Chii Chinonzi Familial Hypercholesterolemia? Zviratidzo, Zvinokonzera, & Kurapa

Familial hypercholesterolemia chirwere chinogara mumhuri chinoita kuti muviri wako uve nechero cholesterol yakakwira kubva pakuberekwa. Kusiyana nechero cholesterol dambudziko rinouya nekudya kana mararamiro, chirwere ichi chinogara mumhuri uye chinoita kuti chiropa chako chishande sei cholesterol.

Vanhu vanenge 1 pakati pe250 vane chirwere ichi, kunyange vazhinji vasingazive. Cholesterol yako inogona kunge iri 2 kusvika ku4 nguva yakakwira kupfuura zvakajairwa, izvo zvinoita kuti uve pangozi yechirwere chemwoyo pane zera duku kupfuura vanhu vazhinji.

Chii Chinonzi Familial Hypercholesterolemia?

Familial hypercholesterolemia inoitika kana wakagara uchigara nemahara anokanganisa anodzora metabolism ye cholesterol. Chiropa chako hachikwanisi kubvisa LDL cholesterol (chero cholesterol “yakaipa”) muropa rako zvakakwana.

Funga nezvazvo sekuvhara mumigwagwa yeropa rako. Chiropa chakajairika chine “nzira dzakakwana” dzekuchenesa cholesterol, asi nechirwere ichi, nzira dzakawanda dzacho dzakavharwa. Izvi zvinoita kuti cholesterol ivakwe muropa rako uye pakupedzisira muma arteries ako.

Kune marudzi maviri makuru. Heterozygous familial hypercholesterolemia zvinoreva kuti wakagara uchigara negene rimwe chete rakakanganisika kubva kune mumwe mubereki. Homozygous familial hypercholesterolemia zvinoreva kuti wakagara uchigara nemahara akakanganisika kubva kuvarabereki vese, zvichiita kuti ive yakanyanya kuipa asi zvakare yakawanda zvikuru.

Ndeapi Zviratidzo zveFamilial Hypercholesterolemia?

Vazhinji vanhu vane familial hypercholesterolemia havazvirware kana kuona zviratidzo zvakajeka. Cholesterol yakakwira inoshanda zvakavanzika, ndosaka kazhinji inonzi chirwere “chakavanzika”.

Nekudaro, zvimwe zviratidzo zvemuviri zvinogona kuoneka izvo zvinogona kukupa mazano:

• Mabhonzo machena kana mavara akapoteredza maziso ako (anonzi xanthelasma)
• Mabhonzo machena pamaoko ako, magaro, kana magaro (tendon xanthomas)
• Mhete chena-chena yakapoteredza chikamu chakajeka cheziso rako (corneal arcus)
• Kurwadziwa pachipfuva kana kushaya mweya panguva yekurovedza muviri
• Zviratidzo zvekurwara kwemoyo kana stroke mune nhengo dzemhuri

Aya maratidzo anooneka akajairika muvanhu vane zvimiro zvakakomba zvechirwere ichi. Vanhu vazhinji vanongowana kuti vane familial hypercholesterolemia panguva yekuongororwa kweropa kana mushure mekunge nhengo yemhuri yadzidziswa.

Ndeapi Marudzi eFamilial Hypercholesterolemia?

Kune marudzi maviri makuru zvichienderana nekuti wakagara uchigara nemahara mangani akakanganisika. Rudzi rwawakagara narwo runokanganisa kuti cholesterol yako ichave yakakomba sei uye kana matambudziko angatanga.

Heterozygous familial hypercholesterolemia ndiyo fomu inowanzoitika. Wakagara uchigara negene rimwe chete rakajairika uye gene rimwe rakakanganisika, saka chiropa chako chichiri kushanda zvishoma. Cholesterol yako inowanzova pakati pe300-500 mg / dL, uye matambudziko emwoyo anowanzoitika mumakore ako makumi mana kana makumi mashanu.

Homozygous familial hypercholesterolemia yakawanda zvikuru asi yakakomba. Wakagara uchigara nemahara akakanganisika kubva kuvarabereki vese, saka chiropa chako chinotambudzika zvikuru nekuchenesa cholesterol. Cholesterol yako inogona kusvika ku600-1000 mg / dL kana kupfuura, uye matambudziko emwoyo anogona kutanga muhudiki kana mumakore ekukura.

Chii Chinokonzera Familial Hypercholesterolemia?

Familial hypercholesterolemia inokonzerwa nekuchinja kwemahara anobatsira chiropa chako kubvisa cholesterol muropa rako. Gene inowanzozivikanwa inonzi LDLR, iyo inoita ma receptors anobata cholesterol kubva muropa rako.

Kana aya magene asingashande zvakanaka, chiropa chako hachikwanisi kuchenesa cholesterol zvakakwana. Zvakaita sekusava nemasuo akawanda ekuti cholesterol ibve muropa rako, saka inovakwa nekufamba kwenguva.

Izvi zvinongogara mumhuri uye hazvina chekuita nekudya kwako, tsika dzekurovedza muviri, kana sarudzo dzemararamire. Wakaberekwa nechirwere ichi nekuti wakagara uchigara nacho kubva kune mumwe kana vese vabereki. Kana mumwe mubereki akave nayo, mwana wese ane mukana we50% wekuigara nayo.

Rini Unofanira Kuona Chiremba weFamilial Hypercholesterolemia?

Unofanira kuona chiremba kana uine nhoroondo yemhuri ye cholesterol yakakwira, kurwara kwemoyo kwakakurumidza, kana stroke. Kuongororwa kwakakosha kana mubereki, munun'una, kana mwana akadzidziswa familial hypercholesterolemia.

Rongedza musangano kana ukaona mabhonzo machena akapoteredza maziso ako kana pamajoini ako. Aya maratidzo anooneka anowanzoita kuti cholesterol ive yakakwira zvikuru inoda kurapwa kwemishonga.

Usamirira kana iwe uine kurwadziwa pachipfuva, kushaya mweya, kana zvimwe zviratidzo zvine chekuita nemwoyo. Kunyangwe iwe uchizonzwa zvakanaka, kuongororwa kwe cholesterol kutanga mumakore ako makumi maviri kunogona kubata chirwere ichi pakutanga apo kurapwa kunonyanya kushanda.

Ndeapi Zvinokonzera Zvinokonzera Familial Hypercholesterolemia?

Chinokonzera chikuru ndechekuva nemubereki ane familial hypercholesterolemia. Sezvo iri mugore, haugone kuwana chirwere ichi usina kugara nacho kubva kumhuri yako.

Pangozi yako inotsamira pane muenzaniso wemhuri yako:

• Mumwe mubereki ane chirwere ichi anokupa mukana we50% wekuve nayo
• Vabereki vese vane chirwere ichi zvinoreva kuti iwe uchava nayo zvechokwadi
• Vana kana vana vevanhu vakabatwa vane mikana yakawanda
• Mamwe marudzi, senge French Canadians neAfrikaners, ane mitengo yakakwira
• Vanhu vane Ashkenazi Jewish heritage vangave nemamwe ma genetic variants

Kusiyana nezvimwe zvirwere zve cholesterol, kudya kwako, uremu, kana tsika dzekurovedza muviri hazvikonzeri familial hypercholesterolemia. Nekudaro, aya mararamire anogona kuchinja kuti cholesterol yako ichave yakakomba sei uye kuti matambudziko anokura sei nekukurumidza.

Ndeapi Matambudziko Anogona Kuitika eFamilial Hypercholesterolemia?

Chinonyanya kunetseka ne familial hypercholesterolemia ndechekuti inowedzera zvakanyanya pangozi yechirwere chemwoyo uye stroke pane zera duku. Pasina kurapwa, vanhu vane chirwere ichi vanowanzova nematambudziko emwoyo makumi emakore usati wasvika vanhu vazhinji.

Matambudziko akajairika anosanganisira:

• Coronary artery disease (ma arteries akavharwa kumoyo wako)
• Kurwara kwemoyo, kazhinji kunoitika mumakore makumi mana kana makumi mashanu
• Stroke kubva kuma arteries akavharwa kuuropi hwako
• Peripheral artery disease (ma arteries akavharwa mumakumbo ako)
• Aortic valve disease kubva pakuvakwa kwe cholesterol

Mashoko akanaka ndeawo ekutanga kuongororwa nekurapwa kunogona kuderedza zvikuru aya njodzi. Nekugadzirisa kwakakodzera, vanhu vazhinji vane familial hypercholesterolemia vanorarama hupenyu hunowanzoitika, hune hutano pasina kuve nematambudziko aya akakomba.

Familial Hypercholesterolemia Inogona Kudzivirirwa Sei?

Sezvo familial hypercholesterolemia iri mugore, haugone kudzivirira kuwana chirwere icho pachacho. Nekudaro, unogona kutora matanho ekudzivirira kana kunonoka matambudziko ayo kana uchiziva kuti une.

Kuongororwa kwakakurumidza ndiyo nzira yako yakanakisa yekudzivirira. Kana uine nhoroondo yemhuri, kuongororwa mumakore ako makumi maviri kunobvumira kurapwa kwakakurumidza usati waenda kukuvadzwa kwe artery.

Kunyangwe usingakwanisi kuchinja magene ako, sarudzo dzemararamire dzine hutano dzinogona kubatsira kudzora cholesterol yako. Kurovedza muviri nguva dzose, kudya kwemoyo kwakanaka, kusvuta, uye kuchengetedza uremu hune hutano zvese zvinotsigira kurapwa kwako uye kuderedza njodzi dzemoyo.

Familial Hypercholesterolemia Inoziviswa Sei?

Kuongororwa kunotanga nekuongororwa kweropa kuri nyore kunonzi lipid panel iyo inoyerera cholesterol yako. Chiremba wako acharamba achitsvaga cholesterol yakazara pamusoro pe300 mg / dL kana LDL cholesterol pamusoro pe190 mg / dL, kunyanya kana uri mudiki uye une hutano.

Chiremba wako achaubvunzawo mibvunzo yakadzama nezvenhoroondo yemhuri yako. Vachatsvaga kuziva kana vabereki, vanun'una, kana vana vakave ne cholesterol yakakwira, kurwara kwemoyo kwakakurumidza, kana stroke.

Kuongororwa kwe genetic kunogona kusimbisa kuongororwa nekutsvaga kuchinja kwe gene chaiyo. Kuongororwa uku kunobatsira zvikuru pakutarisa mhuri uye kuona kuti ndechii chaicho chawakagara nacho. Vamwe vanhu vanowanawo bvunzo dzakakosha kuti vaone kuti chiropa chavo chinoshanda sei cholesterol.

Kurapa kweFamilial Hypercholesterolemia Chii?

Kurapa kunotarisa pakuderedza cholesterol yako kuti uderedze pangozi yechirwere chemwoyo uye stroke. Chinangwa ndechekuwana LDL cholesterol yako yakaderera sezvinobvira, kazhinji pasi pe70 mg / dL.

Vazhinji vanhu vanoda mishonga inonzi statins, iyo inobatsira chiropa chako kushanda zvakanyanya. Statins dzakajairika dzinosanganisira atorvastatin, rosuvastatin, uye simvastatin. Chiremba wako angatanga nerimwe uye agadzirise dose kana kuwedzera mamwe mishonga sezvinodiwa.

Kune zviitiko zvakakomba kana statins dzisingakwani, kurapwa kuwedzerwa kunosanganisira:

• PCSK9 inhibitors (mishonga inoiswa inopiwa mavhiki ese 2-4)
• Ezetimibe (inodzivirira cholesterol kubatwa mumatumbo ako)
• Bile acid sequestrants (inobatsira kubvisa cholesterol mumuviri wako)
• LDL apheresis (maitiro anoyerera cholesterol kubva muropa rako)

Vanhu vane homozygous familial hypercholesterolemia vangada kurapwa kwakanyanya senge apheresis kazhinji kana kunyange kupandikirwa kwechiropa mune zviitiko zvisingawanzoitika. Kiyi ndeyekushanda pedyo nechikwereti chako kuti uwane musanganiswa unoshanda kwauri.

Maitiro Ekutora Kurapa Kwekumba Panguva yeFamilial Hypercholesterolemia?

Kunyangwe mishonga ichikosha, kuchinja mararamire kunogona kutsigira kurapwa kwako uye kukubatsira kunzwa zvakanaka. Funga nezvazvo sezvishandiso zvinoshanda pamwe chete nemishonga yako, kwete zvinotsiva izvo.

Tarisa pakudya kwemoyo kwakanaka nemiriwo yakawanda, miriwo, zviyo zvizere, uye mapuroteni asina mafuta. Dzivisa mafuta asina kugadzirwa, mafuta asina kugadzirwa, uye zvekudya zvine cholesterol yakawanda, kunyange uchifunga kuti mamiriro ako haakonzerwe nekudya.

Kurovedza muviri nguva dzose kunobatsira sisitimu yako yemoyo kuchengetedza simba. Tsvaga kanenge maminitsi 150 ekurovedza muviri pakati pevhiki, senge kufamba nekukurumidza, kushambira, kana kukwira bhasikoro. Tanga zvishoma nezvishoma uye uvakwe zvishoma nezvishoma kana uri mutsva pakurovedza muviri.

Tora mishonga yako chaizvo sezvakanyorwa, kunyangwe iwe uchizonzwa zvakanaka. Gadzira tsika kana kushandisa maorganizers emapiritsi kukubatsira kuyeuka. Usarega kutora mishonga usati wataura nachiremba wako, sezvo cholesterol yako inogona kukwira zvakare nekukurumidza.

Unofanira Kugadzirira Sei Musangano Wako Wechiremba?

Unganidza nhoroondo yemhuri yako yekurapa usati wasangana, uchitarisa chirwere chemwoyo, cholesterol yakakwira, uye rufu rwakakurumidza. Nyora kuti ndiani vehama vakave nematambudziko aya uye pazera ripi rakaitika.

Uyisa runyorwa rwemishonga yese, zvinowedzerwa, uye mavhitamini auri kutora ikozvino. Sanganisira ma dose uye kuti kazhinji unotora sei. Izvi zvinobatsira chiremba wako kudzivirira kusangana uye kuronga kurapwa kwako zvakachengeteka.

Gadzira mibvunzo nezve mamiriro ako, sarudzo dzekurapa, uye zvaunofanira kutarisira. Bvunza nezve cholesterol yakatarwa, zvinogona kuitika zvinokonzerwa nemishonga, uye kuti kazhinji uchada kuongororwa kwekuongorora. Usazengurire kubvunza kuti ujekese kana chimwe chinhu chisinganzwisisiki.

Chii Chinonyanya Kukosha Nezve Familial Hypercholesterolemia?

Familial hypercholesterolemia chirwere chinogara mumhuri chinoda kurapwa kwenguva refu, asi nekutarisirwa kwakakodzera, unogona kurarama hupenyu hwazvo uye hune hutano. Kuongororwa kwakakurumidza nekurapwa zvakakosha pakudzivirira chirwere chemwoyo nezvimwe zvinetso.

Chinonyanya kukosha ndechekuti mamiriro aya haasi mhosva yako, uye haisi chinhu chawaigona kudzivirira kuburikidza nesarudzo dzemararamire. Iyo ingori shanduko yegenetic inokanganisa kuti muviri wako unogadzirisa sei cholesterol.

Nemishonga inoshanda nhasi, vanhu vane familial hypercholesterolemia vanogona kuwana cholesterol yakafanana neyakajairika uye kuderedza zvakanyanya njodzi dzemoyo. Kiyi ndeyekushanda pedyo nechikwereti chako uye kuramba wakazvipira pakuronga kwako kurapwa.

Mibvunzo InowanzoBvunzwa Nezve Familial Hypercholesterolemia

Q1: Vana vanogona kuva ne familial hypercholesterolemia here?

Hongu, vana vanogona kuberekwa ne familial hypercholesterolemia sezvo iri chirwere chinogara mumhuri. Kuongororwa kwevana kunokurudzirwa kwevana vane vabereki vakabatwa, kazhinji kutanga pakati pemakore maviri. Kuonekwa kwakakurumidza kunobvumira kuchinja mararamire uye, kana zvichidiwa, mishonga yekudzivirira matambudziko emwoyo ramangwana.

Q2: Cholesterol yangu ichave yakajairwa here nechirwere ichi?

Kunyangwe cholesterol yako isingasviki zviyero zvakafanana nemunhu asina chirwere ichi, kurapwa kwakakodzera kunogona kuderedza zvikuru zviyero zvako. Vanhu vazhinji vane familial hypercholesterolemia vanowana cholesterol yakatarwa inoderedza njodzi yavo yemoyo kusvika kune zviyero zvakajairwa ne mishonga yakakodzera nekugadzirisa mararamire.

Q3: Ndinoda kutevera kudya kwakasarudzika ne familial hypercholesterolemia here?

Kunyangwe kuchinja kudya kusina kukwana kurapa familial hypercholesterolemia, kutevera kudya kwemoyo kwakanaka kunogona kutsigira kurapwa kwemishonga yako. Tarisa pakuderedza mafuta asina kugadzirwa, mafuta asina kugadzirwa, uye cholesterol yekudya uchinyanya kuisa miriwo, miriwo, zviyo zvizere, uye mapuroteni asina mafuta. Chiremba wako kana nyanzvi yekudya inogona kupa mazano akakodzera.

Q4: Ndingapasa chirwere ichi kuvana vangu here?

Hongu, familial hypercholesterolemia inogona kupaswa kuvana. Kana uine chirwere ichi, mwana wese ane mukana we50% wekuigara nayo. Kuongororwa kwe genetic kunogona kukubatsira kunzwisisa njodzi uye mabhenefiti ekuronga mhuri, uye kuongororwa kwakakurumidza kunogona kuve nechokwadi chekurapwa kwakakurumidza kana vana vako vakabatwa.

Q5: Kune kurapwa kwemhando dzechisikigo kwe familial hypercholesterolemia here?

Kunyangwe nzira dzechisikigo senge kurovedza muviri, kudya kwakanaka, uye zvimwe zvinowedzerwa zvingabatsira kutsigira hutano hwemoyo, hazvina kukwana kurapa familial hypercholesterolemia yoga. Chirwere ichi chinowanzodiwa mishonga inorayirwa kuti uwane cholesterol yakachengeteka. Gara uchikurukura nezvekurapa kwemhando dzechisikigo nachiremba wako usati waedza.