Pancreatitis Ye Autoimmune

Autoimmune pancreatitis chirwere chinopisa chiropa. Inogona kukonzerwa nehurongwa hwekudzivirira muviri huchikuvadza chiropa. Autoimmune pancreatitis inonziwo AIP. Marudzi maviri eAIP ari kuzivikanwa iye zvino, rudzi 1 nerudzi 2.

Rudzi 1 AIP inonzi chirwere chine chekuita ne-IgG4 (IgG4-RD). Rudzi urwu runowanzokanganisa nhengo dzakawanda, kusanganisira chiropa, matura ebile ari muchiropa, mazamu anobudisa mate, itsvo nemahara.

Rudzi 2 AIP rinoita sekunge rinokanganisa chiropa chete, kunyange zvazvo anenge wechitatu vevanhu vane rudzi 2 AIP vane chirwere chekuzvimba chematumbo.

Rudzi 1 AIP inogona kunyengera ichionekwa sekenza yechiropa. Zvirwere zviviri izvi zvine zviratidzo zvakafanana, asi kurapwa kwakasiyana kwazvo, saka zvakakosha kwazvo kusiyanisa rimwe nerimwe.

Autoimmune pancreatitis, inonziwo AIP, inonetsa kuongororwa. Kazhinji, haikonzeri zviratidzo. Zviratidzo zverudzi rwekutanga AIP zvakafanana neaya epancreatic cancer. Zviratidzo zvepancreatic cancer zvinogona kusanganisira: Weti yakasviba. Matumbu akachenuruka kana matumbu anoyangarara muchimbuzi. Ganda nemaziso eyero, anonzi jaundice. Kurwadziwa mudumbu repamusoro kana pakati pemusana. Kusvotwa uye kurutsa. Kusimba kana kuneta zvakanyanya. Kurasikirwa nechido chekudya kana kunzwa kuguta. Kuderera kwehuremu pasina chikonzero chinozivikanwa. Chiratidzo chinonyanya kuoneka cherudzi rwekutanga AIP ndeye jaundice isingarwadzi. Vanenge 80% yevanhu vane rudzi rwekutanga AIP vane jaundice isingarwadzi. Izvi zvinokonzerwa nekuvharika kwemaburi ebile. Vanhu vane rudzi rwechipiri AIP vanogona kuve nezviitiko zvinodzokororwa zveacute pancreatitis. Kurwadziwa mudumbu repamusoro, chiratidzo chakajairika chepancreatic cancer, kazhinji hakuna muautoimmune pancreatitis. Misiyano pakati perudzi rwekutanga nechipiri AIP ndeyekuti: Murudzi rwekutanga AIP, chirwere chinogona kukanganisa mamwe matumbu pamwe nepancreas. Rudzi rwechipiri AIP runobata chete pancreas. Chirwere cherudzi rwechipiri chinobatanidzwawo nechimwe chirwere cheautoimmune chinonzi inflammatory bowel disease. Rudzi rwekutanga AIP runonyanya kubata varume vari mumakore ekutanga kusvika kumakumi manomwe ehupenyu. Rudzi rwechipiri AIP runobata varume nevakadzi zvakaenzana uye runotanga pazera diki kana zvichienzaniswa nerudzi rwekutanga AIP. Rudzi rwekutanga AIP runonyanya kudzoka mushure mekunge kurapwa kwamiswa. Autoimmune pancreatitis kazhinji haikonzeri chero zviratidzo. Ona nyanzvi yehutano, zvisinei, kana uine kuderera kwehuremu kusinganzwisisike, kurwadziwa mudumbu, jaundice kana zvimwe zviratidzo zvinokunetsa.

Kazhinji chirwere chepancreatic autoimmune hachibudisi zviratidzo. Zvisinei, ona chiremba kana iwe uine kurasikirwa kwekuoma kwakashaikwa tsananguro, kurwadziwa mudumbu, jaundice kana zvimwe zviratidzo zvinokunetsa.

Nyanzvi hadzina chokwadi chechinokonzera pancreatitis ye autoimmune, asi zvinofungidzirwa kuti zvinokonzerwa nehurongwa hwekudzivirira muviri uchirova tishu dzemuviri dzakagwinya. Izvi zvinozivikanwa sechiberekero che autoimmune.

Marudzi maviri eAIP anoitika nehuwandu hwakasiyana munzvimbo dzakasiyana dzepasi. MuUnited States, vanhu vanosvika 80% vane autoimmune pancreatitis, inonziwo AIP, vane rudzi rwe 1.

Vanhu vane rudzi rwe 1 AIP kazhinji:

• Vakuru vemakore 60.
• Varume.

Vanhu vane rudzi rwe 2 AIP:

• Kazhinji vane makore gumi kana makumi maviri pasi pevakuru ve rudzi rwe 1.
• Vakadzi nevarume vanenge vakafanana.
• Vane mukana mukuru wekuve ne inflammatory bowel disease, sekunge ulcerative colitis.

Kurwara kwe autoimmune pancreatitis kunogona kukonzera matambudziko akawanda.

• Kushaya simba kwe pancreatic exocrine. AIP inogona kukanganisa kugona kwe pancreas yako kugadzira ma enzymes akakwana. Zviratidzo zvinogona kusanganisira manyoka, kurasikirwa nehuremu, chirwere chemapfupa che metabolic, uye kushomeka kwemavhitamini kana mamineral.
• Chirwere cheshuga. Nekuti pancreas ndiyo nhengo inogadzira insulin, kukuvara kwacho kunogona kukonzera chirwere cheshuga. Ungada kurapwa nemishonga yemukanwa kana insulin.
• **Kuomarara kwe pancreatic ne bile duct, kunonzi stricture.
• Kuora kana matombo epancreatic.

Kurapwa kwe autoimmune pancreatitis, sekushandisa kwenguva refu kwe steroid, kunogona kukonzera matambudziko. Zvisinei, kunyangwe neaya matambudziko, vanhu vanorapwa ne autoimmune pancreatitis vane tarisiro yehupenyu yakajairika.

Hapana hukama hwakasimbiswa pakati peAIP nekenza yepancreatic.

Kurwara ye autoimmune pancreatitis kunyanya kuoma kuziva, nekuti zviratidzo zvayo zvakafanana nezvekenza yepancreas. Zvisinei, kuziva kwakanyatsojeka kwakakosha kwazvo. Kusaongororwa kwekenza kunogona kukonzera kuomerwa kana kusagamuchira kurapwa kunodiwa.

Vanhu vane AIP vanowanzova nekuwedzera kukuru kwe pancreas, asi vanogonawo kuva nehuwandu mu pancreas. Kuti uone chirwere chacho uye uone rudzi rwe AIP, bvunzo dzeropa nemafomu ekufananidzira zvinodikanwa.

Hapana bvunzo imwe chete kana chiratidzo chinoratidza autoimmune pancreatitis. Mirayiridzo inokurudzirwa yekuongorora inoshandisa musanganiswa wemafomu ekufananidzira, bvunzo dzeropa uye mhedzisiro yebiopsy.

Bvunzo dzakakosha dzinogona kusanganisira:

• Bvunzo dzemafomu ekufananidzira. Bvunzo dzepancreas yako nedzimwe nhengo dzinogona kusanganisira CT, MRI, endoscopic ultrasound (EUS) uye endoscopic retrograde cholangiopancreatography (ERCP).
• Bvunzo dzeropa. Ungave nebvunzo yekutarisa mazinga akakwira ei immunoglobulin inonzi IgG4. IgG4 inogadzirwa nehurongwa hwako hwekudzivirira. Vanhu vane rudzi 1 AIP vanowanzove nemazinga akakwira eIgG4 muropa ravo. Vanhu vane rudzi 2 AIP kazhinji havadi.

Zvisinei, bvunzo yakanaka hairevi kuti une chirwere ichi. Huwandu duku hwevanhu vasina autoimmune pancreatitis, kusanganisira vamwe vane kenza yepancreas, vanewo mazinga akakwira eIgG4 muropa ravo.

• Endoscopic core biopsy. Mubvunzo iyi, nyanzvi yekurapa inonzi pathologist inodzidza sampuli yetsinga yepancreas murabhoritari. AIP ine chitarisiko chakasiyana chinogona kuzivikanwa nyore nyore pasi pe microscope ne pathologist ane ruzivo. Chubhu duku inonzi endoscope inoiswa kuburikidza nemuromo kuenda mudumbu, ichitungamirwa ne ultrasound. Sampuli yetsinga inobva yabviswa kubva ku pancreas uchishandisa tsono chaiyo.

Dambudziko nderekuwana sampuli yetsinga yakakura zvakakwana yekudzidza, panzvimbo pema cell mashoma. Maitiro aya haawanikwe kwese kwese, uye mhedzisiro ingave isina chokwadi.

• Steroid trial. Autoimmune pancreatitis kazhinji inopindura kusteroids; vanachiremba vanowanzoshandisa nzira yemishonga iyi kusimbisa chirwere. Zvisinei, hurongwa uhwu hunofanira kuitika pasi pekutungamirwa kwenyanzvi. Hunofanira kushandiswa zvishoma uye hunongofanira kuitwa kana paine humbowo hwakasimba hwekutsigira chirwere che autoimmune pancreatitis. Kupindura kwekukorticosteroids kunoyerwa ne CT uye kuvandudzika mumazinga e serum IgG4.

Bvunzo dzeropa. Ungave nebvunzo yekutarisa mazinga akakwira ei immunoglobulin inonzi IgG4. IgG4 inogadzirwa nehurongwa hwako hwekudzivirira. Vanhu vane rudzi 1 AIP vanowanzove nemazinga akakwira eIgG4 muropa ravo. Vanhu vane rudzi 2 AIP kazhinji havadi.

Zvisinei, bvunzo yakanaka hairevi kuti une chirwere ichi. Huwandu duku hwevanhu vasina autoimmune pancreatitis, kusanganisira vamwe vane kenza yepancreas, vanewo mazinga akakwira eIgG4 muropa ravo.

Endoscopic core biopsy. Mubvunzo iyi, nyanzvi yekurapa inonzi pathologist inodzidza sampuli yetsinga yepancreas murabhoritari. AIP ine chitarisiko chakasiyana chinogona kuzivikanwa nyore nyore pasi pe microscope ne pathologist ane ruzivo. Chubhu duku inonzi endoscope inoiswa kuburikidza nemuromo kuenda mudumbu, ichitungamirwa ne ultrasound. Sampuli yetsinga inobva yabviswa kubva ku pancreas uchishandisa tsono chaiyo.

Dambudziko nderekuwana sampuli yetsinga yakakura zvakakwana yekudzidza, panzvimbo pema cell mashoma. Maitiro aya haawanikwe kwese kwese, uye mhedzisiro ingave isina chokwadi.