Chirwere Checushing

Cushing syndrome inoitika kana muviri uine homoni inonzi cortisol yakawanda kwenguva yakareba. Izvi zvinogona kuitika nekuda kwekuti muviri unogadzira cortisol yakawanda, kana nekuda kwekushandisa mishonga inonzi glucocorticoids, iyo inokanganisa muviri nenzira imwe chete necortisol. Cortisol yakawanda inogona kukonzera zvimwe zviratidzo zvikuru zveCushing syndrome — gumbo remafuta pakati pemafudzi, chiso chakatenderera, uye makwapa machena kana epepuru paganda. Cushing syndrome inogona zvakare kukonzera kuwedzera kweropa kana kurasikirwa nemapfupa. Dzimwe nguva, inogona kukonzera chirwere cheshuga chechirudzi chechipiri. Kurapwa kweCushing syndrome kunogona kudzikisa mazinga ecortisol mumuviri uye kuvandudza zviratidzo. Kana kurapwa kuchitanga nekukurumidza, mukana wekupora unowedzera.

Zviratidzo zveCushing syndrome zvinogona kusiyana zvichienderana nehuwandu hwe cortisol yakawandisa. Kuwedzera uremu mumucheto wemukati, nemaoko nemakumbo akapfava. Kuwedzera uremu pachiso. Izvi dzimwe nguva zvinonzi chiso chemwedzi. Bumbiro remafuta pakati pemafudzi. Izvi zvinogona kunzi hump yebuffalo. Zviratidzo zvitema kana zvipurupuru mudumbu, chiuno, mapapiro, mazamu nepazasi pemabvi. Ganda rakapfava, rakapfava rinorwadza nyore nyore. Kurapa kwakaremara. Acne. Vhudzi rakapfuma, rakasviba pachiso nemuviri. Iyi mamiriro anonzi hirsutism. Nguva dzisingaenzani kana kuti dzimire. Kuderedza zvepabonde. Kuderedza kubereka. Matambudziko ekukwira. Kuneta kwakanyanya. Kushaya simba kwemhasuru. Kuora mwoyo, kunetseka nekutsamwa. Manzwiro akaoma kudzora. Matambudziko ekutarisa kana yekurangarira. Kushaya hope. Kuderera kweropa. Kurwadziwa kwemusoro. Zvirwere. Kuita rima kweganda. Kurasikirwa nemapfupa, izvo zvinogona kukonzera mapfupa akaputsika. Kukura kwakaderera muvana. Fonera chiremba wako kana uine zviratidzo zveCushing syndrome, kunyanya kana uri kutora mishonga ye glucocorticoid kurapa chirwere se asthma, arthritis kana inflammatory bowel disease.

Fonera chiremba wako kana uine zviratidzo zveCushing syndrome, kunyanya kana uri kutora mishonga ye glucocorticoid kurapa chirwere se asthma, arthritis kana inflammatory bowel disease.

System yegland endocrine inosanganisira marunda e adrenal ne gland yepituitary. Zviratidzo kubva ku gland yepituitary zvinotaura ku marunda e adrenal kuti aite cortisol. Gland yepituitary inoziva kana muviri uine huwandu hwakakwana hwe cortisol.

Cushing syndrome inokonzerwa nekuva necortisol yakawanda mumuviri. Cortisol ihormone inogadzirwa mumaruza e adrenal. Inobatsira muviri kupindura kumanomera uye inotamba mabasa akawanda akakosha, anosanganisira:

• Kuderedza kuzvimba.
• Kubatsira moyo nemidziyo yeropa kuti ishande zvakanaka.
• Kutonga shuga yeropa.
• Kubatsira muviri kushandisa chikafu kuti uwane simba.

Cushing syndrome inogona kuitika kubva pakutora mishonga ye glucocorticoid. Idzi kazhinji dzinoshandiswa kurapa zvirwere zvinopisa senge rheumatoid arthritis, lupus ne asthma. Kurwadziwa kana kukuvara kumashure kana majoini nemaronda akawanda eganda zvinogona kurapwa ne glucocorticoids. Zvinogona zvakare kushandiswa kumisa muviri kuti urege kuramba chiungo chitsva mushure mekusimudzirwa.

Glucocorticoids inogona kutengwa nemuromo, ipai se shoti, isukwe muganda kana kupfekerwa mumapapu ne inhaler. Chero fomu re glucocorticoid, kana rakatorwa muhuwandu hukuru kwenguva yakareba, rinogona kukonzera Cushing syndrome.

Hormone inogadzirwa mu gland yepituitary inodzora kuti muviri unoita cortisol yakawanda sei. Izvi zvinonzi adrenocorticotropic hormone (ACTH). Zvimwe zvirwere zvinoita ACTH, izvo zvinoita cortisol yakawanda uye zvinogona kukonzera Cushing syndrome. Matambudziko nemarunda e adrenal anogona zvakare kukanganisa cortisol uye kukonzera Cushing syndrome.

Paunoitika Cushing syndrome nenzira iyi, inogona kukonzerwa ne:

• ACTH-producing pituitary adenoma. Pituitary adenomas ndizvirwere zvinokura mu gland yepituitary. Zvinowanikwa pasi pemusoro uye kazhinji hazvisi kenza. Aya maronda dzimwe nguva anoita ACTH yakawanda. Izvi zvinoita kuti marunda e adrenal aite cortisol yakawanda. Paunoitika Cushing syndrome nenzira iyi, inonzi Cushing disease. Inowanzoitika muvakadzi uye ndiyo yakajairika mhando ye endogenous Cushing syndrome.
• Ectopic ACTH-producing tumor. Zvishoma, chirwere chinoita ACTH yakawanda chinokura muchikamu chisingawanzoiti ACTH. Izvi zvinonzi ectopic ACTH production. Zvinoita kuti muviri uite cortisol yakawanda. Aya maronda anogona kuva kenza, asi haasi nguva dzose. Kazhinji anowanikwa mumapapu, pancreas, thyroid kana thymus gland.
• Marunda egland e adrenal kana chirwere. Matambudziko nemarunda e adrenal anogona kuita kuti aite cortisol yakawanda. Yakajairika ndechirwere chikamu chekunze che gland ye adrenal chinonzi adrenal adenoma. Aya maronda haasi kenza, uye mamwe chete anoita cortisol yakawanda.

Maronda ekenza muchikamu chekunze chemarunda e adrenal, anozivikanwa se adrenocortical carcinoma, mashoma. Asi anogona kuita cortisol uye kukonzera Cushing syndrome. Dzimwe nguva, zvidimbu zvakawanda zvinoita cortisol zvinogona kukura mumaruza e adrenal uye kukonzera Cushing syndrome. Izvi zvinonzi adrenal nodular hyperplasia.

• Familial Cushing syndrome. Zvishoma, vanhu vanogara vachiwana zvirwere pane rimwe kana kupfuura marunda avo endocrine, ayo ari marunda anoita hormones. Kana aya maronda achiita ACTH kana cortisol, Cushing syndrome inogona kuitika.

Marunda egland e adrenal kana chirwere. Matambudziko nemarunda e adrenal anogona kuita kuti aite cortisol yakawanda. Yakajairika ndechirwere chikamu chekunze che gland ye adrenal chinonzi adrenal adenoma. Aya maronda haasi kenza, uye mamwe chete anoita cortisol yakawanda.

Maronda ekenza muchikamu chekunze chemarunda e adrenal, anozivikanwa se adrenocortical carcinoma, mashoma. Asi anogona kuita cortisol uye kukonzera Cushing syndrome. Dzimwe nguva, zvidimbu zvakawanda zvinoita cortisol zvinogona kukura mumaruza e adrenal uye kukonzera Cushing syndrome. Izvi zvinonzi adrenal nodular hyperplasia.

Pasina kurapwa, chirwere cheCushing chinogona kukonzera matambudziko, anosanganisira:

• Kurasikirwa nemapfupa, kunonziwo osteoporosis, kunogona kukonzera mapfupa kupwanya.
• Chidhakwa cheshuga cheType 2.
• Zvirwere zvakakomba kana zvakawanda.
• Kurasikirwa nekusimba kwemhasuru nekukura kwemhasuru.

Kushandisa mishonga ye glucocorticoid ndiyo nzira inonyanya kuzivikanwa yekuwana Cushing syndrome. Mupi wehutano hwako anogona kutarisa mishonga yako yese — mapiritsi, jekiseni, kirimu ne inhalers — kuona kana uri kushandisa mishonga inogona kukonzera syndrome. Kana uri, haufanire kuita bvunzo dzimwe.

Kana Cushing syndrome yakakonzerwa nemuviri uchigadzira cortisol yakawanda, zvinogona kuoma kuziva. Izvozvo ndizvo nekuti zvirwere zvimwe zvine zviratidzo zvakafanana. Kuziva Cushing syndrome kunogona kuva kwenguva refu uye kwakaoma. Uchafona kuona chiremba anoziva nezve chirwere chemahomoni, anonzi endocrinologist.

Endocrinologist angaita bvunzo yemuviri uye kutsvaga zviratidzo zveCushing syndrome, senge chiso chakatenderera, hump kumashure kwemutsipa, uye ganda rakasimba, rakaoma ne stretch marks.

Kana usati wambo shandisa mushonga we glucocorticoid, bvunzo idzi dzinogona kubatsira kuona chikonzero cheCushing syndrome:

• Bvunzo dzeurine neropa. Bvunzo idzi inoyera mahomoni uye inoratidza kana muviri uchigadzira cortisol yakawanda. Kune bvunzo ye urine, ungakumbirwa kuunganidza urine yako kwemaawa makumi maviri nemana. Cortisol, ACTH nemahomoni mamwe anoyerwa mu urine neropa.

  Mupi wehutano hwako anogonawo kukurudzira bvunzo dzimwe. Bvunzo idzi inoyera mazinga e cortisol usati washandisa mishonga yemahomoni kuti usimudzire kana kudzivirira cortisol.

• Bvunzo yesaliva. Mazinga eCortisol anowanzokwira uye anodonha zuva rese. Muvanhu vasina Cushing syndrome, cortisol inodonha manheru. Nekutarisa mazinga e cortisol kubva musampuli diki yesaliva yakaunganidzwa usiku, timu yehutano inogona kuona kana mazinga e cortisol ari akakwirira.

• Bvunzo dzekuona mifananidzo. CT kana MRI scans inogona kutora mifananidzo ye pituitary ne adrenal glands kuona kana chimwe chinhu chiripo, senge zvironda.

• Inferior petrosal sinus sampling. Bvunzo iyi inogona kubatsira kusarudza kana Cushing syndrome yakakonzerwa ne ACTH-producing pituitary adenoma, kana ACTH-producing tumor mune imwe nhengo. Kune bvunzo, masampuli eropa anotangwa kubva mumitsinga inodonhedza pituitary gland, inonzi inferior petrosal sinuses.

  Panguva yebvunzo, unopiwa mushonga kuburikidza nemutsinga kukubatsira kugara wakadzikama uye wakasununguka. Tube diki inoiswa munzvimbo yako ye groin kana mutsipa uye inosungirirwa ku inferior petrosal sinuses kuunganidza sampuli yeropa. Imwe sampuli yeropa inotorwa kubva paruoko rwako. Ipapo unopiwa mushonga unoita kuti tumor iite ACTH yakawanda, uye masampuli eropa anotangwa zvakare kubva munzvimbo dzakafanana. Mazinga e ACTH anozopfuurwa pakati pemasampuli maviri.

  Kana ACTH iri yakakwirira musampuli yesinus, dambudziko rinobva ku pituitary. Kana mazinga e ACTH akafanana pakati pesinus ne forearm, dambudziko riri kunze kwe pituitary gland.

Bvunzo dzeurine neropa. Bvunzo idzi inoyera mahomoni uye inoratidza kana muviri uchigadzira cortisol yakawanda. Kune bvunzo ye urine, ungakumbirwa kuunganidza urine yako kwemaawa makumi maviri nemana. Cortisol, ACTH nemahomoni mamwe anoyerwa mu urine neropa.

Mupi wehutano hwako anogonawo kukurudzira bvunzo dzimwe. Bvunzo idzi inoyera mazinga e cortisol usati washandisa mishonga yemahomoni kuti usimudzire kana kudzivirira cortisol.

Inferior petrosal sinus sampling. Bvunzo iyi inogona kubatsira kusarudza kana Cushing syndrome yakakonzerwa ne ACTH-producing pituitary adenoma, kana ACTH-producing tumor mune imwe nhengo. Kune bvunzo, masampuli eropa anotangwa kubva mumitsinga inodonhedza pituitary gland, inonzi inferior petrosal sinuses.

Panguva yebvunzo, unopiwa mushonga kuburikidza nemutsinga kukubatsira kugara wakadzikama uye wakasununguka. Tube diki inoiswa munzvimbo yako ye groin kana mutsipa uye inosungirirwa ku inferior petrosal sinuses kuunganidza sampuli yeropa. Imwe sampuli yeropa inotorwa kubva paruoko rwako. Ipapo unopiwa mushonga unoita kuti tumor iite ACTH yakawanda, uye masampuli eropa anotangwa zvakare kubva munzvimbo dzakafanana. Mazinga e ACTH anozopfuurwa pakati pemasampuli maviri.

Kana ACTH iri yakakwirira musampuli yesinus, dambudziko rinobva ku pituitary. Kana mazinga e ACTH akafanana pakati pesinus ne forearm, dambudziko riri kunze kwe pituitary gland.