Icyo Tavaborole ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'ibindi

Tavaborole ni umuti ushyirwa ku ruhu uvura indwara ziterwa n'imvuvu mu nzara, by'umwihariko onychomycosis. Ikora mu buryo butandukanye n'ubundi buvuzi bwo kurwanya imvuvu, ikoma mu nkokora enzyme runaka imvuvu zikeneye kugira ngo zibaho kandi zikure. Uyu muti wandikirwa na muganga uza mu iseswa risobanutse ushyirwa ku nzara zanduye buri munsi mu gihe kingana n'ibyumweru 48.

Tavaborole ni iki?

Tavaborole ni umuti wandikirwa na muganga uvura indwara ziterwa n'imvuvu wagenewe by'umwihariko indwara ziterwa n'imvuvu mu nzara z'amano. Ihereranye n'icyiciro cyihariye cy'imiti irwanya imvuvu yitwa boron-based inhibitors, bituma itandukana n'ubuvuzi busanzwe bwo kurwanya imvuvu.

Uyu muti ugamije kurwanya indwara ziterwa n'imvuvu ku rwego rw'uturemangingo dukora protein mu turemangingo tw'imvuvu. Ubu buryo bufasha gukuraho indwara mu gihe cyemerera igice cy'inzara gifite ubuzima bwiza kongera gukura uko igihe kigenda.

Tavaborole ni mushya ugereranije n'ubundi buvuzi bwo kurwanya imvuvu, kuko yemerejwe na FDA mu 2014. Itanga ubundi buryo ku bantu batitabiriye neza imiti yindi ishyirwa ku ruhu irwanya imvuvu cyangwa bakaba badashaka gufata imiti irwanya imvuvu yo kunywa.

Tavaborole ikoreshwa mu kuvura iki?

Tavaborole ivura onychomycosis, izwi cyane nka indwara y'imvuvu mu nzara z'amano cyangwa indwara y'imvuvu mu nzara. Iyi ndwara ituma inzara ziba nini, zihindura ibara, zikamera nk'izitameze neza, rimwe na rimwe zikababaza.

Uyu muti ukora neza ku ndwara zoroheje kugeza ku ziciriritse ziterwa n'imvuvu mu nzara zitagera ku gice cy'inzara (aho inzara itangirira gukura). Bikorera cyane iyo indwara ifashe munsi ya 50% by'ubuso bw'inzara.

Muganga wawe ashobora kugusaba tavaborole niba ufite indwara ziterwa n'imvuvu mu nzara zigaruka cyangwa niba izindi miti ishyirwa ku ruhu zitagize icyo zikora neza. Bitekerezwa kandi iyo imiti irwanya imvuvu yo kunywa idakwiriye kubera ingaruka zishobora guterwa n'imiti cyangwa ibibazo by'umwijima.

Tavaborole ikora ite?

Tavaborole ikora ibyo ikingira enzyme yitwa leucyl-tRNA synthetase, iyi ikaba ari ngombwa ku ngirwafungi kugira ngo zikore poroteyine z'ingenzi zo kubaho. Ubu ni uburyo bwo kurwanya ingirwafungi bufite imbaraga ziringaniye, bugamije by'umwihariko ingirwafungi hatagize ingaruka zigaragara ku turemangingo tw'abantu.

Uyu muti winjira mu gice cy'urwara cy'urwara, ukagera aho indwara yateye munsi y'urwara. Iyo ugezeyo, ubuza ingirwafungi kwikorera no kwirinda, buhoro buhoro ugasukura indwara mu mezi menshi.

Bitandukanye n'imiti imwe ikomeye irwanya ingirwafungi ikora mu mubiri wose, tavaborole ikora ahantu hashyizweho umuti. Ubu buryo bugamije ahantu hamwe butuma habaho ingaruka nkeya mu mubiri wawe wose mugihe ugikora neza mu kuvura ahantu handuye.

Nkwiriye Gufata Tavaborole Nte?

Shyira tavaborole rimwe ku munsi ku nzara z'amano zimeshe, zumye, byaba byiza ukabikora buri munsi ku isaha imwe. Ntabwo bisaba gufatana n'ibiryo cyangwa amata kuko ishyirwa ku ruhu aho kumira.

Mbere yo gushyiraho, karaba intoki zawe n'ibirenge neza n'isabune n'amazi, hanyuma wumuke neza. Shyira umuti muto ku gice cyose cy'urwara, harimo n'urwara rwose n'ahateganye n'urwara niba bishoboka.

Reka umuti wume neza mbere yo kwambara amasogisi cyangwa inkweto, ibi bikunda gufata iminota 2-3. Irinde kumesa ahantu havuriweho byibuze amasaha 6 nyuma yo gushyiraho umuti kugira ngo winjire neza.

Urashobora kurya uko bisanzwe kuko uyu ni umuti ushyirwa ku ruhu, ariko irinda gushyira umuti ku ruhu ruzima ruzengurutse urwara uko bishoboka kose. Niba hariho uwo ushyizeho ku ruhu ruzengurutse, muri rusange ntibigira ingaruka ariko bishobora gutera uburibwe buke.

Nkwiriye Gufata Tavaborole Igihe Kingana Gite?

Abantu benshi bakeneye gukoresha tavaborole mu byumweru 48 (hafi umwaka) kugira ngo babone ibisubizo byuzuye. Iki gihe cyo kuvura kirekire ni ngombwa kuko inzara z'amano zikura buhoro cyane, kandi bifata igihe kugira ngo urwara ruzima rusimbure ibice byanduye.

Ushobora gutangira kubona impinduka mu isura y'inzara nyuma y'ibyumweru 24, ariko ni ngombwa gukomeza kuvurwa mu gihe cyose cyategetswe. Guhagarika kare kenshi bituma ubwandu bugaruka kuko imvange iracyashobora kuba ihari mu gice cy'inzara kigaragara ko gifite ubuzima.

Muganga wawe azakurikiza uko urimo urwara mu gihe uvurwa kandi ashobora guhindura igihe cyo kuvurwa bitewe n'uko inzara zawe zikira. Abantu bamwe bafite indwara zikomeye bashobora gukenera kuvurwa birenze ibyumweru 48, mu gihe abandi bafite ibibazo byoroheje bashobora kubona gukira neza mbere.

Ni izihe ngaruka ziterwa na Tavaborole?

Abantu benshi bafata neza tavaborole, ingaruka zikaba muri rusange zoroheje kandi zigarukira ahantu hakoreshwa umuti. Ingaruka zisanzwe zikunda kugaragara zikora ku ruhu n'inzara aho ukoresha umuti.

Dore ingaruka ushobora guhura nazo, uzi ko nyinshi muri zo ari iz'igihe gito kandi zishobora guhangana nazo:

• Uruhu rurashira cyangwa rugahinduka umutuku hafi y'inzara ivurwa
• Kugurumana guto cyangwa kumva uruma igihe ubanza gukoresha umuti
• Uruhu rwumye cyangwa rurimo rurabukana hafi y'ahakoreshejwe umuti
• Guhinduka kw'ibara ry'inzara ry'igihe gito cyangwa impinduka mu isura y'inzara
• Kubyimba guto kw'urugingo rw'amano cyangwa igice cy'umubiri gikikije

Izi ngaruka zikunda gukira uko uruhu rwawe rwikurikiranya n'umuti mu byumweru bike bya mbere byo kuvurwa.

Ingaruka zitavugwa kenshi ariko zikomeye zirashobora kubaho ku bantu bamwe, nubwo izi zikora ku batarenga 1% by'abawukoresha:

• Uruhare rukomeye rw'uburwayi bw'uruhu hamwe n'ibibazo byo guhumeka
• Kugurumana cyangwa kuribwa bikomeza kandi bikiyongera uko igihe gihita
• Ibimenyetso by'ubwandu bwa bagiteri ya kabiri (kongera umutuku, gushyuha, amashyira)
• Inzara itandukana n'urubaho rw'inzara (onycholysis)
• Uruhu rukomeye rurabukana cyangwa gukomeretsa

Niba uhuye n'ingaruka zikomeye, vugana n'umuganga wawe ako kanya kuko ibi bishobora gusaba guhagarika umuti cyangwa kuvurwa byiyongera.

Ninde utagomba gufata Tavaborole?

Tavaborole ntiribanda kuri buri wese, kandi ibintu bimwe na bimwe bituma bitagira akamaro cyangwa bigasaba ingamba zidasanzwe. Abantu bafite allergie zizwi kuri tavaborole cyangwa ibindi bintu bitagira akamaro bikoreshwa muri yo bagomba kwirinda uyu muti.

Ugomba kuganira n'umuganga wawe ku bindi bisubizo niba ufite imvune zikomeye ku nzara cyangwa indwara zifata hejuru ya 50% by'umuzenguruko w'inzara. Uyu muti ukora neza ku ndwara zoroheje kugeza ku ziciriritse kandi ntushobora kugira akamaro ku zikomeye.

Abantu bafite ubudahangarwa bw'umubiri butameze neza, nk'abarwaye diyabete, SIDA, cyangwa bafata imiti igabanya ubudahangarwa bw'umubiri, bashobora gukenera gukurikiranwa cyane mugihe bavurwa. Nubwo bitabujijwe gukoreshwa, ibi bintu bishobora kugira ingaruka ku gukira no kongera ibyago byo kwandura indwara.

Abagore batwite kandi bonsa bagomba gukoresha tavaborole gusa niba inyungu ziruta cyane ibyago bishobora kubaho. Hariho amakuru make kuri umutekano wayo mugihe cyo gutwita, bityo umuganga wawe azagereranya neza uko ubuzima bwawe buhagaze.

Izina ry'ubwoko bwa Tavaborole

Tavaborole igurishwa ku izina ry'ubwoko rya Kerydin muri Leta Zunze Ubumwe z'Amerika. Ubu ni bwo bwoko bwonyine bwemewe na FDA burimo tavaborole nk'ikintu gikora.

Kerydin ikorwa na Anacor Pharmaceuticals (ubu ni igice cya Pfizer) kandi iza nk'igisubizo cya 5% gikoreshwa hanze y'umubiri mu icupa rifite umwanya wo gushyiraho. Uburyo bw'izina ry'ubwoko ni bwo bwizwe mu igeragezwa ryo kwa muganga kandi bwemerewe kuvura indwara y'uruhu rw'inzara.

Ubwoko bwa tavaborole butari ubw'umwimerere ntiburaboneka cyane, bityo imiti myinshi izuzuzwa n'izina ry'ubwoko rya Kerydin. Ubwishingizi bwawe bushobora gutandukana kubijyanye n'imiti y'izina ry'ubwoko, bityo reba n'umutanga wawe kubijyanye n'uburyo bwo kwishyura.

Uburyo bwo gusimbuza Tavaborole

Hariho uburyo bwinshi bwo kuvura indwara y'uruhu rw'inzara niba tavaborole itagukwiriye cyangwa idafite akamaro kuri wowe. Izi nzira zirimo imiti ikoreshwa hanze y'umubiri, imiti yo kunywa, n'ubuvuzi bukoreshwa.

Izindi nzira zo kuvura umugera zikoreshwa ku ruhu zirimo ciclopirox (Penlac), efinaconazole (Jublia), na amorolfine (ntibiboneka muri Amerika). Zikora mu buryo butandukanye kandi zishobora kugira akamaro igihe tavaborole itagize icyo ikora.

Imiti yo kunywa ivura umugera nka terbinafine (Lamisil) cyangwa itraconazole (Sporanox) ni imiti ikomeye ikoreshwa mu kuvura indwara zikomeye. Ariko, zikubiyemo ibyago byinshi byo kugira ingaruka mbi no guhura kw'imiti ugereranije n'imiti ikoreshwa ku ruhu.

Ubuvuzi bushya burimo uburyo bwa laser, uburyo bwa photodynamic, no gukuraho urwara rw'inzara mu gihe indwara ikomeye. Muganga wawe ashobora kugufasha kumenya uburyo bwiza bwakuvura bushingiye ku ndwara yawe yihariye n'ubuzima bwawe.

Ese Tavaborole iruta Ciclopirox?

Zombi tavaborole na ciclopirox ni imiti ikora neza ivura umugera ikoreshwa ku ruhu, ariko zikora mu buryo butandukanye kandi zifite ibyiza byihariye. Tavaborole ishobora kugira akamaro kurusha abantu bamwe kubera uburyo bwayo bwihariye bwo guhagarika enzyme.

Ubushakashatsi bwa muganga bwerekana ko tavaborole igeraho imitiro yuzuye ya 6-9% ugereranije na 5-8% ya ciclopirox. Nubwo iri tandukaniro risa nk'aho ari rito, uburyo bushya bwa tavaborole bwo gukora bushobora gukora neza ku ndwara zirwanya imiti gakondo ivura umugera.

Ciclopirox isaba gukoreshwa buri munsi hamwe no gukuraho buri cyumweru hakoreshejwe alukolo, mugihe tavaborole ifite gahunda yoroshye yo gukoresha rimwe ku munsi. Abantu bamwe bakunda gahunda yoroshye ya tavaborole kandi ntibitaye ku gihe kirekire cyo kuvurwa.

Gu hitamo hagati y'iyi miti akenshi biterwa n'ubwoko bwawe bw'umugera, uburyo wabanje kuvurwa, n'ibyo ukunda ku giti cyawe. Muganga wawe ashobora kugufasha kumenya uburyo butanga amahirwe meza yo gutsinda ku kibazo cyawe cyihariye.

Ibikunze Kubazwa Kuri Tavaborole

Ese Tavaborole irakwiriye abarwayi ba diyabete?

Tavaborole irashobora gukoreshwa neza n'abantu benshi barwaye diyabete, ariko bisaba gukurikiranwa neza no kwita ku birenge. Diyabete irashobora gutinda gukira no kongera ibyago byo kwandura, bityo muganga wawe azashaka gukurikirana imiterere yawe neza.

Abantu barwaye diyabete bagomba kugenzura ibirenge byabo buri munsi kugira ngo barebe ibimenyetso byose byo kurakara cyangwa kwandura kwisumbuye mugihe bakoresha tavaborole. Kugenzura neza isukari mu maraso bifasha kunoza gukira no kugabanya ibyago byo kugira ibibazo mugihe cyo kuvurwa.

Umuvuzi wawe ashobora kugusaba kujya kwa muganga kenshi kugira ngo yemeze ko umuti utatera kurakara cyane cyangwa ngo uhishe ibimenyetso by'ibindi bibazo by'ibirenge bisanzwe muri diyabete.

Nkwiriye gukora iki niba nkoresheje tavaborole nyinshi ku buryo butunganye?

Niba ushyizeho tavaborole nyinshi, ntugahungabane - ibi ntibitera ibibazo bikomeye kuko ni umuti ushyirwa ku ruhu. Kura umuti wose urenzeho ukoresheje igitambaro cyiza kandi wirinde gushyiraho byinshi kugeza igihe cyo gufata umuti ukurikira.

Gukoresha byinshi ntibizatuma umuti ukora vuba kandi bishobora kongera kurakara kw'uruhu ahantu havurwa. Niba ubonye ko hari gushya cyane, umutuku cyangwa kurakara, urashobora gukaraba ahantu hakoreshejwe amazi akonje.

Komeza gahunda yawe isanzwe yo gukoresha umuti ku munsi ukurikira, ukoresheje gusa umubare wasabwe. Niba kurakara bikomeje cyangwa bikiyongera, vugana n'umuvuzi wawe kugira ngo akugire inama niba ugomba gukomeza kuvurwa.

Nkwiriye gukora iki niba nirengagije gufata umuti wa tavaborole?

Niba wibagiwe gufata umuti, shyiraho tavaborole ako kanya wibukira, keretse igihe cyo gufata umuti ukurikira kigeze. Muricyo gihe, reka gufata umuti wibagiwe ukomeze gahunda yawe isanzwe.

Ntugashyireho imiti myinshi kugira ngo wuzuze umuti wibagiwe. Ibi ntibizatuma gukira byihuta kandi bishobora kongera ibyago byo kurakara kw'uruhu.

Gerageza gushyiraho gahunda ihamye, wenda ukoresha umuti ku gihe kimwe buri munsi, kugira ngo byorohereze kwibuka imiti. Gushyiraho umwanya wo kwibutswa kuri terefone birashobora kugufasha mu gihe cyo kuvurwa igihe kirekire.

Nshobora Kureka Gukoresha Tavaborole Ryari?

Ugomba gukomeza gukoresha tavaborole mu gihe cyose cyateganijwe, akenshi ni ibyumweru 48, kabone n'iyo inzara zawe zatangira kugaragara neza mbere y'igihe. Guhagarika hakiri kare akenshi bituma ubwandu bugaruka kuko imvange ishobora kuguma mu gice cy'inzara kigaragara ko gifite ubuzima bwiza.

Muganga wawe azasuzuma uko urimo utera imbere mu gihe cyo gusurwa kwawe hanyuma akemeza igihe cyiza cyo guhagarika ubuvuzi. Inzara zose zikwiye kugaragara neza, aho inzara yose igaragara neza kandi isanzwe, ni yo ntego mbere yo guhagarika.

Nyuma yo guhagarika tavaborole, komeza gukora isuku nziza y'ibirenge n'inzara kugira ngo wirinde kongera kwandura. Muganga wawe ashobora kugusaba ko wajya usuzumwa kenshi kugira ngo wemeze ko ubwandu butagaruka.

Nshobora Kwambara Polish y'Inzara Mugihe Nkoresha Tavaborole?

Muri rusange birakwiye kwirinda polish y'inzara mugihe ukoresha tavaborole, kuko ishobora kubuza umuti kwinjira mu nzara no kugera ku bwandu. Polish y'inzara kandi bituma bigorana gukurikirana uko uvurwa.

Niba ugomba kwambara polish y'inzara mu birori byihariye, kuyikuraho rwose mbere yo gukoresha tavaborole ukurikira hanyuma utegereze byibuze amasaha 24 nyuma yo gukoresha umuti mbere yo kongera gushyiraho polish.

Shyira imbaraga mu buzima bw'inzara mugihe uvurwa aho kureba isura - wibuke ko inzara nziza, zigaragara neza ari zo ntego nyamukuru y'urugendo rwawe rw'ubuvuzi rw'ibyumweru 48.