Tagraxofusp-erzs ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Tagraxofusp-erzs ni umuti w'indwara ya kanseri ugamije gufasha kurwanya kanseri idasanzwe y'amaraso yitwa blastic plasmacytoid dendritic cell neoplasm (BPDCN). Ubu buvuzi bwihariye bukora binyuze mu kwifatanya na poroteyine zihariye ku ngirangingo za kanseri no gutanga uburozi buzizihiriza imbere. Yagenewe abantu bakuru n'abana bafite ubu bwoko bwihariye bwa kanseri y'amaraso, itanga icyizere igihe izindi nshuti zitabasha gukora.

Tagraxofusp-erzs ni iki?

Tagraxofusp-erzs ni umuti wa kanseri wandikirwa uvanga ibice bibiri bikomeye kurwanya ingirangingo za kanseri. Igice cya mbere gikora nk'igisasu kiyobora, gishaka no kwifatanya na poroteyine zihariye zifite izina rya CD123 ku ngirangingo za kanseri. Igice cya kabiri gitanga uburozi bwangiza izi ngirangingo zigamijwe mugihe zisiga ingirangingo zifite ubuzima bwiza zitangiritse cyane.

Uyu muti ubarirwa mu cyiciro cy'imiti yitwa CD123-directed cytotoxins. Tekereza nk'igisasu cy'ubwenge gishobora gutandukanya ingirangingo zifite ubuzima bwiza n'ingirangingo za kanseri. Uyu muti utangwa binyuze mu gutera urushinge rwa IV, ukemerera kugenda mu maraso yawe kugera ku ngirangingo za kanseri aho zaba zihishe hose.

Itsinda ryawe ry'ubuzima rizategura kandi ritange uyu muti mu kigo cy'ubuvuzi aho ushobora gukurikiranwa neza. Ubu buryo bwitondewe bufasha kumenya umutekano wawe kandi bugatuma habaho igisubizo cyihuse niba hari ingaruka ziterwa n'iyo miti zigaragara mugihe cy'ubuvuzi.

Tagraxofusp-erzs ikoreshwa mu iki?

Tagraxofusp-erzs yemerejwe by'umwihariko kuvura blastic plasmacytoid dendritic cell neoplasm (BPDCN) mu bantu bakuru n'abana bafite imyaka 2 n'abarenze. BPDCN ni kanseri y'amaraso idasanzwe kandi ikaze igira ingaruka ku ngirangingo zidasanzwe z'ubudahangarwa zifite izina rya plasmacytoid dendritic cells.

Ubu bwoko bwa kanseri busanzwe bugaragara nk'ibikomere ku ruhu, imvubura zabyimbye, cyangwa bugafata umushongi w'amagufa n'amaraso. Kubera ko BPDCN ariyo kanseri idakunze kuboneka, ikaba ifata abantu batageze kuri 1 kuri 100,000, mbere y'uko uyu muti utangira gukorwa, hari ubundi buryo bwo kuvura butari bwinshi.

Muganga wawe ashobora kugusaba uyu muti niba warasanzwemo BPDCN kandi izindi miti zitagikora cyangwa zitakwemerera. Uyu muti wagaragaje icyizere mu bigeragezo byakozwe, aho abarwayi benshi bagaragaje iterambere rikomeye mu bimenyetso bya kanseri yabo.

Tagraxofusp-erzs ikora ite?

Tagraxofusp-erzs ikora ikoresheje uburyo bubiri butunganye bugamije kurwanya selile za kanseri neza cyane. Uyu muti wateguwe kugira ngo ushakishe kandi wifatanye na reseptori za CD123, ziboneka ku bwinshi kuri selile za kanseri ya BPDCN ariko ntizikunze kuboneka kuri selile nzima.

Iyo uyu muti wifatanye n'izi reseptori, selile ya kanseri ifasha mu buryo bwo kuyinjiza imbere binyuze mu buryo karemano bita endocytosis. Tekereza nk'uko selile ya kanseri itazi ifungura umuryango wayo kugira ngo uyu muti winjiremo.

Muri selile ya kanseri, uyu muti urekurura uburozi bwawo, bukabangamira ubushobozi bwa selile bwo gukora poroteyine z'ingenzi zo kubaho. Ibi bituma selile ya kanseri ipfa mugihe bigabanya kwangiza selile nzima zitagira reseptori nyinshi za CD123.

Ubu buryo bugamije ni ubwo imbaraga kandi bukora neza kuri BPDCN, nubwo bushobora gutera ingaruka zikomeye kuko hariho selile nzima zifite reseptori za CD123, cyane cyane mu mwijima no mu miyoboro y'amaraso.

Nkwiriye gufata nte Tagraxofusp-erzs?

Tagraxofusp-erzs itangwa nk'urushinge rwinjizwa mu maraso (IV) rutaziguye mu maraso yawe ahantu havurirwa. Ntushobora gufata uyu muti mu rugo, kandi ugomba gutegurwa no gutangwa n'abakozi b'ubuzima babihuguriwe kandi bafite umwuga wo kuvura kanseri.

Uburyo busanzwe bwo kuvura bukubiyemo guhabwa umuti rimwe ku munsi mu minsi itanu ya mbere y'uruziga rw'iminsi 21. Itsinda ryawe ry'ubuzima rizashyira umurongo wa IV mu urugingo rw'amaboko yawe cyangwa binyuze mu murongo wo hagati niba uwufite. Gusuka mubisanzwe bifata iminota 15 kugirango birangire.

Mbere yo gusukwa, uzahabwa imiti mbere yo kuvurwa kugirango ifashe kwirinda ibimenyetso byo kwibasirwa n'umubiri n'izindi ngaruka. Ibi bishobora kuba birimo antihistamines, corticosteroids, n'ibigabanya umuriro. Itsinda ryawe ry'abaganga rizakurikirana ibimenyetso byawe by'ingenzi cyane mugihe no nyuma yo gusukwa.

Ntabwo ukeneye guhangayika kubijyanye no kurya mbere yo kuvurwa, ariko kuguma ufite amazi menshi ni ingenzi. Itsinda ryawe ry'ubuzima rishobora kugusaba kunywa amazi menshi mu minsi ibanziriza kuvurwa kwawe kugirango bifashe impyiko zawe gutunganya imiti neza.

Mbona Nkora Igihe Kingana Gite Nkwiriye Gufata Tagraxofusp-erzs?

Igihe cyo kuvurwa kwawe kwa tagraxofusp-erzs giterwa n'uburyo kanseri yawe isubiza kandi n'uburyo wihanganira umuti. Abantu benshi barwara bahabwa ibizunguruka byinshi byo kuvurwa, buri kizunguruka kimara iminsi 21 kandi kikubiyemo iminsi itanu yo gutanga imiti.

Muganga wawe azakurikiranira hafi kanseri yawe binyuze mu igeragezwa ry'amaraso, amasomo yo gushushanya, n'ibizamini by'umubiri kugirango amenye niba kuvurwa bikora. Niba kanseri yawe isubiza neza kandi wihanganira umuti nta ngaruka zikomeye, urashobora gukomeza kuvurwa mu bizunguruka byinshi.

Abantu barwara bamwe bashobora kugera ku gukira nyuma y'ibizunguruka bike, mugihe abandi bashobora gukenera kuvurwa igihe kirekire. Itsinda ryawe ry'ubuzima rizakorana nawe kugirango ribone uburyo bukwiye bwo kurwanya kanseri yawe neza no gukomeza ubuzima bwawe bwiza.

Ibyemezo byo kuvura bigenda ku giti cyabo cyane, kandi muganga wawe azatekereza ibintu nk'ubuzima bwawe muri rusange, igisubizo cya kanseri, n'ingaruka zose uhura nazo mugihe cyo kumenya igihe cyo gukomeza kuvura.

Ni Ibihe Bikorwa Bigaragara Byatewe na Tagraxofusp-erzs?

Tagraxofusp-erzs ishobora gutera ibikorwa bigaragara bitandukanye, kuva ku byoroheje kugeza ku bikomeye, kuko umuti utagira ingaruka ku turemangingo twa kanseri gusa ahubwo no ku turemangingo duke twiza dufite imirasire ya CD123. Kumva neza ibi bikorwa bishobora gufasha wowe n'ikipe yawe y'ubuvuzi kubicunga neza.

Ibikorwa bigaragara cyane ushobora guhura nabyo birimo umunaniro, isesemi, umuriro, no kubyimba mu maboko yawe, amaguru, cyangwa mu maso. Abarwayi benshi kandi bagira ibibazo byo ku ruhu, impinduka mu bizami by'imikorere y'umwijima, n'umubare muto w'amaraso bishobora kongera ibyago byo kwandura cyangwa kuva amaraso.

Ibikorwa Bisanzwe Bigaragara

Dore ibikorwa bigaragara bibaho ku barwayi benshi bakira uyu muti, nubwo atari buri wese uzabona byose:

• Umunaniro n'intege nke bishobora kubangamira imirimo ya buri munsi
• Isesemi no kuruka, bikunze gucungwa n'imiti irwanya isesemi
• Umuriro n'ubukonje, cyane cyane nyuma y'imiti mike ya mbere
• Ukubyimba (edema) mu ntoki, ibirenge, amaguru, cyangwa mu maso bitewe no kubika amazi
• Ibibazo byo ku ruhu birimo uruhu, gushishuka, cyangwa uruhu rumeze neza
• Impinduka mu bizami by'imikorere y'umwijima, umuganga wawe azakurikirana neza
• Umubare muto w'uturemangingo tw'amaraso tugira ingaruka ku turemangingo twera tw'amaraso, uturemangingo tw'amaraso atukura, cyangwa uturemangingo tw'amaraso
• Umutwe no kuribwa
• Kubura ubushake bwo kurya no guhinduka kw'ibiro

Ibi bikorwa bisanzwe bigaragara bikunze gucungwa n'ubufasha n'imiti. Ikipe yawe y'ubuvuzi izakorana nawe kugirango igabanye ingaruka zabyo ku buzima bwawe bwa buri munsi.

Ibikorwa Bikomeye Bigaragara

Nubwo bidakunze kubaho, abarwayi bamwe bashobora guhura n'ibikorwa bikomeye bigaragara bisaba ubufasha bw'ubuvuzi bwihuse no gukurikiranwa neza:

• Indwara ya capillary leak syndrome, ituma amazi ava mu miyoboro y'amaraso akajya mu bice biyikikije
• Ibibazo bikomeye by'umwijima bishobora guteza akaga iyo bitavuwe vuba
• Indwara zikomeye ziterwa n'umubare muto w'uturemangingo tw'amaraso twera
• Urugero rukomeye rw'uburwayi bw'umubiri mu gihe cyangwa nyuma gato yo guterwa urukingo
• Tumor lysis syndrome, aho uturemangingo twa kanseri dusenyuka vuba cyane
• Kuzana amazi menshi cyane bigira ingaruka ku mikorere y'umutima cyangwa ibihaha
• Hemophagocytic lymphohistiocytosis, uburyo budasanzwe ariko bukomeye bwo kwivumbura kw'umubiri

Itsinda ryawe ry'abaganga rizagukurikiranira hafi ibi bibazo bikomeye kandi rizahagarika kuvura niba bibaye ngombwa kugira ngo rirengere ubuzima bwawe. Byinshi muri ibi bintu biragaruka iyo bavuwe neza.

Ingaruka zidasanzwe ariko z'ingenzi

Abantu bamwe barwara ingaruka zidasanzwe, nubwo bidakunze kubaho, ni ngombwa kuzimenya:

• Ingaruka zikomeye z'imitsi harimo urujijo, gufatwa n'ibihungabanyo, cyangwa impinduka mu miterere y'ubwonko
• Ibibazo by'umutima harimo umutima utera nabi cyangwa amazi azenguruka umutima
• Ibibazo bikomeye by'impyiko bisaba gukaraba imyanda
• Uburwayi bwo gupfundika kw'amaraso bushobora gutera ibipfundikizo by'akaga cyangwa kuva amaraso
• Imikorere mibi ikomeye y'amashanyarazi igira ingaruka ku mikorere y'imitsi n'imitsi y'ubwonko
• Uburwayi bwo mu gifu (pancreatitis) butera kuribwa cyane mu nda

Izi ngaruka zidasanzwe zisaba ubufasha bw'ubuvuzi bwihutirwa kandi zishobora gutuma umuntu ajyanwa mu bitaro kugira ngo akurikiranwe cyane kandi avurwe.

Ninde utagomba gufata Tagraxofusp-erzs?

Tagraxofusp-erzs ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza niba ubu buvuzi bufitiye umutekano. Abantu bafite uburwayi runaka cyangwa ibibazo runaka ntibashobora kuba bakwiriye iyi miti.

Ntabwo wagombye guhabwa uyu muti niba ufite allergie izwi kuri tagraxofusp-erzs cyangwa ibice byawo byose. Muganga wawe azanatekereza ku buzima bwawe muri rusange, harimo imikorere y'umutima, umwijima, n'impyiko, mbere yo kugusaba ubu buvuzi.

Abarwayi bafite indwara ikomeye y'umwijima ntibashobora guhabwa uyu muti mu buryo bwizewe kuko ushobora gutuma ibibazo by'umwijima birushaho kuba bibi. Mu buryo nk'ubwo, abantu bafite indwara zikomeye z'umutima bashobora kuba bafite ibyago byinshi byo guhura n'ingorane zituruka ku kwiyongera kw'amazi n'izindi ngaruka za cardiovascular.

Abagore batwite ntibagombye guhabwa tagraxofusp-erzs kuko ishobora gukomeretsa umwana ukura. Niba uri mu gihe cyo kubyara, muganga wawe azaganira ku buryo bwo kuboneza urubyaro bukoreshwa mu gihe cy'ubuvuzi no mu mezi make nyuma yaho.

Izina ry'ubwoko rya Tagraxofusp-erzs

Tagraxofusp-erzs igurishwa ku izina ry'ubwoko rya Elzonris. Iri zina ry'ubwoko rikoreshwa muri Leta Zunze Ubumwe z'Amerika n'ibindi bihugu aho uyu muti wemerejwe kuvura BPDCN.

Igihe uzakira ubuvuzi bwawe, ushobora kubona izina rimwe muri dosiye zawe z'ubuvuzi cyangwa inyandiko z'ubwishingizi. Amazina yombi yerekeza ku muti umwe, bityo ntugahungabane niba ubonye amazina atandukanye akoreshwa ahantu hatandukanye.

Elzonris ikorwa na Stemline Therapeutics kandi iboneka gusa binyuze mu bigo byihariye bivura kanseri n'ibitaro bifite uburambe muri ubu bwoko bwa terapiya yagenewe.

Uburyo bwo gusimbuza Tagraxofusp-erzs

Kubera ko BPDCN ari kanseri idakunze kuboneka, hari uburyo buke bwo kuvura bushobora kuboneka. Mbere yuko tagraxofusp-erzs yemerwa, abaganga basanzwe bakoresha imvange y'imiti ya chimiothérapie isa n'iyo bakoresha mu zindi kanseri z'amaraso.

Uburyo busanzwe bwa chimiothérapie bushobora gukubiyemo imvange y'imiti nka cyclophosphamide, doxorubicin, vincristine, na prednisone. Ariko, ubu buvuzi akenshi bugira ingaruka nke kuri BPDCN kandi bushobora gutera ingaruka zikomeye.

Ku barwayi bamwe, gushyiraho imitsi ya stem cell bishobora gutekerezwa, cyane cyane niba bageze ku gukira binyuze mu kuvurwa kwa mbere. Iyi nzira ikomeye irimo gusimbuza umushongi w'amagufa urwaye hamwe n'uturemangingo tw'abantu bazima.

Igeragezwa ryo kuvura rishobora kandi gutanga uburyo bwo kubona imiti igeragezwa irimo kwigwa kuri BPDCN. Umuganga wawe w'indwara z'umuvuduko w'amaraso ashobora kugufasha gushakisha uburyo bwose buhari no gushyiraho uburyo bwiza bw'imikorere yihariye.

Ese Tagraxofusp-erzs iruta izindi miti?

Tagraxofusp-erzs ihagarariye iterambere rikomeye mu kuvura BPDCN ugereranije n'uburyo bwa kera bwo kuvura na chemotherapy. Igeragezwa ryo kuvura ryagaragaje ko iyi miti yagenewe gukora ishobora gukora neza kurusha uburyo bwa kera bwo kuvura abarwayi benshi bafite iyi kanseri idasanzwe.

Uburyo bw'iyi miti bugamije gukora bisobanura ko ishobora kurwanya uturemangingo twa kanseri neza cyane kandi bishobora gutera ingaruka nke zikomeye zijyana na chemotherapy yagutse. Ibi bishobora gutuma habaho ibisubizo byiza n'imibereho myiza y'abarwayi benshi.

Ariko,

Muganga wawe azapima imikorere y'umwijima wawe mbere yo gutangira kuvurwa kandi akomeze kugenzura mu gihe cyose uvurwa. Niba ufite ibibazo byoroheje by'umwijima, urashobora gukomeza guhabwa umuti hamwe no kugenzurwa neza kandi birashoboka ko urugero rwawo ruhinduka.

Abantu bafite indwara ikomeye y'umwijima muri rusange ntibakwiriye ubu buvuzi kuko ibyago bishobora kurenga inyungu. Itsinda ryawe ry'ubuvuzi rizakorana nawe kugirango ribone uburyo bwo kuvura bufite umutekano kandi bwiza kubibazo byawe.

Q2. Nzakora iki niba ngize ingaruka zikomeye?

Niba ugize ingaruka zikomeye nk'uguhumeka nabi, kubyimba bikabije, kuribwa cyane mu nda, cyangwa guhinduka mu miterere y'ubwenge, ugomba kwihutira gushaka ubufasha bw'ubuvuzi. Ntukegere urebe niba ibimenyetso bikira byonyine.

Vugana n'itsinda ryawe ry'ubuvuzi ako kanya niba ugize umuriro, ibimenyetso by'ubwandu, kuva amaraso bidasanzwe cyangwa gukomeretsa, cyangwa umunaniro ukabije utuma udashobora gukora imirimo ya buri munsi. Ibi birashobora kuba ibimenyetso by'ingorane zikomeye zikeneye kuvurwa vuba.

Itsinda ryawe ry'ubuvuzi rifite uburambe mu gucunga ingaruka z'uyu muti kandi rishobora gutanga imiti kugirango igufashe kumva neza. Barashobora guhindura gahunda yawe y'imiti, gutanga ubufasha, cyangwa guhagarika kuvura by'agateganyo niba bibaye ngombwa.

Bika urutonde rw'imibare ya terefone yihutirwa y'itsinda ryawe ry'ubuvuzi kandi umenye ivuriro cyangwa ikigo cy'ubuvuzi ujyayo niba ukeneye ubufasha bwihutirwa hanze y'amasaha asanzwe y'ibiro.

Q3. Nzamena nte niba ubuvuzi bukora?

Muganga wawe azagenzura uburyo witwara kuri tagraxofusp-erzs binyuze mu bipimo by'amaraso bisanzwe, ibizamini by'umubiri, n'ubushakashatsi bw'amashusho. Urashobora gutangira kubona impinduka nziza mu bimenyetso nk'umunaniro, ibisebe byo ku ruhu, cyangwa imitsi yabyimbye muminsi mike yo kuvurwa.

Ibizami by'amaraso bizerekana impinduka mu turemangingo twa kanseri n'imibare y'amaraso muri rusange, naho ibizamini by'amashusho nka CT scans cyangwa PET scans bishobora kugaragaza niba ibibyimba bigenda bigabanuka. Muganga wawe azasobanura icyo ibi bizamini byerekana n'icyo bisobanuye kuri gahunda yawe y'ubuvuzi.

Abantu bamwe barwara bashobora kumva barushijeho mbere na mbere uko turemangingo twa kanseri twangizwa, ibyo bishobora kongera by'agateganyo ingaruka zimwe na zimwe. Ibi ntibisobanura ko ubuvuzi butagikora, ariko itsinda ryawe ry'ubuzima rizagufasha gusobanukirwa icyo witegura.

Uburyo umubiri witwara ku buvuzi buratandukanye cyane hagati y'abarwayi, kandi bishobora gufata ibihe byinshi mbere yuko wowe na muganga wawe mushobora gusuzuma neza uburyo umuti ukora kuri wowe.

Q4. Nshobora Gukomeza Ibikorwa Byanjye Bisanzwe Mugihe cy'Ubuvuzi?

Abarwayi benshi bashobora gukomeza ibikorwa bimwe bisanzwe mugihe cy'ubuvuzi, nubwo ushobora gukenera gukora impinduka bitewe nuko wumva n'ingaruka zikugiraho. Umunaniro ni ibisanzwe, bityo ushobora gukenera kuruhuka kurusha uko bisanzwe kandi ukagenda gahoro mukora ibikorwa byawe.

Ugomba kwirinda ahantu hari abantu benshi n'abantu barwaye kuko uyu muti ushobora kugabanya umubare w'uturemangingo twera tw'amaraso, bigatuma wibasirwa n'indwara. Itsinda ryawe ry'ubuzima rizatanga amabwiriza yihariye yerekeye igihe byemewe kuba hafi y'abandi.

Imyitozo yoroheje nko kugenda birashobora kugira akamaro niba wumva ubishoboye, ariko irinda ibikorwa bikomeye bishobora kongera ibyago byo kuvunika, cyane cyane niba umubare wawe w'uturemangingo twa platelet ari muto. Kwoga mumazi rusange bigomba kwirindwa kubera ibyago byo kwandura.

Ganira n'itsinda ryawe ry'ubuzima kubyerekeye akazi kawe, gahunda zo gutembera, n'ibindi bikorwa. Bashobora kugufasha gufata ibyemezo bifitiye akamaro kubyerekeye icyo gikorwa cyiza kandi gikwiye mugihe cy'ubuvuzi bwawe.

Q5. Nzagomba Kurara Mu Bitaro Mugihe cy'Ubuvuzi?

Abantu benshi barwara tagraxofusp-erzs bakirizwa nk'abarwayi basanzwe, bivuze ko ushobora gutaha umunsi umwe nyuma yo guterwa urushinge. Ariko, imiti yawe ya mbere izasaba gukurikiranwa neza, kandi ushobora gukenera kuguma mu kigo kivurirwamo amasaha menshi nyuma yo guterwa urushinge.

Abantu bamwe bashobora gukenera kujyanwa mu bitaro, cyane cyane niba bagize ingaruka zikomeye nk'indwara ya capillary leak syndrome cyangwa ibibazo bikomeye by'umwijima. Itsinda ryawe ry'ubuvuzi rizemeza uburyo bwiza bwo kuvurwa kwawe hashingiwe ku mpamvu zikugiraho ingaruka.

Niba utuye kure y'ikigo kivurirwamo, muganga wawe ashobora kugusaba kuguma hafi mu gihe cyo kuvurwa kwawe kugira ngo ubone ubufasha vuba niba bibaye ngombwa. Ibigo byinshi bivura kanseri bishobora gutanga amakuru yerekeye aho abarwayi n'imiryango yabo barara.

Itsinda ryawe ry'ubuvuzi rizagusobanurira gahunda yo gukurikirana kandi rigufashe gusobanukirwa ibyo witegura mu gihe no nyuma ya buri cyiciro cyo kuvurwa. Bazatanga kandi amabwiriza asobanutse yerekeye igihe cyo gushaka ubufasha bwihuse bw'ubuvuzi.