Chii chinonzi Hairy Cell Leukemia? Zviratidzo, Zvinokonzera, & Kurapa

Hairy cell leukemia rudzi rwakasiyana-siyana rerudzi rwekenza yeropa inokanganisa B-lymphocytes dzako, idzo dziri masero machena eropa anobatsira kurwisa hutachiona. Zita racho rinobva pakutaridzika kwemasero aya asingawanzoonekwa pasi pe microscope - ane ma projection maduku akaita sehuremu anobva pamusoro pavo.

Uyu mhando yekenza inokura zvishoma inonyanya kukanganisa vanhu vakuru vakati vakura, varume vachikwanisa kuwana kanenge kane mana kupfuura vakadzi. Kunyange zvazvo shoko rokuti "leukemia" rinogona kunzwa richitya, hairy cell leukemia kazhinji inokura zvishoma nezvishoma, uye vanhu vakawanda vanorarama hupenyu hwazvo, hwakazara, ne kurapwa kwakakodzera.

Ndeapi zviratidzo zve hairy cell leukemia?

Vanhu vakawanda vane hairy cell leukemia havaoni zviratidzo pakutanga nekuti iyi kenza inokura zvishoma nezvishoma. Kana zviratidzo zvikaonekwa, kazhinji zvinenge zvisina kunaka uye zvinogona kunzwa sekunge uri kungoneta kana kurwisa fodya inogara kwenguva refu.

Zviratidzo zvakajairika zvaunogona kuwana zvinosanganisira kunzwa kuneta kwazvo kana kushaya simba, kunyange mushure mekuzorora zvakakwana. Izvi zvinoitika nekuti masero asingawanzoonekwa anodzvinyirira masero eropa ane hutano anounza oxygen mumuviri wako wose.

Heano zviratidzo zvinowanzoonekwa sezvo mamiriro acho achifambira mberi:

• Kuneta kwenguva refu nekushushikana kunoshaya kugadziriswa nekuzorora
• Hutachiona hwakawanda kana hutachiona hunotora nguva yakareba kupora
• Kutemwa nyore kana kubuda ropa, kusanganisira kubuda ropa mumhino kana kubuda ropa mumazino
• Kunzwa kuzara nekukurumidza paunodya kana kusagadzikana kwemudumbu
• Kurasikirwa nehuremu pasina tsananguro
• Kushaya mweya panguva yemabasa akajairika
• Mashizha akafuta, kunyange zvazvo izvi zvisingawanzoitika

Kunzwa kuzara mushure mekudya zvishoma kunoitika nekuti spleen yako inogona kukura sezvo ichiedza kubvisa masero asingawanzoonekwa. Vamwe vanhu vanorondedzera izvi sekunzwa sekunge vane chinhu chakaoma kurutivi rwavo rworuboshwe.

Zvinokosha kucherechedza kuti zviratidzo izvi zvinogona kuva nezvikonzero zvakawanda, zvizhinji zvacho zvakajairika uye zvisingakuvadzi kupfuura hairy cell leukemia. Zvisinei, kana uri kuona zviratidzo zvakawanda izvi zvichienderera mberi, nguva dzose zvakanaka kubvunza chiremba wako.

Chii chinokonzera hairy cell leukemia?

Chikonzero chaicho che hairy cell leukemia hachizivisike zvizere, asi vatsvakurudzi vakawana zvimwe zvinhu zvikuru zvinokonzera kukura kwayo. Kufanana nekenza dzakawanda, zvinoita sekunge zvinobva pakushanduka kwemajini kunoitika nekufamba kwenguva panzvimbo pechinhu chaunowana kubva kuvabereki vako.

Masayendisiti akawana kuti vanhu vose vane hairy cell leukemia vane mutation chaiyo yemajini inonzi BRAF V600E. Iyi mutation inokonzera B-lymphocytes kuwanda zvisingadzoreki uye kurarama kwenguva refu kupfuura zvavanofanira, zvichikonzera kuunganidzwa kwemasero aya asingawanzoonekwa "hairy".

Kusiyana nekenza dzimwe, hairy cell leukemia haionekwi yakabatana nezvinhu zvemararamiro senge kusvuta, kudya, kana kuiswa kune zvinhu zvekugadzira. Haisi chirwere chinopfuudzwa, uye haugone kuchiwana kubva kune mumwe munhu kana kuchipfuudza kuvana vemhuri.

Mutation inokonzera mamiriro aya inoita sekunge inoitika zvisingatarisirwi panguva yehupenyu hwemunhu. Izvi zvinoreva kuti kazhinji hapana chawaigona kuita zvakasiyana kuti udzikise kubva kuitika.

Rini unofanira kuona chiremba nezviratidzo zve hairy cell leukemia?

Unofanira kufunga nezvekuona chiremba wako kana uri kuona kuneta kwenguva refu, hutachiona hwakawanda, kana kubuda ropa kwasingawanzoitika kunogara kwemavhiki anopfuura mashoma. Kunyange zvazvo zviratidzo izvi zvinowanzo konzerwa nemamiriro ezvinhu akajairika, zvakakosha kuzviongorora.

Tarisisa zvakanyanya kana ukaona zviratidzo zvakawanda zvichiitika pamwe chete, kunyanya kana zvichikanganisa mabasa ako ezuva nezuva. Semuenzaniso, kana uri kunzwa kuneta kwazvo uye uchitamburawo nemafodya akawanda kupfuura kazhinji, kana uri kutemwa nyore pamwe chete nekushaya mweya.

Usamirira kana ukawana chero zviratidzo zvinotyisa senge kuneta kwakanyanya kunoshaya kugadziriswa nekuzorora, kurasikirwa nehuremu pasina tsananguro, kana hutachiona hunoramba huripo kwenguva yakareba kupfuura zvavanofanira. Kuonekwa pakutanga nekurapwa kunogona kuita musiyano mukuru mukugadzirisa mamiriro aya zvinobudirira.

Yeuka, chiremba wako aripo kukubatsira kuona kuti chii chiri kuitika. Vanogona kuita bvunzo dzeropa dzakapusa dzinogona kupa ruzivo rwakakosha nezvehutano hwako hwese uye kana bvunzo dzakawanda dzichigona kudiwa.

Ndeapi njodzi dze hairy cell leukemia?

Kunzwisisa njodzi kunogona kubatsira kuisa mamiriro aya munzvimbo, kunyange zvakakosha kuziva kuti kuva nenjodzi hazvirevi kuti uchakura hairy cell leukemia. Vanhu vakawanda vane njodzi havazomboiti mamiriro aya.

Njodzi huru ndeyekuve murume uye ane makore akati wandei. Vanenge 80% vevanhu vanorwara ne hairy cell leukemia varume, uye avhareji yezera pakuonekwa kwayo iri pakati pemakore 50 kusvika ku 55. Zvisinei, inogona kuitikawo muvakuru vaduku kana vakuru vakuru.

Heano zvinhu zvikuru zvinogona kuwedzera njodzi yako:

• Kuve murume (kane mana kupfuura vakadzi)
• Zera riri pakati pemakore 40 ne 60
• Kuva weAshkenazi Jewish descent (njodzi yakakwirira zvishoma)
• Kuva nemhuri ine nhoroondo yekenza yeropa (kubatana kwakasiyana)

Kusiyana nekenza dzakawanda, hairy cell leukemia haionekwi yakabatana nezvinhu zvakatipoteredza, kurapwa kwekare kwekenza, kana kusarudzwa kwemaitiro ehupenyu. Izvi zvinogona kuva zvinonyaradza nekuti zvinoreva kuti zvimwe hapana chawaigona kuita kuti udzikise kubva kuitika.

Zvakakoshawo kucherechedza kuti hairy cell leukemia yakasiyana zvikuru, ichikanganisa vanhu vaviri chete pane vanhu 100,000. Kunyange kana uine njodzi dzakawanda, mikana yako yekuwana mamiriro aya inoramba iri shoma kwazvo.

Ndeapi matambudziko anogona kuitika e hairy cell leukemia?

Matambudziko mazhinji kubva ku hairy cell leukemia anokura zvishoma nezvishoma uye anogona kugadziriswa zvinobudirira ne kurapwa kwakakodzera. Kunetseka kukuru ndekwekuti masero asingawanzoonekwa anodzvinyirira masero eropa ane hutano, izvo zvinogona kukanganisa kugona kwemuviri wako kurwisa hutachiona uye kudzora kubuda ropa.

Matambudziko akajairika ndeyekuwanda kwenjodzi yehutachiona nekuti hauna masero machena eropa akakwana ekukudzivirira. Hutachiona uhwu hungatora nguva yakareba kubvisa kana kungava kwakakomba kupfuura kazhinji.

Heano matambudziko aunofanira kuziva:

• Hutachiona hwakawanda kana hwakakomba nekuda kwehuwandu hushoma hwe masero machena eropa
• Kubuda ropa nyore kana kutemwa nekuda kwehuwandu hushoma hwe platelets
• Anemia inokonzera kuneta nekushushikana
• Spleen yakakura inogona kukonzera kusagadzikana kwemudumbu
• Kuora kwemigwagwa yematumbu (fibrosis) mumamiriro ezvinhu asingawanzoitika
• Kenza dzinotevera, kunyange zvazvo izvi zvisingawanzoitika

Spleen yakakura yakajairika uye inoitika nekuti uyu nhengo inoshanda zvakanyanya ichiedza kubvisa masero asingawanzoonekwa. Kunyange zvazvo izvi zvingakonzera kusagadzikana, kazhinji zvinovandudzika zvikuru ne kurapwa.

Mashoko akanaka ndeawo kuti ne kurapwa kwazvino, matambudziko akakomba ari kuita asingawanzoitika. Vanhu vakawanda vane hairy cell leukemia vanogona kutarisira kurarama hupenyu hwavo hwese kana mamiriro avo akagadziriswa nechikwata chavo chekurapa.

Hairy cell leukemia inozwiwa sei?

Kuziva hairy cell leukemia kazhinji kunotanga ne bvunzo dzeropa dzinoratidza zvinhu zvisingawanzoitika, senge huwandu hushoma hwe masero eropa kana kuvapo kwemasero asingawanzoonekwa. Chiremba wako anogona kuraira bvunzo idzi kana uri kuona zviratidzo kana sechikamu chekuongorora hutano hwako zuva nezuva.

Nhanho huru yekuziva inosanganisira kuongorora masero eropa ako nemarrow emfupa pasi pe microscope. Nyanzvi yakadzidziswa inogona kuziva chitarisiko che "hairy" che aya asingawanzoonekwa B-lymphocytes, ndicho chikonzero mamiriro acho anonzi kudaro.

Heano zvinhu zvinosanganisirwa mukuongorora:

1. Kuverenga kwakakwana kweropa (CBC) kuongorora mazinga ese emasero eropa
2. Kuongorora ropa kuti uone maumbirwo nemaitiro emasero
3. Flow cytometry kuziva zviratidzo zvemasero chaiwo
4. Bone marrow biopsy kuongorora marudzi nehuwandu hwe masero
5. Genetic testing kutsvaga BRAF mutation
6. CT scan kuongorora nhengo dzakakura

Bone marrow biopsy inogona kunzwa ichitya, asi kazhinji inoitirwa se outpatient procedure ine local anesthesia. Vanhu vakawanda vanorondedzera izvi sekusagadzikana panzvimbo pekurwadziwa, uye inopa ruzivo rwakakosha pakuronga kurapwa kwako.

Kuwana kuongororwa kwakajeka kazhinji kunotora mazuva mashoma kusvika pavhiki kana bvunzo dzese dzapedzwa. Chikwata chako chekurapa chichakufambisa ne nhanho imwe neimwe uye kukutsanangurira zvavari kutsvaga, saka uchanzwisisa chaizvo zviri kuitika mukati mekuongorora.

Kurapa kwe hairy cell leukemia ndechii?

Kurapa kwe hairy cell leukemia kwavandudzwa zvikuru mumakore mashoma apfuura, uye vanhu vakawanda vanowana remission kwenguva refu ne kurapwa kwakapfava. Mashoko akanaka ndeawo kuti mamiriro aya kazhinji anoita zvakanaka pakurapwa, kunyange zvazvo kazhinji asingagoni kupora zvachose.

Hapana munhu wese anoda kurapwa pakarepo. Kana huwandu hwako hweropa hwakagadzikana uye hausi kuona zviratidzo, chiremba wako anogona kukurudzira kuongororwa zvakanyanya panzvimbo pekurapwa pakarepo. Nzira iyi, inonzi "watch and wait," inokubvumira kudzivisa zvinokonzerwa ne kurapwa kunze kwekunge zvave zvakakosha.

Kana kurapwa kuchidiwa, sarudzo dzakajairika uye dzinoshanda dzinosanganisira:

• Cladribine (2-CdA) - mushonga we chemotherapy unopiwa ne IV kana injection
• Pentostatin - imwe sarudzo ye chemotherapy ine kushanda kwakafanana
• Rituximab - kurapwa kunangwa kunorwisa zviratidzo zvemasero chaiwo
• Interferon alpha - inoshandiswa zvishoma asi ichiri kushanda kune vamwe vanhu
• BRAF inhibitors - mishonga mitsva yakatarwa yezviitiko zvinopesana
• Kubviswa kwe spleen (splenectomy) - kunodiwa zvishoma asi kunogona kubatsira vamwe vanhu

Cladribine kazhinji inofungwa seyakakosha kurapwa nekuti inotungamira ku remission yakazara muvanhu vanenge 85% mushure mekurapwa kwemukati. Kurapwa kunowanzo sanganisira infusions zuva nezuva kwemazuva manomwe, uye vanhu vakawanda vanoita zvakanaka kwazvo.

Kana kenza ikadzoka mushure mekurapwa kwekutanga, izvo zvinogona kuitika makore gare gare, kurapwa kwakafanana kazhinji kunoshanda zvakare. Vanhu vakawanda vanopfuura nekuita kurapwa nekudzoka, vachirarama hupenyu hwavo hwese, hwakazara pakati pekurapwa.

Ungagadzira sei hairy cell leukemia kumba?

Kutarisira hairy cell leukemia kumba kunotarisa pakutsigira hutano hwako hwese uye kushanda pedyo nechikwata chako chekurapa. Sezvo mamiriro aya achikanganisa sisitimu yako yekudzivirira, kutora matanho ekudzivirira hutachiona kunova kukosha kwazvo.

Kudya kudya kwakakwana kwakazara ne michero, miriwo, uye mapuroteni mashoma kunogona kubatsira kutsigira sisitimu yako yekudzivirira nemaitiro ako. Haudi kutevera chero kudya kwakakosha, asi kuisa pfungwa pakudya kwakakwana kunogona kukubatsira kunzwa zvakanaka panguva yekurapwa nekudzoreredzwa.

Heano matanho aunogona kutora ekutsigira hutano hwako:

• Geza maoko ako kazhinji uye zvakakwana
• Dzivisa mapoka panguva yechando nemafodya
• Tora jekiseni dzakakurudzirwa (asi dzivisa jekiseni mhenyu)
• Ramba wakanyorova uye udye zvokudya zvakakwana
• Zorora zvakakwana uye gadzira kushushikana
• Ita maekisesaizi zvinyoro nyoro sezvaunogona
• Tarisa zviratidzo zvehutachiona uye uzvizivisa nekukurumidza

Tarisisa mazinga ako esimba uye usazvidzvinyirire zvakanyanya pazuva raunonzwa kuneta. Vanhu vakawanda vanoona kuti mabasa akapfava senge kufamba, kushambira, kana yoga anobatsira kuchengetedza simba ravo nemanzwiro avo pasina kuisa mutoro wakanyanya pamusoro pavo.

Chengeta chinyorwa chezviratidzo zvese kana shanduko mukunzwa kwako, uye usambotya kubata chiremba wako nemibvunzo kana zvinetso. Vanoda kunzwa kubva kwauri nezve chimwe chinhu chidiki kupfuura kukumirira kusvika dambudziko riitwa rakakura.

Ungagadzirira sei kuenda kuchiremba?

Kuagadzirira kuenda kuchiremba kunogona kukubatsira kuita zvakanyanya panguva yako ne chiremba wako uye kuve nechokwadi chekuti mhinduro dzako dzose dzakapindurwa. Funga kunyora zviratidzo zvako, pavakatanga, uye zvinhu zvinoita kuti zvive nani kana zvakanyanya kuipa.

Uya ne rondedzero yemishonga yese, zvinowedzerwa, uye mavhitamini auri kutora, kusanganisira zvinhu zvinowanikwa pasina kuraira. Uyewo, unganidza chero rekodhi dzekurapa dzakakosha, kunyanya mhinduro dzebvunzo dzeropa dzapfuura kana uine.

Heano zvinhu zvaunofanira kugadzirira usati waenda:

• Rondedzero yakadzama yezviratidzo zvako uye pavanoitika
• Rondedzero yakakwana yemishonga kusanganisira madhoshi
• Nhoroondo yemhuri yekurapa, kunyanya kenza yeropa
• Rondedzero yemibvunzo yaunoda kubvunza
• Makadhi e inshuwaransi uye zvinyorwa
• Shamwari yakavimbika kana nhengo yemhuri yekutsigira

Mimwe mibvunzo yakakosha yaunogona kuda kubvunza inosanganisira bvunzo dzinoda kuitwa, zvinoreva mhinduro, sarudzo dzekurapa dziripo, uye zvekutarisira zvichienda mberi. Usazvidya mwoyo nezve kubvunza mibvunzo yakawanda - chikwata chako chekurapa chinoda kuti unzwisise mamiriro ako zvizere.

Funga kuuya nemunhu newe kuenda kuchiremba. Kuva nemunhu wechipiri kunogona kubatsira kana uri kugamuchira ruzivo rutsva rwakawanda, uye vanogona kupa rutsigiro rwemanzwiro panguva inogona kunzwa iri nguva yakaoma.

Chii chinonyanya kukosha nezve hairy cell leukemia?

Hairy cell leukemia rudzi rwakasiyana-siyana asi runorapika rerudzi rwekenza yeropa inowanzo kumera zvishoma nezvishoma uye inopindura zvakanaka pakurapwa kwazvino. Kunyange zvazvo kugamuchira chero kuongororwa kwekensa kunogona kunzwa kuchitya, mamiriro aya ane imwe yehuwandu hwakanaka hwekurapa pakati pekenza yeropa.

Vanhu vakawanda vane hairy cell leukemia vanogona kutarisira kurarama hupenyu hwavo hwese ne kurapwa kwakakodzera. Kurapwa kuripo nhasi kunoshanda kwazvo, uye vanhu vakawanda vanowana nguva refu yekudzoka mushure mekurapwa kwemukati.

Chinhu chakakosha chokuyeuka ndechekuti hausi wega mu rwendo urwu. Chikwata chako chekurapa chine ruzivo rwakawanda pakurapa mamiriro aya, uye kune kurapwa kwakakosha kuripo. Vanhu vakawanda vane hairy cell leukemia vanoramba vachishanda, vachifamba, uye vachifarira mabasa avo ezuva nezuva nekusagadzikana kwakaderera muhupenyu hwavo.

Isa pfungwa pakutora zvinhu nhanho nhanho, gara wakabatana nesimba rako rekutsigira, uye chengeta kutaurirana kwakavhurika nechikwata chako chekurapa. Nekurapa kwakakodzera nekuongororwa, pane chikonzero chekuva netariro nezve hutano hwako hwemangwana uye mhando yehupenyu.

Mibvunzo inobvunzwa kazhinji nezve hairy cell leukemia

Hairy cell leukemia inopfuudzwa here?

Hairy cell leukemia kazhinji haipfuudzirwe kubva kuvabereki vako. Kunyange zvazvo kungave kune njodzi yakakwirira zvishoma kana uine nhengo dzemhuri dzine kenza yeropa, zviitiko zvizhinji zvinoitika zvisingatarisirwi nekuda kwekusanduka kwemajini kunoitika panguva yehupenyu hwemunhu. Haugoni kupfuudza mamiriro aya kuvana vako kuburikidza nemajini ako.

Unogona kurarama kwenguva yakareba sei ne hairy cell leukemia?

Vanhu vakawanda vane hairy cell leukemia vane tarisiro yehupenyu yakajairika kana iri pedyo neyakajairika kana yakarapwa zvakanaka. Mamiriro aya anokura zvishoma nezvishoma, uye kurapwa kwazvino kunoshanda kwazvo. Vanhu vakawanda vanorarama kwemakore akawanda mushure mekuonekwa, uye vamwe vangangoda kurapwa kwemukati chete kuti vawane remission kwenguva refu inogara kwemakore mazhinji.

Hairy cell leukemia inogona kupora zvachose here?

Kunyangwe hairy cell leukemia kazhinji isingagoni kupora zvachose, inogona kudzorwa zvinobudirira kwenguva refu. Vanhu vakawanda vanowana remission yakazara ne kurapwa, zvinoreva kuti hapana masero asingawanzoonekwa anogona kuonekwa muropa ravo kana marrow emfupa. Kunyange kana mamiriro acho akadzokera makore gare gare, kazhinji anoita zvakanaka pakurapwa kwakafanana zvakare.

Remission inorevei ye hairy cell leukemia?

Remission inoreva kuti huwandu hwako hweropa hwadzoka kumazinga akajairika uye masero asingawanzoonekwa e hairy haachaonekwi muropa rako kana marrow emfupa. Remission yakazara hairevi kuti wakapora, asi zvinoreva kuti kurapwa kwave kukunda kwazvo. Vanhu vakawanda vanoramba vari mu remission kwemakore kana kunyange makore mazhinji pasina kudiwa kurapwa zvakare.

Kune chero zvirambidzo zve kudya ne hairy cell leukemia here?

Hapana zvirambidzo zve kudya zve hairy cell leukemia pachayo. Zvisinei, kana huwandu hwako hwe masero machena eropa hushoma, chiremba wako anogona kukurudzira kudzivisa zvokudya zvisina kubikwa zvakanaka zvinogona kuwedzera njodzi yehutachiona. Isa pfungwa pakudya kwakakwana, kwakazara kuti utsigire hutano hwako hwese nesimba rako rekudzivirira. Nguva dzose kurukura chero zvinetso zve kudya nechikwata chako chekurapa.