Serotonin Syndrome

Serotonin syndrome chirwere chakakomba chinoitika nekushandisa mishonga. Inokonzerwa nemishonga inowedzera mazinga e serotonin mumuviri.

Serotonin ikemikari inogadzirwa nemuviri. Inodiwa kuti masero enervhu nehuropi zvishande. Asi serotonin yakawanda inokonzera zviratidzo nezvikonzero zvinogona kubva pazvishoma (kufunganya nekurwara) kusvika pakukomba (kukakama kwemhasuru, kupisa uye kuita). Serotonin syndrome yakakomba inogona kuuraya kana isina kurapwa.

Serotonin syndrome inogona kuitika kana ukawanda huwandu hwemishonga yakati kana kutanga kushandisa mushonga mutsva. Kazhinji inokonzerwa nekubatanidza mishonga ine serotonin, senge mushonga wekurwadziwa kwemusoro uye antidepressant. Mimwe mishonga isina mvumo uye zvinowedzerwa zvekudya zvine hukama ne serotonin syndrome.

Zvimiro zvishoma zve serotonin syndrome zvinogona kupera mukati mezuva rimwe kana maviri ekumisa mishonga inokonzera zviratidzo uye, dzimwe nguva, mushure mekutora mishonga inodzivirira serotonin.

Zviratidzo zveSerotonin syndrome kazhinji zvinoitika mukati memaawa mashoma mushure mekutora mushonga mutsva kana kuwedzera huwandu hwemushonga waunenge uchitora kare.

Zviratidzo nezviratidzo zvinosanganisira:

• Kusagadzikana kana kunetseka
• Kushaya hope
• Kusanzwisisika
• Kuwanda kwemoyo nekukwira kweropa
• Ziso rakafara
• Kurasikirwa nekubatana kwemhasuru kana kuzunguzunguka kwemhasuru
• Ropa rakakwira
• Kuomarara kwemhasuru
• Kuwedzera kwekuparadza kwemuviri
• Manyoka
• Kurwadziwa kwemusoro
• Kuchema
• Ma goose bumps

Serotonin syndrome yakakomba inogona kutyisidzira hupenyu. Zviratidzo zvinosanganisira:

• Kupisa kwakanyanya
• Kuchema
• Kuita
• Kurova kwemoyo kusina kujairika
• Kusaziva

Kana uchifungidzira kuti ungave uine serotonin syndrome mushure mekutanga mushonga mutsva kana kuwedzera huwandu hwemushonga waunenge uchitora, fonera chiremba wako pakarepo kana kuenda kuimba rekuvhuvhuta. Kana uine zviratidzo zvakakomba kana zviri kuwedzera nekukurumidza, tsvaga kurapwa kwekukurumidza pakarepo.

Kuwanikwa kwakanyanya kwe serotonin mumuviri kunokonzera zviratidzo zve serotonin syndrome.

Kazhinji, masero ane nerve emuhuga nemu spine anogadzira serotonin inobatsira kudzora hanya, maitiro uye tembiricha yemuviri.

Mamwe masero ane nerve mumuviri, kunyanya mumatumbu, anogadzirawo serotonin. Serotonin ine basa rekudzora maitiro ekugaya, kuyerera kweropa uye kufema.

Kunyangwe zvichibvira kuti kutora mushonga mumwe chete unowedzera mazinga e serotonin kunogona kukonzera serotonin syndrome kune vamwe vanhu, mamiriro ezvinhu anoitika kazhinji kana vanhu vakasanganisa mishonga yakati.

Semuenzaniso, serotonin syndrome inogona kuitika kana ukatora antidepressant nemushonga wemigraine. Inogonawo kuitika kana ukatora antidepressant nemushonga wekurwadziwa kwe opioid.

Chimwe chikonzero che serotonin syndrome ndechekuzvipa mishonga yakawandisa ye antidepressant.

Mishonga yakawanda inotengeswa pasina chitupa neanenge ane chitupa inogona kusanganiswa ne serotonin syndrome, kunyanya antidepressants. Mishonga isina mvumo uye zvinowedzerwa zvechikafu zvinogonawo kusanganiswa nemamiriro ezvinhu.

Mishonga nezvinowedzerwa zvinogona kukonzera serotonin syndrome zvinosanganisira:

• Selective serotonin reuptake inhibitors (SSRIs), antidepressants senge citalopram (Celexa), fluoxetine (Prozac), fluvoxamine (Luvox), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle) uye sertraline (Zoloft)
• Serotonin and norepinephrine reuptake inhibitors (SNRIs), antidepressants senge desvenlafaxine (Pristiq), levomilnacipran (Fetzima), milnacipran (Savella), duloxetine (Cymbalta, Drizalma Sprinkle) uye venlafaxine (Effexor XR)
• Bupropion (Zyban, Wellbutrin SR, Wellbutrin XL), antidepressant nemushonga wekurapa kusvuta fodya
• Tricyclic antidepressants, senge amitriptyline uye nortriptyline (Pamelor)
• Monoamine oxidase inhibitors (MAOIs), antidepressants senge isocarboxazid (Marplan) uye phenelzine (Nardil)
• Mishonga yekurwisa migraine, senge carbamazepine (Tegretol, Carbatrol, nezvimwewo), valproic acid uye triptans, izvo zvinosanganisira almotriptan, naratriptan (Amerge) uye sumatriptan (Imitrex, Tosymra, nezvimwewo)
• Mishonga yekurwadziwa, senge opioid pain medications kusanganisira codeine, fentanyl (Duragesic, Abstral, nezvimwewo), hydrocodone (Hysingla ER), meperidine (Demerol), oxycodone (Oxycontin, Roxicodone, nezvimwewo) uye tramadol (Ultram, ConZip)
• Lithium (Lithobid), mudzvinyiriri wemanzwiro
• Mishonga isina mvumo, kusanganisira LSD, ecstasy, cocaine uye amphetamines
• Zvinowedzerwa zvemuriwo, kusanganisira St. John's wort, ginseng uye nutmeg
• Mishonga yekukosora nekuoma kwemhino inotengeswa pasina chitupa ine dextromethorphan (Delsym)
• Mishonga yekurwisa kurutsa senge granisetron (Sancuso, Sustol), metoclopramide (Reglan), droperidol (Inapsine) uye ondansetron (Zofran)
• Linezolid (Zyvox), antibiotic
• Ritonavir (Norvir), mushonga we anti-retroviral unoshandiswa kurapa hutachiona hweHIV.

Vanhu vamwe vanonyanya kukanganiswa nezvinodhaka nezvinowedzerwa zvinokonzera serotonin syndrome kupfuura vamwe, asi chirwere ichi chinogona kuitika kune ani naani.

Uri panjodzi yakawedzera ye serotonin syndrome kana:

• Wakango tanga kutora kana kuwedzera mushonga unozivikanwa kuti unowedzera serotonin levels
• Unotora mishonga miviri inopfuura imwe inozivikanwa kuti inowedzera serotonin levels
• Unotora zvinowedzerwa zvemuriwo zvinozivikanwa kuti zvinowedzera serotonin levels
• Unoshandisa zvinodhaka zvisiri pamutemo zvinozivikanwa kuti zvinowedzera serotonin levels

'Kazhinji, serotonin syndrome haikonzere matambudziko chero api kana mazinga e serotonin adzoka kumazinga avo ekutanga.\n\nKana isina kurapwa, serotonin syndrome yakakomba inogona kukonzera kusaziva uye rufu.'

Kushandisa mishonga yakawanda ine chekuita ne serotonin kana kuwedzera huwandu hwemushonga une chekuita ne serotonin kunowedzera njodzi yekuwana serotonin syndrome. Ziva mishonga yaunotora uye ugopa chiremba wako kana mushonga wemishonga runyorwa rwakakwana rwemishonga yako. Iva nechokwadi che kutaura nachiremba wako kana iwe kana mumhuri mako makawana zviratidzo mushure mekutora mushonga. Uyewo taura nachiremba wako nezvenjodzi dzinobvira. Usarega kutora mishonga ipi neipi wega. Kana chiremba wako akanyora mushonga mutsva, ita shuwa kuti anoziva nezvemimwe mishonga yese yaunotora, kunyanya kana uchiwana mishonga kubva kune vanachiremba vakawanda. Kana iwe ne chiremba wenyu mukaona kuti zvakanaka zvekubatanidza mishonga ine chekuita ne serotonin zvinopfuura njodzi, chenjera nezve mukana we serotonin syndrome.

Hapana bvunzo imwe chete inogona kusimbisa chirwere che serotonin syndrome. Chiremba wenyu achazivisa mamiriro acho nekuramba mikana yakasiyana.

Chiremba wenyu angangotanga nekubvunza nezve zviratidzo zvako, nhoroondo yekurapa uye mishonga ipi neipi yaunotora. Chiremba wenyu achaitawo bvunzo yemuviri.

Kuita shuwa kuti zviratidzo zvako zvinokonzerwa ne serotonin syndrome uye kwete nekuda kwechimwe chikonzero, chiremba wenyu angashandisa bvunzo kuti:

Huwandu hwemamiriro ezvinhu hunogona kukonzera zviratidzo zvakafanana nezve serotonin syndrome. Zviratidzo zvidiki zvinogona kukonzerwa nemamiriro akawanda. Zviratidzo zvakanyanya uye zvakakomba zvakafanana nezve serotonin syndrome zvinogona kukonzerwa ne:

Chiremba wenyu angarayira bvunzo dzimwe kuti adzime zvimwe zvinokonzera zviratidzo zvako. Bvunzo dzinogona kusanganisira:

• Kuyeresa mazinga emishonga ipi neipi yaunoshandisa

• Kutarisa zviratidzo zvehutachiona

• Kutarisa mabasa emuviri anogona kukanganiswa ne serotonin syndrome

• Kuita kwakasimba kumishonga yakati, senge mamwe ma anesthetic, mishonga ye antipsychotic uye mamwe ma agent anozivikanwa kuti anogadzira aya maitiro akakomba

• Kuwedzeredza mishonga isina mutemo, mishonga inorwisa kuora mwoyo kana mishonga imwe inowedzera mazinga e serotonin

• Kukuvadzwa kunobatanidzwa nekushandisa mishonga isina mutemo

• Kubvisa doro kwakanyanya

• Bvudzi neropa bvunzo

• Chest X-ray

• Computerized Tomography (CT) scan

• Spinal tap (lumbar puncture)