Icyo Zileuton ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Zileuton ni umuti wandikirwa na muganga ufasha kwirinda ibitero bya asima mu kugabanya umubyimbire mu nzira zawe z'ubuhumekero. Uyu muti ubarirwa mu cyiciro cy'imiti yitwa leukotriene inhibitors, ikora mu buryo butandukanye n'imiti isanzwe ikoreshwa mu kwivura cyangwa steroid ushobora kuba uzi.

Uyu muti ntabwo ari wo wakoresha mu gihe cy'igitero cya asima. Ahubwo, ugomba gufatwa buri munsi nk'igice cy'umugambi wawe wo kuvura asima igihe kirekire, ufasha kugumisha inzira zawe z'ubuhumekero zituje kandi zitagira ibibazo uko igihe kigenda.

Zileuton ikoreshwa mu kuvura iki?

Zileuton ikoreshwa cyane cyane mu kurinda ibimenyetso bya asima ku bantu bakuru n'abana bafite imyaka 12 n'abarenzeho. Muganga wawe ashobora kugusaba uyu muti niba uhura n'ibibazo bya asima kenshi nubwo ukoresha izindi miti.

Uyu muti ukora neza cyane ku bantu asima yabo isa naho iterwa n'imyitozo ngororamubiri, umuyaga ukonje, cyangwa ibintu bitera allergie nka pollen n'uturuka mu mukungugu. Ushobora kandi gufasha niba ufite asima iterwa na aspirine, ubwoko bwihariye aho imiti imwe yo kurwanya ububabare ishobora gutera ibibazo byo guhumeka.

Abaganga bamwe kandi bandikira zileuton ku buryo butemewe mu kuvura izindi ndwara ziterwa n'umubyimbire, nubwo gukumira asima ari cyo gikoreshwa cyane. Umuganga wawe azagena niba uyu muti ukwiriye imiterere yawe yihariye n'ibyo umubiri wawe ukeneye.

Zileuton ikora ite?

Zileuton ikora ibara umusemburo witwa 5-lipoxygenase mu mubiri wawe. Uyu musemburo ufasha gukora imiti itera umubyimbire yitwa leukotrienes, ishobora gutuma inzira zawe z'ubuhumekero zifunga, zigahumeka, kandi zigakora umwuka mwinshi.

Tekereza leukotrienes nk'abantu bafite ibibazo mu nzira zawe z'ubuhumekero. Iyo zikora, zituma inzira zawe z'ubuhumekero zihunguka cyane kandi zikagira ibibazo ku bintu bitera allergie cyangwa ibirakaza. Mu kugabanya iyi miti, zileuton ifasha kugumisha inzira zawe z'ubuhumekero zoroheje kandi zitagira ibibazo.

Uyu muti ufatwa nk'ukomeye ku rugero ruciriritse ugereranije n'indi miti ikingira asima. Ntabwo woroshye nk'imwe muri antihistamines, ariko kandi ntabwo ukaze nk'imiti ya steroid ifite urugero rwo hejuru. Abantu benshi bawufata nk'uwunguka iyo ukoreshwa buri gihe nk'igice cy'imikorere yabo ya buri munsi.

Nkwiriye Kufata Zileuton Nte?

Zileuton iza mu buryo bubiri: ibinini bifatwa ako kanya bifatwa inshuro enye ku munsi n'ibinini bifatwa mu gihe kirekire bifatwa kabiri ku munsi. Muganga wawe azahitamo uburyo bukora neza ku gihe cyawe no ku byo ukeneye.

Urashobora gufata zileuton urya cyangwa utarya, nubwo abantu bamwe babona ko byoroshye mu gifu cyabo iyo bafashe agafunguro gato cyangwa ifunguro. Niba uhisemo uburyo bufatwa ako kanya, gerageza gutandukanya imiti yawe mu gihe cyose cy'umunsi, nk'amasaha atandatu.

Ibinini bifatwa mu gihe kirekire bigomba kumirwa byose kandi ntibigomba gushwanyurwa, guhekenywa, cyangwa gucibwamo. Gukora ibyo bishobora kurekura imiti myinshi icyarimwe, ibyo ntibiteza umutekano. Fata imiti yawe mu gihe kimwe buri munsi kugira ngo bifashe kugumana urugero ruzigama mu mubiri wawe.

Ntugire impungenge niba rimwe na rimwe ukeneye guhindura igihe cyawe n'isaha imwe cyangwa ebyiri. Ikintu cy'ingenzi ni ukugumana imikorere ihamye ushobora gukurikiza igihe kirekire.

Nkwiriye Kufata Zileuton Igihe Kingana Gite?

Zileuton akenshi ni umuti ufata igihe kirekire, bivuze ko ushobora kuwufata amezi cyangwa imyaka aho kuba ibyumweru bike gusa. Abantu benshi bakeneye kuwukoresha buri gihe kugira ngo bagumane ingaruka zayo zirinda ibimenyetso bya asima.

Ushobora gutangira kubona impinduka mu minsi mike, ariko bishobora gufata ibyumweru bibiri kugira ngo wumve inyungu zose. Iyi mpinduka buhoro buhoro ni ibisanzwe kandi ntibivuze ko umuti utari gukora.

Muganga wawe azagenzura buri gihe uko urimo utera imbere kandi ashobora guhindura gahunda yawe yo kuvurwa bitewe n'uko asima yawe igenzurwa neza. Abantu bamwe bashobora gukomeza kugabanya urugero rwabo cyangwa guhindurira ku yindi miti, mu gihe abandi bungukirwa no kuguma kuri zileuton igihe kirekire.

Ntugasize gufata zileuton mu buryo butunguranye utabanje kuvugana n'umuganga wawe. Guhagarara mu buryo butunguranye bishobora gutuma ibimenyetso bya asima bisubira cyangwa ndetse bigatuma urugero rukabije rw'indwara rugaruka.

Mbese ni izihe ngaruka ziterwa na Zileuton?

Kimwe n'imiti yose, zileuton ishobora gutera ingaruka ziterwa n'imiti, nubwo abantu benshi bayihanganira neza. Ingaruka zikunze kugaragara muri rusange ziba zoroshye kandi zikunda gukira uko umubiri wawe wimenyereza umuti.

Dore ingaruka ushobora guhura nazo, zashyizwe mu matsinda hakurikijwe uburyo zikunze kugaragara:

Ingaruka zisanzwe (zigira ingaruka ku bantu barenga 1 kuri 10):

• Umutwe
• Isesemi cyangwa kuribwa mu nda
• Impiswi
• Uburibwe bw'imitsi cyangwa intege nke
• Urugero

Ingaruka zitagaragara cyane (zigira ingaruka ku muntu 1 kuri 100):

• Uruhu ruruka cyangwa kuribwa
• Ibibazo byo gusinzira cyangwa kutagira ibitotsi
• Uburibwe mu gituza
• Urubore
• Impinduka mu buryohe

Ingaruka zidakunze kugaragara ariko zikomeye (zigira ingaruka ku bantu bakeya bari munsi ya 1 kuri 1.000):

• Ibibazo by'umwijima (uruhu cyangwa amaso y'umuhondo, inkari z'umukara, umunaniro ukabije)
• Urugero rukabije rw'uburwayi (kubura umwuka, kubyimba mu maso cyangwa mu muhogo)
• Impinduka zidasanzwe z'imitekerereze cyangwa agahinda gakabije
• Uburibwe bukomeye mu nda
• Ibimenyetso by'ubwandu (umuriro udashira, intege nke zidasanzwe)

Ingaruka zifitanye isano n'umwijima zikwiye kwitabwaho by'umwihariko kuko muganga wawe azakenera gukurikirana imikorere y'umwijima wawe akoresheje ibizamini by'amaraso bisanzwe. Uku gukurikirana ni ibisanzwe kandi bifasha gufata ibibazo byose hakiri kare igihe bivurwa neza.

Ingaruka nyinshi zirashobora gucungwa kandi ntizisaba guhagarika umuti. Ariko, vugana n'umuganga wawe niba uhuye n'ibimenyetso bihoraho cyangwa biteye impungenge.

Ninde utagomba gufata Zileuton?

Zileuton ntabwo ikwiriye buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Umuti ntushobora kuba ukwiriye niba ufite indwara zimwe na zimwe cyangwa ufata imiti runaka.

Ntabwo ukwiriye gufata zileuton niba ufite indwara y'umwijima ikora cyangwa ibimenyetso byo mu mwijima byazamutse cyane. Kubera ko umuti ushobora kugira ingaruka ku mikorere y'umwijima, gutangira ufite umwijima wamugaye bishobora guteza akaga.

Abantu bafite amateka y'uburwayi bukomeye bwo kwibasirwa na zileuton cyangwa ibintu byose bigize uyu muti bagomba kwirinda uyu muti. Byongeye kandi, niba utwite cyangwa wonka, ganira ku byago n'inyungu neza na muganga wawe, kuko amakuru yerekeye umutekano muri ibi bihe ari make.

Zileuton irashobora guhura n'indi miti myinshi, harimo warfarin (ikora amaraso), theophylline (undi muti wa asima), na imiti imwe na imwe ifasha mu guhagarika ibibazo byo mu mutwe. Muganga wawe azakenera guhindura imiti cyangwa kugukurikiranira hafi niba ufata iyi miti iyo ari yo yose.

Abana bari munsi y'imyaka 12 ntibagomba gufata zileuton, kuko umutekano wayo n'ubushobozi bwayo bitarashyirwaho muri iki cyiciro cy'imyaka. Muganga wawe w'abana ashobora kugusaba izindi mpinduka zikwiriye ku bana bato bafite asima.

Amazina ya Zileuton

Zileuton iboneka munsi y'izina rya Zyflo, hamwe na verisiyo yongerewe yitwa Zyflo CR. Byombi birimo ibintu bimwe bikora ariko bikozwe muburyo butandukanye kubera gahunda zitandukanye zo gutanga imiti.

Verisiyo rusange ya zileuton nayo iraboneka, irimo ibintu bimwe bikora ariko bishobora kugaragara ukundi cyangwa bikava kubandi bakora. Umufarumasiti wawe ashobora kugufasha gusobanukirwa verisiyo urimo kwakira no kureba niba uyifata neza.

Niba ukoresha izina ry'ubwoko cyangwa verisiyo rusange, umuti ukora kimwe. Abantu bamwe bakunda kimwe kuruta ikindi bitewe n'ikiguzi, ubwishingizi, cyangwa icyifuzo cyawe ku bunini cyangwa imiterere y'ikibahasha.

Izindi mpinduka za Zileuton

Niba zileuton itagukorera neza cyangwa ikagutera ingaruka zitishimirwa, imiti myinshi isimbura iyo ishobora kugufasha kwirinda ibimenyetso bya asima. Muganga wawe ashobora kugufasha gushakisha izi nzira zishingiye ku byo ukeneye byihariye.

Izindi nzitizi za leukotriene zirimo montelukast (Singulair) na zafirlukast (Accolate). Izi zikora kimwe na zileuton ariko zishobora kugira ingaruka zitandukanye cyangwa gahunda yo gufata imiti ituma ibereyeho imibereho yawe.

Imiti ya corticosteroid ihumekwa nka fluticasone (Flovent) cyangwa budesonide (Pulmicort) akenshi ifatwa nk'imiti ya mbere yo kwirinda asima. Iyi miti itererwa mu bihaha byawe kandi ishobora kugira akamaro kanini hamwe n'ingaruka nke zikwirakwira mu mubiri.

Ku bantu bafite asima ikomeye, imiti mishya ya biyolojiya nka omalizumab (Xolair) cyangwa dupilumab (Dupixent) ishobora kuba inzira. Izi zikoreshwa cyane cyane mu gihe izindi miti zitatanze uburyo buhagije bwo kuyirinda.

Ihumeka ry'imiti ihuriweho irimo steroid na bronchodilator ikora igihe kirekire nayo ishobora kuba izindi nzira zikora neza, itanga korohereza no gucunga asima mu buryo bwuzuye mu gikoresho kimwe.

Ese Zileuton iruta Montelukast?

Zileuton na montelukast zombi ni inzitizi za leukotriene, ariko zikora mu buryo butandukanye kandi zifite inyungu zihariye. Guhitamo

Ikibazo gikomeye cya zileuton ugereranije na montelukast ni uko bisaba gukurikiranwa buri gihe imikorere y'umwijima no gufata imiti kenshi. Montelukast yagiye ifitanye isano n'imihindagurikire y'amarangamutima ku bantu bamwe, naho ibibazo bya zileuton byibanze ku mikorere y'umwijima.

Muganga wawe azatekereza ku mateka yawe y'ubuzima, imibereho yawe, n'uburemere bwa asima mugihe ahitamo hagati y'iyi miti. Rimwe na rimwe, icyakorera neza umuntu umwe ntigishobora kuba cyiza ku wundi, kabone n'iyo bafite uburwayi bwa asima busa.

Ibikunze Kubazwa Kuri Zileuton

Ese Zileuton irakoreshwa neza ku barwayi b'indwara z'umutima?

Zileuton muri rusange ifatwa nk'umuti ukoreshwa neza ku bantu barwaye indwara z'umutima, kuko akenshi ntigira ingaruka ku mutima cyangwa umuvuduko w'amaraso. Ariko, muganga wawe w'umutima n'uw'ibihaha bagomba gufatanya mu kwita ku buzima bwawe kugira ngo barebe ko imiti yose ukoresha ikora neza.

Abantu bamwe barwaye indwara z'umutima bafata imiti ituma amaraso ataguma, ishobora kugirana imikoranire na zileuton. Muganga wawe azakurikirana igihe amaraso yawe akoreramo cyane kandi ashobora gukenera guhindura doze y'imiti yawe uko bikwiye.

Niba ufite asima n'indwara y'umutima, kugenzura asima yawe hamwe n'imiti nka zileuton birashobora kungukira umutima wawe mu kugabanya umunaniro ibibazo byo guhumeka bishyira ku mikorere y'umubiri wawe w'imitsi y'amaraso.

Nigute nakora niba nanyweye zileuton nyinshi bitunguranye?

Niba utunguranye ufata zileuton nyinshi kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya. Nubwo kwirenza doze bidasanzwe, gufata nyinshi birashobora kongera ibyago byo kugira ingaruka ziterwa n'imiti, cyane cyane ibibazo by'umwijima.

Ntugerageze "gukosora" kwirenza doze ukora utareba doze yawe ikurikira. Ahubwo, kurikiza ubuyobozi bw'umuganga wawe ku gihe cyo gusubukura gahunda yawe isanzwe yo gufata imiti.

Ibimenyetso biranga ko ushobora kuba waranyoye nyinshi birimo isesemi ikabije, kuruka, gusinzira cyane, cyangwa urujijo. Shakisha ubufasha bw'ubuvuzi bwihuse niba ubonye kimwe muri ibi bimenyetso nyuma yo gufata imiti yinyongera.

Nkwiri Kora Iki Niba Nsibye Urubuto rwa Zileuton?

Niba wibagiwe gufata urubuto rwa zileuton, rufate uko wibukije, keretse igihe cyo gufata urubuto rukurikira kigeze. Muri icyo gihe, reka urubuto wasibye urukure ukomeze gahunda yawe isanzwe.

Ntuzigere ufata imiti ibiri icyarimwe kugira ngo usimbure urubuto wasibye, kuko ibyo bishobora kongera ibyago byo kugira ingaruka zidakunda. Niba ufata urubuto rurekurwa buhoro buhoro, ibi ni ngombwa cyane kwirinda.

Niba ukunda kwibagirwa gufata imiti, tekereza gushyiraho ibyibutso kuri terefone cyangwa gukoresha umuteguro w'imiti. Gukoresha buri munsi bihoraho ni ngombwa kugira ngo zileuton ikore neza mu kurinda ibimenyetso bya asima.

Nshobora Kureka Gufata Zileuton Ryari?

Ugomba kureka gufata zileuton gusa uyobowe na muganga wawe. Abantu benshi bakeneye gukomeza gufata umuti igihe kirekire kugira ngo bagumane ingaruka zayo zirinda ibimenyetso bya asima.

Muganga wawe ashobora gutekereza kureka cyangwa kugabanya zileuton niba asima yawe yaragenzurwa neza igihe kirekire, niba ugize ingaruka zidakunda, cyangwa niba izindi miti zigaragaye ko zikora neza ku miterere yawe.

Umwanzuro wo kureka uzashingira ku kugenzura asima yawe muri rusange, izindi miti ufata, n'ibintu byawe by'umwihariko by'ibibazo. Ntuzigere uhagarara ako kanya, kuko ibyo bishobora gutuma ibimenyetso bisubira cyangwa bigatuma asima yiyongera.

Nshobora Gufata Zileuton Muri Igihe Cy'Inda?

Umutekano wa Zileuton muri icyo gihe nturasobanurwa neza, bityo muganga wawe azagereranya neza inyungu n'ibibazo bishobora kuvuka. Asima itagenzurwa muri icyo gihe ishobora kuba akaga kuri wowe no ku mwana wawe, bityo kugenzura neza asima ni ngombwa.

Niba uteganya gutwita cyangwa uvumbuye ko utwite ukoresha zileuton, ganira ku mahitamo yawe na muganga wawe w'indwara z'abagore n'umuganga w'indwara z'umwuka. Bashobora kugusaba guhindura ku muti ufite amakuru menshi y'umutekano wo gutwita.

Itsinda ry'abaganga bakwitaho bazakorana nawe kugira ngo babone uburyo bwizewe kandi bufite akamaro bwo kuvura asima yawe mu gihe cyose utwite, bakemeza ko ubuzima bwawe n'ubw'umwana wawe burinzwe.