Acromegaly

Zviratidzo zve acromegaly zvinosanganisira chiso nemahwoko makuru. Kushanduka pachiso kunogona kuita kuti mapfupa emuromo nemuromo wepasi abude, uye mhino nemiromo ikure.

Acromegaly chirwere chemahomoni chinoitika kana gland yako yepituitary ichigadzira homoni yekukura yakawanda panguva yehudiki.

Kana uine homoni yekukura yakawanda, mapfupa ako anowedzera kukura. Muhudiki, izvi zvinoita kuti ukure, uye zvinonzi gigantism. Asi pakuva mukuru, kuchinja pakukura hakumboiti. Pane kudaro, kuwedzera kukura kwepfupa kunoganhurirwa kumafupa emuwoko, tsoka nechiso, uye kunonzi acromegaly.

Nekuti acromegaly haina kujairika uye kuchinja kwemuviri kunoitika zvishoma nezvishoma kwemakore mazhinji, dambudziko rinotora nguva yakareba kuti rizivikanwe. Kana risina kurapwa, mahomoni ekukura akawanda anogona kukanganisa zvimwe zvikamu zvemuviri, pamwe chete nemafupa ako. Izvi zvinogona kukonzera matambudziko ehutano akakomba — dzimwe nguva kunyangwe anotyisa —. Asi kurapwa kunogona kuderedza njodzi yako yematambudziko uye kuvandudza zviratidzo zvako zvakanyanya, kusanganisira kukura kwezvikamu zvako.

Chiratidzo chinowanzoitika che acromegaly ndekukuwedzera kwemaoko nemaoko. Semuenzaniso, unogona kuona kuti haukwanisi kupfeka zvinorema zvaimbokuenderera, uye kuti saizi yeshoko rako yakawedzera zvishoma nezvishoma. Acromegaly inogona zvakare kukonzera shanduko dzakawanda muchimiro chechiso chako, sekunge jaw yakabuda uye bhonzo rechipfuva, mhino yakakura, miromo yakakura, uye nzvimbo yakakura pakati pezino rako. Nekuti acromegaly inowanzoenderera mberi zvishoma nezvishoma, zviratidzo zvepakutanga zvingasave pachena kwemakore. Dzimwe nguva, vanhu vanoona shanduko dzemuviri chete nekutarisa mifananidzo yekare neitsva. Zvese zvakatarwa, zviratidzo zvezviratidzo zve acromegaly zvinosiyana kubva kune mumwe munhu kuenda kune mumwe, uye zvinogona kusanganisira chero chezvinotevera: Maoko nemaoko makuru. Zvimiro zvechiso zvakakura, kusanganisira mapfupa echiso, miromo, mhino nemutauro. ganda rakaoma, rakanyorova, rakaonda. Kuwedzera kwekuwedzera kwemuviri uye kunhuhwirira kwemuviri. Zviduku zviduku zve ganda (zviratidzo zve ganda). Kushaya simba uye kupera simba kwemhasuru kana tsandanyama. Kurwadziwa uye kushomeka kwekufamba kwezvibatanidzwa. Inzwi rakadzika, rakaoma nekuda kwekuwedzera kwezwi rekutaura uye sinuses. Kuchema kwakasimba nekuda kwekukanganisa kwekumusoro kwekufema. Matambudziko ekutarisa. Kurwadziwa kwemusoro, izvo zvinogona kunge zviripo kana zvakakomba. Kusagadzikana kwekumwedzi muvakadzi. Kushaya simba pabonde muvarume. Kurasikirwa kufarira pabonde. Kana uine zviratidzo zvinosanganisirwa ne acromegaly, taura nachiremba wako kuti uite bvunzo. Acromegaly inowanzoitika zvishoma nezvishoma. Kunyange nhengo dzemhuri yako dzingasaziva shanduko dzemuviri dzinoitika nechirwere ichi pakutanga. Asi kuongororwa pakutanga kwakakosha kuitira kuti ugone kutanga kuwana kurapwa kwakakodzera. Acromegaly inogona kukonzera matambudziko akakomba ehutano kana isina kurapwa.

Kana uine zviratidzo nezvikonzero zvine chekuita neacromegaly, taura nachiremba wako kuti aongorore. Acromegaly kazhinji inoonekwa zvishoma nezvishoma. Kunyange hama dzako dzinogona kusaziva kuchinja kwemuviri kunoitwa nechirwere ichi pakutanga. Asi kuongororwa pakutanga kwakakosha kuitira kuti ugone kutanga kuwana kurapwa kwakakodzera. Acromegaly inogona kukonzera matambudziko emutano akaoma kana isina kurapwa.

Acromegaly inoitika kana gland ye pituitary ichigadzira homoni yekukura (GH) yakawanda kwazvo kwenguva yakareba. Gland ye pituitary igland duku iri pasi pehuropi hwako, kumashure kwechidzitiro chemhino yako. Inogadzira GH nemamwe mahomoni akawanda. GH ine basa rinokosha mukugadzirisa kukura kwako kwemuviri. Kana gland ye pituitary ikasunungura GH muropa rako, inokurudzira chiropa chako kugadzira homoni inonzi insulin-like growth factor-1 (IGF-1) — dzimwe nguva inonziwo insulin-like growth factor-I, kana IGF-I. IGF-1 ndiro rinoita kuti mapfupa ako nematishu ako akure. GH yakawanda inotungamira kuIGF-1 yakawanda, izvo zvinogona kukonzera zviratidzo zve acromegaly, zviratidzo nematambudziko. Muvakuru, ganda ndiro rinonyanya kukonzera kugadzirwa kweGH yakawanda: Matumbu ePituitary. Zviitiko zvizhinji zve acromegaly zvinokonzerwa ne ganda risina kenza (benign) (adenoma) ye gland ye pituitary. Ganda rinogadzira huwandu hwakawanda hwehormone yekukura, zvichikonzera zviratidzo zvizhinji nezviratidzo zve acromegaly. Zvimwe zvezviratidzo zve acromegaly, senge kurwadziwa kwemusoro uye kuona kwakashata, zvinokonzerwa neganda richimanikidza matishu ehuropi ari pedyo. Matumbu asingawanikwi muPituitary. Muvanhu vashoma vane acromegaly, matumbu mune dzimwe nzvimbo dzemuviri, senge mapapu kana pancreas, anokonzera chirwere ichi. Dzimwe nguva, matumbu aya anoburitsa GH. Muzvimwe zviitiko, matumbu anogadzira homoni inonzi growth hormone-releasing hormone (GH-RH), iyo inoratidza gland ye pituitary kuti iite GH yakawanda.

Vanhu vane chirwere chinonheredzwa chisingawanzoitika chinonzi multiple endocrine neoplasia, rudzi 1 (MEN 1), vane mukana mukuru wekurwara acromegaly. MuMEN 1, mazamu e endocrine — kazhinji mazamu e parathyroid, pancreas ne pituitary gland — anokura zvimba uye anoburitsa mahomoni akawanda. Aya mahomoni anogona kutungamirira ku acromegaly.

Kana isingarapwa, acromegaly inogona kukonzera matambudziko makuru ehutano. Matambudziko anogona kusanganisira:

• Cholesterol yakakwira.
• Matambudziko emwoyo, kunyanya kukura kwemwoyo (cardiomyopathy).
• Osteoarthritis.
• Type 2 diabetes.
• Kukura kwegiramu ye thyroid (goiter).
• Kukura kwekenza (polyps) pamusoro pekoloni rako.
• Sleep apnea, mamiriro ayo kufema kusingamire uye kunotanga panguva yekurara.
• Carpal tunnel syndrome.
• Kuwedzera njodzi yekenza.
• Kushanduka kwekuona kana kurasikirwa nekuona.

Kurapwa kwakakurumidza kwe acromegaly kunogona kudzivirira aya matambudziko kuti arege kuitika kana kuipa. Isingarapwi, acromegaly neematambudziko ayo anogona kukonzera rufu usati wasvika nguva.

Chiremba wenyu achakubvunza nezve nhoroondo yenyu yezvokurapa uye kuita bvunzo yemuviri. Ipapo anogona kukurudzira matanho anotevera: Kuyerwa kweIGF-1. Mushure mekutsanya usiku hwese, chiremba wenyu acatora sampuli yeropa kuti ayerere nhanho yeIGF-1 mumuviri wako. Nhanho yakakwira yeIGF-1 inoratidza acromegaly. bvunzo yekudzikisira kukura kwehomoni. Iyi ndiyo nzira yakanakisa yekusimbisa chirwere cheacromegaly. Panguva yebvunzo iyi, nhanho yeropa reGH yako inoyerwa usati wanwa uye mushure mekunge wanwa mushonga weshuga (glucose). Kune vanhu vasina acromegaly, kunwa glucose kazhinji kunokonzera kuti nhanho yeGH idzike. Asi kana uine acromegaly, nhanho yako yeGH icharamba yakakwira. Mifananidzo. Chiremba wenyu anogona kukurudzira bvunzo yemifananidzo, senge magnetic resonance imaging (MRI), kuti akubatsire kuona nzvimbo nehukuru hwetumor pamusoro pegland yako yepituitary. Kana pasina mapituitary tumors akaonekwa, chiremba wenyu anogona kuraira mamwe bvunzo emifananidzo kuti atsvake mapituitary tumors asina pituitary. Rumwe Ruzivo CT scan MRI

Kurapa acromegaly kunoenderana nemunhu. Chirongwa chekurapa chako zvichida chichaenderana nekwakagara uye saizi yetumor yako, kuomarara kwezviratidzo zvako, uye makore ako nehutano hwese. Kuti kubatsira kuderedza mazinga ako eGH neIGF-1, sarudzo dzekurapa kazhinji dzinosanganisira kuvhiya kana kurapa kubvisa kana kuderedza saizi yetumor inokonzera zviratidzo zvako, uye mushonga kubatsira kugadzirisa mazinga ehormone ako. Kana uri kunetseka nezvematambudziko ehutano semugumisiro we acromegaly, chiremba wako anogona kukurudzira kurapwa kuwedzerwa kubatsira kudzora matambudziko ako. Kuvhiya Kuvhiya kweEndoscopic transnasal transsphenoidal Wedzera mufananidzo Vhara Kuvhiya kweEndoscopic transnasal transsphenoidal Kuvhiya kweEndoscopic transnasal transsphenoidal Mukuvhiya kweEndoscopic transnasal transsphenoidal, chishandiso chekuvhiya chinowanikwa kuburikidza nehuro uye pamwe chete ne nasal septum kuwana tumor ye pituitary. Vanachiremba vanogona kubvisa zvimwe zvitumor zvepituitary vachishandisa nzira inonzi transsphenoidal surgery. Panguva ino, chiremba wako anoshanda kuburikidza nemuromo wako kubvisa tumor kubva kuganda rako repituitary. Kana tumor inokonzera zviratidzo zvako isina kuwanikwa paganda rako repituitary, chiremba wako achakurudzira imwe mhando yekuvhiya kubvisa tumor. Muzviitiko zvakawanda - kunyanya kana tumor yako iri diki - kubviswa kwetumor kunodzorera mazinga ako eGH kune akajairika. Kana tumor yakanga ichimanikidza matishu ari kumativi eganda rako repituitary, kubvisa tumor kunobatsirawo kuderedza kurwadziwa kwemusoro uye kuchinja kwekuona. Muzvimwe zviitiko, chiremba wako angakwanise kubvisa tumor yese. Kana zvakadaro, unogona kunge uchiri nema GH mazinga akakwirira mushure mekuvhiya. Chiremba wako anogona kukurudzira imwe kuvhiya, mishonga kana kurapwa kwemwaranzi. Mishonga Chiremba wako anogona kukurudzira imwe yemishonga inotevera - kana musanganiswa wemishonga - kubatsira mazinga ako ehormone kudzoka kune akajairika: Mishonga inoderedza kugadzirwa kwehomoni yekukura (somatostatin analogues). Mumuviri, homoni yehuropi inonzi somatostatin inoshanda kurwisa (inodzivisa) kugadzirwa kweGH. Mishonga yeoctreotide (Sandostatin) ne lanreotide (Somatuline Depot) ndizvo zvinhu zvakagadzirwa (synthetic) zve somatostatin. Kutora imwe yemishonga iyi kunoratidza ganda repituitary kuti rigadzire GH shoma, uye kunogona kuderedza saizi yetumor ye pituitary. Kazhinji, mishonga iyi inopfurwa mumasumbu emuviri wako (gluteal muscles) kamwe chete pamwedzi nemunhu ane hutano. Mishonga yekuderedza mazinga ehormone (dopamine agonists). Mishonga yemukanwa ye cabergoline ne bromocriptine (Parlodel) inogona kubatsira kuderedza mazinga eGH neIGF-1 kune vamwe vanhu. Mishonga iyi inogona kubatsira kuderedza saizi yetumor. Kurapa acromegaly, mishonga iyi inofanirwa kutora pane yakakwirira, izvo zvinogona kuwedzera njodzi yemhedzisiro. Mhedzisiro yakajairika yemishonga iyi inosanganisira kurutsa, kurutsa, mhino yakazvimba, kuneta, kuzvidza, matambudziko ekurara uye kuchinja kwemanzwiro. Mushonga wekudzivirira basa reGH (growth hormone antagonist). Mushonga we pegvisomant (Somavert) unodzivirira mhedzisiro yeGH pamatishu emuviri. Pegvisomant inogona kubatsira zvikuru kune vanhu vasina kubudirira nemamwe kurapwa. Inopiwa sejekiseni yezuva nezuva, mushonga uyu unogona kubatsira kuderedza mazinga eIGF-1 uye kuderedza zviratidzo, asi haideredzi mazinga eGH kana kuderedza saizi yetumor. Mwaranzi Kana chiremba wako asina kukwanisa kubvisa tumor yese panguva yekuvhiya, chiremba wako anogona kukurudzira kurapwa kwemwaranzi. Kurapa kwemwaranzi kunoparadza chero masero etumor anenge asara uye zvishoma nezvishoma kunoderedza mazinga eGH. Zvinogona kutora makore kuti kurapwa uku kuvandudze zviratidzo zve acromegaly. Kurapa kwemwaranzi kazhinji kunoderedza mazinga emamwe mahomoni epituitary, zvakare - kwete GH chete. Kana iwe uchigamuchira kurapwa kwemwaranzi, iwe uchazoda kushanya kazhinji kune chiremba wako kuve nechokwadi chekuti ganda rako repituitary riri kushanda zvakanaka, uye kuongorora mazinga ako ehormone. Kuraira uku kunogona kureba kwoupenyu hwako hwese. Mhando dzekurapa kwemwaranzi dzinosanganisira: Kurapa kwemwaranzi kwakajairika. Mhando iyi yekurapa kwemwaranzi kazhinji inopiwa zuva rega rega kwemavhiki mana kusvika matanhatu. Unogona kusawona mhedzisiro yakazara yekurapa kwemwaranzi kwakajairika kwemakore gumi kana kupfuura mushure mekurapwa. Stereotactic radiosurgery. Stereotactic radiosurgery inoshandisa mifananidzo ye3D kupa chiyero chakakwirira chemwaranzi kumasero etumor, nepo ichideredza huwandu hwemwaranzi kumatishu akapoteredza akajairika. Kazhinji inogona kupihwa mune imwe dose. Mhando iyi yemwaranzi inogona kudzorera mazinga eGH kune akajairika mukati memakore mashanu kusvika gumi. Rumwe Ruzivo Kurapa kwemwaranzi Stereotactic radiosurgery Kumbira musangano