Vcjd

Chirwere cheCreutzfeldt-Jakob (KROITS-felt YAH-kobe), chinozivikanwawo seCJD, chirwere chisina kujairika cheuropi chinoita kuti munhu ave ne dementia. Chinobva muchikwata chezvirwere zvevanhu ne zvipfuwo zvinozivikanwa se prion disorders. Zviratidzo zvechirwere cheCreutzfeldt-Jakob zvinogona kufanana nezvezvirwere zveAlzheimer. Asi chirwere cheCreutzfeldt-Jakob kazhinji chinoipisisa nekukurumidza uye chinoita kuti munhu afe.

Chirwere cheCreutzfeldt-Jakob (CJD) chakatanga kuzivikanwa nevanhu muma1990 apo vamwe vanhu muUnited Kingdom vakarwara neimwe mhando yechirwere ichi. Vakawana variant CJ, inozivikanwa se vCJD, mushure mekudya nyama yemombe dzakarwara. Zvisinei, kazhinji kazhinji nyaya dzechirwere cheCreutzfeldt-Jakob hadzina kubatana nekudya nyama yemombe.

Marudzi ose eCJD akakomba asi asingawanzoitika. Anenge 1 kusvika ku 2 nyaya dzeCJD dzinoonekwa pagumi miriyoni yevanhu pasi rose gore rega rega. Chirwere ichi chinonyanya kukanganisa vakuru vakwegura.

Chirwere cheCreutzfeldt-Jakob chinoratidzwa nekuchinja kwehunhu hwepfungwa. Zviratidzo zvinoita zvakanyanya kukura nekukurumidza, kazhinji mukati memasvondo mashoma kusvika kumwedzi mishoma. Zviratidzo zvepakutanga zvinosanganisira:

• Kuchinja kwehunhu.
• Kurasikirwa neye ndangariro.
• Kusakwanisa kufunga zvakanaka.
• Kuona kusapfava kana kuburira.
• Kushaya hope.
• Matambudziko ekurongeka kwemuviri.
• Matambudziko ekukurukura.
• Matambudziko ekuruma.
• Kufamba kwenguva pfupi, kwakasimba.

Rufu runowanzoitika mukati megore. Vanhu vane chirwere cheCreutzfeldt-Jakob vanowanzo fa nekuda kwezvinetso zvemuviri zvine chekuita nechirwere ichi. Izvi zvinogona kusanganisira kunetseka kuruma, kudonha, matambudziko emwoyo, kukuvara kwemapapu, kana chibayiro kana mamwe marwadzo.

Muvanhu vane CJD yakasiyana, kuchinja kwehunhu hwepfungwa kunogona kuoneka zvakajeka pakutanga kwechirwere. Muzviitiko zvakawanda, dementia inoitika gare gare muchirwere. Zviratidzo zve dementia zvinosanganisira kurasikirwa nehunyanzvi hwekufunga, kufunga uye yekurangarira.

CJD yakasiyana inokanganisa vanhu vakadzikama kupfuura CJD. CJD yakasiyana inoita kunge inogara kwemwedzi gumi nemaviri kusvika gumi nemana.

Imwe fomu isingawanzoitika ye chirwere cheprion inonzi variably protease-sensitive prionopathy (VPSPr). Inogona kutevedzera mamwe marudzi e dementia. Inokonzera kuchinja kwehunhu hwepfungwa nematambudziko ekukurukura nekufunga. Nzira yechirwere yakareba kupfuura mamwe marudzi echirwere cheprion - anenge mwedzi makumi maviri nemana.

Chirwere cheCreutzfeldt-Jakob nedzimwe nguva dzinoenderana zvinoita sekunge zvinokonzerwa nekuchinja kwemhando yepuroteni inonzi prion. Mapuroteni aya kazhinji anoitwa mumuviri. Asi kana vasangana ne prions dzine hutachiona, vanopfugama uye vanova chimiro chimwe chisina kujairika. Vanogona kupararira uye kukanganisa maitiro mumuviri.

Kazhinji kazhinji chirwere cheCreutzfeldt-Jakob chinoitika pasina zvikonzero zvinozivikanwa. Saka zvinokonzera njodzi hazvigone kuzivikanwa. Asi zvinhu zvishoma zvinoita sekunge zvakabatana nemhando dzakasiyana dzeCJD.

• Age. Sporadic CJD inowanzoitika panguva yekukwegura, kazhinji anenge makore 60. Kutanga kwefamilial CJD kunoitika kare zvishoma. Uye chirwere chevariant Creutzfeldt-Jakob (vCJD) chakabata vanhu vakakura zvishoma, kazhinji vari mumakore avo makumi maviri nematanhatu.
• Genetics. Vanhu vane familial CJD vane shanduko dzemajini dzinoita kuti chirwere chiitike. Kuti chirwere ichi chibude, mwana anofanira kuva nekopi imwe chete yegene rinoita kuti CJD iitike. Igene rinogona kupfuudzwa kubva kuna mubereki. Kana uine gene, mukana wekupfuudza kuvana vako ndewe 50%.
• Kuonekwa kune tishu yakasvibiswa. Vanhu vakagamuchira homoni yekukura yevanhu inosvibiswa vangave vari panjodzi yeiatrogenic CJD. Kugamuchira kusimudzirwa kwetishu inofukidza uropi, inonzi dura mater, kubva kune munhu ane CJD kunogonawo kuisa munhu panjodzi yeiatrogenic CJD.

Njodzi yekuwana vCJD kubva pakudya nyama yemombe yakasvibiswa yakaderera kwazvo. Munyika dzakashandisa matanho ehutano ehutano anoshanda, njodzi haisipo. Chirwere chekuparara kwenguva refu (CWD) chirwere cheprion chinotapura mhuka dzesango, elk, reindeer ne moose. Chakawanikwa munzvimbo dzakati dzeNorth America. Kusvika pari zvino, hapana nyaya dzakanyorwa dzechirwere chekuparara kwenguva refu (CWD) dzakakonzeresa chirwere kuvanhu.

Chirwere cheCreutzfeldt-Jakob chine ngozi huru kuuropi nemuviri. Chirwere ichi chinowanzokura nekukurumidza. Kufamba kwenguva, vanhu vane CJD vanozvitora kubva kuhama neshamwari. Vanorasikirwawo nehunyanzvi hwekutarisira ivo pachavo. Vakawanda vanowira mukati mekoma. Chirwere ichi chinouraya nguva dzose.

Hapana nzira inozivikanwa yekudzivirira CJD isingawanzoitika. Kana uine nhoroondo yemhuri yerudzi rwechirwere chepfungwa, unogona kubatsirwa nekutaura nachiremba we genetics. Mutevedzeri anogona kukubatsira kuronga njodzi dzako.

Kuongorora tishu yehuropi kana bvunzo yetishu yehuropi mushure mekufa, inozivikanwa sekuongororwa kwekufa, ndiyo nzira yakanakisa yekusimbisa kuvapo kwechirwere cheCreutzfeldt-Jakob, chinozivikanwa seCJD. Asi vanachiremba vanowanzogona kuita chirwere chaicho usati wafa. Vanobva pakurapa kwako uye nhoroondo yemunhu, bvunzo yehuropi, uye bvunzo dzakati dzokuongorora.

Kuongorora huropi kunogona kuratidza chirwere cheCreutzfeldt-Jakob (CJD) kana uri kuita izvi:

Pamusoro pezvo, vanachiremba vanowanzoshandisa bvunzo idzi kubatsira kuona CJD:

Bvunzo dzemvura yemuzongoza. Mvura yemuzongoza inotenderera uye inodzivirira huropi nemuzongoza. Mubvunzo unonzi lumbar puncture, unozivikanwawo se spinal tap, huwandu duku hwemvura yemuzongoza hunotorwa kuti huongororwe. Bvunzo iyi inogona kubvisa zvirwere zvimwe zvinoita zviratidzo zvakafanana neCJD. Inogona zvakare kuona mazinga emapuroteni anogona kuratidza CJD kana chirwere cheCreutzfeldt-Jakob (vCJD).

A bvunzo itsva inonzi real-time quaking-induced conversion (RT-QuIC) inogona kuona kuvapo kwemaprion mapuroteni anokonzera CJD. Bvunzo iyi inogona kuongorora CJD usati wafa, zvisina kufanana nekuongorora kwekufa.

• Kuchema kwemhasuru nekutambanudza.

• Kushanduka kwemareflexes.

• Matambudziko ekurongeka.

• Matambudziko ekuona.

• Uburasi.

• Electroencephalogram, inozivikanwawo se EEG. Bvunzo iyi inoyera basa remagetsi rehuropi. Inoitwa nekugadzira madhisiki madiki emagetsi anonzi electrodes pamusoro. Mhedzisiro ye electroencephalogram (EEG) yevanhu vane CJD ne variant CJD inoratidza muenzaniso usingawanzoitika.

• Magnetic resonance imaging (MRI). Izvi zvekufananidzira zvinoshandisa ma radio waves nema magnetic field kugadzira mifananidzo yakajeka yemusoro nemuviri. MRI inobatsira zvikuru pakutsvaga matambudziko ehuropi. MRI inogadzira mifananidzo yakajeka. Vanhu vane CJD vane shanduko dzakakosha dzinogona kuonekwa pane mamwe ma MRI scans.

• Bvunzo dzemvura yemuzongoza. Mvura yemuzongoza inotenderera uye inodzivirira huropi nemuzongoza. Mubvunzo unonzi lumbar puncture, unozivikanwawo se spinal tap, huwandu duku hwemvura yemuzongoza hunotorwa kuti huongororwe. Bvunzo iyi inogona kubvisa zvirwere zvimwe zvinoita zviratidzo zvakafanana neCJD. Inogona zvakare kuona mazinga emapuroteni anogona kuratidza CJD kana chirwere cheCreutzfeldt-Jakob (vCJD).

A bvunzo itsva inonzi real-time quaking-induced conversion (RT-QuIC) inogona kuona kuvapo kwemaprion mapuroteni anokonzera CJD. Bvunzo iyi inogona kuongorora CJD usati wafa, zvisina kufanana nekuongorora kwekufa.

Hapana mushonga unoshanda uripo wechirwere cheCreutzfeldt-Jakob kana chero imwe yemhando dzacho. Mishonga yakawanda yakaedzwa asi haina kuratidza kubatsira. Vanopa utano vanotarisa pakuderedza marwadzo nezvimwe zviratidzo uye pakuita kuti vanhu vane zvirwere izvi vagare zvakanaka sezvinobvira.