Icyo Rimabotulinumtoxinb ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'ibindi

Rimabotulinumtoxinb ni umuti wandikirwa na muganga urimo ubwoko bwa botulinum toxin B, poroteyine isukuye ituma imitsi ikora cyane iruhuka by'agateganyo. Ushobora kuyimenya neza ku izina ryayo ry'ubucuruzi, Myobloc, kandi ikomoka mu muryango umwe w'imiti nka Botox, nubwo ikoresha ubwoko butandukanye bwa botulinum toxin.

Uyu muti ukora ubuza ibimenyetso by'imitsi bibwira imitsi yawe kwikurura. Iyo yatewe mu mitsi runaka, itanga ubufasha ku mvune ziterwa n'imitsi kandi ishobora kugabanya ibyuya birenze urugero mu bice bimwe na bimwe by'umubiri wawe.

Rimabotulinumtoxinb ikoreshwa mu iki?

Rimabotulinumtoxinb ivura cervical dystonia, uburwayi bwo mu bwonko aho imitsi yo mu ijosi no mu bitugu byawe yikurura itabigizemo uruhare. Ubu burwayi butuma umutwe wawe uhinduka cyangwa ugahindukira mu myanya itari myiza, akenshi bikaba bijyana n'ububabare bukomeye no kugorana mu bikorwa bya buri munsi.

Uyu muti kandi wemerejwe kuvura ibyuya bikabije byo mu kwaha (axillary hyperhidrosis) iyo izindi nshuti zitagize icyo zigera ku murwayi. Muganga wawe ashobora gutekereza ubu buvuzi niba imiti isanzwe ikoreshwa mu kwirinda ibyuya, imiti yandikirwa na muganga, cyangwa izindi nshuti zitagize icyo zigera ku murwayi.

Rimwe na rimwe, abaganga bakoresha rimabotulinumtoxinb ku zindi ndwara zijyanye n'imitsi, nubwo ibi byafatwa nk'ibitari ku rutonde rw'ibyo ikoreshwa. Muganga wawe azaganira niba uyu muti ukwiriye kubera ibimenyetso byawe byihariye.

Rimabotulinumtoxinb ikora ite?

Rimabotulinumtoxinb ikora ibuza by'agateganyo irekurwa rya acetylcholine, ubutumwa bw'imiti bubwira imitsi yawe igihe igomba kwikurura. Tekereza nk'igikorwa cyo gukuraho by'agateganyo umurongo w'itumanaho hagati y'imitsi yawe n'imitsi yawe.

Uyu muti ufatwa nk'ukomeye kandi ugamije cyane. Bitandukanye n'imiti inyobwa igira ingaruka ku mubiri wawe wose, rimabotulinumtoxinb igira ingaruka ku misitsi yihariye yateweho inshinge gusa, ibi bikaba bifasha kugabanya ingaruka mbi mu bindi bice by'umubiri wawe.

Ingaruka zikunze gutangira nyuma y'iminsi mike kugeza ku byumweru bibiri nyuma yo guterwa urushinge kandi zishobora kumara hagati y'amezi atatu n'atandatu. Uko umuti ugenda ushiramo, imikoranire y'imitsi igenda igaruka buhoro buhoro, kandi imikorere y'imitsi igasubira mu buryo bwayo bwa mbere.

Nkwiriye Gufata Uyu Muti Nte?

Rimabotulinumtoxinb itangwa buri gihe nk'urushinge rutewe mu misitsi yafashwe na muganga ubifitiye uburenganzira. Ntushobora gufata uyu muti uri mu rugo cyangwa unywa mu kanwa - bisaba ko utangwa n'abantu babigize umwuga ahantu hakorerwa ibizamini by'ubuvuzi.

Mbere yo guterwa urushinge, ntugomba kwiyiriza cyangwa kwirinda kurya, nubwo abaganga bamwe basaba kwirinda inzoga mu masaha 24 mbere y'uko guterwa urushinge. Urashobora kurya uko bisanzwe kandi ugafata imiti yawe isanzwe keretse muganga wawe akubwiye ibitandukanye.

Uburyo bwo guterwa urushinge busanzwe bufata iminota 15 kugeza kuri 30, bitewe n'umubare w'imisitsi ikeneye kuvurwa. Muganga wawe azakoresha urushinge ruto atere umuti mu duce twihariye tw'imisitsi yafashwe, akoresheje ubumenyi bwe bw'imyubakire y'umubiri rimwe na rimwe afashijwe no gukoresha amashanyarazi kugirango abone ahantu hakwiye.

Nyuma yo guterwa urushinge, mubisanzwe urashobora gusubira mu bikorwa bisanzwe ako kanya. Ariko, muganga wawe ashobora kugusaba kwirinda imyitozo ikomeye cyangwa kuryama mu masaha make kugirango umuti ugume mu misitsi wagenewe.

Nkwiriye Gufata Rimabotulinumtoxinb Igihe Kingana Gite?

Ingaruka za rimabotulinumtoxinb ni iz'igihe gito, bityo uzakenera guterwa inshinge zisubiramo kugirango ugumane inyungu. Abantu benshi baterwa inshinge buri mezi atatu cyangwa ane, nubwo gahunda yawe yihariye iterwa n'uko umubiri wawe witwara ku muti.

Abantu bamwe basanga ibimenyetso byabo bigaruka buhoro buhoro mu gihe cy'amezi menshi, mu gihe abandi babona ko imitsi yabo itangira guhagarara cyangwa gutwega mu buryo butunguranye. Muganga wawe azakorana nawe kugira ngo abone igihe gikwiye cyo gukora inshinge zo gukurikirana, bitewe n'igihe ibimenyetso byawe bitangira kugaruka.

Nta gihe ntarengwa cyagenewe ubu buvuzi. Abantu benshi bakomeza guhabwa inshinge mu gihe cy'imyaka myinshi mu rwego rwo guhangana n'uburwayi bwabo burambye. Muganga wawe azajya asuzuma buri gihe niba umuti ukomeje kugira akamaro kandi ufite umutekano ku miterere yawe bwite.

Mbese ni izihe ngaruka ziterwa na Rimabotulinumtoxinb?

Abantu benshi bafata neza rimabotulinumtoxinb, ariko nk'imiti yose, ishobora gutera ingaruka. Ingaruka zisanzwe zikunda kuba zoroshye kandi z'igihe gito, zikaba ahantu hakorerwa inshinge cyangwa hafi yaho.

Dore ingaruka ushobora guhura nazo, dutangiriye ku zisanzwe cyane:

• Urubavu, gukomeretsa, cyangwa kubyimba ahakorewe inshinge
• Umutwe ushobora kumara iminsi mike
• Ibimenyetso by'ibicurane birimo umuriro woroshye cyangwa kubabara umubiri
• Kugabanuka kw'imbaraga by'agateganyo mu mitsi yakorewe inshinge
• Umunwa wumye, ushobora kugaragara cyane iyo bakorewe inshinge mu ijosi
• Kugorana kumeza (dysphagia) mugihe bavura imitsi yo mu ijosi

Izi ngaruka zisanzwe zikunda gukira mu minsi mike cyangwa mu byumweru, kandi ntizisanzwe zisaba ubuvuzi butarenze ibipimo by'ihumure.

Ingaruka zitari zisanzwe ariko zikomeye zirashobora kubaho, nubwo zifata abantu batarenze 5% bahawe uyu muti:

• Kugorana gukomeye kumeza cyangwa guhumeka
• Kugabanuka kw'imbaraga mu mitsi hose hanze y'ahakorewe inshinge
• Impinduka mu iyerekwa cyangwa kureba ibintu bibiri
• Urugero rukomeye rwo kwivumbura kw'umubiri harimo ibibara, kuribwa, cyangwa kubyimba
• Kugorana kuvuga cyangwa guhinduka kw'ijwi

Niba uhuye n'izo ngaruka zikomeye, vugana n'umuganga wawe ako kanya cyangwa ushake ubufasha bw'ubuvuzi bwihutirwa.

Mu bintu bike cyane, uburozi bwa botulinum bushobora gukwira hanze yaho batera urushinge maze bugateza ibimenyetso bisa n'ibya botulisme mu mubiri wawe wose. Ibi bibaho ku bantu batarenze 1% kandi bikubiyemo ibimenyetso nk'intege nke zikabije z'imitsi, kugorana guhumeka, cyangwa ibibazo byo kureba no kuvuga. Nubwo ibi bidakunze kubaho cyane, ni ngombwa kwitondera ibi bimenyetso kandi ugahita usaba ubufasha bw'ubuvuzi bwihuse nibibaye.

Ninde utagomba gufata Rimabotulinumtoxinb?

Rimabotulinumtoxinb ntirigirira umutekano buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuvuzi mbere yo kugusaba ubu buvuzi. Ntugomba guhabwa uyu muti niba ufite allergie ku burozi bwa botulinum cyangwa ibintu byose bikubiye muri uyu muti.

Indwara zimwe na zimwe zituma rimabotulinumtoxinb ishobora kuba ikomeye. Muganga wawe ashobora kugusaba kutagira ubu buvuzi niba ufite:

• Uburwayi bukomeye ahantu hateganyijwe guterwa urushinge
• Indwara z'imitsi n'imitsi nk'indwara ya myasthenia gravis cyangwa syndrome ya Lambert-Eaton
• Indwara zituma amaraso ava cyangwa niba ufata imiti ituma amaraso ataguma
• Ibibazo bikomeye byo guhumeka cyangwa kugorana kumeza

Gusama no konsa bisaba kwitonderwa byihariye. Nubwo nta bimenyetso bifatika byerekana ko rimabotulinumtoxinb yangiza abana bakiri bato, abaganga basanzwe basaba kubyirinda mugihe cyo gutwita keretse inyungu zirusha ingaruka.

Niba ufata imiti imwe na rimwe, muganga wawe ashobora gukenera guhindura gahunda yawe y'ubuvuzi. Antibiyotike nka aminoglycosides, imiti iruhura imitsi, n'indi miti imwe na rimwe ishobora guhura na rimabotulinumtoxinb kandi ikongera ibyago byo kugira ingaruka ziterwa n'iyo miti.

Amazina y'ubwoko bwa Rimabotulinumtoxinb

Izina ry'ubwoko bwa rimabotulinumtoxinb ni Myobloc, ikorwa na Solstice Neurosciences. Ubu nicyo gusa ubwoko bwa rimabotulinumtoxinb bugurishwa muri Amerika.

Myobloc iza mu ducupa dukoreshwa rimwe rukumbi turimo imiti ifite ingano zitandukanye. Muganga wawe azahitamo ingano ikwiriye bitewe n'uburwayi bwawe bwihariye n'imitsi ivurwa.

Bitandukanye n'ibindi bicuruzwa bimwe na bimwe bya botulinum toxin, Myobloc ntisaba kongera gukora cyangwa kuvanga mbere yo gukoreshwa. Iza yiteguye guterwa inshinge, ibyo bishobora koroshya uburyo bwo kuyitegura ku baganga.

Izindi nzira zishobora gukoreshwa mu gihe rimabotulinumtoxinb itabasha gukoreshwa

Hariho ibindi bicuruzwa byinshi bya botulinum toxin biboneka niba rimabotulinumtoxinb itagukwiriye. Uburyo buzwi cyane ni onabotulinumtoxinA (Botox), ikoresha botulinum toxin yo mu bwoko bwa A aho gukoresha ubwoko bwa B.

Ibindi bicuruzwa bya botulinum toxin yo mu bwoko bwa A birimo abobotulinumtoxinA (Dysport) na incobotulinumtoxinA (Xeomin). Nubwo iyi miti ikora kimwe na rimabotulinumtoxinb, ifite uburyo butandukanye bwo gukorwa kandi ishobora gukora neza cyangwa nabi ku bantu bamwe na bamwe.

Ku zindi nzira zitari botulinum toxin, uburyo bwo kuvurwa kwawe buterwa n'uburwayi bwawe bwihariye. Cervical dystonia ishobora kuvurwa n'imiti yo kunywa nk'imiti iruhura imitsi, imiti irwanya ibyuririzi, cyangwa ndetse n'uburyo bwo kubaga mu gihe bikomeye. Kubira ibyuya birenze urugero rimwe na rimwe bishobora gucungwa n'imiti irwanya ibyuya yandikiwe na muganga, imiti yo kunywa, cyangwa uburyo nk'ubwa miraDry.

Muganga wawe azagufasha gushakisha izi nzira niba rimabotulinumtoxinb itatanga ubufasha buhagije cyangwa niba ubonye ingaruka zitakwemerwa.

Ese Rimabotulinumtoxinb iruta Botox?

Niba rimabotulinumtoxinb iruta Botox biterwa n'uburyo umubiri wawe ubyakira n'uburwayi bwawe bwihariye. Iyi miti yombi ni ibicuruzwa bya botulinum toxin bikora neza, ariko bikoresha ubwoko butandukanye bwa toxin kandi bishobora gukora mu buryo butandukanye mu mubiri wawe.

Abantu bamwe basubiza neza kuri rimabotulinumtoxinb (ubwoko B bwa toxin) kurusha Botox (ubwoko A bwa toxin), cyane cyane niba baragize ubudahangarwa ku bicuruzwa by'ubwoko A. Gutangira gukora bishobora no gutandukana gato, aho abantu bamwe babona ingaruka vuba kuri kimwe mu bicuruzwa kurusha ikindi.

Ku bijyanye na cervical dystonia by'umwihariko, imiti yombi yagaragaje imikorere isa nk'iyo mu bushakashatsi bwa kliniki. Guhitamo akenshi biterwa n'uburyo wowe ubwawe ubyakira, uburambe bw'abaganga bafite kuri buri gicuruzwa, n'ibitekerezo bifatika nk'ikiguzi n'ubwishingizi.

Muganga wawe ashobora kugufasha gusobanukirwa uburyo bwiza bushobora kuba bwiza kuri wowe, ndetse ushobora no kugerageza ibicuruzwa byombi mu bihe bitandukanye kugirango urebe icyo kigukorera neza.

Ibikunze Kubazwa Kuri Rimabotulinumtoxinb

Ese Rimabotulinumtoxinb irakwiriye abantu barwaye diyabete?

Rimabotulinumtoxinb muri rusange irakwiriye abantu barwaye diyabete, kandi kugira diyabete ntibigutera guhagarikwa guhabwa ubu buvuzi. Ariko, muganga wawe azashaka kumenya neza ko diyabete yawe igenzurwa neza mbere yo gukomeza gutera inshinge.

Abantu barwaye diyabete bashobora kugira ibyago byinshi byo kwandura cyangwa gukira gahoro ahaterwa inshinge, bityo umuganga wawe ashobora gufata ingamba zidasanzwe. Bashobora kandi kugukurikiranira hafi nyuma yo gutera inshinge kugirango barebe niba hari ibintu bidasanzwe bibaho.

Nigute nakora niba nkoze amakosa ngakoresha rimabotulinumtoxinb nyinshi cyane?

Kubera ko rimabotulinumtoxinb itangwa gusa n'abanyamwuga bo mu buvuzi, gukoresha dosiye nyinshi cyane ntibishoboka. Ariko, niba uhabwa imiti nyinshi cyane, ikintu cy'ingenzi cyaba ari ukugabanuka cyane kw'imbaraga z'imitsi cyangwa gukwirakwiza ingaruka ku misitsi itagombaga kuvurwa.

Niba ubonye intege nke zidasanzwe mu mikaya, kugorwa no guhumeka, cyangwa ibibazo byo kumira nyuma yo guterwa urushinge, vugana n'umuganga wawe ako kanya cyangwa ushake ubufasha bwihutirwa. Ibi bishobora kuba ibimenyetso byerekana ko umuti wagize ingaruka ku mikaya myinshi kurusha uko byari byitezwe.

Nta muti wihariye wo kurwanya rimabotulinumtoxinb, bityo kuvura byibanda ku gucunga ibimenyetso no gutanga ubufasha mu gihe ingaruka z'umuti zigenda zigabanuka buhoro buhoro mu mezi menshi.

Nkwiriye gukora iki niba nciwe urushinge rwa Rimabotulinumtoxinb?

Niba ucikanwe n'urushinge rwawe rwari ruteganyijwe, vugana n'umuganga wawe kugira ngo uteganyirize urundi rushinge vuba bishoboka. Igihe cy'urushinge rwawe rutaha giterwa n'igihe ibimenyetso byawe byagarukiyeho n'igihe gishize uvurwa bwa nyuma.

Ushobora kubona imitsi yawe yikanyaga cyangwa ibyuya byinshi bigaruka buhoro buhoro uko ingaruka z'urushinge rwa mbere zigenda zigabanuka. Ibi ni ibisanzwe kandi birateganyijwe, kandi guterwa urushinge rwawe rutaha bizafasha kugarura kugenzura ibimenyetso.

Ntugerageze gusimbura urushinge rwawe rwatanzwe ukoresha imiti y'inyongera mu gihe cy'urushinge rwawe rutaha. Umuganga wawe azagena urugero rukwiye rwa imiti ashingiye ku bimenyetso byawe by'ubu n'igihe gishize uvurwa bwa nyuma.

Nshobora kureka guterwa Rimabotulinumtoxinb ryari?

Ushobora kureka guterwa inshinge za rimabotulinumtoxinb igihe icyo aricyo cyose, kandi nta bimenyetso byo gukurwaho cyangwa ingaruka ziteje akaga zo guhagarika umuti. Ariko, ibimenyetso byawe bya mbere bizagaruka buhoro buhoro uko ingaruka z'umuti zigenda zigabanuka mu mezi menshi.

Abantu bamwe bahitamo guhagarika kuvurwa niba uburwayi bwabo bwateye imbere, niba bagize ingaruka zitemewe, cyangwa niba babonye uburyo bwo kuvura butandukanye bubakorera neza. Abandi bashobora guhagarika kuvurwa kugira ngo barebe uko ibimenyetso byabo byahindutse uko imyaka igenda.

Mbere yo guhagarika imiti, ganira n'umuganga wawe. Ashobora kugufasha gusobanukirwa icyo witegura igihe imiti igenda ikama kandi ashobora gutanga izindi miti niba bikwiye.

Nshobora gukora imyitozo nyuma yo guterwa inshinge za Rimabotulinumtoxinb?

Abaganga benshi basaba kwirinda imyitozo ikomeye mu masaha make ya mbere nyuma yo guterwa inshinge za rimabotulinumtoxinb. Iyi ngamba ifasha kumenya neza ko umuti uguma mu misitsi wagenewe aho kugera mu turere twegereye.

Ibikorwa byoroheje nk'ukugenda mubisanzwe biragenda neza nyuma yo guterwa urushinge. Muri rusange ushobora gusubira mu myitozo yawe isanzwe umunsi ukurikira guterwa inshinge, nubwo ugomba kumva umubiri wawe kandi ukirinda ibikorwa bitera ububabare ahaterwa inshinge.

Niba uri guterwa inshinge za cervical dystonia, witondere cyane imyitozo ikubiyemo ijosi n'imitsi y'urutugu kugeza umenye uko umuti ukugiraho ingaruka. Umuganga wawe ashobora gutanga ubujyanama bwihariye bushingiye ku misitsi yavuwe n'uko ubuzima bwawe bumeze.