Icyo Oritavancin ari cyo: Ibyo ikoreshwa, urugero rwo kuyifata, ingaruka zayo n'ibindi

Oritavancin ni umuti ukomeye wa antibiyotike utangwa unyuze mu muyoboro w'amaraso (intravenous) kugira ngo uvure indwara zikomeye ziterwa na mikorobe zifata uruhu. Uyu muti ubarirwa mu cyiciro gishya cya antibiyotike zizwi nka lipoglycopeptides, zikora mu buryo butandukanye na antibiyotike nyinshi zisanzwe uzi.

Igituma oritavancin iba umwihariko ni uko yateguwe nk'umuti utangwa rimwe gusa. Aho gufata imiti myinshi mu minsi myinshi, uhabwa urukingo rumwe rukomeza gukora mu mubiri wawe mu gihe cy'icyumweru. Ubu buryo bushobora gufasha cyane iyo uhanganye n'indwara zikomeye zititabiriye neza izindi miti.

Oritavancin ikoreshwa mu kuvura iki?

Oritavancin ivura indwara zikomeye ziterwa na mikorobe zifata uruhu n'imyubakire yarwo (ABSSSI) ku bantu bakuru. Izi ni indwara zikomeye zirenga uruhu gusa kandi zishobora kwibasira imitsi, imikaya, cyangwa ibinure biri munsi y'uruhu.

Muganga wawe ashobora kugusaba oritavancin iyo ufite indwara ziterwa na mikorobe zimwe na zimwe, harimo na methicillin-resistant Staphylococcus aureus (MRSA). MRSA ni ubwoko bwa mikorobe butitabira antibiyotike nyinshi zisanzwe, bigatuma bigorana cyane kuvurwa. Oritavancin kandi ifite akamaro ku zindi mikorobe ya gram-positive ishobora gutera indwara zifata uruhu.

Uyu muti akenshi ukoreshwa mu bihe izindi antibiyotike zitagize icyo zikora cyangwa iyo ufite indwara ikomeye ikeneye kuvurwa cyane. Umuganga wawe azagena niba oritavancin ari wo muti ukwiriye bitewe n'indwara yawe yihariye n'amateka yawe y'ubuzima.

Oritavancin ikora ite?

Oritavancin ifatwa nk'antibiyotike ikomeye ikora mu buryo bwo guhungabanya uburyo mikorobe yubaka inkuta zayo z'uturemangingo. Tekereza inkuta z'uturemangingo twa mikorobe nk'intwaro zirinda zituma mikorobe zibaho kandi zigakora neza.

Uyu muti wica mikorobe mu buryo bwinshi icyarimwe. Ubuza mikorobe gukora ibikoresho bishya byo ku rukuta rw'uturemangingo kandi unyangiza urukuta rw'uturemangingo twazo dusanzweho. Iki gikorwa cyombi gituma mikorobe itabasha kubaho no kwororoka, bigaha umubiri wawe amahirwe yo kurwanya iyo ndwara.

Uyu muti ukora mu mubiri wawe igihe kirekire nyuma yo kuwutera, ugakomeza kurwanya mikorobe mu gihe cy'iminsi nka irindwi. Iki gikorwa kirambye nicyo gituma ukeneye urugero rumwe gusa aho guhabwa imiti myinshi mu gihe cy'iminsi myinshi.

Nkwiriye Gufata Oritavancin Nte?

Oritavancin itangwa gusa binyuze mu muyoboro wa IV mu bitaro cyangwa ahantu hakorerwa ibizamini by'ubuvuzi. Ntushobora gufata uyu muti uri mu rugo cyangwa unywa. Uyu muti uza mu ifu abaganga bavanga n'amazi atagira mikorobe kugira ngo bakore urukingo.

Uburyo bwo gutera urukingo bufata nk'amasaha atatu. Itsinda ry'abaganga bazakugenzura cyane muri iki gihe kugira ngo barebe niba hari icyo byagutera. Uzashyirwa ku muyoboro wa IV, kandi umuti uzajya mu maraso yawe gahoro gahoro.

Mbere yo guterwa urukingo, ntugomba kwirinda kurya cyangwa kunywa keretse muganga wawe akugiriye inama zihariye. Ariko, ni ngombwa kubwira umuganga wawe imiti yose urimo gufata, kuko hari imiti imwe ishobora guhura na oritavancin.

Mugihe cyo guterwa urukingo, birashoboka ko uzagomba kuguma ahantu hamwe mu bitaro cyangwa mu ivuriro. Ubusanzwe urashobora gusoma, gukoresha terefone yawe, cyangwa kwishora mu bikorwa byoroshye mugihe umuti urimo gutangwa.

Mbwiriza Gufata Oritavancin Igihe Kingana Gite?

Oritavancin yateguwe nk'umuti utangwa urugero rumwe. Uzarushyirwaho urukingo rumwe gusa, kandi akenshi nicyo gusa ukeneye kugira ngo uvurwe indwara yawe.

Umuti ukomeza gukora mu mubiri wawe mu gihe cy'iminsi nka irindwi nyuma yo guterwa urukingo. Iki gihe cy'igikorwa kirambye cyashyizwe mu buryo uyu muti ukora, bityo ntukeneye ibindi bice nkuko byagenda kuri antibiotike nyinshi.

Muganga wawe azakurikiranira hafi uko urimo urushaho mu minsi n'ibyumweru bikurikira kugira ngo yemeze ko ubwandu burimo burakira neza. Mu bihe bidasanzwe, niba ubwandu butitabira neza, umuganga wawe ashobora gutekereza ku zindi nshuti, ariko ibi byasaba uburyo butandukanye aho gutanga oritavancin nyinshi.

Mbese ni izihe ngaruka ziterwa na Oritavancin?

Kimwe n'imiti yose, oritavancin ishobora gutera ingaruka, nubwo atari buri wese uzazibona. Abantu benshi bakira neza uyu muti, ariko ni ngombwa kumenya icyo ugomba kwitaho.

Dore ingaruka zisanzwe ushobora guhura nazo:

• Umutwe
• Isesemi
• Urubavu cyangwa kubabara kw'ukuguru
• Impiswi
• Ibimenyetso ahantu umuti watewe (umutuku, kubyimba, cyangwa kubabara)

Izi ngaruka zisanzwe zoroheje kandi zikunda gukira zonyine mu minsi mike. Itsinda ry'abaganga baragufasha guhangana n'ububabare bwose wahura nabwo.

Ingaruka zikomeye ntizisanzwe ariko zisaba ubufasha bwihutirwa bw'abaganga. Izi zirimo ibimenyetso bikomeye byo kwibasirwa n'umubiri, bishobora gutera ingorane zo guhumeka, kubyimba mu maso cyangwa mu muhogo, cyangwa ibiheri byinshi. Niba uhuye n'ikimenyetso icyo aricyo cyose muri ibi, genda vuba na bwangu kwa muganga.

Abantu bamwe bashobora kurwara indwara ikomeye y'amara yitwa C. difficile-associated diarrhea (CDAD) mugihe cyangwa nyuma yo kuvurwa. Ibi bishobora kubaho nyuma y'ibyumweru byinshi umaze guhabwa umuti. Vugana na muganga wawe niba ufite impiswi ihoraho, cyane cyane niba ivanzemo amaraso cyangwa ikubiyemo ururenda.

Ninde utagomba gufata Oritavancin?

Oritavancin ntabwo ikwiriye kuri buri wese. Muganga wawe azasuzuma neza amateka yawe mbere yo kugusaba ubu buvuzi.

Ntabwo ugomba guhabwa oritavancin niba warigeze kugira ibimenyetso byo kwibasirwa n'umubiri kuri yo cyangwa kuri antibiyotike zisa nka vancomycin cyangwa telavancin. Bwira umuganga wawe ibyerekeye allergie zose za antibiyotike wigeze kugira, nubwo zasa nkizoroheje.

Abantu bafite indwara zimwe na zimwe z'umutima bakeneye kwitabwaho by'umwihariko. Oritavancin ishobora kugira ingaruka ku bizami byo gupima amaraso mu gihe cy'amasaha 120 (iminsi itanu) nyuma yo kuvurwa. Niba ufata imiti ituma amaraso ataguma, nka warfarin, muganga wawe azagomba kugukurikiranira hafi kandi ashobora gukenera guhindura imiti ufata.

Uyu muti nturakorwaho ubushakashatsi bwimbitse ku bagore batwite, bityo muganga wawe azagereranya inyungu n'ibishobora guteza akaga niba utwite cyangwa ufite gahunda yo gutwita. Kimwe n'ibyo, ntibizwi niba oritavancin yinjira mu mata y'ibere, bityo ababyeyi bonka bagomba kugirwa inama ku giti cyabo.

Izina ry'ubucuruzi rya Oritavancin

Oritavancin igurishwa ku izina ry'ubucuruzi rya Orbactiv muri Leta Zunze Ubumwe z'Amerika. Iri ni ryo zina ry'ubucuruzi uzabona ku mbonerahamwe z'ibitaro no mu nyandiko z'ubuvuzi.

Uyu muti ukorwa na Melinta Therapeutics kandi wemejwe na FDA mu mwaka wa 2014. Iyo abaganga bavuga kuri ubu buvuzi, bashobora gukoresha izina rusange (oritavancin) cyangwa izina ry'ubucuruzi (Orbactiv).

Uburyo bwo gusimbura Oritavancin

Izindi antibiyotike nyinshi zishobora kuvura indwara zisa, nubwo muganga wawe azahitamo bitewe n'uko ubuzima bwawe buhagaze n'agakoko gatera indwara.

Vancomycin ni uburyo busanzwe bukoreshwa, cyane cyane ku ndwara ziterwa na MRSA. Ariko, bisaba doze nyinshi mu minsi myinshi aho gukoresha doze imwe ya oritavancin. Linezolid ni ubundi buryo bushobora gutangwa binyuze mu muyoboro w'amaraso cyangwa mu kanwa.

Ku ndwara zimwe na zimwe, daptomycin ishobora gukwira. Iyi antibiyotike itangwa rimwe ku munsi binyuze mu muyoboro w'amaraso kandi ikora ku bagera ku gakoko gakora nka oritavancin. Telavancin ni indi antibiyotike ya lipoglycopeptide isa na oritavancin ariko isaba doze ya buri munsi.

Umuvuzi wawe w’ubuzima azatekereza ku bintu nk'agakoko gashinzwe, imikorere y'impyiko zawe, imiti yindi urimo gufata, n'ubuzima bwawe muri rusange mugihe ahitamo umuti wica mikorobe mwiza kuri wowe.

Ese Oritavancin iruta Vancomycin?

Oritavancin na vancomycin ni imiti yica mikorobe ikora neza kubera indwara ziterwa n'agakoko gakomeye, ariko buri imwe ifite inyungu zidasanzwe bitewe n'uko ubuzima bwawe bumeze.

Inyungu nyamukuru ya Oritavancin ni ukubona ibintu byoroshye. Uhabwa urushinge rumwe gusa aho guhabwa doze nyinshi muminsi myinshi. Ibi birashobora kugira akamaro cyane niba ugira ingorane zo kubona urushinge cyangwa niba ushaka kugabanya igihe cyo kumara mu bitaro.

Vancomycin imaze imyaka myinshi ikoreshwa kandi ifite umutekano wemejwe. Akenshi ntirihagaze amafaranga menshi kuruta oritavancin kandi iboneka ahantu henshi hatangirwa ubuvuzi. Ariko, bisaba gukurikiranwa kw'amaraso n'imikorere y'impyiko mugihe cy'ubuvuzi.

Ubushakashatsi bwerekana ko imiti yombi ikora kimwe mugukiza indwara z'uruhu n'imitsi yoroshye. Muganga wawe azatekereza ku bintu nk'imikorere y'impyiko zawe, indi miti, ubwishingizi, n'ibyo ukunda mugihe afata icyemezo cy'umuti wica mikorobe ukugirira neza.

Ibikunze Kubazwa Kuri Oritavancin

Ese Oritavancin irakwiriye abantu barwaye indwara y'impyiko?

Oritavancin isa nkaho ifite umutekano kurusha abantu bafite ibibazo by'impyiko ugereranije n'indi miti yica mikorobe. Uyu muti ntusaba guhindura doze bitewe n'imikorere y'impyiko, ibyo bikaba ari inyungu kurusha imiti yica mikorobe nka vancomycin.

Ariko, muganga wawe azakomeza gukurikirana imikorere y'impyiko zawe mbere na nyuma yo kuvurwa. Niba urwaye indwara ikomeye y'impyiko cyangwa uri kuri diyarese, umuvuzi wawe azasuzuma neza niba oritavancin ariyo nziza kuri wowe.

Nigomba gukora iki niba ngize allergie kuri Oritavancin?

Niba ubonye ibimenyetso byo kwibasirwa n'umubiri (allergie) igihe cyangwa nyuma yo guterwa urushinge, genda vuba kwa muganga. Ibyo bimenyetso birimo kubura umwuka, kubimba mu maso cyangwa mu muhogo, kuribwa umubiri hose, cyangwa kuribwa cyane.

Kubera ko uterwa oritavancin ahantu havurirwa, abaganga bazahita baboneka kugira ngo bavure ibibazo byose bishobora kuvuka. Bafite imiti n'ibikoresho byiteguye guhangana n'ibibazo byo kwibasirwa n'umubiri vuba kandi neza.

Niba ugize ikibazo cyo kwibasirwa n'umubiri nyuma yo kuva mu bitaro, jya mu cyumba cy'ubutabazi cyegereye cyangwa uhamagare 911. Ntuzategereze ngo urebe niba ibimenyetso bizivana.

Nigira nte niba nciwe urukingo rwa Oritavancin?

Iki kibazo ntikireba oritavancin kuko itangwa nk'urukingo rumwe ahantu havurirwa. Ntabwo ushobora gucikanwa n'urukingo kuko urabona imiti yose mu gihe kimwe cyo gusura ibitaro.

Niba hari impamvu urushinge rwahagarara cyangwa rugahagarikwa hakiri kare, ikipe yawe y'abaganga izagena uburyo bwiza bwo gukora. Bashobora kurangiza urushinge igihe byemewe gukora cyangwa bagatekereza ku zindi miti.

Nshobora guhagarika ryari gufata Oritavancin?

Ntabwo ukeneye guhagarika gufata oritavancin kuko ni umuti utangwa rimwe gusa. Nyuma yo guterwa urushinge rumwe, umuti ukomeza gukora mu mubiri wawe mu gihe cy'icyumweru nta zindi doze zongerewe.

Muganga wawe azategura gahunda yo kugusuzuma kugira ngo akurikirane imikorere yawe kandi yemeze ko icyorezo kirimo gukira neza. Komeza gufata indi miti yose nk'uko byategetswe keretse muganga wawe abikubwiye ukundi.

Nshobora gutwara imodoka nyuma yo guterwa Oritavancin?

Ugomba kwirinda gutwara imodoka nyuma yo guterwa urushinge rwa oritavancin, cyane cyane niba wumva uribwa, unaniwe, cyangwa utameze neza. Uburyo bwo guterwa urushinge bufata amasaha menshi, kandi ushobora kumva unaniwe nyuma.

Saba umuntu kukugeza iwawe nyuma yo kuvurwa, cyangwa utegure uburyo bwo gutwara butandukanye. Abantu benshi bumva basubiye mu buryo busanzwe mu gihe cy'umunsi umwe cyangwa ibiri, ariko umva umubiri wawe kandi ntugatware imodoka niba utiyumva neza kandi utunganye.