Paraganglioma

Paraganglioma chirwere chinokura chema cell chinogona kuitika munzvimbo dzakasiyana siyana mumuviri. Kukura uku, kunonzi tumor, kunoumbwa kubva kumhando inokosha yemasero anetaura anowanikwa mumuviri wose. Paragangliomas kazhinji kazhinji anotanga kumusoro, mutsipa, mudumbu kana mu pelvis.

Paraganglioma isingawanzoitika. Uye kazhinji kazhinji, haisi cancer. Kana tumor isiri cancer, inonzi benign. Dzimwe nguva paraganglioma inenge iri cancer. Tumor ine cancer inogona kupararira kune dzimwe nharaunda dzemuviri.

Paragangliomas kazhinji haina chikonzero chakajeka. Mamwe paragangliomas anokonzerwa nekuchinja kweDNA kunopfuudzwa kubva kuvabereki kuenda kuvana.

Paragangliomas inogona kuumbwa pazera ripi neripi. Vanachiremba kazhinji vanoawana muvakuru vane makore ari pakati pemakore 20 ne 50.

Kurapwa kweParaganglioma kazhinji kunosanganisira kuvhiya kubvisa tumor. Kana paraganglioma iri cancer uye ikapararira kune dzimwe nzvimbo dzemuviri, kurapwa kuwedzerwa kunogona kudiwa.

Zviratidzo zveParaganglioma zvinogona kuenderana nekuti ganda rinotanga kupi. Paragangliomas kazhinji kazhinji anotanga kumusoro, mutsipa, nzvimbo yemudumbu kana pelvis. Zviratidzo zveparaganglioma mumusoro kana mutsipa zvinogona kusanganisira: Inzwi rinopfugama kana rinopfugama mumakumbo, rinonzi pulsatile tinnitus. Kunetseka kumeza. Inzwi rakapfava. Kurasikirwa kunzwa. Kuona kusapfava. Kuwedzera. Zviratidzo zveparaganglioma mumusoro nemutsipa zvinogona kuitika sezvo ganda richikura. Ganda rinogona kudzvanya pazvinhu zviri pedyo. Kana paragangliomas ichikura kune dzimwe nzvimbo mumuviri, zviratidzo zvinowanzo konzerwa nemahomoni anoita paraganglioma. Mahomoni, anonzi catecholamines, ane basa mukuita kwemuviri kune kushushikana. Anosanganisira adrenaline, inozivikanwawo sehomoni yehondo-kana-kubhururuka. Zviratidzo zveparagangliomas dzinoita mahomoni zvinosanganisira: BP yakakwira. Manzwiro ekukurumidza kurova, kuzunguza kana kurova kwemoyo. Kurasikirwa kamwe kamwe kwevara pachiso. Kupererwa. Kurwadziwa kwemusoro. Kuzunguza kusina kudzorwa mumaoko kana mumaoko. Kushaya simba kwakajairika. Aya maratidzo anogona kuuya nekufamba. Vamwe vanhu vane paragangliomas havafaniri kuva nezviratidzo. Vanogona kudzidza kuti vane aya ganda kana bvunzo dzekuongorora dzakaitwa nezvimwe zvikonzero zvichiitika kuti zviwane ganda. Ita musangano nachiremba kana mumwe mushandi wehutano kana iwe uchitya kuti ungave nezviratidzo zveparaganglioma. Izvi zvakakosha kana iwe uine zviratidzo zvakawanda zveparaganglioma panguva imwe chete. Taura nemushandi wehutano nezve njodzi yako yeParaganglioma kana iwe uine BP yakakwira iyo yakaoma kudzora. Izvi zvinosanganisira BP yakakwira inoda kurapwa nemishonga yakawanda. Uyewo taura nemushandi wehutano kana BP yako ikakwira nguva nenguva kana iwe kana mushandi wehutano achiiyera.

Enda kuonana nachiremba kana mumwe munyanzvi wehutano kana iwe uchitya kuti ungave uine zviratidzo zveparaganglioma. Izvi zvakakosha kana iwe uine zviratidzo zvakawanda zveparaganglioma panguva imwe chete. Taura nachiremba wako nezve njodzi yako ye paraganglioma kana iwe uine BP yakakwirira iyo yakaoma kudzora. Izvi zvinosanganisira BP yakakwirira inoda kurapwa nemishonga yakawanda kupfuura imwe. Uyewo taura nachiremba wako kana BP yako ikakwira nguva nenguva kana iwe kana munyanzvi wehutano achiiyera.

Paragangliomas kazhinji haina chikonzero chakajeka. Dzimwe nguva zvironda izvi zvinomhanya mumhuri. Zvinogona kukonzerwa nekushanduka kweDNA kunopfuudzwa kubva kuvabereki kuenda kuvana. Asi vanhu vazhinji vane paragangliomas havafaniri nhoroondo yemhuri yezvironda izvi uye chikonzero hachizivikanwi. Paraganglioma kuwedzera kwemaseli. Inoumbwa kubva mumhando yemasero enerve inonzi chromaffin cell. Chromaffin cells ine mabasa akakosha mumuviri, kusanganisira kudzora kumanikidza eropa. Paraganglioma inotanga apo chromaffin cells inokura kuchinja muDNA yavo. DNA yese inobata mirairo inoudza sero kuti riite sei. Mumasero ane hutano, DNA inopa mirairo yekukura nekukura nekukurumidza kwakatarwa. Mirayiridzo inoudzawo masero kuti afe panguva yakatarwa. Mumasero eparaganglioma, kuchinja kweDNA kunopa mirairo yakasiyana. Kuchinja kunoudza masero eparaganglioma kuti aite masero akawanda nekukurumidza. Masero anoramba achirarama apo masero ane hutano aizoenda. Izvi zvinoita kuti kuwedzere kwemaseli kunonzi tumor. Paragangliomas mazhinji anoramba ari kwaakatanga. Haaparari kune dzimwe nhengo dzemuviri. Asi dzimwe nguva masero anogona kuputsika kubva kuparaganglioma uye kupararira. Kana izvi zvikaitika, zvinonzi metastatic paraganglioma. Kana paraganglioma ikapararira, kazhinji inopararira ku lymph nodes iri pedyo. Inogona zvakare kupararira kumapapu, chiropa nemapfupa. Paraganglioma inobatanidzwa zvakanyanya kune imwe tumor isingawanzoitika inonzi pheochromocytoma. Pheochromocytoma tumor inotanga mu chromaffin cells mu adrenal glands. Adrenal glands ndidzo mbiri dziri pamusoro peitsvo.

Ngozi yekuwana paraganglioma yakakwira kune vanhu vane nhoroondo yemhuri yeiyi tumor. Mamwe paraganglioma anokonzerwa nekuchinja kweDNA kunopfuudzwa kubva kuvabereki kuenda kuvana. Kuva nenhoroondo yemhuri ye paraganglioma kunogona kuva chiratidzo chekuti kuchinja kweDNA kunomhanya mumhuri yako.

Mamwe mamiriro ezveutano anokonzerwa nekuchinja kweDNA kunopfuudzwa kubva kuvabereki kuenda kuvana kunosimudzira ngozi ye paragangliomas. Aya mamiriro anosanganisira:

• Multiple endocrine neoplasia, rudzi 2. Multiple endocrine neoplasia, rudzi 2, inonziwo MEN 2, inogona kukonzera matumor mumwe kana kupfuura meglands inogadzira mahomoni, kusanganisira thyroid ne parathyroid glands. Kune marudzi maviri eMEN 2 - rudzi 2A ne rudzi 2B. Zvose zvinosimudzira ngozi ye paragangliomas.
• Von Hippel-Lindau chirwere. Von Hippel-Lindau chirwere chinogona kukonzera matumor ne cysts kuumbwa muzvikamu zvakawanda zvemuviri. Nzvimbo dzinogona kusanganisira uropi, spinal cord neitsvo.
• Neurofibromatosis 1. Neurofibromatosis 1 inokonzera matumor anonzi neurofibromas kuumbwa paganda. Iyi mamiriro anogona kukonzerawo matumor e optic nerve. Optic nerve ndey nerve iri kumashure kweziso inobatanidza neuropi.
• Hereditary paraganglioma syndromes. Hereditary paraganglioma syndromes inogona kukonzera pheochromocytomas kana paragangliomas. Vanhu vane aya syndromes kazhinji vane kupfuura paraganglioma imwe.
• Carney-Stratakis dyad. Carney-Stratakis dyad inokonzera matumor e digestive tract ne paragangliomas.

Kuongororwa kweParaganglioma kazhinji kunotanga nekuongororwa kweropa nemukaka. Kuongororwa uku kunogona kutsvaga zviratidzo zvekunge hutachiona huri kuita mahomoni akawanda. Kuongororwa kwakasiyana kunogona kusanganisira kuongororwa kwemuviri nekuongororwa kwemajini.

Kuongororwa kweropa nemukaka kunogona kuyera mazinga emahomoni mumuviri. Zvinogona kuwana mahomoni e catecholamine akawanda akaitwa ne paraganglioma. Kana zvingawana zvimwe zviratidzo zve paraganglioma senge puroteni inonzi chromogranin A.

Munachiremba wenyu anogona kukurudzira kuongororwa kwemuviri kana zviratidzo zvenyu, nhoroondo yemhuri, kana kuongororwa kweropa nemukaka zvichiratidza kuti mungave ne paraganglioma. Mifananidzo iyi inogona kuratidza nzvimbo nehukuru hwehutachiona. Zvinogona zvakare kubatsira kutungamira sarudzo dzekurapa kwenyu.

Kuongororwa kwemuviri kunotevera kunogona kushandiswa kwe paraganglioma:

• Magnetic resonance imaging, inonziwo MRI, inoshandisa ma radio wave nema magnetic field kuita mifananidzo yakadzama.
• Computerized tomography scan, inonziwo CT scan, inosanganisa akatevedzana emifananidzo ye X-ray yakatorwa kubva pakona dzakasiyana-siyana dzemuviri.
• Metaiodobenzylguanidine scan, inonziwo MIBG scan, inowana tracer yeradioactive yakapinzwa inotorwa ne paragangliomas.
• Positron emission tomography scan, inonziwo PET scan, inowanawo tracer yeradioactive inotorwa nehutachiona.

Kuchinja kweDNA kwakapfuudzwa kubva kuvabereki kuenda kuvana kunoita kuti paragangliomas ive yakakosha. Kana uine paraganglioma, munachiremba wenyu anogona kukurudzira kuongororwa kwemajini kutsvaga kuchinja uku kweDNA mumuviri mako. Mhedzisiro yekuongororwa kwemajini inogona kubatsira kufanotaura mikana yekudzoka kwehutachiona hwako mushure mekurapa.

Vabereki vako, vana kana hama dzako vanogonawo kuongororwa kuti vaone kuchinja kweDNA kunowedzera njodzi ye paragangliomas. Timu yako yekurapa inogona kukutumira kune genetic counselor kana mumwe munachiremba akadzidziswa mune genetics. Munhu uyu anogona kukubatsira iwe nevanoda kwauri kusarudza kana kuwana kuongororwa kwemajini.

Kazhinji, kurapa kwe paraganlioma kunosanganisira kuvhiya kubvisa ganda. Kana ganda richigadzira mahomoni, vanachiremba kazhinji vanoshandisa mishonga yekuvhara mahomoni kutanga. Kana paraganlioma risinga bviswe nekuvhiya kana richikwira, unogona kuda kurapwa kwakasiyana. Sarudzo dzako dzekurapa paraganlioma zvinoenderana nezvinhu zvakasiyana. Izvi zvinosanganisira: Kwakagara ganda. Kana iri kenza uye yakapararira kune dzimwe nhengo dzemuviri. Kana ichigadzira mahomoni akawanda anokonzera zviratidzo. Sarudzo dzekurapa dzinosanganisira: Kurapa kudzora mahomoni anoitwa neganda Kana paraganlioma yako ichigadzira catecholamines yakawanda, iwe ungangoda kurapwa kudzivirira migumisiro kana kuderedza mazinga ema hormones aya. Kurapa uku kunoderedza BP yepamusoro uye kunodzora zvimwe zviratidzo. Zvakakosha kuti BP nezviratidzo zvive pasi pekudzora usati watanga kurapwa kwe paraganlioma. Izvozvo ndizvo nekuti kurapwa kunogona kukonzera ganda kuburitsa catecholamines yakawanda uye izvo zvinogona kukonzera matambudziko akakomba. Mishonga inoshandiswa kudzora migumisiro ye catecholamine inosanganisira mishonga yeBP. Mishonga iyi inosanganisira alpha blockers, beta blockers ne calcium channel blockers. Zvimwe zviyero zvinogona kusanganisira kudya kudya kwakakwirira mu sodium uye kunwa mvura yakawanda. Kuvhiya Kuvhiya kunogona kuitwa kubvisa paraganlioma. Kunyangwe paraganlioma isingabviswe zvizere, chiremba wako anogona kukurudzira kuvhiya kubvisa ganda rakawanda sezvinobvira. Rudzi rwekuvhiya runoshandiswa kubvisa paraganlioma zvinoenderana nekwakagara. Nzvimbo yeganda inotsanangurawo rudzi rwechiremba anoita nzira yacho. Semuenzaniso: Maganda ari mumusoro nemutsipa anogona kurapwa nevanachiremba vemusoro nemutsipa. Maganda anokanganisa uropi, musana nemitsipa anogona kurapwa ne neurosurgeons. Maganda anokanganisa marunda anoita mahomoni anogona kurapwa ne endocrine surgeons. Maganda anokanganisa midziyo yeropa anogona kurapwa ne vascular surgeons. Dzimwe nguva vanachiremba vanobva kumasangano akasiyana anoshanda pamwe chete panguva yekuvhiya kwe paraganlioma. Kurapa kwemwaranzi Kurapa kwemwaranzi kushandisa ma beam simba kuti kurapa maganda. Simba rinogona kubva ku X-rays, protons kana mimwe misoro. Chiremba wako anogona kukurudzira mwaranzi kana paraganlioma yako isingabviswe zvizere nekuvhiya. Mwaranzi inogona kubatsira kudzikamisa marwadzo anokonzerwa neganda rinopararira kune dzimwe nhengo dzemuviri. Dzimwe nguva rudzi rwakasarudzika rwemwaranzi rinonzi stereotactic radiosurgery rinoshandiswa kurapa paragangliomas munzvimbo yemusoro nemutsipa. Rudzi urwu rwemwaranzi runangisa ma beam akawanda esimba paganda. Beam imwe neimwe haina simba. Asi poindi iyo ma beam anosangana inowana chikamu chikuru chemwaranzi kuuraya masero eganda. Kurapa kwe ablation Kurapa kwe ablation kushandisa kupisa kana chando kuuraya masero eganda uye kudzora kukura kwe paraganlioma. Izvi zvinogona kuva sarudzo kana paraganlioma yakapararira kune dzimwe nhengo dzemuviri. Radiofrequency ablation inoshandisa simba remagetsi kupisa masero eganda. Imwe rudzi rwe ablation inonzi cryoablation inoshandisa gasi rinotonhora kufungisa masero eganda. Chemotherapy Chemotherapy kurapa kunoshandisa mishonga ine simba. Kana paraganlioma yako yakapararira, chiremba wako anogona kukurudzira chemotherapy kubatsira kudzikisa maganda. Kana paraganlioma yako ichigadzira mahomoni akawanda, unowana mishonga yekudzora mazinga ema hormones usati watanga chemotherapy. Kurapa kwakatarwa Kurapa kwakatarwa kushandisa mishonga inorwisa kemikari chaiyo mumasero eganda. Nekuvhara kemikari idzi, kurapwa kwakatarwa kunogona kukonzera masero eganda kufa. Kune paraganlioma, mishonga yekurapa yakatarwa inogona kushandiswa kana kuvhiya kusiri sarudzo. Kurapa kwakatarwa kunogona kushandiswawo kana ganda richikwira kune dzimwe nhengo dzemuviri. Peptide receptor radionuclide therapy Peptide receptor radionuclide therapy, inonziwo PRRT, inoshandisa mushonga kupa mwaranzi zvakananga kumasero eganda. Mushonga unosanganisa chinhu chinowana masero eganda nechinhu chine mwaranzi. Mushonga unopiwa kuburikidza ne tsinga. Mushonga unofamba mumuviri uye unonamatira kumasero e paraganlioma. Mazuva kusvika mavhiki, mushonga unounza mwaranzi zvakananga kumasero eganda. Imwe mishonga inoshanda nenzira iyi lutetium Lu 177 dotatate (Lutathera). Inogona kushandiswa kana kuvhiya kusiri sarudzo kana paraganlioma ikapararira kune dzimwe nhengo dzemuviri. Ongororo dzekuongorora Ongororo dzekuongorora ndidzidzo dzekurapa kwatsva kana nzira itsva yekushandisa kurapwa kwakare. Kana uchifarira ongororo dzekuongorora dze paraganlioma, taura nachiremba wako nezve sarudzo dzako. Pamwe chete munogona kuenzanisa mabhenefiti nenjodzi dzekurapa vanhu vanoongorora vari kuongorora. Kumirira kwenguva refu Dzimwe nguva, vanachiremba vanokurudzira kusatanga kurapwa kwe paraganlioma nekukurumidza. Panzvimbo iyoyo, vanogona kufarira kutarisa mamiriro ako ezvinhu nekuongororwa kwehutano nguva dzose. Izvi zvinozivikanwa sekumirira kwenguva refu. Semuenzaniso, kumirira kwenguva refu kunogona kuva sarudzo kana paraganlioma ikakura zvishoma nezvishoma uye isingakonzere zviratidzo. Rumwe ruzivo Kurapa kwe ablation Kurapa kwemwaranzi Kumbira musangano