Ni iki Tafasitamab: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'iyo miti n'ibindi

Tafasitamab ni umuti uvura kanseri ugamije gukoreshwa cyane cyane mu bwoko bumwe na bumwe bwa kanseri y'amaraso. Uyu muti ukubiye mu cyiciro cy'imiti yitwa imibiri irwanya indwara ya monoclonal, ikora nk'ibisasu bigenda biyoborwa kugira ngo bishake kandi bigabe ibitero ku turemangingo twa kanseri mu gihe turemangingo tw'umubiri twuzuye dusigara tutagize icyo tuba.

Niba wowe cyangwa umuntu ukwitaho yarandikiwe tafasitamab, birashoboka ko ufite ibibazo byinshi byerekeye ibyo witegura. Uyu muti uhagarariye iterambere rikomeye mu kuvura kanseri zimwe na zimwe z'amaraso, kandi gusobanukirwa uko ikora birashobora kugufasha kumva witeguye neza urugendo rwawe rwo kuvurwa.

Tafasitamab ni iki?

Tafasitamab ni umubiri urwanya indwara wakorewe muri laboratori ugamije proteyine runaka iboneka ku turemangingo tumwe na tumwe twa kanseri. Tekereza nk'urufunguzo rwihariye rwinjira gusa mu byuma biboneka ku turemangingo twa kanseri, rufasha urwego rwawe rw'ubudahangarwa kumenya no kurimbura utwo turemangingo twangiza neza.

Uyu muti utangwa binyuze mu gutera urushinge rwa IV, bivuze ko utangwa mu maraso yawe unyuze mu urugingo rw'umubiri. Ibi bituma umuti ugenda mu mubiri wawe wose kugira ngo ugerere uturemangingo twa kanseri aho bishoboka ko bihishe.

Tafasitamab izwi kandi ku izina ry'ubucuruzi rya Monjuvi. Izina ryuzuye rya chimique ririmo

Uyu muti wagenewe abantu bakuru, utunyangingo twa kanseri twabo tugasangwa dufite poroteyine yitwa CD19. Itsinda ry'abaganga bawe rizakora ibizamini byihariye kugira ngo bemeze ko tafasitamab ari wo muti ukwiriye wo kuvura ubwoko bwawe bwihariye bwa limfoma.

Tafasitamab ikora ite?

Tafasitamab ikora yifatanya na poroteyine yitwa CD19 yisanga ku gice cyo hejuru cy'utunyangingo tumwe na tumwe twa kanseri. Iyo imaze kwifatanya, itegeka urugingo rwawe rw'ubudahangarwa kurwanya no kurimbura utwo tunyangingo.

Uyu muti ufatwa nk'umuti uvura kanseri ukomeye ku rugero ruciriritse. Ufite imbaraga zihagije zo kurwanya neza utunyangingo twa kanseri ariko akenshi utera ingaruka zoroheje ugereranyije n'imiti gakondo ya shimi.

Ubuvuzi bukora mu buryo bubiri bukuru. Icya mbere, buhagarika mu buryo butaziguye ibimenyetso bifasha utunyangingo twa kanseri kubaho no kwiyongera. Icya kabiri, butumiza utunyangingo kamere tw'ubudahangarwa bwo mu mubiri wawe ngo bifatanye kurwanya kanseri.

Nkwiriye gufata tafasitamab nte?

Tafasitamab itangwa gusa binyuze mu gutera urushinge mu urugingo rw'ubuvuzi, bityo ntuzajya ufata uyu muti uri mu rugo. Itsinda ryawe ry'ubuvuzi rizakora imyiteguro yose n'imicungire yawo.

Mbere yo gutera urushinge rwa buri gihe, akenshi uzahabwa imiti yabanje kugira ngo ifashe kwirinda ibimenyetso by'uburwayi. Iyi miti ishobora kuba irimo imiti irwanya allergie, igabanya umuriro, cyangwa steroid. Itsinda ryawe ry'ubuvuzi rizakugenzura neza mu gihe cyo gutera urushinge no nyuma yaho.

Ntabwo ukeneye gukurikiza ibyo kurya byihariye hamwe na tafasitamab. Ariko, ni ngombwa kuguma ufite amazi ahagije mbere na nyuma yo kuvurwa. Itsinda ryawe ry'ubuvuzi rishobora gutanga amabwiriza yihariye yerekeye kurya no kunywa ku munsi wo kuvurwa.

Nkwiriye gufata tafasitamab igihe kingana iki?

Uburyo busanzwe bwo kuvurwa na tafasitamab bumara amezi agera kuri 12, nubwo ibi bishobora gutandukana bitewe n'uko wemera umuti. Gahunda yawe yo kuvurwa ishobora gukubiyemo gutera urushinge buri byumweru bike muri iki gihe.

Muganga wawe azajya akurikirana imiterere yawe buri gihe akoresheje ibizamini by'amaraso n'amashusho. Ibi bizamini bifasha kumenya niba imiti ikora neza kandi niba hari ibihinduka byakorwa.

Urufatiro rwo gukomeza cyangwa guhagarika imiti rushingiye ku bintu bitandukanye, harimo uburyo kanseri yitwara, ingaruka zikubaho, n'ubuzima bwawe muri rusange. Itsinda ry'abaganga rizajya rifatanya nawe kugira ngo bafate ibi byemezo.

Ni izihe ngaruka ziterwa na Tafasitamab?

Kimwe n'imiti yose ivura kanseri, tafasitamab ishobora gutera ingaruka, nubwo abantu benshi bayihanganira neza. Kumva icyo witegura bishobora kugufasha kwitegura no kumenya igihe cyo kuvugana n'itsinda ryawe ry'ubuvuzi.

Ingaruka zisanzwe zishobora kukubaho zirimo umunaniro, ushobora kuva ku kunanirwa guto ukagera ku kunanirwa gukabije. Abantu benshi kandi babona impinduka mu mubare w'amaraso yabo, ibyo itsinda ryawe ry'ubuvuzi rizakurikirana neza binyuze mu bizamini by'amaraso bya buri gihe.

Dore ingaruka zivugwa kenshi:

• Umunaniro n'intege nke
• Umubare muto w'uturemangingo twera tw'amaraso (byongera ibyago byo kwandura indwara)
• Umubare muto w'uturemangingo tw'amaraso tutukura (anemiya)
• Umubare muto w'uturemangingo dutuma amaraso avura (tugira uruhare mu kuvura amaraso)
• Impiswi
• Kubura ubushake bwo kurya
• Inkorora
• Urubore

Izi ngaruka muri rusange zirashoboka kuzitaho hakoreshejwe ubufasha n'ubugenzuzi bukwiriye. Itsinda ryawe ry'ubuvuzi rifite uburambe mu gufasha abarwayi banyura muri ibi bibazo.

Abantu bamwe bashobora guhura n'ingaruka zikomeye ariko zitabaho kenshi. Izi zikeneye ubufasha bw'ubuvuzi bwihuse kandi zirimo indwara zikomeye, kuva amaraso cyane, cyangwa ibimenyetso bikomeye bya allergie mugihe cyo kuvura.

Ingaruka zitabaho kenshi ariko zikomeye zirimo:

• Udukoko dukomeye kubera umubiri udashobora kwirinda indwara
• Tumor lysis syndrome (ukwiyongera vuba kw'uturemangingo twa kanseri)
• Uburwayi bukomeye bwo kwivumbura ku bintu
• Progressive multifocal leukoencephalopathy (ubwandu bw'ubwonko butavugwa cyane)
• Gusubira mu murimo kwa hepatite B ku bantu bari barayanduye mbere

Itsinda ryawe ry'abaganga rizakurikirana neza ibi bibazo bitavugwa cyane kandi bazafata ingamba zo kubikumira igihe bibaye ngombwa. Ntuzazuyaze gutanga raporo y'ibimenyetso bidasanzwe, kabone niyo byaba bisa nk'ibito.

Ninde utagomba gufata Tafasitamab?

Tafasitamab ntabwo ikwiriye kuri buri wese, kandi muganga wawe azagenzura neza niba ari umutekano kuri wowe. Abantu bafite uburwayi runaka cyangwa ibibazo by'ubuzima bashobora gukenera kwirinda uyu muti cyangwa bagasaba gukurikiranwa byihariye.

Ntabwo ugomba guhabwa tafasitamab niba waragize uburwayi bukomeye bwo kwivumbura ku bintu kuri uyu muti cyangwa ibice byawo byose mu gihe gishize. Muganga wawe azitonda kandi niba ufite amateka y'uburwayi bukomeye bwo kwivumbura ku bintu ku zindi ntungamubiri za monoclonal.

Itsinda ryawe ry'abaganga rizagira ubushishozi bwihariye niba ufite kimwe muri ibi bibazo:

• Udukoko dukora, cyane cyane indwara ziterwa na bagiteri, virusi, cyangwa fungus
• Amateka y'ubwandu bwa hepatite B
• Umutekano w'umubiri wacitse intege cyane
• Gusama cyangwa guteganya gusama
• Konsa
• Ibikenewe bya vaccine nzima

Niba utwite cyangwa uteganya gusama, uyu muti ushobora gushobora gukomeretsa umwana wawe ukiri mu nda. Itsinda ryawe ry'ubuvuzi rizaganira nawe kubyerekeye uburyo bwo kuboneza urubyaro bwizewe n'uburyo bwo gutegura umuryango.

Izina ry'ubwoko bwa Tafasitamab

Tafasitamab igurishwa ku izina ry'ubwoko rya Monjuvi muri Leta Zunze Ubumwe z'Amerika. Iri zina ry'ubwoko ni ryo uzasanga ku ngengabihe yawe y'imiti n'inyandiko z'ubwishingizi.

Uyu muti ukorwa na MorphoSys kandi ukagurishwa ku bufatanye na Incyte Corporation. Igihe uvugana n'amasosiyete y'ubwishingizi cyangwa abandi baganga ku bijyanye n'imiti uvuzwa, amazina yombi (tafasitamab na Monjuvi) yerekeza ku muti umwe.

Izindi miti isimbura Tafasitamab

Hariho ubundi buryo bwinshi bwo kuvura kanseri ya diffuse large B-cell lymphoma, nubwo guhitamo neza biterwa n'uko ubuzima bwawe bumeze. Muganga wawe azatekereza ku bintu nk'ubuzima bwawe muri rusange, imiti wabanje gufata, n'uko kanseri yawe yitwara.

Ubuvuzi busimbura ubu bushobora kuba bukubiyemo imiti ya kera ya chemotherapy nk'imiti ya R-CHOP cyangwa imiti mishya igamije. Ubuvuzi bwa CAR T-cell bugize ubundi buryo buhanitse kuri bamwe barwaye, nubwo bisaba ibigo by'ubuvuzi byihariye.

Abantu bamwe bashobora kungukirwa n'igerageza ry'imiti mishya ikigeragezwa. Muganga wawe w'inzobere mu kuvura kanseri ashobora kugufasha gusobanukirwa niba hari ubushakashatsi ubwo aribwo bwose bushobora kuba bukwiye kubera uko ubuzima bwawe bumeze.

Ese Tafasitamab iruta Rituximab?

Tafasitamab na rituximab byombi ni imiti ya monoclonal antibodies ikoreshwa mu kuvura kanseri z'amaraso, ariko zikora mu buryo butandukanye kandi zikoreshwa mu bihe bitandukanye. Kubigereranya ntibiba byoroshye buri gihe kuko akenshi bikoreshwa mu byiciro bitandukanye by'ubuvuzi.

Rituximab imaze igihe kinini iboneka kandi akenshi ikoreshwa nk'igice cy'imiti ikoreshwa mu rugero rwa mbere. Tafasitamab akenshi yagenewe ibihe kanseri yagarutse cyangwa ititwaye neza ku miti yabanje.

Muganga wawe azahitamo umuti ukwiye cyane bitewe n'ubwoko bwihariye bwa lymphoma ufite, amateka y'ubuvuzi bwawe, n'ubuzima bwawe muri rusange. Imiti yombi yagaragaje ko ifite akamaro mu bikoreshwa, kandi guhitamo

Tafasitamab ikoreshwa neza ku bantu bafite indwara z'umutima, ariko muganga w'umutima na muganga w'indwara z'umubiri bazakorana kugira ngo bakurikirane neza. Uyu muti ntugera ku mutima mu buryo bweruye, ariko imiti ivura kanseri rimwe na rimwe ishobora kugira ingaruka ku buzima bw'imitsi y'umubiri.

Itsinda ry'abaganga bawe rishobora gukora ibizamini by'imikorere y'umutima mbere yo gutangira kuvurwa no kugukurikirana mu gihe cyose uvurwa. Niba ufite ibibazo bikomeye by'umutima, bashobora guhindura gahunda yawe yo kuvurwa cyangwa gutanga ingamba zindi zo kurinda umutima.

Nkwiriye gukora iki niba nirengagije guterwa Tafasitamab?

Kubera ko tafasitamab itangwa mu kigo cy'ubuvuzi, gusiba urukingo akenshi biterwa n'ibibazo by'igihe cyangwa ibibazo by'ubuzima. Vugana n'itsinda ryawe ry'ubuzima ako kanya niba ukeneye gusiba cyangwa gusubika gahunda.

Itsinda ryawe ry'ubuzima rizagufasha gusubika gahunda vuba bishoboka. Bashobora guhindura gahunda yawe yo kuvurwa gato, ariko ni ngombwa kutareka imiti udafashijwe n'abaganga, kuko ibi bishobora kugira ingaruka ku buryo ubuvuzi bwawe bukora neza.

Nshobora guhagarika ryari gufata Tafasitamab?

Umwanzuro wo guhagarika tafasitamab biterwa n'uburyo kanseri yawe yitwara ku buvuzi n'ingaruka z'uruhande ubona. Abantu benshi barangiza kuvurwa amezi agera kuri 12, ariko ibi birashobora gutandukana.

Muganga wawe azakoresha ibizamini bisanzwe n'ibizamini by'amaraso kugira ngo akurikirane iterambere ryawe. Niba kanseri izimira cyangwa ikaba itagaragara, urashobora kurangiza gahunda y'ubuvuzi yateguwe. Niba ingaruka zikomeye zigaragaye, muganga wawe ashobora kugusaba guhagarika kare no guhindurira ku bundi buryo.

Nshobora guhabwa inkingo nkanwa Tafasitamab?

Ukwiye kwirinda inkingo zikora mu gihe uhabwa tafasitamab kuko umuti ugira ingaruka ku mikorere y'umubiri wawe. Ariko, inkingo zitagira akamaro (nk'urukingo rwa grip) muri rusange ni nziza kandi akenshi zirashimwa.

Itsinda ry'ubuvuzi bwanyu rizabatanga ubuyobozi bwihariye ku bijyanye n'inkingo zifite umutekano mu gihe cyo kuvurwa. Bashobora kubagira inama yo guhabwa inkingo zimwe na zimwe mbere yo gutangira tafasitamab cyangwa gutegereza kugeza igihe kuvurwa kwanyu kurangiriye.

Ese Tafasitamab izagira ingaruka ku bushobozi bwanjye bwo gukora cyangwa gutwara ikinyabiziga?

Abantu benshi barashobora gukomeza gukora no gutwara ibinyabiziga mu gihe bakira tafasitamab, nubwo bishobora kuba ngombwa ko mukora impinduka zimwe na zimwe. Umunaniro ni ingaruka zisanzwe zishobora kugira ingaruka ku rwego rw'imbaraga zanyu no kwibanda.

Mutegure guhinduka gato mu gihe cyanyu, cyane cyane ku munsi wo kuvurwa no ku munsi ukurikira inshinge. Abantu bamwe barumva bananiwe umunsi umwe cyangwa ibiri nyuma ya buri kuvurwa, mu gihe abandi bakomeza urwego rwabo rusanzwe rw'imbaraga mu gihe cyose cyo kuvurwa.