Icyo Valbenazine ari cyo: Ibikoreshwa, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Valbenazine ni umuti wandikirwa na muganga ufasha kugenzura imyitwarire idashimishije kandi isubiramo yitwa tardive dyskinesia. Niba umaze igihe ufite imitsi idashaka mu maso yawe, ururimi, cyangwa ibindi bice by'umubiri wawe, uyu muti ushobora gutanga ubufasha wari umaze igihe ushakisha.

Iyi myitwarire akenshi iterwa n'ingaruka ziterwa n'imiti imwe na rimwe ya psychiatrie, kandi valbenazine ikora igihe yongera imisemburo yo mu bwonko igenzura imitsi. Yagenewe by'umwihariko gufasha abantu kongera kugenzura imibiri yabo kandi bakumva bameze neza mu buzima bwabo bwa buri munsi.

Valbenazine ni iki?

Valbenazine ni umuti wo mu cyiciro cy'imiti yitwa VMAT2 inhibitors. Ikora igihe ibuza poroteyine yihariye mu bwonko bwawe ipakira dopamine, ubutumwa bw'imiti bugenzura imyitwarire.

Bitekereze nk'uburyo bwo guhagarika gahoro gahoro ibimenyetso by'imyitwarire y'umurengera mu bwonko bwawe. Mugabanya umubare wa dopamine uboneka mu bice bimwe na bimwe by'ubwonko, valbenazine ifasha gutuza imikorere y'imitsi ikabije itera imyitwarire idashaka.

Uyu muti uza mu buryo bwa capsule kandi ufashwe mu kanwa rimwe ku munsi. Yemejwe by'umwihariko na FDA mu kuvura tardive dyskinesia mu bantu bakuru, bituma iba uburyo bwo kuvura bwihariye kuri iyi ndwara igoye.

Valbenazine ikoreshwa mu iki?

Valbenazine ikoreshwa cyane mu kuvura tardive dyskinesia, indwara itera imyitwarire idashaka kandi isubiramo. Iyi myitwarire akenshi igira ingaruka ku maso yawe, ururimi, iminwa, rimwe na rimwe amaboko yawe, amaguru, cyangwa umubiri wawe.

Tardive dyskinesia akenshi iterwa nyuma yo gufata imiti imwe na rimwe ya psychiatrie mu mezi cyangwa imyaka. Iyi myitwarire irimo gukubita iminwa, gusohora ururimi, gukora mu maso, cyangwa imyitwarire isubiramo y'intoki udashobora kugenzura.

Iyi ndwara ishobora kuba itoroheye umubiri kandi ikabangamira mu byiyumvo, ikagira ingaruka ku kwigirira icyizere mu mibanire yawe n'abandi. Valbenazine ifasha kugabanya izi ngendo, bigatuma wumva urimo kugenzura umubiri wawe kandi ukumva umeze neza mu bikorwa byawe bya buri munsi.

Valbenazine ikora ite?

Valbenazine ikora yibanda kuri poroteyine yihariye yitwa VMAT2 mu bwonko bwawe. Iyi poroteyine ishinzwe gupakira dopamine mu bikoresho byo kubikamo, nk'udusanduku duto tubika imiti y'ubwonko.

Iyo valbenazine yabuza VMAT2, igabanya umubare wa dopamine uboneka mu turere tumwe na tumwe tw'ubwonko. Ibi bifasha kugarura imiterere ya chimie y'ubwonko yari yarabangamiwe n'imiti yabanje, mu buryo bwo gutuza ibimenyetso byinshi bituma habaho ingendo zitaziguye.

Uyu muti ufatwa nk'ufite imbaraga ziringaniye kandi ukora buhoro buhoro uko igihe kigenda gihita. Ushobora kutabona impinduka ako kanya, ariko abantu benshi batangira kubona impinduka mu ngendo zabo nyuma y'ibyumweru bike batangira kuvurwa.

Nkwiriye gufata Valbenazine nte?

Fata valbenazine nk'uko umuganga wawe abikwandikiye, akenshi rimwe ku munsi hamwe n'ibiryo cyangwa utabifite. Urashobora kuyifata hamwe n'amazi, amata, cyangwa umutobe - icyo cyose wumva kigushimishije.

Mimina ibinini byose utabifunguye, utabikubise cyangwa ngo ubisye. Uyu muti wateguwe kugira ngo usohoke buhoro buhoro mu mubiri wawe, bityo gukubura ikinini bishobora kubangamira uburyo gikora.

Ntabwo ukeneye gushyira igihe cyo gufata umuti wawe ku mafunguro, ariko kuwufata ku gihe kimwe buri munsi bifasha kugumana urwego ruzigama mu mubiri wawe. Abantu benshi basanga byoroshye kwibuka iyo babihuza n'ibikorwa bya buri munsi nk'ifunguro rya mu gitondo cyangwa igihe cyo kuryama.

Niba ugira ikibazo cyo kumira ibinini, ganira n'umuganga wawe ku buryo bwo kubikora. Ashobora kuba ashobora gutanga ibitekerezo cyangwa izindi nzira zikora neza kuri wewe.

Nkwiriye gufata Valbenazine igihe kingana iki?

Ubukure bw'imiti ya valbenazine buratandukana ku muntu ku muntu kandi biterwa n'uko wemera imiti. Abantu bamwe bayikeneye mu mezi menshi, mu gihe abandi bashobora kuyifata mu myaka myinshi.

Muganga wawe akenshi azagutangiza ku gipimo gito buhoro buhoro akongera mu byumweru byinshi. Ibi bifasha umubiri wawe kumenyera umuti kandi bigatuma muganga wawe ashobora kubona urugero rukora neza rufite ingaruka nke.

Abantu benshi batangira kubona impinduka mu ngendo zabo zitunguranye mu byumweru 4 kugeza kuri 6 batangira kuvurwa. Ariko, bishobora gufata amezi 3 kugira ngo umenye neza inyungu zose z'umuti.

Ntuzigere uhagarika gufata valbenazine ako kanya utabanje kuvugana na muganga wawe. Guhagarika ako kanya bishobora gutuma ibimenyetso byawe bisubira cyangwa bikiyongera, bityo muganga wawe ashobora gukugira inama yo kugabanya buhoro buhoro urugero rwawe igihe kigeze cyo guhagarika umuti.

Ni izihe ngaruka ziterwa na Valbenazine?

Kimwe n'imiti yose, valbenazine ishobora gutera ingaruka, nubwo atari buri wese uzibona. Ingaruka nyinshi ziba zoroshye kugeza hagati kandi akenshi zikongera uko umubiri wawe umenyera umuti.

Dore ingaruka zisanzwe ushobora guhura nazo:

• Gusinzira cyangwa kunanirwa
• Isesemi cyangwa kuribwa mu nda
• Umutwe
• Urugero
• Umunwa wumye
• Kugara
• Kureba nabi

Izi ngaruka zikunda kubaho mu byumweru bya mbere byo kuvurwa kandi akenshi zigabanyuka uko umubiri wawe wimenyereza. Gufata umuti hamwe n'ibiryo birashobora gufasha kugabanya kuribwa mu nda.

Abantu bamwe bashobora guhura n'ingaruka zitazwi ariko zikomeye zisaba ubufasha bwa muganga:

• Gusinzira cyane bibuza gukora imirimo ya buri munsi
• Impinduka z'amarangamutima cyangwa agahinda
• Kugorana kwibanda
• Ibibazo byo kuringaniza cyangwa kongera ibyago byo kugwa
• Ubukarishye budasanzwe bw'imitsi cyangwa guteguka

Vugana na muganga wawe niba ubonye ibi bimenyetso, cyane cyane niba bikomeje cyangwa bikiyongera uko iminsi igenda.

Ingaruka zidakunze kubaho ariko zikomeye zirimo guhinduka kw'umuvuduko w'umutima (QT interval), ibimenyetso bikomeye by'uburwayi bwo kwivumbura ku bintu runaka, cyangwa koroshya indwara zo mu ngingo zisanzweho. Nubwo ibi bidakunze kubaho, ni ngombwa kubimenya kandi ugahita usaba ubufasha bw'ubuvuzi bwihutirwa niba wumva ububabare mu gituza, ugahura n'ingorane zo guhumeka, cyangwa ibimenyetso bikomeye byo ku ruhu.

Ninde utagomba gufata Valbenazine?

Valbenazine ntabwo ikwiriye kuri buri wese, kandi muganga wawe azagenzura neza niba ari umutekano kuri wowe. Abantu bamwe bagomba kwirinda uyu muti kubera ibyago by'ubuzima.

Ntabwo ugomba gufata valbenazine niba ufite allergie ku muti cyangwa ibikubiye muri wo. Ibimenyetso byo kwivumbura ku bintu runaka birimo uruhu rurya, kubyimba, kuribwa cyane, cyangwa ingorane zo guhumeka.

Abantu bafite indwara zimwe na zimwe z'umutima bashobora gukenera kwirinda valbenazine cyangwa gukenera kugenzurwa byihariye:

• Indwara ya Long QT cyangwa izindi ndwara z'umutima
• Umutima wa vuba aha watewe n'indwara cyangwa indwara y'umutima idahagaze neza
• Kunanirwa gukora kw'umutima bikomeye
• Amateka y'umuryango yo gupfa urupfu rutunguranye rw'umutima

Muganga wawe ashobora gutuma bakora electrocardiogram (ECG) mbere yo gutangira kuvurwa kugirango bagenzure umuvuduko w'umutima wawe.

Valbenazine ntishobora gukwiriye niba ufite indwara ikomeye y'umwijima cyangwa impyiko, kuko izi ngingo zifasha gutunganya umuti. Muganga wawe ashobora gukenera guhindura urugero rwawe cyangwa guhitamo uburyo bwo kuvura butandukanye.

Niba utwite, ufite gahunda yo gutwita, cyangwa uri konjesha, ganira ku byago n'inyungu na muganga wawe. Umutekano wa valbenazine mugihe cyo gutwita no konjesha nturashyirwaho neza.

Izina ry'ubwoko bwa Valbenazine

Valbenazine iboneka munsi y'izina ry'ubwoko Ingrezza. Iri niryo zina ry'ubwoko rimwe rukumbi ririho muri Leta Zunze Ubumwe z'Amerika.

Ingrezza iza mu muti w'ibitumbwe bifite imbaraga zitandukanye: 40 mg, 60 mg, na 80 mg. Ibitumbwe bifite amabara atandukanye kugira ngo bigufashe kumenya urugero rwa dose umuganga wawe yagutegetse.

Ubu, nta miti isanzwe ya valbenazine iboneka, bivuze ko Ingrezza ari yo muti wenyine w'uyu muti ushobora kubona. Ibi bishobora kugira ingaruka ku biciro no kwishyurwa n'ubwishingizi, bityo bikwiye kuganira ku buryo bwo gufashwa mu bijyanye n'amafaranga n'umuganga wawe cyangwa umufarimasi.

Uburyo bwo gusimbuza Valbenazine

Niba valbenazine itagukwiriye, hari ubundi buryo bwo kuvura tardive dyskinesia. Umuganga wawe ashobora kugufasha gushakisha izi nzira zishingiye ku miterere yawe yihariye.

Deutetrabenazine (Austedo) ni undi muti wa VMAT2 ukora kimwe na valbenazine. Na wo wemerejwe na FDA kuvura tardive dyskinesia kandi ushobora kuba igisubizo cyiza niba udashobora kwihanganira valbenazine cyangwa ukeneye gukoresha imiti kabiri ku munsi.

Abaganga bamwe bashobora gutekereza ku miti itemewe yo kuvura tardive dyskinesia, harimo:

• Clonazepam (benzodiazepine ishobora gufasha mu ngendo z'imitsi)
• Amantadine (mubyukuri umuti wa Parkinson)
• Inshinge za botulinum toxin ku ngendo z'ahantu hihariye
• Vitamin E (nubwo ibimenyetso bicye)

Mu bihe bimwe na bimwe, guhindura cyangwa guhindura umuti wateje tardive dyskinesia bishobora gufasha, nubwo ibi bikorwa witonze cyane hakoreshejwe ubuyobozi bwa psychiatrist wawe.

Uburyo bwiza bwo gusimbuza buterwa n'ibimenyetso byawe byihariye, amateka yawe y'ubuvuzi, n'uburyo wabyitwayemo ku miti yakoreshejwe mbere. Umuganga wawe azakorana nawe kugira ngo abone uburyo bukwiye.

Ese Valbenazine iruta Deutetrabenazine?

Valbenazine na deutetrabenazine ni imiti ikora neza yo kuvura tardive dyskinesia, ariko bafite itandukaniro rishobora gutuma umwe akwira kurusha undi.

Valbenazine itanga uburyo bwo gufata umuti rimwe ku munsi, ibintu abantu benshi babona ko byoroshye kwibuka no gukurikiza. Deutetrabenazine isaba gufata umuti kabiri ku munsi, ibyo bikaba bishobora kuba ingorabahizi gukurikiza buri gihe.

Mu bijyanye n'ubushobozi, imiti yombi yerekana ibisubizo bisa mu kugabanya imyitwarire idashakishwa. Ubushakashatsi bwa muganga bwerekana ko byombi bishobora kunoza cyane ibimenyetso bya tardive dyskinesia, abantu benshi bagaragaza impinduka igaragara mu byumweru 4 kugeza kuri 6.

Imiterere y'ingaruka ziterwa n'imiti isa cyane, imiti yombi ishobora gutera ibitotsi, isesemi, no kunanirwa. Ariko, abantu bamwe bashobora kwihanganira umwe kurusha undi bitewe n'itandukaniro ry'uko imibiri yabo itunganya iyi miti.

Muganga wawe azatekereza ibintu nk'imikorere yawe ya buri munsi, indi miti ufata, imikorere y'impyiko, n'ibyo ukunda ku giti cyawe mugihe afata icyemezo cy'umuti ushobora kugukorera neza. Nta

Niba wanyoye valbenazine nyinshi kuruta uko wagombaga, vugana n'umuganga wawe cyangwa ikigo gishinzwe ubumara ako kanya. Kunywa nyinshi bishobora kongera ibyago byo kugira ingaruka zirimo gusinzira cyane, kuribwa umutwe, cyangwa ibibazo by'umutima.

Ntugerageze kwivuruguta cyangwa gukoresha imiti yo mu rugo. Ahubwo, hamagara umuganga wawe, jya mu cyumba cy'indembe kiri hafi yawe, cyangwa uhamagare umurongo wa Poison Help kuri 1-800-222-1222. Zana icupa ry'umuti hamwe nawe kugira ngo abaganga bamenye neza icyo wanyoye n'ingano yacyo.

Q3. Nkwiriye gukora iki niba nciweho urugero rwa valbenazine?

Niba waciweho urugero rwa valbenazine, unywe ako kanya wibukije, keretse igihe cyo kunywa urugero rukurikira kigeze. Muri urwo rubanza, reka urugero waciweho ukomeze gahunda yawe isanzwe.

Ntunyweho urugero ebyiri icyarimwe kugira ngo usimbure urugero waciweho, kuko ibi bishobora kongera ibyago byo kugira ingaruka. Niba ukunda kwibagirwa urugero, tekereza gushyiraho alarme ya buri munsi cyangwa gukoresha umuteguro w'ibinini kugira ngo bigufashe kwibuka.

Q4. Nshobora kureka kunywa valbenazine ryari?

Ugomba kureka kunywa valbenazine gusa ukurikije ubuyobozi bw'umuganga wawe. Guhagarika ako kanya bishobora gutuma ibimenyetso byawe bya tardive dyskinesia bisubira cyangwa bikaba bibi, rimwe na rimwe mu minsi cyangwa mu byumweru.

Umuganga wawe akenshi azagusaba kugabanya buhoro buhoro urugero rwawe mu byumweru byinshi aho guhagarika ako kanya. Ibi bifasha kugabanya ibyago byo gusubira inyuma kw'ibimenyetso kandi bituma umubiri wawe uhinduka buhoro buhoro ku muti uhinduka.

Q5. Nshobora gutwara imodoka nkanwa valbenazine?

Valbenazine ishobora gutera gusinzira, kuribwa umutwe, cyangwa guhumirwa, cyane cyane iyo utangiye kuyinywa. Ugomba kwirinda gutwara imodoka cyangwa gukoresha imashini kugeza umenye uko umuti ukugiraho ingaruka.

Abantu benshi bashobora gutwara imodoka neza bamaze kumenyera imiti kandi batagira ingaruka zikomeye. Ariko, jya ukoresha ubwenge bwawe kandi wirinde gutwara niba wumva uruhutse, uribwa umutwe, cyangwa utameze neza kurusha uko bisanzwe, n'ubwo umaze igihe ufata umuti.