Dementia Yelewy Body
Pfupiso
Dementia yeLewy body ndiro rudzi rwechipiri rwakajairika rekuora kwepfungwa mushure mechirwere cheAlzheimer. Nzvimbo dzemapuroteni dzinonzi Lewy bodies dzinokura mune masero enhengo mudumbu. Nzvimbo dzemapuroteni dzinotapura nzvimbo dzehuropi dzinosanganisira kufunga, ndangariro nekuenda. Iyi mamiriro anozivikanwawo sekuora kwepfungwa neLewy bodies.
Dementia yeLewy body inokonzera kudzikira mukukwanisa kwepfungwa kunowedzera zvishoma nezvishoma nekufamba kwenguva. Vanhu vane dementia yeLewy body vangangoona zvinhu zvisiripo. Izvi zvinozivikanwa sekuona zvinhu zvisiripo. Vangavewo vane shanduko mukungwarira nekuteerera.
Vanhu vane dementia yeLewy body vangave vane zviratidzo zvechirwere cheParkinson. Aya maratidzo anogona kusanganisira minyoro yakaoma, kufamba kwakanyanya kunonoka, dambudziko rekuenda uye kukuya.
Zviratidzo
Zviratidzo zveLewy body dementia zvinogona kusanganisira:
- Kuona zvinhu zvisiripo. Kuona zvinhu zvisiripo, kunozivikanwa se hallucinations, kunogona kuva chimwe chezviratidzo zvekutanga zveLewy body dementia. Ichi chiratidzo chinowanzoitika nguva dzose. Vanhu vane Lewy body dementia vanogona kuona maumbirwo, mhuka kana vanhu vasipo. Hallucinations dzinosanganisira kurira, kunhuwa kana kubata zvinobvira.
- Matambudziko ekufamba. Zviratidzo zveParkinson's disease, zvinozivikanwa se parkinsonian signs, zvinogona kuitika. Aya maratidzo anosanganisira kufamba kwakaderera, tsandanyama dzakasimba, tremor kana kufamba kwakafanana nekutambanudza. Izvi zvinogona kukonzera munhu kuti awire.
- Matambudziko ekufunga. Vanhu vane Lewy body dementia vanogona kuva nematambudziko ekufunga akafanana neaAlzheimer's disease. Anogona kusanganisira kusagadzikana, kusakwanisa kunyatsoteerera, matambudziko ekuona-nzvimbo uye kurasikirwa nekuyeuka.
- Matambudziko ekurara. Vanhu vane Lewy body dementia vanogona kuva ne rapid eye movement (REM) sleep behavior disorder. Iyi chirwere chinoita kuti vanhu vaite zviroto zvavo vachirara. Vanhu vane REM sleep behavior disorder vanogona kurova, kukanda, kuchema kana kuchema vachirara.
- Kunyatsoteerera kwakasiyana-siyana. Zvikamu zvehope, nguva refu yekutarisa munzvimbo, hope refu masikati kana kutaura kusina kurongeka zvinobvira.
- Kusava nehanya. Kurasikirwa nehanya kunogona kuitika.
Zvinokonzera
Dementia yeLewy body inoratidzirwa nekuunganidzwa kwemaproteni kuita mapazi anozivikanwa seLewy bodies. Iyi puroteni inobatanidzwawo nechirwere cheParkinson. Vanhu vane Lewy bodies mhuuropi hwavo vanewo ma plaques nema tangles anobatanidzwa nechirwere cheAlzheimer.
Zvinhu zvinokonzera njodzi
Zvinhu zvishoma zvinoita kunge zvinosimudzira njodzi yekuwana Lewy body dementia, kusanganisira:
- Age (Zera). Vanhu vakwegura kupfuura makore 60 vari panjodzi yakakura.
- Sex (Bonde). Lewy body dementia inokanganisa varume vakawanda kupfuura vakadzi.
- Family history (Nhoroondo yemhuri). Avo vane nhengo yemhuri ine Lewy body dementia kana Parkinson's disease vari panjodzi yakakura.
Matambudziko
Dementia yeLewy body inokura zvishoma nezvishoma. Izvi zvinoreva kuti inowedzera kuipa nguva yose. Sezvo zviratidzo zvichiwedzera kuipa, Dementia yeLewy body inogona kukonzera:
- Dementia yakakomba.
- Ushamwari hunotyisa.
- Kuwedzera kwenjodzi yekuwa nekukuvara.
- Kuwedzera kwezviratidzo zveParkinson, sekuderera.
- Rufu, pakati nepakati makore anenge 7 kusvika ku8 mushure mekunge zviratidzo zvatanga.
Kuongorora
Vanhu vanorwara neLewy body dementia vanoderera zvishoma nezvishoma pakukwanisa kufunga. Vanewo zviratidzo zviviri kana kupfuura izvi zvinotevera:
- Kucherechedzwa kwekunzwa uye kushanda kwepfungwa kunochinja-chinja.
- Kuona zvinhu zvisiripo kakawanda.
- Zviratidzo zveParkinsonian.
- REM kurara kusagadzikana, umo vanhu vanoita zviroto zvavo pavanorara.
Kunzwisisika mishonga inorapira psychosis kunotsigirawo chirwere ichi. Izvi zvinonyanya kuitika pamishonga yakadai sehaloperidol (Haldol). Mishonga inorwisa psychosis haishandiswi kune vanhu vane Lewy body dementia nekuti inogona kuita kuti zviratidzo zviome.
Hapana bvunzo imwe chete inogona kuona Lewy body dementia. Kuongororwa kunobva pazviratidzo zvako uye nekubvisa mamiriro ekurapa mamwe. Bvunzo dzinogona kusanganisira:
Chiremba wenyu anogona kutarisa zviratidzo zveParkinson's chirwere, kurohwa neropa, zvipembenene kana mamwe mamiriro ekurapa anogona kukanganisa uropi uye basa remunhu. Kuongororwa kweneurological kunovhara:
- Reflexes.
- Simba.
- Kufamba.
- Tone yemhasuru.
- Kufamba kwemaziso.
- Kureruka.
- Kunzwa kubata.
Chikamu chiduku chebvunzo iyi, chinoongorora hunyanzvi hwemurangariro uye kufunga, chinogona kuitwa mumaminitsi asingasviki gumi. Bvunzo haina kazhinji kusiyanisa pakati peLewy body dementia neAlzheimer's chirwere. Asi bvunzo inogona kuona kana une kusagadzikana kwepfungwa. Bvunzo refu dzinotore maawa akawanda dzinopa rubatsiro pakutsvaga Lewy body dementia.
Izvi zvinogona kubvisa matambudziko emuviri anogona kukanganisa basa reuropi, sekushomeka kwevhitamini B-12 kana gland ye thyroid isina basa.
Chiremba wenyu anogona kuraira MRI kana CT scan kuti aone kurohwa neropa kana kubuda ropa uye kuti abvise tumor. Dementia inoororwa zvichienderana nehupenyu hwemishonga uye kuongororwa kwemuviri. Asi zvimwe zvinhu pane zvidzidzo zvekuona zvinogona kuratidza marudzi akasiyana eDementia, akadai seAlzheimer's kana Lewy body dementia.
Kana kuongororwa kuchishaya kana zviratidzo zvisiri zvemazuva ose, unogona kuda mamwe bvunzo dzekuona. Aya bvunzo dzekuona dzinogona kutsigira kuongororwa kweLewy body dementia:
- Fluorodeoxyglucose PET brain scans, dzinoongorora basa reuropi.
- Single-photon emission computerized tomography (SPECT) kana PET imaging. Aya bvunzo anogona kuratidza kuderedzwa kwe dopamine transporter uptake muuropi. Izvi zvinogona kubatsira kuona Lewy body dementia.
Mumativi mamwe, vanachiremba vezveutano vanogona kurairawo bvunzo yemoyo inonzi myocardial scintigraphy. Izvi zvinoongorora kuyerera kweropa kumoyo wako kuti uwane zviratidzo zveLewy body dementia. Zvisinei, bvunzo iyi haishandiswi kuUnited States.
Kutsvagisa kuri kuenderera mberi pane zvimwe zviratidzo zveLewy body dementia. Aya biomarkers anogona pakupedzisira kuita kuti kuongororwa kwekutanga kweLewy body dementia kuitike usati wasvika chirwere chacho chose.
Kurapa
Hakuna mushonga wekurapa chirwere cheLewy body dementia, asi zviratidzo zvizhinji zvinogona kuvanduka nekurapwa kwakaringana.
- Vachikanganisi veCholinesterase. Mishonga iyi yeAlzheimer's chirwere inoshanda nekukwidziridza mazinga emessengers emakemikari mubongo, inozivikanwa se neurotransmitters. Aya makemikari messengers anotendwa kuva akakosha yekurangarira, kufunga nekutonga. Anosanganisira rivastigmine (Exelon), donepezil (Aricept, Adlarity) uye galantamine (Razadyne ER). Mishonga iyi inogona kubatsira kuvandudza kucherechedza nekufunga. Inogona kuderedzawo hallucinations nezvimwe zviratidzo zvemaitiro.
Zvinogona kuva nezvinetso zvinosanganisira kurwadziwa kwemudumbu, marwadzo emhasuru uye kuenda kunzvimbo kazhinji. Inogonawo kuwedzera njodzi yekusagadzikana kwemoyo.
Pavanhu vamwe vane dementia yakanyanya kana yakakomba, mushonga unonzi N-methyl-d-aspartate (NMDA) receptor antagonist anonzi memantine (Namenda) ungawedzerwa kumushonga wecholinesterase.
- Mishonga yeParkinson's chirwere. Mishonga yakadai se carbidopa-levodopa (Sinemet, Duopa, nezvimwe) inogona kubatsira kuderedza tsandanyama dzakasimba nekufamba kwakaderera. Zvisinei, mishonga iyi inogonawo kuwedzera kusagadzikana, hallucinations uye mazano asina kururama.
- Mishonga yekurapa zvimwe zviratidzo. Chiremba wenyu anganyorera mishonga yekurapa zvimwe zviratidzo, sekushaya hope kana matambudziko ekufamba.
Vachikanganisi veCholinesterase. Mishonga iyi yeAlzheimer's chirwere inoshanda nekukwidziridza mazinga emessengers emakemikari mubongo, inozivikanwa se neurotransmitters. Aya makemikari messengers anotendwa kuva akakosha yekurangarira, kufunga nekutonga. Anosanganisira rivastigmine (Exelon), donepezil (Aricept, Adlarity) uye galantamine (Razadyne ER). Mishonga iyi inogona kubatsira kuvandudza kucherechedza nekufunga. Inogona kuderedzawo hallucinations nezvimwe zviratidzo zvemaitiro.
Zvinogona kuva nezvinetso zvinosanganisira kurwadziwa kwemudumbu, marwadzo emhasuru uye kuenda kunzvimbo kazhinji. Inogonawo kuwedzera njodzi yekusagadzikana kwemoyo.
Pavanhu vamwe vane dementia yakanyanya kana yakakomba, mushonga unonzi N-methyl-d-aspartate (NMDA) receptor antagonist anonzi memantine (Namenda) ungawedzerwa kumushonga wecholinesterase.
Mishonga yakati wandei inogona kuipa kurangarira. Usatore mishonga yekurara ine diphenhydramine (Advil PM, Aleve PM). Usatorewo mishonga inoshandiswa kurapa kuenda kunzvimbo kazhinji senge oxybutynin (Ditropan XL. Gelnique, Oxytrol).
Deredza mishonga inorara uye mishonga yekurara. Taura nachiremba nezvekuti mishonga ipi yaunotora inogona kuipa kurangarira kwako.
Mishonga yeAntipsychotic inogona kukonzera kusagadzikana kwakanyanya, parkinsonism yakanyanya, kurara uye dzimwe nguva rufu. Zvishoma chaizvo, mishonga yakati wandei yeantipsychotic yezvizvarwa zviviri, senge quetiapine (Seroquel) kana clozapine (Clozaril, Versacloz) inogona kunyorerwa kwenguva pfupi pane dose yakaderera. Asi inopiwa chete kana mabhenefiti akakura kupfuura njodzi.
Mishonga yeAntipsychotic inogona kuipa zviratidzo zveLewy body dementia. Zvingabatsira kutanga kuedza nzira dzakasiyana, dzakadai se:
- Kutsungirira maitiro acho. Vamwe vanhu vane Lewy body dementia havazvidzivirire ne hallucinations. Kana izvi zviri zvechokwadi, zvinetso zve mushonga zvinogona kuva zvakanyanya kupfuura hallucinations pachayo.
- Kuchinja nharaunda. Kuderedza zvinhu zvakawanda uye ruzha kunogona kuita kuti zvive nyore kune munhu ane dementia kushanda. Mhinduro dzevarapi dzimwe nguva dzinowedzera maitiro. Dzivisa kugadzirisa uye kubvunza munhu ane dementia. Paa nyaradzo uye bvumira zvaanofunga.
- Kuita maitiro ezuva nezuva uye kuchengeta mabasa ari nyore. Parai mabasa mune matanho ari nyore uye tarisa pakubudirira, kwete kukundikana. Kuronga uye maitiro zuva nezuva kunogona kusava nekusagadzikana.
Chiziviso: August ipuratifomu yemashoko ehutano uye mhinduro dzayo haisi zano rekurapa. Gara uchibvunza nyanzvi yezvekurapa ine rezinesi pedyo newe usati waita chero shanduko.
Yakagadzirwa muIndia, kune nyika