu muti ukora mu buryo butandukanye n'ubundi buvuzi bwa Parkinson kuko ubuza enzyme isenya dopamine, imisemburo yo mu bwonko ukeneye kugira ngo ugende neza kandi ufatanye.

Muganga wawe ashobora kukwandikira selegiline igihe umuti wawe wa Parkinson utagikora neza nk'uko byahoze. Ifatwa nk'ubuvuzi bufasha bushobora gufasha kongera akamaro k'umuti wawe w'ibanze, bikaguha amasaha menshi meza ku munsi.

Selegiline ni iki?

Selegiline ni umwe mu itsinda ry'imiti yitwa MAO-B inhibitors, bivuze ko ibuza enzyme yihariye mu bwonko bwawe yitwa monoamine oxidase B. Iyi enzyme isanzwe isenya dopamine, ariko iyo urwaye indwara ya Parkinson, usangamo dopamine nkeya kurusha uko ukeneye.

Tekereza selegiline nk'ingabo irinda dopamine yawe isigaye. Mu kubuza enzyme isenya dopamine, iyi misemburo y'ingenzi yo mu bwonko irakomeza kuboneka kugira ngo ifashe mu kugenzura imigendekere yawe no kugabanya umutwaro.

Uyu muti uza mu buryo bw'ibinini bisanzwe n'ibinini bishonga mu kanwa bishongera ku rurimi rwawe. Muganga wawe azahitamo uburyo bwiza bushingiye ku byo ukeneye byihariye n'uburyo ushobora kumira ibinini.

Selegiline ikoreshwa mu iki?

Selegiline ikoreshwa cyane cyane mu kuvura indwara ya Parkinson, cyane cyane iyo ibimenyetso byawe bitagenzurwa neza na levodopa na carbidopa bonyine. Ifasha mu gucunga ibimenyetso bya moteri nk'umutwaro, umubyimba, no kugenda gahoro bituma ibikorwa bya buri munsi bigorana.

Muganga wawe ashobora kongera selegiline ku gahunda yawe y'ubuvuzi igihe utangiye guhura n'ibihe byo "gushira". Ibi ni ibihe umuti wawe w'ibanze wa Parkinson utangira gutakaza ingaruka zawo mbere yo gufata urundi rugero, bikagusigira ibimenyetso byiyongereye.

Rimwe na rimwe abaganga bandika selegiline mu ntangiriro z'indwara ya Parkinson. Muri ibyo bihe, bishobora gufasha kugabanya uko ibimenyetso bikomeza ndetse no gutinda gukenera imiti ikomeye nka levodopa.

Uyu muti kandi ushobora gufasha kugabanya ihindagurika ry'ibimenyetso byawe umunsi wose. Abantu benshi barwaye indwara ya Parkinson babona ibimenyetso byabo bihinduka cyane kuva isaha kugeza ku yindi, kandi selegiline irashobora gufasha kunoza ibyo bizamuka n'ibimanuka.

Selegiline ikora ite?

Selegiline ikora ibuza MAO-B, uruganda rwangiza dopamine mu bwonko bwawe. Iyo urwaye indwara ya Parkinson, uturemangingo tw'ubwonko dukora dopamine buhoro buhoro turapfa, bityo kurinda dopamine ufite bisigaye bikaba ingenzi mu gucunga ibimenyetso.

Uyu muti ufatwa nk'ukomeye ku rugero rwo hagati mu kuvura indwara ya Parkinson. Ntabwo ukomeye nka levodopa, akenshi yitwa urugero rwa zahabu, ariko yibanze cyane kandi ishobora gutanga imbaraga zifatika zo kugabanya ibimenyetso hamwe n'ingaruka nke.

Ingaruka zo kurinda za selegiline zimara iminsi myinshi nyuma yo kuyifata. Ibi bivuze ko uruganda ruguma ruzitiwe kabone niyo umuti wavuye mu maraso yawe, bitanga inyungu zirambye kurusha imiti imwe ya Parkinson.

Bitandukanye n'imiti imwe ya Parkinson isimbura dopamine yaburiwe, selegiline ifasha kubungabunga umubiri wawe ukora dopamine. Ubu buryo bushobora kuba bworoheje ku mubiri wawe kandi bushobora gutera ibibazo bike uko imyaka igenda yicuma.

Nkwiriye gufata selegiline nte?

Fata selegiline nk'uko umuganga wawe abitegeka, akenshi rimwe cyangwa kabiri ku munsi hamwe n'ibiryo cyangwa utabifite. Urutonde rusanzwe rwo gutangira ni 5mg kabiri ku munsi, ifatwa mu gitondo na saa sita kugirango wirinde ibibazo byo gusinzira.

Niba ufata ibinini bisenyuka mu kanwa, ubishyire ku rurimi rwawe ubireke bishire rwose. Ntukarume, ntukoreshe cyangwa umire ibi binini byose, kuko ibi bishobora kugira ingaruka ku buryo umuti ukora neza.

Igihe ni ingenzi kuri selegiline kuko ishobora kubangamira ibitotsi niba ifashwe nyuma y'amasaha y'umunsi. Fata urugero rwawe rwa nyuma mbere ya saa saba za mugitondo kugirango wirinde kutagira ibitotsi cyangwa umutuzo muke mugihe cyo kuryama.

Urashobora gufata selegiline hamwe cyangwa utaranye n'ibiryo, ariko kuyifata hamwe n'akaboga gato bishobora gufasha kugabanya ibibazo byo munda. Irinde kuyifata hamwe n'amafunguro manini arimo ibiryo byinshi bikungahaye kuri tyramine nk'amakeke ashaje, inyama zitunganyirijwe, cyangwa ibicuruzwa byavuye mu mwuka.

Ntugahagarike gufata selegiline ako kanya utabanje kuvugana na muganga wawe. Ibimenyetso byawe bya Parkinson bishobora kwiyongera vuba niba uhagaritse imiti ako kanya.

Nzagomba Gufata Selegiline Igihe Kingana Gite?

Abantu benshi barwaye indwara ya Parkinson bafata selegiline imyaka myinshi nk'igice cy'umugambi wabo wo kuvura igihe kirekire. Umuti ukora neza iyo ufashwe buri gihe uko igihe kigenda, ugufasha gukomeza urwego rwa dopamine mu bwonko bwawe.

Muganga wawe azagenzura buri gihe uburyo selegiline ikora neza kuri wowe binyuze mu nama zikurikira. Bazagenzura niba ibimenyetso byawe bigenda neza kandi niba hari impinduka zikenewe kumugambi wawe wo kuvura.

Abantu bamwe bashobora gukenera gufata selegiline ubuzima bwabo bwose, cyane cyane niba bigaragara ko byongera ubuzima bwabo bwiza no kugenzura ibimenyetso. Ibi ni ibisanzwe kandi byitezwe kubibazo bikomeye nka indwara ya Parkinson.

Igihe cyo kuvurwa kandi giterwa n'uburyo ubuzima bwawe bugenda ndetse niba izindi miti ziba ngombwa. Muganga wawe ashobora kongeramo izindi miti cyangwa agahindura urugero rwawe rwa selegiline uko ibikenewe byawe bihinduka uko igihe kigenda.

Ni Ibihe Bikorwa Bigaragara Byo Ku Ruhande Bya Selegiline?

Kimwe n'indi miti yose, selegiline irashobora gutera ibikorwa bigaragara ku ruhande, nubwo abantu benshi bayihanganira neza. Ibikorwa bigaragara ku ruhande bisanzwe ni bike kandi akenshi birakosoka uko umubiri wawe wimenyereza umuti.

Dore ibikorwa bigaragara ku ruhande ushobora guhura nabyo, uhereye ku bisanzwe:

• Kurwara isesemi no kuribwa mu nda
• Kuribwa umutwe cyangwa kumva uruhuka
• Kugorwa no gusinzira cyangwa kurota inzozi zigaragara
• Umunwa wumye
• Kuribwa umutwe
• Kuvurungana cyangwa gutekereza ibitariho
• Kuzamuka kw'imitsi idashaka

Ibi bimenyetso bikunze kugaragara bikunze gushira mu byumweru bike umubiri wawe umaze kumenyera umuti. Niba bikomeje cyangwa bikaba bibangamye, muganga wawe ashobora guhindura urugero rw'umuti cyangwa igihe wo ufata kugira ngo bifashe.

Ingaruka zikomeye ariko zitagaragara cyane zirimo guhinduka gukomeye kw'amarangamutima, kuribwa mu gituza, cyangwa kuzamuka kw'umuvuduko w'amaraso. Ibi bisaba ubufasha bwihuse bw'abaganga kandi bishobora kubaho cyane niba urya ibiryo bimwe na bimwe cyangwa ufata indi miti ivanga na selegiline.

Abantu bamwe baribwa bati "ingaruka za foromaje" niba bariye ibiryo byinshi bikungahaye kuri tyramine bakoresha selegiline. Ibi bishobora gutera kuzamuka kw'umuvuduko w'amaraso, nubwo bitamenyerewe ku rugero rukoreshwa mu ndwara ya Parkinson.

Ninde utagomba gufata Selegiline?

Abantu bamwe bagomba kwirinda selegiline kuko ishobora kuvanga n'indi miti cyangwa indwara. Muganga wawe azasuzuma neza amateka yawe y'ubuzima n'imiti ukoresha mbere yo kuyandika.

Ntabwo ugomba gufata selegiline niba ukoresha imiti imwe na rimwe yo kurwanya depression, cyane cyane SSRIs, SNRIs, cyangwa tricyclic antidepressants. Ubu buryo bushobora gutera indwara ikomeye yitwa serotonin syndrome, ishobora gutera urupfu.

Abantu bafata imiti yo kurwanya ububabare bwa opioid nka meperidine, tramadol, cyangwa methadone bagomba kwirinda selegiline. Izi mvange zishobora gutera ibisubizo bikomeye harimo umuriro mwinshi, imitsi igoye, n'imihindagurikire ikomeye y'umuvuduko w'amaraso.

Niba ufite indwara ikomeye y'umwijima, muganga wawe ashobora guhitamo undi muti kuko selegiline ikorwa n'umwijima. Mu buryo nk'ubwo, abantu bafite indwara ikomeye y'impyiko bashobora gukenera guhindura urugero rw'umuti cyangwa uburyo bwo kuvura.

Buri gihe ujye ubwira muganga wawe imiti yose urimo gufata, harimo imiti igurishwa itagomba uruhushya rwa muganga, imiti yongera imbaraga, n'imiti ikomoka ku bimera. Ndetse n'ibicuruzwa bisa nk'ibidafite akaga nka St. John's wort bishobora gukorana nabi na selegiline.

Amazina y'ubwoko bwa Selegiline

Selegiline iboneka mu mazina y'ubwoko butandukanye, Eldepryl ikaba ari ryo zina rizwi cyane. Iri ni ryo zina ry'ubwoko bw'umwimerere bw'ibinini bisanzwe bya selegiline abaganga bamaze imyaka myinshi bandikira abarwayi.

Zelapar ni irindi zina ry'ubwoko, cyane cyane ry'ibinini bishonga mu kanwa bishongera ku rurimi rwawe. Ibi binini akenshi biroroshye ku bantu bagorwa no kumira ibinini bitewe na indwara ya Parkinson.

Ubwoko bwa selegiline busanzwe buraboneka kandi bukora neza nk'ubwoko bw'amazina. Umufarumasiti wawe ashobora kukubwira ubwoko urimo guhabwa kandi agasubiza ibibazo byose ku itandukaniro riri hagati y'ubwoko butandukanye.

Ikirimo gikora ni kimwe hatitawe ku zina ry'ubwoko, bityo guhindura hagati y'abakora imiti batandukanye mubisanzwe ntigihindura uburyo umuti ukora kuri wowe.

Izindi miti isimbura Selegiline

Niba selegiline itagukwiriye, indi miti myinshi ishobora gufasha mu gucunga ibimenyetso bya indwara ya Parkinson. Muganga wawe ashobora gutekereza rasagiline, ikaba ari MAO-B inhibitor nshya ikora kimwe na selegiline ariko ishobora kugira ingaruka nke.

Dopamine agonists nka pramipexole cyangwa ropinirole zikora mu buryo butandukanye binyuze mu gushishikariza imiterere ya dopamine mu bwonko bwawe. Iyi miti ishobora kuba igisubizo cyiza, cyane cyane mu ntangiriro za indwara ya Parkinson.

COMT inhibitors nka entacapone cyangwa tolcapone ni ubundi buryo bufasha kwagura ingaruka za levodopa. Izi zikora zibungabunga enzyme itandukanye isenya levodopa mbere yo kugera mu bwonko bwawe.

Muganga wawe ashobora no gutekereza ku muti wa amantadine, ufite uburyo bwinshi bwo gufasha mu bimenyetso bya Parkinson kandi ushobora gufasha cyane mu kugabanya imitsi idashakisha iterwa n'indi miti.

Umuti mwiza usimbura biterwa n'ibimenyetso byawe byihariye, indi miti urimo gufata, n'uko umubiri wawe witwara ku miti itandukanye. Muganga wawe azakorana nawe kugirango abone umuti mwiza.

Ese Selegiline iruta Rasagiline?

Bombi selegiline na rasagiline ni MAO-B inhibitors zikora muburyo bumwe, ariko zifite itandukaniro rikomeye. Rasagiline ni umuti mushya ushobora gutera ingaruka nke kandi ntugire ingaruka mbi kurusha selegiline.

Selegiline imaze igihe kinini ikoreshwa kandi ifite ubushakashatsi bwinshi bushingiye ku mikorere yayo, cyane cyane iyo ihujwe na levodopa. Iraboneka kandi mumitangire myinshi, harimo n'ibinini bisenyuka mumunwa abantu bamwe basanga byoroshye gufata.

Rasagiline birashoboka ko itatera ibibazo byo gusinzira kuko ntisenyuka mubintu bisa na amphetamine mumubiri wawe. Ibi bituma ari amahitamo meza kubantu bafite ubushake bwo gukoresha ibintu bitera imbaraga.

Nta muti numwe uruta undi. Guhitamo hagati yabo biterwa n'uburyo wabyakiriye, ingaruka ziterwa n'umuti, n'indi miti urimo gufata.

Muganga wawe azatekereza ibintu nk'imyaka yawe, imikorere y'impyiko, izindi ndwara, n'uburyo wabanje kwitwara ku miti mugihe afata icyemezo hagati yaya mahitamo abiri.

Ibikunze Kubazwa Kuri Selegiline

Q1. Ese Selegiline irakwiriye kubantu barwaye indwara z'umutima?

Selegiline muri rusange irakwiriye kubantu barwaye indwara z'umutima, ariko muganga wawe azakugenzura neza niba ufite indwara z'umutima. Uyu muti rimwe na rimwe ushobora gutera impinduka mumuvuduko wamaraso cyangwa umuvuduko w'umutima, cyane cyane mugihe utangiye kuvurwa.

Niba urwaye indwara y'umutima, muganga wawe ashobora gutangira kukugaburira urugero ruto hanyuma akaruzamura buhoro buhoro. Bazashaka kandi kukubona kenshi mu mezi make ya mbere kugira ngo barebe uko umutima wawe witwara ku muti.

Bwira muganga wawe ako kanya niba wumva ububabare mu gituza, umutima utera nabi, cyangwa guhumeka nabi mu buryo budasanzwe mugihe ukoresha selegiline. Ibi bimenyetso bishobora kugaragaza ko uburwayi bw'umutima wawe bukeneye gukurikiranwa cyane cyangwa guhindura imiti.

Q2. Nkwiriye gukora iki niba nanyweye selegiline nyinshi bitunguranye?

Niba unyweye selegiline nyinshi bitunguranye, vugana na muganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya, kabone niyo wumva umeze neza. Ibyo bimenyetso byo kunywa imiti myinshi ntibishobora kugaragara ako kanya ariko bishobora kurimo kubabara umutwe cyane, kubabara mu gituza, cyangwa impinduka ziteje akaga mu mitsi y'amaraso.

Ntugerageze kwivuruguta cyangwa gufata indi miti yo kurwanya iyo miti myinshi. Ahubwo, shaka icupa ry'imiti yawe hanyuma ujye mu cyumba cy'ubutabazi cyegereye niba muganga wawe abikugiriye inama.

Gira urutonde rw'imiti yawe yose ufite, harimo urugero nyarwo rwa selegiline wanyoye. Iri somo rizafasha abaganga gutanga ubuvuzi bwiza niba ukeneye ubuvuzi bwihutirwa.

Q3. Nkwiriye gukora iki niba nirengagije urugero rwa selegiline?

Niba wirengagije urugero rwa selegiline, unywe ako kanya wibuka, keretse niba ari nimugoroba. Kunywa selegiline nyuma y'amasaha menshi bishobora kubangamira gusinzira kwawe.

Niba amasaha yarenze saa saba za mugitondo mugihe wibuka urugero wibagiwe, rureka hanyuma unywe urugero rwawe rukurikira ku gihe gisanzwe. Ntukongereho urugero kugira ngo usubize urwo wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti.

Kwirengagiza urugero rimwe na rimwe ntizakugiraho ingaruka, ariko gerageza kugumana gahunda ihamye kugira ngo ugere ku miyoborere myiza y'ibimenyetso. Tekereza gushyiraho ibyibutso kuri terefone cyangwa gukoresha umuteguro w'imiti kugira ngo bigufashe kwibuka.

Q4. Nshobora kureka kunywa selegiline ryari?

Ntugasize gufata selegiline ako kanya utabanje kuvugana na muganga wawe. Ibimenyetso byawe bya Parkinson birashoboka ko biziyongera vuba niba uhagaritse imiti ako kanya, kandi ushobora guhura n'ingaruka zisa n'iz'ubuvuzi.

Muganga wawe azagufasha kugabanya buhoro buhoro urugero rwawe mu byumweru byinshi niba ari ngombwa guhagarika selegiline. Ubu buryo bwo kugabanya buhoro buhoro bufasha kwirinda gusubira vuba kw'ibimenyetso kandi butuma umubiri wawe uhinduka.

Icyemezo cyo guhagarika selegiline gikunze kubaho iyo ingaruka ziba zikabije cyangwa iyo izindi miti iba ikwiriye kurwanya indwara yawe. Muganga wawe azakorana nawe kugirango abone ubundi buryo bwiza mbere yo guhagarika selegiline.

Q5. Nshobora kunywa inzoga nkanwa selegiline?

Nibyiza kugabanya kunywa inzoga mugihe ufata selegiline, kuko inzoga irashobora gukomeza ingaruka zimwe nk'izunguruka no guhuzagurika. Inzoga ntoya mubisanzwe zirabyemewe, ariko irinde kunywa cyane cyangwa kunywa inzoga nyinshi.

Witondere cyane divayi itukura na byeri, kuko ibi bikubiyemo tyramine, ishobora guhura na selegiline kugirango itere kuzamuka kw'amaraso. Ibintu bisobanutse nka vodka cyangwa gin mubisanzwe nibyiza niba uhisemo kunywa.

Vugana na muganga wawe kubyerekeye imigenzo yawe yo kunywa inzoga kugirango baguhe inama zihariye. Barashobora kugusaba kwirinda inzoga rwose niba urimo guhura n'ingaruka zimwe na zimwe cyangwa ufata izindi miti ihura n'inzoga.