Chii Chinonzi Multiple System Atrophy? Zviratidzo, Zvinokonzera, & Kurapa

Multiple system atrophy (MSA) chirwere chisingawanzoitika cheuropathology chinotapura masystem akawanda emuviri panguva imwe chete. Inoitika kana masero ataura anoita basa rekufamba, kuenzanisa, uye mabasa omuviri asingadi kufunga achitanga kuparara zvishoma nezvishoma voita basa ravo zvakanaka.

Ichi chirwere chinowedzera zvishoma nezvishoma, zvinoreva kuti chinoipisisa nguva yose. Kunyange zvazvo MSA ichifanana neParkinson's disease, inotapura nzvimbo dzakawanda dzehuropi panguva imwe chete uye inowanzo kuwedzera nekukurumidza. Kunzwisisa MSA kunogona kukubatsira kuziva zviratidzo zvaro uye kuziva nguva yekutsvaka rubatsiro rwechiremba.

Chii Chinonzi Multiple System Atrophy?

Multiple system atrophy chirwere chinoparadza masero ehuropi chinotapura vanhu vakuru vane makore anopfuura 50. Zita rayo rinotsanangura chaizvo zvinoitika - masystem akawanda emuviri anorega kushanda zvakanaka nekuda kwekuvadzwa kwemasero ehuropi.

Uropi hwako hune masero chaiwo anoita protein inonzi alpha-synuclein. MuMSA, iyi protein inoumbwa nenzira isina kunaka uye inokuvadza masero anoita basa rekufamba, kuenzanisa, kumanikidza kweropa, uye mamwe mabasa omuviri asingadi kufunga senge kufema nekudya.

Kune marudzi maviri makuru eMSA. Rudzi rwekutanga runotapura zvikuru kufamba uye runonzi MSA-P (P inomiririra parkinsonian features). Rudzi rwechipiri runotapura zvikuru kuenzanisa nekubatana uye runonzi MSA-C (C inomiririra cerebellar features).

MSA inotapura vanhu vanenge 4 pavagumi ve100,000. Kunyange zvazvo ichifungwa kuti haina kujairika, kuwana chirwere chaicho kwakakosha nekuti kurapwa kunogona kubatsira kudzora zviratidzo uye kuvandudza hupenyu.

Ndeapi Marudzi eMultiple System Atrophy?

MSA ine mafomu maviri makuru, imwe neimwe inotapura zvikamu zvakasiyana zvehuropi nemuviri wako. Kunzwisisa marudzi aya kunobatsira vanachiremba kupa rubatsiro rwakanaka uye kunobatsira iwe kuziva zvaunofanira kutarisira.

MSA-P (Parkinsonian type) inotapura nzvimbo dzehuropi dzinoita basa rekufamba. Ungacherechedza kufamba kuri nyore, kuoma kwemisungo, kudedera, uye kuoma nekuenzanisa. Rudzi urwu runogona kutaridzika zvakafanana neParkinson's disease pakutanga.

MSA-C (Cerebellar type) inokuvadza zvikuru cerebellum, nzvimbo yehuropi inotarisira kubatana nekuenzanisa. Vanhu vane rudzi urwu vanowanzoratidza kufamba kusina kusimba, kuoma nekuita zvinhu zvakarurama, uye matambudziko ekukurukura.

Vamwe vanhu vane zviratidzo zvemarudzi maviri, izvo zvinogona kuita kuti kuwana chirwere kuve kwakaoma. Chiremba wako achaongorora zviratidzo zvako zvakakosha kuti azive rudzi rwawakaita uye agadzire chirongwa chekurapa chakanaka chakakodzera mamiriro ako.

Ndeapi Zviratidzo zveMultiple System Atrophy?

Zviratidzo zveMSA zvinoonekwa zvishoma nezvishoma uye zvinogona kusiyana zvikuru kubva kune munhu kune mumwe. Zviratidzo zvepakutanga zvinowanzova zvishoma uye zvinogona kufungidzirwa sekuchembera kwakajairika kana mamwe mamiriro.

Zviratidzo zvepakutanga zvinowanzoitika zvinosanganisira:

• Kuora musoro pakumira (nekuda kwekuchinja kwekumanikidza kweropa)
• Kunetseka nekuenzanisa nekubatana
• Kufamba kuri nyore, misungo yakaoma
• Kuchinja mukutaura, kusanganisira kutaura kwakaoma kana kuri nyore
• Matambudziko emukati, senge kunetseka kana kuoma kubvisa zvakakwana
• Matambudziko ekurara, kunyanya kuita zviroto

Sezvo MSA ichikura, ungawana zvimwe zviratidzo. Izvi zvinogona kusanganisira kuoma kwemisungo, kudedera kunoitika pakuzorora, kuoma kukurira, uye matambudziko ekudzora tembiricha yemuviri.

Vamwe vanhu vanonzwawo kuoma kufema, kunyanya panguva yekurara. Kuchinja muhunyanzvi hwezwi, senge kutaura kwakapfava kana kwakanyanya, zvakajairika sezvo mamiriro acho achikura.

Zviratidzo zvisingawanzoitika asi zvakakomba zvinogona kusanganisira kudonha kwakanyanya kwekumanikidza kweropa, kuoma kufema, uye matambudziko ekudzora tembiricha yemuviri. Izvi zviratidzo zvinoda rubatsiro rwechiremba nekukurumidza kana zvikaitika.

Chii Chinokonzera Multiple System Atrophy?

Chikonzero chaicho cheMSA hachizivikanwi, asi vatsvakurudzi vakawana zvinhu zvakakosha zvakati wandei. Mamiriro acho anoita kunge ari mugumisiro wekusanganiswa kwekushaya simba kwemajini nekuita kwemhuka dzakapoteredza.

Dambudziko guru muMSA rinobatanidza protein inonzi alpha-synuclein. Kazhinji, iyi protein inobatsira masero enerve kushanda zvakanaka. MuMSA, protein inotanga kuita basa rakaipa uye inoungana mune masero ehuropi, pakupedzisira ichikonzeresa kuti afe.

Zvinhu zvemajini zvinogona kutamba basa, kunyange zvazvo MSA isiri nhaka zvakananga senge mamwe mamiriro. Vanyanzvi vakawana shanduko dzemajini dzinoita kuti vamwe vanhu vave panjodzi yakakura, asi kuva nezvishanduko izvi hazvirevi kuti uchave neMSA.

Zvinhu zvakapoteredza zviri kuongororwawo. Vamwe vatsvakurudzi vari kutsvaga kana kuiswa kune zvinhu zvine chepfu, zvirwere, kana zvimwe zvinhu zvakapoteredza zvingakonzera kukura kweMSA muvanhu vane njodzi nekuda kwemajini avo.

Zera ndiro njodzi huru inozivikanwa. MSA inowanzoitika muvanhu vane makore ari pakati pe50 ne70, neavhareji yezera rekutanga iri makore anenge 60.

Rini Unofanira Kuona Chiremba nekuda kweMultiple System Atrophy?

Unofanira kubata chiremba wako kana ukaona matambudziko asingaperi ekufamba, kuenzanisa, kana kudzora kumanikidza kweropa. Kuongororwa nekukurumidza kwakakosha nekuti kuwana chirwere nekukurumidza kunogona kutungamira pakudzora zviratidzo zvakanaka.

Tsvaka rubatsiro rwechiremba kana ukaona kuora musoro kazhinji pakumira, kudonha kusina tsananguro, kana kuchinja kukuru mufamba rako kana kubatana. Izvi zviratidzo zvinogona kuratidza MSA kana mamwe mamiriro akakomba anoda kuongororwa nemunyanzvi.

Fonera chiremba wako nekukurumidza kana ukawana matambudziko akakomba ekufuha, kuchinja kukuru kwekumanikidza kweropa, kana kuipisisa kwakapfupi kwezviratidzo zvehuropi. Izvi zvinogona kuva zviratidzo zvematambudziko akakomba anoda rubatsiro rwekukurumidza.

Usamirira kana uri kunetseka kukurira kana kufema panguva yekurara. Izvi zviratidzo zvinogona kuva ngozi uye zvinoda kuongororwa nechiremba nekukurumidza kudzivirira matambudziko senge kukwakuka kana matambudziko ekufuha panguva yekurara.

Ndeapi Njodzi dzeMultiple System Atrophy?

Zvinhu zvakati wandei zvinogona kuwedzera mukana wako wekuwana MSA, kunyange zvazvo kuva nenjodzi hazvirevi kuti uchave nechinetso ichocho. Kunzwisisa zvinhu izvi kunogona kukubatsira kuramba uchiri pakati pezviratidzo zvepakutanga.

Zera ndiro njodzi huru. MSA inowanzotapura vanhu vakuru vane makore anopfuura 50, nemazhinji acho achiitika pakati pemakore 55 ne75. Njodzi inowedzera nezera rinowedzera munzvimbo iyi.

Rudzi rwunotamba basa, nevarume vane mukana wakakura wekuwana MSA kupfuura vakadzi. Nekudaro, musiyano wacho wakaderera, uye varume nevakadzi vose vanogona kutapurwa.

Zvimwe zvinhu zvemajini zvinogona kuwedzera njodzi yeMSA. Kunyange zvazvo mamiriro acho asingawanikwi zvakananga, kuva nezvimwe zvinhu zvemajini zvinogona kukugadzirira kuti uwane MSA kana ukaiswa kune zvinhu zvakapoteredza.

Kuita basa kana kuiswa kune zvinhu zvakapoteredza kuri kuongororwa senzvimbo dzenjodzi. Vamwe vatsvakurudzi vanofunga kuti kuiswa kune zvimwe zvinhu zvine chepfu kana zvinhu zvine chepfu zvinogona kuwedzera njodzi, asi ukama uhwu hahuzivikanwi zvizere.

Ndeapi Matambudziko Anogona Kuitika eMultiple System Atrophy?

MSA inogona kutungamira kune matambudziko akakomba akawanda sezvo ichikura, asi kunzwisisa mikana iyi kunobatsira iwe nechikwata chako chehutano kugadzirira uye kudzora zvinhu zvakanaka.

Matambudziko emwoyo ndiwo matambudziko akajairika uye akakomba. Kudonha kwakanyanya kwekumanikidza kweropa pakumira kunogona kukonzera kudonha nekuvadzwa. Vamwe vanhu vanogonawo kuva nekutambudzika kwemwoyo kana mamwe matambudziko emwoyo.

Kunetseka kufema kunogona kuva kukuru sezvo MSA ichikura. Ungawana sleep apnea, uko kufema kunomira kwenguva pfupi panguva yekurara, kana kunetseka kufema panguva yekumuka. Matambudziko aya anogona kuva ngozi kana asingadzorwi zvakanaka.

Matambudziko ekukurira (dysphagia) anogona kukura, achiwedzera njodzi yekukwakuka kana kupinza chikafu mumapapu. Izvi zvinogona kutungamira ku pneumonia, iyo iri dambudziko rakakomba rinoda kurapwa nekukurumidza.

Matambudziko ekufamba anosanganisira kuwedzera njodzi yekudonha nekuda kwekushaya kuenzanisa nekuoma kwemisungo. Kudonha kunogona kutungamira pakuputsika, kukuvara kwemusoro, uye mamwe kukuvara akakomba anogona kukanganisa hupenyu zvakanyanya.

Matambudziko asingawanzoitika asi akakomba anogona kusanganisira autonomic dysfunction yakakomba, uko muviri wako unorasikirwa nekudzora mabasa ekutanga senge kumanikidza kweropa, kuzunguza kwemwoyo, nekufema. Matambudziko emukati nemabhawa anogonawo kuva akakomba, dzimwe nguva achida kuvhiya.

MSA Inozwiwa Sei?

Kuziva MSA kunoda kuongororwa kwakanyatsojeka ne neurologist ane hunyanzvi mune zvirwere zvekutambudzika. Hapana bvunzo imwe chete inogona kuziva MSA zvakajeka, saka vanachiremba vanoshandisa nzira dzakasiyana-siyana.

Chiremba wako anotanga ne nhoroondo yakakwana yezvokurapa nekuongororwa kwemuviri. Vachabvunza nezvezviratidzo zvako, pavakatanga, uye maitiro avo akakurira. Kuongororwa kwemuviri kunotarisa pakuyedza kufamba kwako, kuenzanisa, reflexes, uye mabasa e autonomic.

Kuongororwa kwehuropi kwakakosha pakuzivisa chirwere. MRI scans inogona kuratidza kuchinja kwakakosha mune zvimiro zvehuropi izvo zvinotsigira chirwere cheMSA. Izvi scans zvinogonawo kubatsira kubvisa mamwe mamiriro anogona kukonzera zviratidzo zvakafanana.

Autonomic function tests inoyera kuti system yako inodzora sei mabasa emuviri asingadi kufunga. Izvi zvinogona kusanganisira bvunzo dzinotarisa mhinduro yekumanikidza kweropa pakumira kana bvunzo dzekufema dzinotarisa matambudziko ekufuha panguva yekurara.

Dzimwe nguva vanachiremba vanoshandisa kurapwa kwelevodopa (murapi weParkinson's) kubatsira kusiyanisa MSA kubva kuParkinson's disease. Vanhu vane MSA vanowanzoita shanduko shoma kana kuti hapana neichi mushonga, nepo avo vane Parkinson's vanowanzoita zvakanaka.

Muimwe nguva, vanachiremba vanogona kukurudzira bvunzo dzakakosha senge DaTscan (inotarisa basa re dopamine muhuropi) kana autonomic testing kuti vawane mifananidzo yakajeka yemiriro yako.

Kurapa kweMultiple System Atrophy

Kunyangwe pasina mushonga weMSA ikozvino, kurapwa kwakasiyana-siyana kunogona kubatsira kudzora zviratidzo uye kuvandudza hupenyu hwako. Chinhu chikuru ndechekushanda nechikwata chehutano chakanyatsojeka kuti utarise chimwe nechimwe chezviratidzo.

Zviratidzo zvekutambudzika zvinowanzo kurapwa nemishonga yakafanana neinoshandiswa yeParkinson's disease. Levodopa/carbidopa inogona kupa rubatsiro rwakati, kunyange zvazvo mhinduro yacho yakaderera zvikuru kana ichienzaniswa neParkinson's disease. Chiremba wako anogonawo kuyedza mishonga yakaita seamantadine kana dopamine agonists.

Matambudziko ekumanikidza kweropa anoda kudzorwa zvakanaka nemishonga nezviito zveupenyu. Fludrocortisone inogona kubatsira kuwedzera kumanikidza kweropa, nepo compression stockings nekuwedzera munyu zvinogonawo kukurudzirwa kudzivirira kudonha kunotyisa pakumira.

Physical therapy yakakosha pakuchengetedza kufamba uye kudzivirira kudonha. Physical therapist ane hunyanzvi anogona kukudzidzisa maekisesaizi ekuvandudza kuenzanisa, simba, uye kubatana uchikuratidza nzira dzakachengeteka dzekutambudzika nekufamba.

Speech therapy inobatsira kugadzirisa matambudziko ekukurukura nekukurira. Speech-language pathologists vanogona kudzidzisa nzira dzekuvandudza kujeka kwekutaura uye nzira dzakachengeteka dzekukurira kudzivirira kukwakuka.

Kune matambudziko ekufuha, chiremba wako anogona kukurudzira CPAP machine ye sleep apnea kana mamwe maturusi ekutsigira kufema. Muzviitiko zvakakomba, rutsigiro rwakakomba rwekufema runogona kudikanwa.

Dysfunction yemukati inowanzodikanwa mishonga senge oxybutynin ye overactive bladder kana mamwe kurapwa zvichienderana nezviratidzo zvako. Vamwe vanhu vanogona kudikanwa intermittent catheterization kubvisa mukati zvakakwana.

Nzira Yekurapa Kumba Panguva yeMultiple System Atrophy

Kudzorwa kweMSA kumba kunosanganisira kugadzira nzvimbo yakachengeteka uye kutevera mazano anokubatsira kuchengetedza kuzvimiririra uchichengetedzeka. Kuchinja duku kunogona kuita musiyano mukuru mukunyaradza kwako kwezuva nezuva nekuchengetedzeka.

Kudzivirira kudonha kwakakosha mune zvaunogadzira kumba. Bvisa makarpeti asina kusimba, ita shuwa kuti kune chiedza chakanaka mumba mako, uye isa grab bars mumabhafu. Funga kushandisa chigaro chekushambira nemamats anodzivirira kudonha mubhafu.

Kudzorwa kwekumanikidza kweropa kunoda kuchinja kwemaitiro ehupenyu. Simuka zvishoma nezvishoma kubva pakurara kana kugara, gara wakanyatsoguta mvura, uye pfeka compression stockings kana chiremba wako akakurudzira. Chengetera chigaro pedyo kana wakamira kwenguva yakareba.

Kuchinja kudya kunogona kubatsira nekuoma kukurira. Tora zvidimbu zviduku, chewa zvakanaka, uye dzivisa zvikafu zvakaoma kukurira. Kugara wakamira panguva yekudya neminiti makumi matatu mushure mekudya kunogona kudzivirira kukwakuka.

Kurara kunova kwakakosha zvikuru neMSA. Shandisa matresi akasimba, funga nezve hospital bed kana kusimuka nekudzika kuchiva kuoma, uye tevera mazano echiremba wako ekurapa sleep apnea kana zvichidikanwa.

Rambai muchiita maekisesaizi akapfava, kufamba, nezviitiko zvamunofarira. Kufamba kazhinji kunobatsira kuchengetedza simba remisungo uye kunogona kuvandudza manzwiro nehupenyu hwese.

Nzira Yaungagadzirira Nayo Kuona Chiremba

Kugadzirira zvakanaka kuenda kuona chiremba kunobatsira kuve nechokwadi chekuti unowana zvakanakira nguva yako nechikwata chehutano. Kugadzirira zvakanaka kunotungamira pakukurukurirana kwakanaka nekurapwa kwakanyanya kushanda.

Chengeta bhuku rezviratidzo zvako kwevhiki rimwe usati waenda kuona chiremba. Nyora nguva zviratidzo zvinoitika, zvawaiita, uye kuti zvakakomba sei. Ruzivo urwu runobatsira chiremba wako kunzwisisa maitiro uye kugadzirisa kurapwa zvakakodzera.

Uya ne rondedzero yakakwana yemishonga yose, zvinowedzerwa, nemavhitamini aunotora, kusanganisira zviyero nenguva. Uyawo nemagwaro ezvokurapa kubva kune vamwe vanachiremba kana migumisiro yebvunzo dzichangobva kuitwa dzichiremba wako angave asina.

Nyora mibvunzo yako usati waenda kuona chiremba kuti usakanganwa zvinhu zvakakosha. Rangarira mibvunzo yako yakakosha kana nguva ikasara shoma panguva yekushanya.

Funga kuuya nemhuri kana shamwari kuti ikubatsire kuyeuka ruzivo rwakakurukurwa uye kupa rutsigiro. Vanogonawo kubatsira kurondedzera kuchinja kwavanonzwa kwaungave usingazivi.

Gadzirira kukurukura maitiro ezviratidzo zvako zvinotapura mabasa ako ezuva nezuva. Taura zvakajeka nezvezvinhu zvakava zvakaoma uye mazano awakamboedza kudzora matambudziko.

Chinhu Chikuru Chekuziva nezveMultiple System Atrophy

Multiple system atrophy chirwere chakakomba asi chinogona kudzorwa kana uine chikwata chekurapa chakanaka uye system yekutsigira. Kunyange zvazvo MSA ichikura zvishoma nezvishoma, vanhu vakawanda vanorarama hupenyu hunofadza kwemakore mazhinji mushure mekuwana chirwere ne kurapwa kwakakodzera nekutarisirwa.

Kuziva chirwere nekukurumidza nekurapwa kunogona kuvandudza hupenyu hwako zvikuru uye kubatsira kudzivirira matambudziko. Usanetseka kutsvaka rubatsiro rwechiremba kana ukaona zviratidzo zvinokunetsa, kunyanya matambudziko ekufamba, kuenzanisa, kana kumanikidza kweropa.

Yeuka kuti MSA inotapura munhu wese zvakasiyana, uye ruzivo rwako runogona kusiyana zvakanyanya nezvamwe vanhu vanorondedzera. Tarisa pakushanda nechikwata chako chehutano kuti utarise zviratidzo zvako zvakakosha uye kuchengetedza kuzvimiririra kwako sezvinobvira.

Rutsigiro kubva kumhuri, shamwari, neMSA support groups zvinogona kukosha. Vanhu vakawanda vanoona kuti kubatana nevamwe vanonzwisisa mamiriro acho kunopa rutsigiro rwepfungwa nezano rinobatsira pazvinetso zvezuva nezuva.

Mibvunzo InowanzoBvunzwa nezveMultiple System Atrophy

Unogona kurarama kwenguva yakareba sei nemultiple system atrophy?

Kukura kweMSA kunosiyana zvikuru kubva kune munhu kune mumwe, asi vanhu vakawanda vanorarama makore 6-10 mushure mekuwana chirwere. Vamwe vanhu vane kukura kuri nyore uye vanogona kurarama kwenguva yakareba, nepo vamwe vanogona kuona kuchinja kukurumidza. Hupenyu hwakanaka nekudzora zviratidzo zvinowanzova zvinhu zvakakosha kupfuura nguva yekurarama, uye vanhu vakawanda vanoramba vachifarira mabasa anoremekedzwa nehukama mukufamba kwavo neMSA.

Multiple system atrophy inhaka here?

MSA haisi nhaka zvakananga senge mamwe marudzi ezvirwere, saka haina kujairika mumhuri. Nekudaro, vatsvakurudzi vakawana kuti shanduko dzakati dzemajini dzinogona kuita kuti vamwe vanhu vave panjodzi yakakura yekuwana MSA kana vakasangana nezvinhu zvakapoteredza. Kuva nemhuri ine MSA hakuwedzeri njodzi yako yekuwana mamiriro acho.

Multiple system atrophy inogona kudzivirirwa here?

Ikozvino, hapana nzira inozivikanwa yekudzivirira MSA nekuti hatinzwisisi zvachose zvinokonzera. Sezvo zera riri njodzi huru uye mamiriro acho anoita kunge ari mugumisiro wekusanganiswa kwezvinhu zvemajini nezvakapoteredza, mazano ekudzivirira haasi akasimbiswa. Kuchengetedza hutano hwese nekuita maekisesaizi nguva dzose, kudya kwakanaka, uye kudzivirira zvinhu zvine chepfu zvinogona kuva zvakanaka kune hutano hwemuviri wose, asi izvi hazvina kuratidzwa kuti zvinodzivirira MSA chaiyo.

MSA inosiyana sei neParkinson's disease?

Kunyangwe MSA neParkinson's disease zvichishandisa zviratidzo zvakafanana, zviri zvirwere zvakasiyana. MSA inowanzo kukura nekukurumidza uye inotapura masystem akawanda emuviri panguva imwe chete, kusanganisira kudzora kumanikidza kweropa, kufema, uye basa remukati. Vanhu vane MSA vanowanzoita shanduko shoma kana kuti hapana nemushonga welevodopa, uyo anowanzo kubatsira vanhu vane Parkinson's disease. MSA inowanzoita matambudziko makuru ekuenzanisa ne autonomic dysfunction kana ichienzaniswa neParkinson's disease.

Ndinofanira kuitei kana ndichitya kuti ndine MSA?

Kana uri kuona zviratidzo zvinokunetsa, ronga kuona chiremba wako wekutanga. Vanogona kuongorora zviratidzo zvako uye kukutumira kune neurologist kana zvichidikanwa. Usazviedza kuzvizivisa chirwere, sezvo mamiriro akawanda anogona kukonzera zviratidzo zvakafanana. Chengeta zviratidzo zvako, nguva yavanouya, uye maitiro avo anokanganisa mabasa ako ezuva nezuva. Kuongororwa nekukurumidza kwakakosha nekuti kuziva chirwere nekurapwa kwakakodzera kunogona kubatsira kudzora zviratidzo uye kuvandudza hupenyu hwako.