Icyo Tetrabenazine ari cyo: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Tetrabenazine ni umuti wandikirwa na muganga ufasha kugenzura imyitwarire idashimishije, y'umurengera mu bantu bafite indwara zimwe na zimwe zo mu bwonko. Ukora ugabanya umubare wa dopamine, imisemburo yo mu bwonko igira uruhare mu myitwarire, mu duce twihariye tw'ubwonko bwawe.

Niba wowe cyangwa umuntu witaho yarandikiwe uyu muti, ushobora kuba ufite ibibazo byerekeye uko ukora n'icyo wakwitega. Iyi ngamba izakuyobora mu byose ukeneye kumenya kuri tetrabenazine mu magambo asobanutse kandi yoroshye.

Tetrabenazine ni iki?

Tetrabenazine ni umuti wo mu cyiciro cy'imiti yitwa vesicular monoamine transporter 2 (VMAT2) inhibitors. Tekereza nk'umuti ufasha "gutuza" ibimenyetso by'imyitwarire y'umurengera mu bwonko bwawe.

Uyu muti watejwe imbere by'umwihariko kugira ngo uvure indwara z'imyitwarire aho abantu bahura n'imyitwarire idashakashakwa batabasha kugenzura. Ifatwa nk'umuti wihariye usaba gukurikiranwa neza n'abaganga bazi indwara zo mu bwonko.

Bitandukanye n'imiti imwe ikora mu mubiri wawe wose, tetrabenazine igamije inzira zihariye cyane mu bwonko bwawe bigenzura imyitwarire. Ubu buryo bwibanze bufasha kugabanya imyitwarire idashakashakwa mugihe bigabanya ingaruka ku zindi sisitemu z'umubiri.

Tetrabenazine ikoreshwa mu iki?

Tetrabenazine ikoreshwa cyane cyane mu kuvura chorea ijyanye n'indwara ya Huntington. Chorea yerekeza ku myitwarire idashakashakwa, yo guhinda umushyitsi ishobora kugira ingaruka ku maboko yawe, amaguru, mu maso, n'ibindi bice by'umubiri wawe.

Indwara ya Huntington ni indwara ya genetike igenda igira ingaruka ku myitwarire, gutekereza, n'amarangamutima. Imyitwarire ya chorea irashobora guhangayikisha kandi ikabangamira imirimo ya buri munsi nko kurya, kugenda, cyangwa kuvuga neza.

Muganga wawe ashobora kandi gutekereza tetrabenazine kubindi bibazo byimyitwarire, nubwo ibi byaba ari icyo bita "gukoresha hanze y'icyo yagenewe". Izi ndwara zirashobora kuba zirimo:

• Dyskinesia ya tardive (imyitwarire idashakashaka iterwa n'imiti imwe ya psychiatrie)
• Tics muri syndrome ya Tourette itarasubizwa n'izindi mvura
• Ubwoko bundi bwa chorea butajyanye n'indwara ya Huntington
• Ibyiciro bimwe bya dystonia (imitsi yikurura itera imyanya idasanzwe)

Imiterere ya buri muntu irihariye, kandi muganga wawe azasuzuma neza niba tetrabenazine ikwiriye indwara yawe n'ibimenyetso byawe.

Tetrabenazine ikora ite?

Tetrabenazine ikora ibuza ububiko no kurekura dopamine mu bice by'ubwonko bigenzura imyitwarire. Ifatwa nk'umuti ukomeye cyane usaba guhindura urugero buhoro buhoro.

Kugirango usobanukirwe uko ikora, tekereza dopamine nk'intumwa itwara ibimenyetso by'imyitwarire mu bwonko bwawe. Mu ndwara nka Huntington, ibi bimenyetso birarenga, bigatuma habaho imyitwarire idashakashaka.

Umuti mu by'ukuri "ugabanya ijwi" kuri ibi bimenyetso bya dopamine birenga. Abikora abuza dopamine kubikwa neza no kurekurwa ku mpera z'imitsi, ibi bifasha kugabanya ibimenyetso by'imyitwarire y'ikirenga.

Ingaruka za tetrabenazine ziragaruka, bivuze ko nuhagarika gufata umuti, urwego rwawe rwa dopamine ruzagenda rusubira uko rwari rumeze mbere. Ibi bitandukanye n'indi miti imwe itera impinduka zihoraho.

Nkwiriye gufata tetrabenazine nte?

Fata tetrabenazine nk'uko muganga wawe abitegeka, akenshi hamwe n'ibiryo kugirango bifashe kugabanya isesemi. Uyu muti uza mu buryo bw'ibinini kandi ugomba kumirwa wose hamwe n'amazi.

Muganga wawe azagutangiza ku rugero ruto kandi arushaho kuruzamura mu byumweru byinshi. Ubu buryo buhoro bufasha umubiri wawe kumenyera umuti kandi bugabanya ibyago by'ingaruka.

Ibi nibyo ukwiriye kumenya kubyerekeye gufata tetrabenazine neza:

• Fata umuti ku masaha amwe buri munsi kugira ngo urugero rwawo mu mubiri wawe rugume ruhagaze
• Ntugasye, ntukore cyangwa ucagagure ibinini
• Fata hamwe n'ibiryo cyangwa amata kugira ngo ugabanye uburibwe bwo mu gifu
• Niba uwufata inshuro nyinshi ku munsi, shyira intera ingana hagati y'imiti
• Ntuhagarike kuwufata ako kanya utabanje kuvugana na muganga wawe

Muganga wawe azakugenzura neza, cyane cyane mu mezi make ya mbere yo kuvurwa. Ashobora guhindura urugero rwawo bitewe n'uburyo umuti ukora neza n'ingaruka zose ubona.

Nzamara Igihe Kingana Nde Ndafatwa Tetrabenazine?

Igihe cyo kuvurwa na tetrabenazine giterwa n'uburwayi bwawe bwihariye n'uburyo wemera umuti. Ku ndwara ya Huntington, kuvurwa mubisanzwe ni igihe kirekire kuko ni uburwayi bukomeza.

Muganga wawe azajya asuzuma buri gihe niba umuti ugufasha kandi niba inyungu zigikomeza kurusha ingaruka zose. Abantu bamwe bashobora gukenera kuwufata imyaka myinshi, mu gihe abandi bashobora kuwukoresha mu gihe gito.

Umwanzuro wo gukomeza cyangwa guhagarika kuvurwa ugomba gufatwa buri gihe hamwe n'umuganga wawe. Bazatekereza ibintu nk'uburyo umuti ufasha ibimenyetso byawe, ingaruka zose ubona, n'impinduka mu miterere yawe yose.

Niba ukeneye guhagarika gufata tetrabenazine, muganga wawe mubisanzwe azagabanya urugero rwawo buhoro buhoro aho kuwuhagarika ako kanya. Ibi bifasha kwirinda ingaruka zishobora guterwa no kuwukuraho cyangwa guhagarika ibimenyetso ako kanya.

Ni Iyihe Ngaruka Ziterwa na Tetrabenazine?

Kimwe n'imiti yose, tetrabenazine irashobora gutera ingaruka, nubwo atari buri wese uzibona. Ingaruka zisanzwe ni zoroshye cyangwa ziciriritse kandi akenshi zikora neza uko umubiri wawe wimenyereza umuti.

Kumenya ibyo witegura bishobora kugufasha kumva witeguye kandi ukamenya igihe cyo kuvugana n'umuganga wawe. Reka turebe ubwoko butandukanye bw'ingaruka zishobora kukubaho.

Ingaruka zisanzwe

Izi ngaruka zibaho ku bantu benshi bafata tetrabenazine kandi akenshi zirashobora gucungwa:

• Gusinzira cyane cyangwa kunanirwa (kumva unaniwe cyane kurusha uko bisanzwe)
• Kugira agahinda gakabije cyangwa guhinduka kw'amarangamutima
• Kutagira umutuzo cyangwa guhangayika
• Kugorwa no gusinzira (kubura ibitotsi)
• Kuruka cyangwa kuribwa mu nda
• Kuribwa umutwe, cyane cyane iyo uhagurutse
• Kugorwa no kwibuka

Inyinshi muri izi ngaruka zigaragara cyane iyo utangiye gufata umuti cyangwa iyo urugero rwawo ruzamutse. Akenshi zigenda zigabanuka uko umubiri wawe umenyera uwo muti.

Ingaruka zikomeye

Nubwo bitabaho kenshi, hariho ingaruka zimwe na zimwe zisaba ubufasha bwihutirwa bw'abaganga. Vugana n'umuganga wawe ako kanya niba ubonye:

• Agahinda gakabije cyangwa gutekereza kwiyahura
• Kugorwa no kumira cyangwa guhumeka
• Urubavu rwinshi ruri kumwe no gukakara kw'imitsi
• Umutima utera nabi cyangwa kuribwa mu gituza
• Kutagira umutuzo cyane cyangwa guhagarara umutima
• Kudashobora kugenzura imitsi yo mu maso cyangwa mu mubiri

Izi ngaruka zikomeye ntizibaho kenshi, ariko ni ngombwa kuzimenya kandi ugashaka ubufasha bw'abaganga ako kanya niba zibayeho.

Ingaruka zitabaho kenshi

Abantu bamwe bashobora guhura n'ingaruka zitabaho kenshi ariko zigomba kwitabwaho:

• Neuroleptic malignant syndrome (uburwayi butabaho kenshi ariko bukomeye burangwa n'umuriro mwinshi, gukakara kw'imitsi, no kuyoba)
• QT interval yongerewe (ihinduka ry'umuvuduko w'umutima rigaragara kuri EKG)
• Igabanuka rikomeye ry'umuvuduko w'amaraso
• Parkinsonism (gutungana, gukakara, no kugenda gahoro)
• Akathisia (kutagira umutuzo cyane no gukenera guhora wimuka)

Muganga wawe azakugenzura kuri izi ngaruka zidakunze ariko zikomeye, cyane cyane mu ntangiriro zo kuvurwa.

Ninde Utagomba Gufata Tetrabenazine?

Tetrabenazine ntibereye buri wese, kandi ibintu bimwe na bimwe cyangwa ibihe bituma bidatekanye gukoresha. Muganga wawe azasuzuma neza amateka yawe y'ubuvuzi mbere yo kwandika uyu muti.

Ntabwo ugomba gufata tetrabenazine niba ufite agahinda gakabije cyangwa ufite ibitekerezo byo kwiyahura. Uyu muti ushobora gukomeza agahinda, bityo ni ngombwa gukemura ibibazo byose byo mu mutwe mbere yo gutangira kuvurwa.

Izindi mpamvu zikomeye zirimo:

• Agahinda katavuwe cyangwa katavuwe neza
• Ibitekerezo byo kwiyahura bikomeye cyangwa igerageza ryo kwiyahura rya vuba
• Gufata ibiyobyabwenge bya monoamine oxidase inhibitors (MAOIs) cyangwa waba warabifashe mu minsi 14 ishize
• Ibibazo bikomeye by'umwijima
• Allergie izwi kuri tetrabenazine cyangwa ibiyigize

Ibihe bimwe na bimwe bisaba kwitonda cyane no kugenzurwa neza niba ufata tetrabenazine:

• Amateka y'agahinda gakabije cyangwa izindi ngorane zo mu mutwe
• Ibibazo by'umutima cyangwa imirimo y'umutima idahwitse
• Indwara y'umwijima
• Ibibazo by'impyiko
• Indwara ya Parkinson
• Kugorana kumeza

Buri gihe bwire muganga wawe ibyerekeye ibibazo byawe byose by'ubuvuzi, harimo amateka y'ibibazo byo mu mutwe, niyo bisa nkaho bitajyanye n'indwara yawe yo kugenda.

Amazina ya Tetrabenazine

Tetrabenazine iboneka munsi y'izina rya Xenazine muri Leta Zunze Ubumwe z'Amerika. Iyi niyo fomu isanzwe yandikwa y'uyu muti.

Hariho kandi umuti mushya, ujyanye witwa deutetrabenazine, ugurishwa munsi y'izina rya Austedo. Iyi ni verisiyo yahinduwe ya tetrabenazine ishobora kugira ibyiza bijyanye n'uburyo bwo gutanga imiti n'ingaruka zayo.

Muganga wawe azagena uburyo bwiza bw'umuti bukwiye kubera uko ubuzima bwawe bumeze. Imiti yombi ikora kimwe, ariko hariho itandukaniro mu buryo ugomba kuyifata n'ingaruka zayo.

Jya ukoresha neza ubwoko bw'umuti n'uburyo muganga wawe yaguteye, kuko guhindura hagati y'ubwoko butandukanye bikwiye gukorwa gusa hakurikijwe ubujyanama bw'abaganga.

Uburyo bwo gusimbuza Tetrabenazine

Niba tetrabenazine itagukwiriye cyangwa idakora neza, muganga wawe ashobora gutekereza ku zindi nzira zo kuvura. Guhitamo izindi nzira biterwa n'uburwayi bwawe n'ibimenyetso byawe.

Kubera indwara ya Huntington, uburyo bwo gusimbuza bushobora kuba:

• Deutetrabenazine (Austedo) - umuti mushya, usa nawo
• Imiti ivura indwara zo mu mutwe nka haloperidol cyangwa olanzapine
• Benzodiazepines yo kugabanya impungenge n'ibimenyetso bimwe byo kwimuka
• Imiti ivura ibibazo byo gufatwa nka valproic acid

Kubera izindi ndwara zo kwimuka, muganga wawe ashobora gutekereza:

• Inshinge za Botulinum toxin kubera ibibazo by'imitsi byo mu gace kamwe
• Gushyira ibikoresho mu bwonko kubera ibibazo bimwe
• Izindi miti ifunga dopamine
• Kuvurwa mu buryo bw'umubiri no kuvurwa mu kazi

Uburyo bwiza bwo kuvura akenshi bukubiyemo guhuza imiti n'ubundi buryo bwo kuvura nko kuvurwa mu buryo bw'umubiri, kuvura ijwi, cyangwa inama kugira ngo hakemurwe ibibazo bitandukanye byo kwimuka.

Ese Tetrabenazine iruta Deutetrabenazine?

Tetrabenazine na deutetrabenazine ni imiti ikora neza mu kuvura indwara zo kwimuka, ariko ifite itandukaniro rikomeye rishobora gutuma imwe ikwira kurusha iyindi.

Deutetrabenazine (Austedo) ni umuti mushya watejwe imbere kugira ngo utunganye tetrabenazine. Inyungu zikomeye za deutetrabenazine zirimo:

• Gukoresha imiti gake (akenshi kabiri ku munsi aho kuba gatatu ku munsi)
• Uburyo imiti ikora mu mubiri wawe bwizewe kurushaho
• Bishobora kugabanya ingaruka ziterwa n'imiti
• Guhura guke n'ibintu bimwe na bimwe bya genetike bigira uruhare mu mikorere y'imiti

Ariko, tetrabenazine imaze igihe kinini ikoreshwa kandi ifite ubushakashatsi bwinshi bumaze gukorwa kuri yo. Abantu bamwe bashobora kwitwara neza ku muti umwe kurusha undi, kandi ibiciro nabyo bishobora kugira uruhare mu gufata icyemezo.

Muganga wawe azatekereza ku bintu nk'ibimenyetso byawe byihariye, indi miti ufata, gahunda yawe ya buri munsi, n'ubwishingizi bwawe mu gufata icyemezo cy'umuti ukugukwiriye. Nta muti n'umwe ushobora kuvugwa ko ari "mwiza" kurusha undi - guhitamo biterwa n'imimerere yawe bwite.

Ibikunze Kubazwa Kuri Tetrabenazine

Ese Tetrabenazine irakwiriye ku bantu barwaye indwara z'umutima?

Tetrabenazine bisaba ko ubitekerezaho neza niba ufite ibibazo by'umutima. Uyu muti ushobora kugira ingaruka ku mutima wawe, by'umwihariko ikintu cyitwa QT interval kuri EKG.

Mbere yo gutangira gufata tetrabenazine, muganga wawe ashobora gutegeka ko ukorerwa EKG kugirango arebe uko umutima wawe ukora. Niba ufite indwara zimwe na zimwe z'umutima cyangwa ufata imiti igira ingaruka ku mutima, ushobora gukenera gukurikiranwa kenshi cyangwa uburyo bwo kuvura butandukanye.

Abantu barwaye indwara z'umutima rimwe na rimwe bashobora gufata tetrabenazine mu buryo bwizewe, ariko bisaba ubufatanye bukomeye hagati ya muganga w'imitsi yawe n'umuganga w'umutima kugirango barebe ko umutima wawe ukomeza kuba muzima mugihe uvurwa.

Nigute nzakora niba mfata tetrabenazine nyinshi ku buryo butunguranye?

Niba ufata tetrabenazine nyinshi kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe imiti ihumanya ako kanya, kabone niyo wumva umeze neza. Kwifata imiti myinshi bishobora gutera ingaruka zikomeye zitagaragara ako kanya.

Ibimenyetso byo gufata tetrabenazine nyinshi bishobora kuba harimo gusinzira cyane, urujijo, kugorana guhumeka, umubiri uguma gukomera cyane, cyangwa kutagira ubwenge. Niba ubonye kimwe muri ibi bimenyetso, genda kwa muganga ako kanya.

Kugirango wirinde gufata imiti irenze urugero ku buryo butunguranye, bika imiti yawe mu gikoresho cyayo cy'umwimerere, shyiraho ibyibutsa igihe cyo kuyifata, kandi ntuzigere wongera doze niba wibagiwe imwe. Tekereza gukoresha umuteguro w'imiti niba ufata imiti myinshi.

Nkwiriye gukora iki niba nibagiwe doze ya Tetrabenazine?

Niba wibagiwe doze ya tetrabenazine, yifate ako kanya wibukirije, keretse igihe cyo gufata doze yawe ikurikira kigeze. Muricyo gihe, reka doze wibagiwe hanyuma ufate doze yawe ikurikira ku gihe gisanzwe.

Ntuzigere ufata doze ebyiri icyarimwe kugirango usimbure doze wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti. Niba ukunda kwibagirwa doze, ganira na muganga wawe kubijyanye n'uburyo bwo kugufasha kwibuka, nko gushyiraho alarme kuri terefone cyangwa gukoresha porogaramu yibutsa imiti.

Niba wibagirwa doze buri gihe, ibimenyetso byawe bishobora kwiyongera, bityo ni ngombwa gushaka gahunda ikugirira akamaro. Abantu bamwe basanga bifasha gufata imiti yabo icyarimwe n'ibindi bikorwa bya buri munsi, nk'amafunguro.

Nshobora kureka gufata Tetrabenazine ryari?

Umwanzuro wo kureka gufata tetrabenazine ugomba gufatwa buri gihe hamwe na muganga wawe. Ntuzahagarike kuyifata ku buryo butunguranye wenyine, kuko ibi bishobora gutuma ibimenyetso byawe bisubira vuba cyangwa bikaba bibi by'agateganyo.

Muganga wawe ashobora kugusaba guhagarika cyangwa kugabanya tetrabenazine niba ingaruka ziterwa n'imiti ziba zikabije, niba uburwayi bwawe buhinduka, cyangwa niba izindi nshuti ziba zikwiriye kuruta izindi kubera uko wifashe.

Igihe kigeze cyo guhagarika, muganga wawe azagabanya doze yawe buhoro buhoro mu byumweru byinshi. Ibi bifasha kugabanya ingaruka zishobora guterwa no guhagarika imiti kandi bituma umubiri wawe wimenyereza buhoro gukora utafite imiti.

Nshobora kunywa inzoga niba mfata Tetrabenazine?

Ni byiza kwirinda inzoga igihe urimo gufata tetrabenazine, kuko byombi bishobora gutera ibitotsi no kugira ingaruka ku mikoranire yawe. Kubihuriza hamwe bishobora kongera izi ngaruka kandi bikagutera kumva uruhutse cyane kuruta uko byari bisanzwe.

Inzoga kandi ishobora gukomeza umubabaro, icyo kikaba ari ikibazo gihangayikishije kuri tetrabenazine. Niba uhisemo kunywa rimwe na rimwe, ganira na muganga wawe ku kintu gishobora kuba cyiza kuri wowe, kandi ntunywe na rimwe niba wumva urwaye cyangwa ufite impinduka z'amarangamutima.

Witondere uko inzoga ikugiraho ingaruka igihe ufata uyu muti, kuko ushobora gusanga wumva cyane ingaruka zayo kuruta mbere yo gutangira kuvurwa.