Tapinarof ni iki: Ibikoresho, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Tapinarof ni umuti mushya ushyirwa ku ruhu ufasha kuvura psoriasis ya plaque ukora mu buryo butandukanye n'ubuvuzi busanzwe. Ni ikirimo ushyira ku bice by'uruhu byagizweho ingaruka, kandi kigwa mu cyiciro cy'imiti yitwa aryl hydrocarbon receptor agonists. Uyu muti utanga icyizere ku bantu bifuza uburyo butandukanye na cream ya steroid cyangwa batabonye intsinzi mu bundi buvuzi bwa psoriasis.

Tapinarof ni iki?

Tapinarof ni cream ishyirwa ku ruhu idakoresha steroid yagenewe kuvura psoriasis ya plaque mu bantu bakuru. Bitandukanye na cream ya steroid ishobora gucisha uruhu rwawe uko igihe kigenda, tapinarof ikora hakoreshejwe uburyo butandukanye butagira ibyago bimwe na bimwe byo mu gihe kirekire.

Uyu muti wemejwe na FDA mu 2022, bituma uba umwe mu buryo bushya buhari bwo kuvura psoriasis. Ukomoka ku kintu gisanzwe kiboneka muri bagiteri, ariko verisiyo ikoreshwa mu buvuzi ikorerwa mu laboratori kugira ngo habeho isuku n'imikorere myiza.

Uzabona tapinarof iboneka nk'ikirimo cya 1% kiza mu tuyunguruzo tw'ingano zitandukanye. Iki kirimo gifite isura yoroshye, yera kandi gikwirakwizwa byoroshye ku ruhu rwawe kitasiga ibisigisigi by'amavuta.

Tapinarof ikoreshwa mu kuvura iki?

Tapinarof ikoreshwa cyane cyane mu kuvura psoriasis ya plaque, ariyo miterere ya psoriasis ikunze kugaragara cyane ikibasira abantu babarirwa muri miliyoni ku isi hose. Psoriasis ya plaque itera ibice byijimye, bitukura bitwikiriye ibipimo by'ifeza bishobora kugaragara ahantu hose ku mubiri wawe.

Uyu muti ukora neza cyane cyane kuri psoriasis ya plaque yoroheje kugeza hagati. Muganga wawe ashobora kugusaba tapinarof niba ufite ibice bya psoriasis ku bice nk'inkokora zawe, amavi, uruhu rwo ku mutwe, cyangwa ibindi bice by'umubiri bitaragaragaje igisubizo cyiza ku bundi buvuzi.

Abaganga bamwe na bamwe na bo bandika tapinarof iyo abarwayi bifuza kwirinda gukoresha imiti ya steroid mu gihe kirekire. Kubera ko atari steroid, urashobora kuyikoresha igihe kirekire utagize impungenge zo gutonda uruhu cyangwa izindi ngaruka ziterwa na steroid.

Tapinarof ikora ite?

Tapinarof ikora ikoresha ikintu cyitwa aryl hydrocarbon receptor mu turemangingo tw'uruhu rwawe. Uyu receptor ukora nk'ikintu gihindura cyunganira mu kugenzura umubyimbire kandi kikongerera imikurire isanzwe y'uturemangingo tw'uruhu.

Iyo psoriasis yongeye gukomera, uturemangingo tw'uruhu rwawe twiyongera vuba cyane kandi bigatuma habaho ibice byinini, bifite imikaka. Tapinarof ifasha kugabanya iyi mikurire yihuse y'uturemangingo mugihe igabanya umubyimbire utera umutuku no kurakara.

Uyu muti ufatwa nk'ukomeye ku rugero ruciriritse ariko woroshye kurusha imiti myinshi ya psoriasis yandikirwa. Muri rusange bifata ibyumweru byinshi kugirango bigaragaze ingaruka zayo zose, bityo kwihangana ni ngombwa mugihe utangiye ubu buvuzi.

Nkwiriye gufata tapinarof nte?

Shyira amavuta ya tapinarof rimwe ku munsi ku bice by'uruhu rwawe byagizweho ingaruka, cyane cyane ku gihe kimwe buri munsi. Ntabwo ukeneye kuyifata hamwe n'ibiryo cyangwa amazi kuko ishyirwa ku ruhu rwawe.

Uku niko wakoresha tapinarof neza:

1. Karaba intoki zawe neza mbere yo gushyira amavuta
2. Sukura ahantu h'uruhu hagizweho ingaruka witonze hanyuma uhahanagure wumisha
3. Shyira igice gito cy'amavuta kugirango utwikire ibice bya psoriasis byose
4. Kora amavuta witonze kugeza igihe ashyiriwe mu ruhu rwawe
5. Karaba intoki zawe wongere nyuma yo kuyashyiraho keretse urimo kuvura intoki zawe

Urashobora gushyira tapinarof ku kigereranyo cya 20% cy'uruhu rwawe. Ntugasuke amavuta menshi kuruta uko byategetswe, kuko ibi ntibizatuma bikora vuba kandi bishobora kongera ibyago byo kugira ingaruka.

Amavuta akora neza iyo ashyizwe ku ruhu rumeze neza kandi rwumye. Ntabwo ukeneye kwirinda kurya ibiryo bimwe na bimwe cyangwa gufata ingamba zidasanzwe zifitanye isano n'amafunguro kuko tapinarof ishyirwa ku ruhu.

Mvuga tapinarof igihe kingana iki?

Abantu benshi bakoresha tapinarof mu mezi menshi kugira ngo babone impinduka zigaragara ku bimenyetso bya psoriasis. Ubushakashatsi bwakozwe bwerekanye ko abarwayi benshi babonye inyungu zigaragara nyuma y'ibyumweru 12 byo gukoresha buri munsi.

Muganga wawe ashobora gusaba gukoresha tapinarof byibuze amezi 3 kugeza kuri 6 kugira ngo igire igihe cyo gukora neza. Abantu bamwe bashobora gukenera kuyikoresha igihe kirekire, bitewe n'uko uruhu rwabo rwitwara ku buvuzi.

Bitandukanye na za cream za steroid zisaba guhagarara kugira ngo birinde ingaruka, tapinarof irashobora gukoreshwa buri gihe mu gihe kirekire. Muganga wawe azakurikiza iterambere ryawe kandi ashobora guhindura gahunda yawe yo kuvura bitewe n'uko uruhu rwawe rumeze neza.

Ni izihe ngaruka za tapinarof?

Abantu benshi bakoresha tapinarof neza, ariko nk'umuti uwo ari wo wose, ushobora gutera ingaruka. Inkuru nziza ni uko ingaruka zikomeye zitagaragara cyane kuri ubu buvuzi bwo ku ruhu.

Ingaruka zisanzwe ushobora guhura na zo zirimo:

• Uruhu rurakara cyangwa rutukura ahantu hakoreshejwe umuti
• Urubavu cyangwa kumva urushye igihe cyambere ukoresheje
• Uruhu rwumye ahantu havuriwe
• Kugurumana guto gusanzwe kuzamo impinduka uko igihe kigenda
• Folliculitis (udupfu duto dukikije imisatsi)

Izi ngaruka zirasanzwe kandi zikunda gukira uko uruhu rwawe rumenyera umuti. Abantu benshi basanga irari ryambere rigabanuka nyuma y'ibyumweru bike byambere byo gukoresha.

Ingaruka zitagaragara ariko zikomeye zirimo ibimenyetso bikomeye byo kwibasirwa n'umubiri. Niba ubonye ibibara byinshi, guhumeka bigoye, cyangwa kubyimba mu maso, iminwa, cyangwa umuhogo, shakisha ubufasha bw'ubuvuzi ako kanya.

Abantu bamwe bashobora kurwara contact dermatitis, itera uruhu kurakara cyane kuruta uko bisanzwe. Ibi ntibisanzwe ariko bisaba guhagarika umuti no kugisha inama muganga wawe kubijyanye n'ubundi buvuzi.

Ninde utagomba gufata tapinarof?

Tapinarof ntibagenewe buri wese, nubwo abantu bakuru benshi bafite psoriasis ya plaque bashobora kuyikoresha neza. Ugomba kwirinda uyu muti niba ufite allergie kuri tapinarof cyangwa ibindi bintu biri muri cream.

Abana bari munsi y'imyaka 18 ntibagomba gukoresha tapinarof kuko ubushakashatsi butaragaragaza umutekano wayo n'ubushobozi bwayo ku barwayi bato. Abagore batwite bagomba kuganira ku byago n'inyungu na muganga wabo mbere yo gukoresha uyu muti.

Abantu bafite indwara zimwe na zimwe z'uruhu zituma bafata imiti yo ku ruhu cyane bashobora gukenera kwirinda tapinarof. Muganga wawe ashobora kugufasha kumenya niba uyu muti ukwiriye kubera uko urwaye.

Amazina ya Tapinarof

Tapinarof igurishwa ku izina rya Vtama muri Leta Zunze Ubumwe z'Amerika. Iri ni ryo zina ryonyine ririho ry'uyu muti, kuko rikiri rishya ku isoko.

Vtama irimo 1% ya tapinarof nk'ikintu gikora. Iyi cream iza mu tube ya garama 30 na garama 60, bitewe n'ubuso bw'uruhu ukeneye kuvura.

Ubundi bwoko bwa tapinarof ntiburaboneka kuko uyu muti ukiri mu buryo bwo kurindwa na patent. Ibi bivuze ko Vtama ari yo nzira imwe yo kubona ubuvuzi bwa tapinarof ubu.

Izindi nzira zikoreshwa mu kuvura

Imiti myinshi yo ku ruhu ishobora kuvura psoriasis ya plaque niba tapinarof itagukundiye cyangwa itakwemerera. Ubu buryo bukoresha uburyo butandukanye kandi bushobora kuba uburyo bwiza bitewe n'ibyo ukeneye.

Corticosteroids yo ku ruhu ikomeza kuba imiti ikoreshwa cyane mu kuvura psoriasis. Ibi birimo imiti nka clobetasol, betamethasone, na triamcinolone, igabanya umubyimbirwe vuba ariko bisaba gukurikiranwa neza mugihe kirekire.

Vitamin D analogues nka calcipotriene (Dovonex) itanga ubundi buryo butari bwa steroid. Iyi miti ifasha gusanzura imikurire y'uturemangingo tw'uruhu kandi ishobora gukoreshwa igihe kirekire nta byago bifitanye isano na steroids.

Izindi nzira zigezweho zirimo roflumilast (Zoryve), undi muti ushyirwa ku ruhu utari steroid ukora binyuze mu kubuza enzyme yitwa PDE4. Uyu muti wemejwe hafi icyo gihe kimwe na tapinarof kandi utanga inyungu zisa.

Ese Tapinarof iruta Clobetasol?

Tapinarof na clobetasol bikora mu buryo butandukanye kandi bifite inyungu zihariye bitewe n'uko ubuzima bwawe bumeze. Clobetasol ni steroid ikomeye cyane ishyirwa ku ruhu ikora vuba ariko ikagira ingaruka nyinshi mu gihe kirekire.

Clobetasol akenshi yerekana ibisubizo mu minsi cyangwa mu byumweru, naho tapinarof bishobora gufata ibyumweru byinshi cyangwa amezi kugira ngo bikore neza. Ariko, clobetasol ishobora gutera uruhu kunanuka, ibimenyetso byo kuruka, n'izindi ngaruka iyo ikoreshejwe igihe kirekire.

Tapinarof itanga inyungu zo kuba umutekano mu gihe kirekire nta mpungenge zihari zijyanye na steroid zikomeye. Akenshi bifatwa nk'ibiza kurusha ibindi mu kuvura igihe psoriasis yawe imeze neza.

Muganga wawe ashobora kugusaba gutangira na clobetasol kugira ngo ubone ubufasha bwihuse, hanyuma ukimukire kuri tapinarof kugira ngo ubungabunge igihe kirekire. Ubu buryo buhuza imikorere yihuse ya steroid n'umutekano wa tapinarof.

Ibikunze Kubazwa Kuri Tapinarof

Ese Tapinarof irakwiriye ku barwayi ba diyabete?

Yego, tapinarof muri rusange irakwiriye ku bantu barwaye diyabete kuko ishyirwa ku ruhu kandi ntigira ingaruka zigaragara ku isukari yo mu maraso. Uyu muti ukora ahantu ku ruhu rwawe kandi ntugira icyo utwara imiti ya diyabete cyangwa insuline.

Ariko, abantu barwaye diyabete bagomba gukurikiranira hafi uruhu rwabo iyo bakoresha umuti mushya ushyirwa ku ruhu. Diyabete ishobora gutuma gukira kw'ibikomere bigenda gahoro kandi ikongera ibyago byo kwandura, bityo bikaba byiza kumenyesha muganga wawe impinduka zidasanzwe ku ruhu rwawe vuba.

Nigira iki niba nshizeho tapinarof nyinshi ku buryo butunganye?

Gukoresha tapinarof nyinshi rimwe na rimwe ntibiteje akaga, ariko ntibizatuma umuti ukora neza. Sangira gusa amavuta yose arenzeho hanyuma ukomeze gahunda yawe isanzwe yo kuyashyiraho umunsi ukurikira.

Niba ukoresha amavuta menshi buri gihe, ushobora guhura n'uburibwe bwinshi ku ruhu kurusha uko byari bisanzwe. Gabanura umubare ukoresha, hanyuma ushyireho gusa urwungano ruto ruziba ahantu hose hagaragaye uburwayi.

Nkwiriye gukora iki niba nirengagije gukoresha Tapinarof?

Niba wibagiwe gukoresha tapinarof, yikoreshe vuba na bwangu wibukije kuri uwo munsi. Ntukongere gukoresha amavuta ku munsi ukurikira kugira ngo ushyire mu gaciro urwungano rwatanzwe.

Kutagira urwungano rimwe na rimwe ntibizakugiraho ingaruka, ariko kuyikoresha buri munsi biguha umusaruro mwiza. Tekereza gushyiraho umwanya wo kwibutswa kuri terefone yawe kugira ngo bigufashe kwibuka igihe cyo kuyikoresha.

Nshobora guhagarika ryari gukoresha Tapinarof?

Ushobora guhagarika gukoresha tapinarof igihe muganga wawe yemeje ko psoriasis yawe ifashwe neza cyangwa niba uhuye n'ingaruka zikomeye kurusha inyungu. Ntuhagarike ako kanya utabanje kugisha inama umuganga wawe.

Abantu bamwe bashobora gukenera gukoresha tapinarof igihe kirekire kugira ngo bagumane uruhu rwiza, mu gihe abandi bashobora guhindukira bakajya mu bundi buryo bwo kuvura. Muganga wawe azagufasha gukora gahunda nziza yo gufata neza psoriasis yawe igihe kirekire.

Nshobora gukoresha Tapinarof hamwe n'ubundi buryo bwo kuvura psoriasis?

Tapinarof akenshi ishobora gufatanya n'ubundi buryo bwo kuvura psoriasis, ariko ugomba kubanza kubiganiraho na muganga wawe. Uburyo bumwe bukora neza hamwe, mu gihe ubundi bushobora kongera ibyago byo kuribwa ku ruhu.

Muganga wawe ashobora kugusaba gukoresha tapinarof hamwe n'amavuta yo kwisiga, amasabune yoroheje, cyangwa n'indi miti yo kwisiga. Bazagufasha gukora gahunda yuzuye yo kuvura izamura inyungu mu gihe igabanya ingaruka ziterwa.