Trientine ni iki: Ibikoresho, Urutonde rw'imiti, Ingaruka ziterwa n'ibindi

Trientine ni umuti wihariye ufasha gukuramo umuringa urenze urugero mu mubiri wawe igihe wiyongereye ukagera ku rwego rw'akaga. Uyu muti ukoreshwa cyane mu kuvura indwara ya Wilson, indwara idasanzwe iterwa n'imirerere aho umuringa wibika mu mwijima wawe, mu bwonko, no mu zindi ngingo kubera ko umubiri wawe utabasha kuwukuramo neza mu buryo busanzwe.

Uyu muti ukora nk'umufasha witonze, ukifatanya n'umuringa wiyongereye mu mubiri wawe ugashyigikira impyiko zawe mu kuwusohora binyuze mu nkari. Nubwo bishobora kumvikana bigoye, trientine imaze imyaka myinshi ifasha abantu mu gucunga umuringa wiyongereye, ihabwa abarwayi uburyo bwizewe bwo kurengera ingingo zabo zikomerekejwe n'umuringa.

Trientine ni iki?

Trientine ni umuti ukurura ibyuma, bivuze ko ukora nk'imbaraga zikurura molekile zikurura umuringa mu mubiri wawe. Izina ryuzuye ry'uyu muti ni triethylene tetramine dihydrochloride, ariko abaganga n'abarwayi bawita trientine kugira ngo byoroshye.

Uyu muti unyobwa mu kanwa uza mu buryo bwa capsule kandi ukaba mu cyiciro cyihariye cy'imiti yagenewe gukoreshwa cyane mu guhangana no guhumeka ibyuma byinshi cyangwa ibyiyongera byinshi. Bitandukanye n'imiti isanzwe, trientine ifite akazi kagaragara - igamije umuringa by'umwihariko kandi ifasha umubiri wawe gukuramo ibirenze urugero binyuze mu mpyiko zawe.

Uyu muti wemejwe na FDA kandi ufite amateka maremare y'umutekano iyo ukoreshejwe neza mu bugenzuzi bwa muganga. Ufatwa nk'umuti w'ingenzi ku bantu batabasha gufata penicillamine, uwo nawo ukaba ari undi muti ukurura umuringa.

Trientine ikoreshwa mu kuvura iki?

Trientine ikoreshwa cyane mu kuvura indwara ya Wilson, indwara iterwa n'imirerere igira ingaruka ku bantu bagera kuri 1 kuri 30,000 ku isi hose. Mu ndwara ya Wilson, umubiri wawe ubura poroteyine yihariye ikenewe kugira ngo itware umuringa hanze y'umwijima wawe, bigatuma wibika mu ngingo zawe mu buryo bw'akaga.

Uyu muti akenshi ukoreshwa iyo abarwayi batabasha kwihanganira penicillamine, umuti wa mbere uvura indwara ya Wilson. Abantu bamwe bagira ibimenyetso byo kwivumbura ku miti cyangwa ingaruka zikomeye za penicillamine, bituma trientine iba indi nzira y'ingenzi.

Mu bihe bidasanzwe, abaganga bashobora kwandika trientine ku zindi ndwara zo guhumeka umuringa cyangwa ibibazo byo kwiyongera kwawo. Ariko, ibi bintu ntibisanzwe kandi byaba gusa mu bihe by'ubuvuzi byihariye hamwe no gukurikiranwa neza.

Trientine ikora ite?

Trientine ikora ikora ifatanya imiti ikomeye n'imolekile za umuringa mu maraso yawe n'imitsi. Tekereza nk'ikipe yihariye yo gusukura yibanda by'umwihariko kandi ifata umuringa urenze umubiri wawe utabasha kwihanganira wenyine.

Iyo trientine imaze gufatana na umuringa, irema ikintu gihamye imyanya yawe y'inkari ishobora gukuramo byoroshye kandi igakurwamo binyuze mu nkari. Ubu buryo buroroshye ariko bufite akamaro, bugabanya buhoro buhoro urwego rwa umuringa uko igihe kigenda gihita aho guteza impinduka zidasanzwe kandi zikomeye.

Uyu muti ufashwe nk'ukomeye mu bushobozi bwawo bwo gufata umuringa. Birakomeye bihagije kugirango bikureho umuringa urenze ariko biroroshye bihagije ku buryo bitazakuraho umubare muto wa umuringa umubiri wawe ukeneye kugirango ukore imirimo isanzwe nko gukora uturemangingo dutukura tw'amaraso no gukomeza imitsi ifatanya ifite ubuzima bwiza.

Nkwiriye gufata trientine nte?

Fata ibinini bya trientine ku gifu cyambaye ubusa, byibuze isaha imwe mbere yo kurya cyangwa amasaha abiri nyuma yo kurya. Ibiryo bishobora kubuza umuti ubushobozi bwo gufatana na umuringa, bityo igihe ni ingenzi kugirango ubone ibisubizo byiza.

Mimina ibinini byose hamwe n'ikirahure cyuzuye cy'amazi. Ntugasenye, ukoremo agafu, cyangwa ubyumve, kuko ibi bishobora kugira ingaruka ku buryo umuti winjizwa kandi ukarekurwa mu mubiri wawe. Niba ugira ibibazo byo kumira ibinini, ganira na muganga wawe kubyerekeye ubundi buryo.

Irinde gufata trientine hamwe n'amata, antacids, cyangwa ibiyobyabwoba by'icyuma, kuko ibi bishobora kugabanya imikorere yayo. Shyira ibi bintu byibuze amasaha abiri hagati y'urugero rwawe rwa trientine kugirango wirinde imbogamizi iyo ari yo yose yo kwinjizwa.

Muganga wawe ashobora gutangira kuri gahunda yihariye yo gupima, akenshi agabanya urugero rwawe rwa buri munsi mu doze ebyiri cyangwa eshatu ntoya umunsi wose. Ibi bifasha gukomeza gukuraho umuringa kandi bigabanya amahirwe yo kurwara mu gifu.

Mbona Ndebera Trientine Igihe Kingana Gite?

Abantu benshi barwaye indwara ya Wilson bakeneye gufata trientine ubuzima bwabo bwose, kuko imiterere ya genetike idashira. Umuti ucunga urugero rw'umuringa aho gukiza indwara, bityo guhagarika imiti byatuma umuringa wongera kwiyongera.

Muganga wawe azagenzura urugero rwawe rw'umuringa binyuze mu igeragezwa risanzwe ry'amaraso n'inkari kugirango yemeze ko imiti ikora neza. Ibi bizafasha kumenya niba urugero rwawe rukeneye guhindurwa no kwemeza ko urugero rw'umuringa rukomeza kuba mu rwego rwiza.

Abantu bamwe bashobora gukenera guhagarika imiti by'agateganyo niba bagize ingaruka mbi cyangwa bakeneye kubagwa. Ariko, ibi byemezo bigomba gufatwa buri gihe hamwe n'ubuyobozi bwa muganga wawe, kuko guhagarika trientine nta buyobozi bwa muganga bishobora gutera umuringa wongera kwiyongera mu buryo buteye akaga.

Ni Iyihe Ngaruka Ziterwa na Trientine?

Ingaruka zisanzwe za trientine muri rusange ziroroshye kandi zishobora gucungwa. Abantu benshi bahura n'ibibazo bike hamwe n'uyu muti, cyane cyane iyo ugereranije n'ubundi buryo bwo gukuraho umuringa.

Ingaruka zivugwa kenshi zirimo kurwara mu gifu, isesemi, na diarhe rimwe na rimwe. Ibi bimenyetso akenshi birakosoka uko umubiri wawe wimenyereza imiti, mubisanzwe mu byumweru bike bya mbere byo kuvurwa.

Dore ingaruka zisanzwe ushobora guhura nazo:

• Uburibwe mu nda cyangwa kubabara gake
• Urugaruka, cyane cyane igihe utangiye kuvurwa
• Imyanda yoroshye cyangwa impiswi
• Uburyohe bw'icyuma mu kanwa kawe
• Urubabare ruto mu mutwe
• Kubura ubushake bwo kurya

Ibi bimenyetso mubisanzwe birashira uko umubiri wawe umenyera umuti, kandi gufata trientine hamwe n'ibiryo bito bishobora gufasha kugabanya uburibwe mu nda.

Ingaruka zikomeye ziragabanuka ariko zishobora kubaho iyo zimaze igihe kinini zikoreshwa. Izi zikeneye ubufasha bwihuse bw'abaganga kandi zigakurikiranwa neza n'ikipe yawe y'ubuzima.

Ingaruka zikomeye ariko zikaba zibaho zirimo:

• Kubura amaraso kubera icyuma cyinshi cyane
• Uruhu rwakomeretse cyane cyangwa amabara
• Ubugwari bw'imitsi cyangwa kubabara mu ngingo
• Gukomereka cyangwa kuva amaraso bidasanzwe
• Urugero rukomeye rwo kwibasirwa n'umubiri
• Ibyiciro bya lupus hamwe no kubyimba kw'ingingo

Muganga wawe azakurikirana ibi bibazo binyuze mu bipimo by'amaraso bisanzwe no gusuzuma umubiri. Kumenya hakiri kare bituma habaho guhindura vuba uburyo bwo kuvura niba bibaye ngombwa.

Ninde utagomba gufata Trientine?

Abantu bafite allergie zizwi kuri trientine cyangwa ibintu byayo byose bagomba kwirinda uyu muti. Niba waragize allergie ku bintu bisa n'ibi bikuraho ibyuma, ganira neza n'umuganga wawe mbere yo gutangira kuvurwa.

Abagore batwite bakeneye kwitabwaho by'umwihariko, kuko trientine ishobora kwambuka inzitizi ya placenta. Nubwo abagore batwite bafite indwara ya Wilson bafata trientine bakurikiranwa neza, icyemezo gisaba gupima ibyago byo kwegeranya umuringa utavuwe n'ingaruka zishobora kuba ku mwana ukura.

Ababyeyi bonka bagomba kandi kwitonda, kuko trientine nto ishobora kwinjira mu mata y'ibere. Muganga wawe azagufasha gupima inyungu n'ibyago kuri wowe no ku mwana wawe.

Abantu barwaye indwara ikomeye y'impyiko bashobora gukenera guhindura urugero rw'imiti cyangwa ubundi buryo bwo kuvura, kuko trientine yishingikiriza ku mikorere y'impyiko kugira ngo ikure umuringa mu mubiri neza.

Amazina y'ubwoko bwa Trientine

Izina risanzwe rya trientine ni Syprine, riboneka muri Leta Zunze Ubumwe z'Amerika. Ubu bwoko bumaze imyaka myinshi bukoreshwa kandi bwashyizweho neza mu kuvura indwara ya Wilson.

Mu bihugu bimwe na bimwe, trientine ishobora kuboneka mu mazina y'ubundi bwoko cyangwa nk'imiti rusange. Ariko, kubera imiterere yihariye y'uyu muti, akenshi iboneka gusa binyuze muri farumasi zihariye cyangwa sisitemu z'ibitaro.

Muganga wawe azagena uburyo bwiza bukwiriye icyo gihe, kandi ni ngombwa gukoresha ubwoko bumwe keretse niba umuganga wawe aguteye inkunga yo guhindura, kuko uburyo butandukanye bushobora kugira imikorere itandukanye yo kwinjizwa.

Uburyo bwo gusimbuza Trientine

Penicillamine ni uburyo busanzwe bwo gusimbuza trientine mu kuvura indwara ya Wilson. Akenshi ni umuti wa mbere abaganga bagerageza, ariko abarwayi bamwe ntibashobora kwihanganira ingaruka zayo, zirimo ibibazo by'uruhu, ibibazo by'impyiko, cyangwa guhagarika umusokoro wo mu magufa.

Zinc acetate cyangwa zinc sulfate bigaragaza ubundi buryo bwo kuvura. Aho gukuraho umuringa nk'uko trientine ibikora, zinc ikora ibuza umuringa kwinjira mu mara yawe, ikabuza umuringa mushya kwinjira mu mubiri wawe.

Ku barwayi badashobora gufata imiti iyo ari yo yose muri iyi, abaganga bashobora gutekereza ammonium tetrathiomolybdate, uburyo bwo kuvura bugikorwa igeragezwa. Ariko, iyi nzira akenshi igenewe ibibazo bikomeye aho ubundi buryo bwo kuvura byananiranye.

Abarwayi bamwe bakoresha uburyo bwo kuvura buvanga imiti, bafata zinc hamwe na trientine cyangwa penicillamine, bitewe n'ibyo bakeneye byihariye n'uburyo bitwara neza ku miti yihariye.

Ese Trientine iruta Penicillamine?

Nta trientine cyangwa penicillamine na kimwe "cyiza" ku isi yose - guhitamo biterwa n'uburyo umuntu ku giti cye abyakira n'uburyo yihanganira buri muti. Byombi bifasha mu gukuraho umuringa urenze urugero, ariko bikora mu buryo butandukanye kandi bifite ingaruka zitandukanye.

Penicillamine akenshi igeragezwa mbere kuko imaze igihe kinini ikoreshwa kandi hariho amakuru menshi y’ubushakashatsi. Ariko, hafi 20-30% by'abarwayi ntibashobora kwihanganira penicillamine kubera ingaruka zirimo ibibara ku ruhu, ibibazo by'impyiko, cyangwa indwara z'amaraso.

Trientine ikunda gutera ingaruka nke zikomeye kurusha penicillamine, bituma ihitamo ryiza ku barwayi bahura n'ibibazo byo kuvurwa bwa mbere. Abantu benshi basanga trientine byoroshye kwihanganira mu gihe kirekire.

Muganga wawe azatekereza ibintu nk'urugero rw'umuringa ufite ubu, izindi ndwara ufite, n'uburyo wakira imiti igihe afata icyemezo cy'umuti ukora neza ku miterere yawe yihariye.

Ibibazo Bikunze Kubazwa Kuri Trientine

Ese Trientine irakwiriye ku ndwara z'umutima?

Yego, trientine muri rusange irakwiriye ku bantu bafite indwara z'umutima. Mubyukuri, kugabanya urugero rw'umuringa rwongera kungukira umutima wawe, kuko umuringa urenze urugero ushobora gutera ibibazo by'imitsi y'amaraso ku barwayi bafite indwara ya Wilson.

Ariko, umuganga w'umutima wawe n'umuganga uvura indwara ya Wilson bagomba guhuza ubuvuzi bwawe. Imwe mu miti y'umutima ishobora guhura na trientine, kandi indwara yawe y'umutima ishobora kugira uruhare mu gufata imiti.

Ubugenzuzi buhoraho burushaho kuba ingenzi iyo ufite izo ndwara zombi, kuko itsinda ryawe ry'abaganga rigomba kumenya neza ko gukuraho umuringa bitabangamira ubuvuzi bw'umutima wawe cyangwa ibinyuranye.

Nigira nte niba mfashe trientine nyinshi ku buryo butunguranye?

Niba wanyoye trientine nyinshi kuruta uko wagombaga, vugana n'umuganga wawe cyangwa ikigo gishinzwe ubumara ako kanya. Kunywa nyinshi bishobora gukuraho imyunyungugu y'ingenzi mu mubiri wawe cyangwa bigateza ibibazo bikomeye mu gifu.

Ntugerageze kwisuka amavunja keretse niba ubisabwe n'abaganga. Ahubwo, nywa amazi menshi kandi ushake ubufasha bw'ubuvuzi ako kanya kugira ngo umenye niba hari uburyo bwo kuvura bukenewe.

Ujye wandika neza ingano y'umuti wanyoye n'igihe wanyoye, kuko aya makuru azagufasha abaganga kumenya uburyo bwiza bwo gukora. Gukoresha umuti mwinshi mu buryo butunganye ntibitera ibibazo bikomeye, ariko buri gihe ni byiza kwirinda.

Nkwiriye gukora iki niba nciweho urugero rwa trientine?

Fata urugero wibagiwe ako kanya wibukiye, keretse niba igihe cyo gufata urugero rukurikira kigeze. Niba ugiye gufata urugero rukurikira, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero rurenze rumwe kugira ngo usimbure urugero wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'umuti. Ni byiza kwibagirwa urugero rumwe kuruta gushyira mu kaga kunywa umuti mwinshi icyarimwe.

Niba ukunda kwibagirwa urugero, tekereza gushyiraho alarme kuri terefone cyangwa gukoresha igikoresho cyo gutegura imiti kugira ngo bigufashe gukurikiza gahunda. Gufata imiti buri gihe bifasha gukuraho umuringa neza kandi bigatanga imiti myiza.

Nshobora guhagarika ryari gufata trientine?

Ugomba guhagarika gufata trientine gusa niba ubisabwe n'umuganga wawe. Abantu benshi barwaye indwara ya Wilson bakeneye kuvurwa ubuzima bwabo bwose kugira ngo birinde umuringa mwinshi utera akaga gusubira.

Umuvuzi wawe ashobora kugabanya by'agateganyo cyangwa akahagarika urugero rwawe niba ugize ingaruka ziterwa n'umuti, ukeneye kubagwa, cyangwa niba urwego rwawe rw'umuringa rumanutse cyane. Ariko, ibi byemezo bisaba gukurikiranwa neza kandi bikunze gukubiyemo ibizamini by'amaraso bihoraho.

Abantu bamwe bashobora guhindukira bakajya mu buvuzi bwo kubungabunga ubuzima bakoresheje zinc nyuma y'uko urugero rw'umuringa rwabo rugaragara neza bakoresheje imiti ya trientine. Icyemezo nk'iki giterwa n'uburyo umubiri wawe witwara n'uko muganga wawe abona ibyo ukeneye mu gihe kirekire.

Nshobora gufata vitamine nkorera kuri trientine?

Yego, ushobora gufata vitamine nyinshi nkorera kuri trientine, ariko igihe ni ingenzi. Imisemburo ya feri (iron) igomba gufatwa byibuze amasaha abiri atandukanye na trientine kugira ngo birinde kwivanga mu gufata umuringa.

Muganga wawe ashobora rwose kugusaba gufata imisemburo ya vitamine, cyane cyane niba ibizamini by'amaraso byerekana ko hari ibitagenda neza. Abantu bamwe bakoresha trientine bakeneye imisemburo ya feri niba umuti ufata feri hamwe n'umuringa.

Buri gihe menyesha muganga wawe vitamine cyangwa imisemburo yose ufata, kuko bashobora gutanga ubuyobozi ku gihe gikwiye n'urugero rwo gufata kugira ngo byemeze ko imisemburo yawe na trientine bikora neza.