Icyo Zavegepant ari cyo: Ibyo ikoreshwa, urugero, ingaruka ziterwa n'ibindi

Zavegepant ni umuti mushya wo mu mazuru wagenewe kuvura umutwe w'imigraine umaze gutangira. Ubarizwa mu cyiciro cy'imiti yitwa CGRP receptor antagonists, ikora ibyo ikingira ibimenyetso by'ububabare mu bwonko bwawe bigira uruhare mu gitero cy'imigraine.

Uyu muti utanga icyizere ku bantu bakeneye ubufasha bwihuse ku migraine, cyane cyane iyo imiti isanzwe itagize icyo ikora cyangwa yateje ingaruka zitifuzwa. Uburyo bwo mu mazuru busobanura ko butangira gukora vuba, akenshi mu masaha abiri nyuma yo gukoreshwa.

Zavegepant ikoreshwa mu iki?

Zavegepant yemerejwe by'umwihariko kuvura ibitero by'imigraine bikaze ku bantu bakuru. Ibi bivuze ko yagenewe guhagarika imigraine umaze gutangira, aho gukumira imigraine yo mu gihe kizaza.

Muganga wawe ashobora kugusaba zavegepant niba ufite umutwe w'imigraine wo hagati cyangwa ukaze utuma utabasha gukora imirimo yawe ya buri munsi. Irashobora gufasha kugabanya ububabare bukaze, isesemi, no kumva urumuri n'urusaku bikunze kujyana na migraine.

Uyu muti ni ingirakamaro cyane cyane ku bantu badashobora gufata triptans (ikindi cyiciro cy'imiti ivura imigraine) kubera indwara z'umutima cyangwa izindi mpungenge z'ubuzima. Irashobora kandi kuba uburyo niba wagerageje izindi miti ivura imigraine ikaze ariko ntigire icyo ikora.

Zavegepant ikora ite?

Zavegepant ikora ikingira CGRP receptors mu bwonko bwawe no mu miyoboro y'amaraso. CGRP isobanura calcitonin gene-related peptide, ari poroteyine igira uruhare runini mu kubabara no kubyimbirwa kwa migraine.

Mugihe cy'igitero cya migraine, urwego rwa CGRP ruriyongera kandi rutuma imiyoboro y'amaraso yo mu mutwe wawe yaguka kandi igahinduka. Mugihe ukingira izi CGRP receptors, zavegepant ifasha gukumira ibi biba bituma habaho ububabare bwa migraine.

Uyu muti ufatwa nk'ukomeye ku rugero ruciriritse mu kuvura umutwe w'ururenda. Ntiwongera imbaraga nk'imiti imwe y'urushinge, ariko ugenewe kurwanya ibimenyetso by'umutwe w'ururenda kurusha imiti isanzwe yo kurwanya ububabare nka ibuprofen cyangwa acetaminophen.

Nkwiriye Gufata Zavegepant Nte?

Zavegepant iza mu ishusho ya spray yo mu mazuru ukoresha igihe cyose ubonye ibimenyetso bya mbere by'umutwe w'ururenda. Urutonde rusanzwe ni spray imwe (10 mg) mu zuru rimwe, kandi ukwiriye kuyikoresha gusa igihe ufite umutwe w'ururenda.

Mbere yo gukoresha spray, humeka mu mazuru yawe gahoro kugira ngo usukure umwuka mubi. Kura umupfundikizo, shyira urutoki mu zuru rimwe, hanyuma ukande neza igikoresho cyo gukanda mu gihe uhumeka gahoro mu mazuru yawe. Ntabwo bisaba kuyifata hamwe n'ibiryo cyangwa amazi.

Ibi nibyo ukwiriye kumenya ku bijyanye n'igihe n'imyiteguro:

• Koresha spray ako kanya ubonye ibimenyetso by'umutwe w'ururenda bitangiye
• Ntukarye cyangwa tunywe ikintu icyo aricyo cyose mbere cyangwa nyuma yo gukoresha spray
• Tegereza byibuze amasaha 24 mbere yo gukoresha urundi rugero
• Bika umuti ku bushyuhe busanzwe, kure y'ubushyuhe n'izuba ritaziguye
• Tegura igikoresho cya spray mbere yo gukoresha bwa mbere ukanda igikoresho cyo gukanda kugeza ubonye umwuka mwiza

Uyu muti ntusaba ibyo kurya byihariye, ariko kuwukoresha igihe wicishije inzara birashobora gufasha gukora vuba. Buri gihe ukurikize amabwiriza yihariye ya muganga wawe, kuko ashobora guhindura igihe bitewe n'ibyo ukeneye.

Nkwiriye Gufata Zavegepant Igihe Kingana Gite?

Zavegepant yagenewe gukoreshwa igihe gito mu gihe cy'ibitero by'umutwe w'ururenda, ntabwo ari nk'umuti wo gukumira wa buri munsi. Ukwiriye kuyikoresha gusa igihe urimo guhura n'umutwe w'ururenda ukora, kandi ingaruka zikunda kumara igihe cy'icyo gice cy'umutwe.

Abantu benshi babona imbaraga mu masaha 2 nyuma yo gukoresha spray yo mu mazuru, nubwo bamwe bashobora kubona impinduka mbere. Ingamba z'umuti zirashobora kumara amasaha 24, niyo mpamvu ugomba gutegereza umunsi wose mbere yo gukoresha urundi rugero.

Ntabwo wagombye gukoresha zavegepant kurenza inshuro 8 mu kwezi. Niba wibona ukenera kuvurwa umutwe w'umutwe kenshi kurusha ibi, ni ngombwa kuganira na muganga wawe ku bijyanye n'imiti ikingira umutwe w'umutwe.

Mbese ni izihe ngaruka za Zavegepant?

Abantu benshi boroherwa na zavegepant, ariko nk'imiti yose, ishobora gutera ingaruka. Izisanzweho cyane zikunda kuba zoroshye kandi zifitanye isano n'uburyo bwo gutanga spray yo mu mazuru.

Dore ingaruka ushobora guhura nazo cyane:

• Uburyohe buhindutse mu kanwa kawe (bukunda gusobanurwa nk'icyuma cyangwa gisharira)
• Kutoroherwa mu mazuru cyangwa kurakara
• Isesemi (nubwo ibi bishobora guterwa n'umutwe wawe w'umutwe)
• Kurakara mu muhogo cyangwa umunwa wumye
• Kunanirwa cyangwa gusinzira

Izi ngaruka zisanzweho zikunda gushira zonyine mu masaha make kandi ntizisaba ubuvuzi keretse ziramutse zikomeye cyangwa zigahoraho.

Ingaruka zitagaragara cyane ariko zikomeye zirashobora kubaho, nubwo bidakunze kubaho. Izi zirimo ibimenyetso bikomeye byo kwivumbura ku miti, byatera ibimenyetso nk'ingorane zo guhumeka, kubyimba mu maso cyangwa mu muhogo, cyangwa uruhu rwakwiriye hose. Niba ubonye ibimenyetso byose muri ibi, genda kwa muganga ako kanya.

Abantu bamwe bashobora kandi guhura no kurakara cyane mu mazuru, harimo no kuva amaraso mu mazuru cyangwa kumva uburyate butagira icyo buhindura. Nubwo bitari biteje akaga, ibi bimenyetso bisaba kuganira n'umuganga wawe.

Ninde utagomba gufata Zavegepant?

Zavegepant ntikwiriye kuri buri wese, kandi muganga wawe azagenzura neza niba ari umutekano kuri wowe bitewe n'amateka yawe y'ubuzima n'ubuzima bwawe ubu.

Ntugomba gukoresha zavegepant niba ufite allergie kuri iyo miti cyangwa ibiyigize byose. Byongeye kandi, ntibisabwa ku bana bari munsi y'imyaka 18, kuko umutekano n'imikorere byayo bitarashyirwaho muri iki cyiciro cy'imyaka.

Muganga wawe azashaka kuganira ku mateka yawe y'ubuzima mbere yo kugusabira zavegepant, cyane cyane niba ufite:

• Indwara ikomeye y'impyiko cyangwa ibibazo by'umwijima
• Amateka y'imyitwarariko ikomeye ya allergique ku miti
• Umuvundo w'amazuru udakira cyangwa kuvira amaraso kenshi mu mazuru
• Kubagwa mu mazuru vuba aha cyangwa imvune
• Gusama cyangwa guteganya gusama

Niba utwite cyangwa wonsha, umutekano wa zavegepant nturashyirwaho neza. Muganga wawe azagereranya inyungu zishoboka n'ibishobora kuba byose mbere yo kugusaba uyu muti.

Izina ry'ubwoko bwa Zavegepant

Zavegepant igurishwa ku izina ry'ubwoko rya Zavzpret muri Leta Zunze Ubumwe z'Amerika. Iri ni ryo zina ry'ubwoko ririho kuri ubu kuri uyu muti, kuko ari mushya ku isoko.

Iyo ufata umuti wawe, uzabona "Zavzpret" ku ipaki no ku byapa. Uyu muti uza mu gikoresho kimwe cyo gutera mu mazuru gitanga neza 10 mg ya zavegepant kuri buri dose.

Uburyo bwo gusimbuza Zavegepant

Niba zavegepant itagukundira neza cyangwa ikagutera ingaruka ziteye isoni, hariho ubundi buryo bwo kuvura migraine. Muganga wawe ashobora kugufasha kubona igisubizo cyiza gishingiye ku byo ukeneye byihariye n'amateka yawe y'ubuzima.

Abandi barwanya CGRP receptor barimo rimegepant (Nurtec) na ubrogepant (Ubrelvy), bifatwa nk'ibinini byo kunywa aho gutera mu mazuru. Ibi bikora kimwe na zavegepant ariko bishobora kwihanganirwa neza n'abantu bagira uburakari mu mazuru.

Imiti gakondo ya migraine ishobora kuba ibisimbura harimo:

• Triptans nka sumatriptan (Imitrex) cyangwa rizatriptan (Maxalt)
• NSAIDs nka ibuprofen cyangwa naproxen, akenshi zifatanyije na cafeine
• Imiti ivanze irimo acetaminophen, aspirine, na cafeine
• Imiti irwanya isesemi nka metoclopramide iyo isesemi ikomeye

Uko guhitamo hagati y'ibi bintu biterwa n'ibintu nk'ubuzima bw'umutima wawe, imiti yindi urimo gufata, n'uburyo wabyitwayemo ku miti yabanje.

Ese Zavegepant iruta Sumatriptan?

Zavegepant na sumatriptan zombi ni imiti ikora neza ku mutwe, ariko zikora mu buryo butandukanye kandi zishobora gukwira abantu batandukanye. Guhitamo

Yego, zavegepant akenshi ifatwa nk'umuti utagira ingaruka ku bantu barwaye indwara z'umutima ugereranije n'indi miti myinshi ivura migraine. Bitandukanye na triptans, zavegepant ntishobora gutuma imitsi ifunga, bivuze ko ntishobora kongera ibyago byo gufatwa n'umutima cyangwa stroke.

Ibi bituma iba uburyo bwiza cyane ku bantu barwaye indwara z'imitsi y'umutima, umuvuduko ukabije w'amaraso, cyangwa ibibazo by'umutima byabayeho mbere. Ariko, ugomba kuganira ku buzima bw'umutima wawe na muganga wawe mbere yo gutangira umuti mushya uvura migraine.

Nkwiriye gukora iki niba nanyweye zavegepant nyinshi mu buryo butunganye?

Niba unyweye doze zirenze imwe ya zavegepant mu masaha 24, ntugahagarike umutima, ariko wigenzure niba hari ingaruka zikomeye. Vugana na muganga wawe cyangwa ikigo gishinzwe kugenzura uburozi kugira ngo baguhe ubujyanama, cyane cyane niba wumva isesemi ikabije, isereri, cyangwa ibimenyetso bidasanzwe.

Ingaruka zishoboka cyane zo kunywa nyinshi zaba ari uko ingaruka zisanzwe zikomeza, nk'uko guhinduka kw'uburyohe bikomeye cyangwa kurakara mu mazuru. Nubwo ingaruka zikomeye zo kunywa nyinshi bidashoboka, buri gihe ni byiza gushaka inama ya muganga igihe ushidikanya.

Nkwiriye gukora iki niba nanyimye doze ya zavegepant?

Kubera ko zavegepant ikoreshwa gusa igihe ufite migraine, nta gahunda isanzwe yo "kwimwa." Urayikoresha gusa igihe ukeneye kuvura migraine ikora.

Niba wibagiwe kuyikoresha mu ntangiriro ya migraine, uracyashobora kuyikoresha nyuma, ariko ntishobora gukora neza igihe umutwe umaze gukomera. Uyu muti ukora neza igihe ukoreshejwe ku kimenyetso cya mbere cy'ibimenyetso bya migraine.

Nshobora guhagarika ryari kunywa zavegepant?

Ushobora guhagarika gukoresha zavegepant igihe icyo aricyo cyose, kuko si umuti usaba guhagarikwa buhoro buhoro. Kubera ko ikoreshwa gusa mugihe migraine ikora, urahagarika kuyikoresha igihe utakiyikeneye kuvura migraine ikaze.

Abantu bamwe basanga imirire yabo igabanuka kenshi cyangwa ikagabanuka ubukana uko igihe kigenda gihita, bigatuma batagikeneye imiti ikoreshwa vuba nka zavegepant. Abandi bashobora guhindura bakajya mu muti utandukanye ubakorera neza. Buri gihe ganira ku mpinduka zose zigaragara ku mirire yawe cyangwa ibyo ukeneye mu kuvurwa n'umuganga wawe.

Nshobora gukoresha Zavegepant hamwe n'indi miti ivura imirire?

Zavegepant akenshi ishobora gukoreshwa hamwe n'indi miti ivura imirire, ariko igihe n'uburyo bishyirwa hamwe biragira uruhare. Ntugomba kuyikoresha hamwe n'indi miti ivura imirire ikoreshwa vuba icyarimwe, kuko ibyo bishobora kongera ibyago byo kugira ingaruka mbi bitagize icyo byongera ku nyungu.

Ariko, muri rusange birizewe gukoresha zavegepant niba ufata imiti ikoreshwa buri munsi yo gukumira imirire nka topiramate, propranolol, cyangwa inshinge zikumira CGRP. Muganga wawe azasuzuma imiti yawe yose kugira ngo arebe ko nta ngaruka zibaho kandi ko gahunda yawe yo kuvurwa ifite ishingiro ku miterere yawe yihariye.