Icyo Dextromethorphan na Quinidine ari cyo: Ibikoreshwa, Uburyo bwo kubikoresha, Ingaruka zabyo n'ibindi

Dextromethorphan na quinidine ni umuti wandikirwa na muganga uvanga ibintu bibiri bikora kugira ngo uvure indwara yo mu bwonko yitwa pseudobulbar affect (PBA). Ubu buryo bukorana mu buryo butandukanye n'uko imiti yombi yakora yonyine, bigatuma habaho uburyo bwihariye bwo kuvura abantu bagira ibihe byo guseka cyangwa kurira bitagendanye n'uko bumva bameze imbere.

Niba wowe cyangwa umuntu witaho yarandikiwe uyu muti, birashoboka ko urimo guhangana n'indwara ishobora kumvikana nk'ikomeye kandi iteye isoni. Kumva uko uyu muti ukora bishobora kugufasha kumva ufite icyizere ku bijyanye n'uburyo bwo kwivuza n'icyo witegura.

Icyo Dextromethorphan na Quinidine ari cyo?

Dextromethorphan na quinidine ni umuti wandikirwa na muganga uvanga imiti ibiri itandukanye mu gipimo kimwe. Izina ry'ubwoko bw'uyu muti ni Nuedexta, kandi yagenewe by'umwihariko kuvura pseudobulbar affect (PBA).

Dextromethorphan ni ikintu ushobora kumenyera mu miti ivura inkorora itangwa nta cyemezo cya muganga, ariko muri ubu buryo, ifite icyo ikora gitandukanye rwose. Quinidine ni umuti uvura indwara z'umutima umaze imyaka myinshi ukoreshwa mu kuvura umutima utera nabi. Iyo iyi miti yombi ivanzwe mu bipimo byihariye, ikorera hamwe kugira ngo ifashe kugenzura inzira zo mu bwonko zifite aho zihurira no kugaragaza amarangamutima.

Ubu buryo burihariye kuko quinidine ifasha dextromethorphan kuguma ikora mu mubiri wawe igihe kirekire. Hatariho quinidine, dextromethorphan yajyanwa vuba na vuba n'umwijima wawe ku buryo itagira akamaro mu kuvura PBA.

Icyo Dextromethorphan na Quinidine bikoreshwa

Uyu muti wemewe by'umwihariko kuvura indwara ya pseudobulbar affect (PBA), indwara yo mu bwonko itera ibihe byo guseka cyangwa kurira bitunguranye kandi bidashoboka kubihagarika. Ibi bihe biba nta kibazo cyabiteye kandi akenshi ntibihura n'uko wumva umeze mu mutima wawe.

PBA ikunda kubaho ku bantu bafite indwara zimwe na zimwe zo mu bwonko cyangwa ibikomere byo mu bwonko. Ushobora kugira PBA niba ufite amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), indwara ya Alzheimer, indwara ya Parkinson, cyangwa niba waragize sitiroko cyangwa igikomere cyo mu bwonko.

Ibi bihe bishobora gutera isoni kandi bikababaza kuko bisa nkaho biva ahantu hatariho. Ushobora kwisanga urira cyane mu gihe cy'umunezero, cyangwa ugaseka mu buryo butari bwo mu gihe cy'ikiganiro gikomeye. Ibi bikorwa bishobora gushyira umwuka mubi mu mibanire y'abantu no gutuma ibihe by'imibanire biba bibi.

Ni ngombwa gusobanukirwa ko PBA itandukanye no kwiheba cyangwa indwara zo mu mutima. Ibyo gusohoka kw'amarangamutima ntibigaragaza uko wumva umeze, kandi biterwa no kwangirika kw'inzira zo mu bwonko zisanzwe zigenzura uko amarangamutima agaragara.

Dextromethorphan na Quinidine bikora gute?

Uyu muti ukora ukoresha inzira zimwe na zimwe zo mu bwonko zigenzura uko amarangamutima agaragara. Ubu buryo bufatwa nk'ubuvuzi bukomeye buzatuma ibihe bya PBA bigabanuka cyane iyo bikoreshejwe buri gihe.

Dextromethorphan igira ingaruka ku bimera bimwe na bimwe byo mu bwonko byitwa neurotransmitters, cyane cyane ibyo bifatanya mu nzira zo mu bwonko zigenzura kurira no guseka. Bifasha guhagarika izi nzira kugirango zitagira icyo zikora mu buryo butari bwo.

Quinidine igira uruhare rwo gufasha mu guhagarika enzyme yo mu mwijima wawe isanzwe isenya dextromethorphan vuba. Ibi bituma dextromethorphan iguma ikora mu mubiri wawe igihe gihagije kugirango igire akamaro mu kuvura PBA.

Umuti ntukiza indwara yo mu bwonko itera PBA yawe, ariko ushobora kugabanya cyane uburemere n'ubwinshi bw'ibihe byo guseka cyangwa kurira bidashoboka. Abantu benshi babona impinduka mu byumweru bike bya mbere by'imiti.

Nkwiriye Gufata Dextromethorphan na Quinidine Nte?

Ukwiriye gufata uyu muti nk'uko muganga wawe abikwandikiye, akenshi kabiri ku munsi hamwe n'ibiryo cyangwa utabifatanije. Urutonde rusanzwe rwo gutangira ni akenshi ikinini kimwe buri masaha 12, ariko muganga wawe ashobora kubihindura bitewe n'uko witwara ku miti.

Ushobora gufata ibinini hamwe n'amazi, amata, cyangwa umutobe. Nta bisabwa byihariye byo kubifata hamwe n'ibiryo, ariko niba wumva mu nda hababara, kubifata hamwe n'ifunguro rito cyangwa ifunguro ryoroshye birashobora gufasha.

Gerageza gufata imiti yawe mu gihe kimwe buri munsi kugirango ugumane urwego rwawo rwo hejuru mu mubiri wawe. Gushyiraho ibyibutso kuri terefone cyangwa gukoresha umuteguro w'ibinini birashobora kugufasha kuguma ukurikiza gahunda yawe yo gufata imiti.

Ntugasenye, utahe cyangwa ufungure ibinini. Byateguwe kugirango birekure umuti mu buryo bwihariye, kandi guhindura ikinini birashobora kugira ingaruka ku buryo imiti ikora neza cyangwa ikongera ibyago byo kugira ingaruka ziterwa n'imiti.

Nkwiriye Gufata Dextromethorphan na Quinidine Mugihe Kingana Gite?

Igice cy'imiti gitandukanye bitewe n'uko umuntu yitwara n'uko yitwara neza ku miti. Abantu benshi bakeneye kuyifata igihe kirekire kugirango bagumane kugenzura ibimenyetso bya PBA yabo.

Muganga wawe ashobora gushaka kukubona buri gihe mu mezi make ya mbere yo kuvurwa kugirango akurikirane uko imiti ikora neza kandi arebe niba hari ingaruka ziterwa n'imiti. Ashobora guhindura urugero rwawe cyangwa igihe bitewe n'uko witwara.

Abantu bamwe babona impinduka mu bihe byabo bya PBA mu byumweru bike bya mbere, mugihe abandi bashobora gukenera amezi menshi kugirango babone inyungu zose. Ikintu cyingenzi ni ukwihangana no gukomeza gufata imiti nk'uko byategetswe.

Ntugasize gufata uyu muti mu buryo butunguranye utabanje kuvugana na muganga wawe. Ashobora kwifuza kugabanya urugero rw'umuti gahoro gahoro kugira ngo wirinde ingaruka zishobora guterwa no kuwuhagarika cyangwa gusubira kw'ibimenyetso bya PBA.

Ni Ibihe Bikorwa Bigaragara Byatewe na Dextromethorphan na Quinidine?

Kimwe n'imiti yose, dextromethorphan na quinidine bishobora gutera ibikorwa bigaragara, nubwo atari buri wese ubyumva. Kumva icyo witegura bishobora kugufasha kumva witeguye kandi ukamenya igihe cyo kuvugana n'umuganga wawe.

Ibikorwa bigaragara bikunze kugaragara muri rusange biroroshye kandi akenshi birakosoka uko umubiri wawe wimenyereza umuti mu byumweru bya mbere by'ubuvuzi.

Ibikorwa bigaragara ushobora guhura nabyo birimo:

• Impiswi cyangwa imyanda yoroshye
• Urugero cyangwa kumva ureremba
• Isesemi cyangwa kuribwa mu nda
• Ukubura mu ntoki, ibirenge, cyangwa mu birenge
• Umunaniro cyangwa gucika intege
• Inkorora cyangwa ibimenyetso byo mu myanya y'ubuhumekero
• Indwara z'inzira y'inkari

Ibi bikorwa bigaragara bisanzwe bikunze gucungwa kandi bikagabanuka uko igihe kigenda. Ariko, ugomba kuvugana na muganga wawe niba bibaye bibangamiye cyangwa bikabangamira imirimo yawe ya buri munsi.

Hariho kandi ibikorwa bigaragara bidakunze kugaragara ariko bikomeye bisaba ubufasha bw'ubuvuzi bwihuse. Nubwo ibi bidakunze kubaho, ni ngombwa kubimenya.

Ibikorwa bigaragara bikomeye bisaba ubufasha bw'ubuvuzi bwihuse birimo:

• Ibibazo by'umutima cyangwa umutima utera mu buryo butunganye
• Urugero rukabije cyangwa guta ubwenge
• Uko umubiri wanga imiti nko kuribwa, kurigata, cyangwa guhumeka bigoranye
• Isesemi ikabije, kuruka, cyangwa impiswi
• Ukuvunika cyangwa gukomeretsa bidasanzwe
• Urujijo cyangwa impinduka mu miterere y'ubwenge
• Gucika intege kw'imitsi gukabije

Niba uhuye n'ibikorwa bigaragara bikomeye, vugana na muganga wawe ako kanya cyangwa ushake ubufasha bw'ubuvuzi bwihutirwa. Umutekano wawe ni wo uza imbere, kandi abaganga bafite ibikoresho byose byo gufasha gucunga ibimenyetso byose bibangamiye.

Ninde Utagomba Gufata Dextromethorphan na Quinidine?

Uyu muti ntugira umutekano kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe mbere yo kuwugusaba. Indwara zimwe na zimwe n'imiti irashobora gutuma uyu muti utabereye cyangwa ugakomera.

Ntabwo ukwiye gufata uyu muti niba ufite indwara zimwe na zimwe z'umutima, cyane cyane ubwoko bwihariye bw'umutima utera cyangwa guhagarara k'umutima. Igice cya quinidine gishobora kugira ingaruka ku mikorere y'amashanyarazi y'umutima wawe, bityo muganga wawe ashobora gushaka kureba uko umutima wawe utera mbere yo gutangira kuvurwa.

Abantu bafite indwara zikomeye z'umwijima cyangwa impyiko ntibashobora gufata uyu muti mu buryo bwizewe. Umubiri wawe ukeneye umwijima n'imikorere myiza y'impyiko kugirango ukoreshe neza uyu muti, kandi imikorere y'ingingo yangiritse irashobora gutuma urwego ruteje akaga ruzamuka mu mubiri wawe.

Niba ufata indi miti, iyi mvange irashobora kutagukwira. Ibi birimo imiti imwe yo kurwanya depression, imiti ituma amaraso atavura, n'indi miti y'umutima ishobora guhura n'uburyo buteye akaga na dextromethorphan na quinidine.

Muganga wawe azakenera kumenya niba ufite amateka y'indwara z'amaraso, kutaringana kwa electrolyte, cyangwa niba utwite cyangwa ufite gahunda yo gutwita. Umutekano w'uyu muti mugihe cyo gutwita nturashyirwaho neza.

Izina ry'ubwoko bwa Dextromethorphan na Quinidine

Izina ry'ubwoko bw'iyi mvange y'imiti ni Nuedexta. Iri niryo bwoko ryemewe na FDA rya dextromethorphan na quinidine rihari muri Leta Zunze Ubumwe z'Amerika.

Nuedexta ikorwa na Avanir Pharmaceuticals kandi iza mu gakapu karimo 20 mg ya dextromethorphan na 10 mg ya quinidine. Agakapu kamwe gakozwe kugirango gatange umubare nyirizina w'iyi miti ibiri ikenewe kugirango ivure PBA neza.

Rimwe na rimwe ushobora kubona uyu muti witaweho ku izina rusange, ariko ubu, nta miti rusange ihari. Ibi bivuze ko mubisanzwe uzahabwa umuti witwa Nuedexta iyo uruhushya rwawe rwanditswe.

Uyu muti uza mu macupa arimo ibinini 60 cyangwa 30, bitewe n'uruhushya rwawe n'ubwishingizi. Umufarumasiti wawe ashobora kugufasha gusobanukirwa uruhushya rwawe rwihariye kandi agasubiza ibibazo byose bijyanye n'umuti urimo guhabwa.

Uburyo bwo gusimbuza Dextromethorphan na Quinidine

Ubu, dextromethorphan na quinidine ni wo muti wemewe na FDA wenyine wo kuvura pseudobulbar affect. Ariko, muganga wawe ashobora gutekereza ku zindi nzira niba uyu muti utagukwiriye cyangwa utatanga ubufasha buhagije.

Abaganga bamwe bashobora kwandika imiti imwe yo kurwanya depression itari iyemewe kugira ngo ifashe mu gukemura ibimenyetso bya PBA. Imiti irwanya depression ya Tricyclic nka amitriptyline cyangwa selective serotonin reuptake inhibitors (SSRIs) yagaragaje akamaro gato mu bushakashatsi bwa kliniki, nubwo itemewe by'umwihariko mu kuvura PBA.

Uburyo butari ubw'imiti nabwo bushobora gufasha nk'imiti yunganira. Imvugo y'imvugo, inama, n'ingamba zo guhangana zirashobora kugufasha gucunga imbogamizi zo mu mibanire n'iz'amarangamutima zizana n'ibihe bya PBA.

Gukorana n'inzobere mu by'imitsi cyangwa umuganga w'indwara zo mu mutwe ufite uburambe muri PBA birashobora kugufasha gushakisha uburyo bwose buhari. Bashobora kugufasha gupima inyungu n'ibibazo by'inzira zitandukanye zishingiye ku miterere yawe yihariye n'izindi ndwara.

Ikintu cy'ingenzi ni ugukorana bya hafi n'ikipe yawe y'ubuzima kugira ngo ubone uburyo bwo kuvura bukugirira akamaro. Ntukazuyaze kubaza ibibazo cyangwa kugaragaza impungenge zerekeye gahunda yawe yo kuvurwa.

Ese Dextromethorphan na Quinidine biruta izindi miti ya PBA?

Dextromethorphan na quinidine ubu ni umuti wemewe wo kuvura ibimenyetso bya pseudobulbar affect kuko ari wo muti wenyine wemewe na FDA wo kuvura iyi ndwara. Ubushakashatsi bwakozwe bwerekanye ko ufite akamaro kanini kurusha placebo mu kugabanya ibyiciro bya PBA.

Ugereranije n'imiti itandukanye ikoreshwa nk'imiti igabanya ubwoba, uyu muti wavuzweho by'umwihariko kandi wagaragaye ko ufitiye PBA akamaro. Ibyegeranyo by'ubushakashatsi byagaragaje ko hafi 85% by'abantu bafata uyu muti bagaragaje impinduka zigaragara mu bimenyetso bya PBA.

Inyungu yo kugira umuti wemewe na FDA ni uko ushobora kwizera umutekano n'ubushobozi bwawo. Uyu muti wanyuzwe mu bizami bikomeye byagenewe PBA, bitandukanye n'indi miti ikoreshwa mu buryo butemewe.

Ariko,

Niba waragize ibibazo by'umutima, ntugahite wumva ko uyu muti atari mwiza kuri wowe. Abantu benshi bafite ibibazo by'umutima barawufata neza bagenzura neza. Muganga wawe w'umutima n'umuganga wandika imiti barashobora gufatanya kugirango barebe umutekano wawe.

Q2. Nakora iki niba nanyweye umuti wa Dextromethorphan na Quinidine mwinshi bitunguranye?

Niba unyweye umuti mwinshi kuruta uko wategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe imiti ihumanya ako kanya. Kunywa umuti mwinshi bishobora guteza akaga, cyane cyane kubera ingaruka za quinidine ku mutima wawe.

Ibimenyetso byo kunywa umuti mwinshi bishobora kuba isereri rikomeye, guta ubwenge, umutima utera nabi, isesemi, kuruka, cyangwa urujijo. Niba ubonye kimwe muri ibi bimenyetso nyuma yo kunywa umuti mwinshi, genda kwa muganga ako kanya.

Ntugerageze "kwishyura" kunywa umuti mwinshi ureka kunywa umuti ukurikira. Ahubwo, kurikiza inama z'umuganga wawe cyangwa ikigo gishinzwe imiti ihumanya ku gihe cyo gusubukura gahunda yawe isanzwe yo kunywa imiti.

Q3. Nakora iki niba nanyimye umuti wa Dextromethorphan na Quinidine?

Niba wimye umuti, wunywe ako kanya wibuka, keretse igihe cyo kunywa umuti ukurikira kigeze. Muri icyo gihe, reka kunywa umuti wimye ukomeze gahunda yawe isanzwe yo kunywa imiti.

Ntunywe imiti ibiri icyarimwe kugirango wishyure umuti wimye. Ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'umuti, cyane cyane ibibazo by'umutima bitewe na quinidine nyinshi icyarimwe.

Niba ukunda kwibagirwa kunywa imiti, tekereza gushyiraho ibyibutso kuri terefone cyangwa ukoreshe agasanduku k'imiti kugirango bigufashe kuguma ku murongo. Kunywa imiti buri gihe ni ngombwa kugirango ugumane imiterere yawe ya PBA.

Q4. Nshobora guhagarika ryari kunywa Dextromethorphan na Quinidine?

Ntabwo wagombye guhagarika kunywa uyu muti utabanje kuvugana n'umuganga wawe. PBA akenshi ni indwara idakira, kandi guhagarika kuvurwa akenshi bisobanura ko ibimenyetso byawe bizagaruka.

Muganga wawe ashobora gutekereza kugabanya cyangwa guhagarika imiti niba uburwayi bwawe bw'imitsi n'imitsi y'ubwonko buri gukira, niba wumva ibibazo bitihanganirwa, cyangwa niba izindi ndwara zituma gukomeza kuvurwa bidatekanye.

Niba ukeneye guhagarika gufata umuti, muganga wawe ashobora gusaba kugabanya buhoro buhoro urugero rwawo aho guhagarika ako kanya. Ibi bifasha kwirinda ingaruka zishobora guterwa no kuva ku muti kandi bituma bishoboka gukurikirana neza ibimenyetso byawe bya PBA.

Q5. Nshobora kunywa inzoga nkanwa Dextromethorphan na Quinidine?

Ugomba kwirinda inzoga cyangwa ukazigabanya cyane mugihe ufata uyu muti. Inzoga irashobora kongera ingaruka zo gutuza za dextromethorphan kandi irashobora no kugira ingaruka ku mutima wawe, ibyo bishobora kuba byateza akaga iyo bivanzwe na quinidine.

Niba uhisemo kunywa inzoga rimwe na rimwe, ganira na muganga wawe kubyerekeye imbibi zitekanye zishingiye ku buzima bwawe bwite. Bashobora gutanga ubuyobozi bwihariye kubyerekeye uko ubuzima bwawe bumeze n'indi miti ushobora kuba ufata.

Wibuke ko inzoga ishobora kandi gukomeza zimwe mu ndwara z'imitsi n'imitsi y'ubwonko kandi ishobora gutuma ibimenyetso byawe bya PBA bigorana gucunga. Ubuzima bwawe muri rusange no kugenzura ibimenyetso birashobora kuzamura no kugabanya kunywa inzoga.