Waldenstrom Macroglobulinemia Chii? Zviratidzo, Zvinokonzera, & Kurapa

Waldenstrom macroglobulinemia chirwere chisingawanzoitika chekenza yeropa inokanganisa simba remuviri wako rekudzivirira hutachiona. Inowanikwa kana masero machena eropa anonzi B-lymphocytes akakura zvisina kumira uye achigadzira protein yakawanda inonzi IgM antibody.

Ichi chirwere chinofamba zvishoma zvichienzaniswa nemamwe marwere eropa, zvinoreva kuti vanhu vazhinji vanogona kurarama naro kwemakore vachidzora zviratidzo zvavo. Kunyange zvazvo zvinonzwa zvakanyanya pakutanga, kunzwisisa zviri kuitika mumuviri wako kunogona kukubatsira kunzwa uchikwanisa kudzora rwendo rwehutano hwako.

Waldenstrom Macroglobulinemia Chii?

Waldenstrom macroglobulinemia, kazhinji inonzi WM, ikenza inotanga mumapfupa ako apo masero eropa anoitwa. Masero ekenza rudzi rwakatarwa rwe sero jena reropa rinowanzo kukubatsira kudzivirira hutachiona.

Aya masero asingawanzoitiki anogadzira huwandu hwakawanda hwe protein inonzi immunoglobulin M kana IgM. Kana IgM yakawanda ikaunganidzwa muropa rako, inoita kuti ropa rako rive rakapfupika kupfuura kazhinji, sekachena panzvimbo yemvura. Iyi kupfupika kunogona kukonzera matambudziko ekufamba kweropa mumuviri wako wese.

WM inofungwa serudzi rwe lymphoma, kunyanya rudzi rwe non-Hodgkin lymphoma. Inonyorwawo se lymphoplasmacytic lymphoma nekuti masero ekenza anoita sekusanganiswa kwe lymphocytes ne plasma cells pasi pe microscope.

Zviratidzo zveWaldenstrom Macroglobulinemia Ndezvipi?

Vanhu vazhinji vane WM havaone zviratidzo pakutanga, uye chirwere ichi chinowanzoonekwa pakuongororwa kweropa kwenguva dzose. Kana zviratidzo zvikaonekwa, zvinoonekwa zvishoma nezvishoma uye zvinogona kunzwa sekuneta kwakanyanya kana matambudziko maduku ehutano.

Zviratidzo zvakajairika zvaunogona kuona zvinosanganisira:

• Kuneta kwenguva refu kunoshaya kugadziriswa nekuzorora
• Kushaya simba kunoita kuti mabasa ezuva nezuva ave akaoma
• Kuvara nyore kana kubuda ropa, kunyange kubva pakukuvadzwa kwakaderera
• Kubuda ropa kwemhuno kazhinji kana kubuda ropa kwegumbo
• Kuwedzera kwe lymph nodes mumutsipa wako, armpits, kana groin
• Kusveta usiku kunonyorova nguo dzako kana mashiti
• Kurasikirwa nehuremu usingatarisirwi kwemavhiki mazhinji
• Hutachiona hunodzokororwa hunotora nguva yakareba kupora

Vamwe vanhu vanogadzirawo zviratidzo zvine chekuita neropa rakapfupika, izvo vanachiremba vanonzi hyperviscosity syndrome. Aya maratidzo anoitika nekuti ropa rakapfupika rine dambudziko rekufamba nemidziyo midiki mumuviri wako.

Zviratidzo zveropa rakapfupika zvinosanganisira:

• Kuona kusapfava kana kuchinja mukuona
• Misoro inonzwa yakasiyana nemisoro yako yakajairwa
• Kuzvitarisa kana kunzwa uchida kuwira
• Kusanzwisisa kana kuoma kuisa pfungwa
• Kushaya mweya panguva yebasa rakajairika

Zvisingawanzoitiki, unogona kuona kunzwa kusinganzwisisiki kana kusanzwa mumaoko ako nemakumbo. Izvi zvinoitika kana protein yakawandisa yeIgM ikakanganisa tsinga dzako, mamiriro anonzi peripheral neuropathy.

Chii Chinokonzera Waldenstrom Macroglobulinemia?

Chikonzero chaicho cheWM hachizivisike zvizere, asi vatsvakurudzi vanotenda kuti chinotanga kana kuchinja kweDNA kuchitika muB-lymphocytes. Aya magenetic changes anoudza masero kuti akure uye arambe achigovera kana asingafanire, zvichikonzera kuunganidzwa kwemasero asingawanzoitiki.

Zviitiko zvizhinji zveWM zvinoitika zvisina chikonzero chakajeka. Kuchinja kweDNA kunokonzera WM kazhinji kunoitika muhupenyu hwemunhu panzvimbo yekuwana kubva kuvabereki.

Nekudaro, masayendisiti akaona zvinhu zvinogona kuwedzera mukana wekuwana WM. Anenge 20% yevanhu vane WM vane nhengo dzemhuri dzinewo WM kana marwere eropa ane hukama, zvichiratidza kuti genetics inogona kuita basa mune dzimwe nyaya.

Zera ndiro njodzi huru yatinayo. WM inonyanya kukanganisa vakuru vakuru, nevanhu vazhinji vanozviratidzwa mumakore avo makumi matanhatu kana makumi manomwe. Varume vanonyanya kuwana WM kupfuura vakadzi.

Rini Unofanira Kuona Chiremba weWaldenstrom Macroglobulinemia?

Unofanira kubata nachiremba wako kana ukaona zviratidzo zvisingaperi izvo zvisingagadzirisiki mushure memavhiki mashoma. Kunyange aya maratidzo anogona kuva nezvikonzero zvakawanda, zvakakosha kuazviongorora, kunyanya kana uine zviratidzo zvakawanda pamwe chete.

Rongedza musangano kana ukaona kuneta kwenguva refu kunokanganisa hupenyu hwako hwezuva nezuva, kurasikirwa nehuremu usingazivikanwe, kana hutachiona hunowanzoitika. Aya maratidzo anoda kutarisirwa kwechiremba pasinei nechinokonzera.

Tsvaka rubatsiro rwekurapa nekukurumidza kana ukaona kuchinja kwekuona kamwe kamwe, misoro yakanyanya, kusanzwisisa, kana kushaya mweya kwakanyanya. Izvi zvinogona kuva zviratidzo zvekuti ropa rakapfupika riri kukanganisa nhengo dzakakosha uye rinoda kurapwa nekukurumidza.

Usazvidya mwoyo nezvekuita sekunge uri kungwarira zvakanyanya. Chiremba wako angada kuongorora zviratidzo zvinoratidzika kuva zviduku pane kukanganisa chimwe chinhu chinoda kutarisirwa.

Ndezvipi Zvinokonzera Njodzi dzeWaldenstrom Macroglobulinemia?

Zvinhu zvakati wandei zvinogona kuwedzera mikana yako yekuwana WM, kunyange kuva nezvinokonzera njodzi hazvirevi kuti uchawana chirwere ichocho. Vanhu vazhinji vane zvinokonzera njodzi havambovi neWM, uye vamwe vanhu vasina njodzi dzinozivikanwa vanoita.

Zvinokonzera njodzi huru zvinosanganisira:

• Zera rinopfuura makore 60, nenjodzi ichikwira sezvaunokura
• Kuva murume, sezvo varume vanowana WM zvakanyanya kupfuura vakadzi
• Kuva ne nhoroondo yemhuri yeWM kana marwere eropa ane hukama
• Kuva nemamiriro anonzi monoclonal gammopathy of undetermined significance (MGUS)
• Kuonekwa kare kwehepatitis C virus
• Mamwe autoimmune conditions

MGUS mamiriro apo muviri wako unogadzira mapuroteni asingawanzoitiki akafanana neaWM, asi muhuwandu hudiki. Vanhu vazhinji vane MGUS havambovi nekenza, asi zvinoita kuti njodzi yeWM nemamwe marwere eropa iwedzere zvishoma.

Zvinhu zvakatipoteredza senge kuonekwa kwemakemikari akati kana mwaranzi zvakadzidzwa, asi hapana hukama hwakajeka hwakawanikwa neWM. Mashoko akanaka ndeakuti zvinokonzera njodzi zvizhinji zveWM hazvisi zvinhu zvausingakwanisi kudzora, zvinoreva kuti hapana chawakaita kukonzera chirwere ichocho.

Ndezvipi Zvinogona Kuitika Zvinetso zveWaldenstrom Macroglobulinemia?

WM inogona kukonzera matambudziko akawanda, kunyanya nekuda kweropa rakapfupika uye kukanganisa kwemasero ekenza kune immune system yako. Kunzwisisa aya mikana kunogona kukubatsira kuziva kana uchifanira kutsvaka rubatsiro rwekurapa.

Chinetso chakakomba ndicho hyperviscosity syndrome, apo ropa rinopfuura rakapfupika kuti rifambe zvakakodzera. Izvi zvinokanganisa anenge 10-30% yevanhu vane WM uye zvinogona kukonzera matambudziko ekuona, kubuda ropa, uye mune dzimwe nguva dzisina kujairika, kurohwa kana matambudziko emwoyo.

Zvinetso zvakajairika zvinosanganisira:

• Kuwedzera kwenjodzi yehutachiona nekuda kwe immune system yakasimba
• Anemia, ichikonzera kuneta nekushushikana kwemweya
• Matambudziko ekubuda ropa nekuda kwehuwandu hudiki hwe platelets
• Spleen yakakura inogona kukonzera kusagadzikana kwemudumbu
• Matambudziko eitsvo kubva pakuunganidzwa kwe protein
• Kukuvadzwa kwetsiva kunokonzera kusanzwa kana kusanzwa

Vamwe vanhu vanogadzira mamiriro anonzi cryoglobulinemia, apo mapuroteni muropa anoungana pamwechete mumamiriro ekutonhora. Izvi zvinogona kukonzera kurwadziwa kwejoini, zvirwere zve ganda, kana matambudziko ekufamba mumamiriro ekutonhora.

Zvisingawanzoitiki, WM inogona kuchinja kuva rudzi rwakanyanya rwe lymphoma rinonzi diffuse large B-cell lymphoma. Izvi zvinoitika mune zvishoma kupfuura 10% yezviitiko uye kazhinji zvinoitika makore mazhinji mushure meWM yekutanga.

Mashoko akanaka ndeakuti kurapwa kwazvino kunogona kudzivirira kana kudzora zvizhinji zveizvi zvinetso zvakakodzera. Kuongororwa nguva dzose kunobatsira kubata nematambudziko pakutanga kana zviri nyore kurapa.

Waldenstrom Macroglobulinemia Inozviratidzwa Sei?

Kuziva WM kunosanganisira bvunzo dzakati kuti kuti uone kuvapo kwemasero ekenza uye kuyera mazinga eIgM protein muropa rako. Chiremba wako anotanga nekuongororwa kweropa uye anogona kuda mamwe maitiro kuti awane mufananidzo wakakwana.

Maitiro ekurapa anowanzo tanga nekuongororwa kweropa kunoratidza mazinga asingawanzoitiki e protein kana nhamba dzemasero eropa. Chiremba wako achaodza bvunzo dzakakosha kuyera mazinga eIgM uye kutsvaga muenzaniso we protein wakajairika weWM.

Bvunzo dzakakosha dzekuongorora dzinosanganisira:

1. Kuverenga kwakakwana kweropa kuongorora marudzi ese emasero eropa
2. Comprehensive metabolic panel kuongorora kushanda kwenhengo
3. Serum protein electrophoresis kuziva mapuroteni asingawanzoitiki
4. Immunofixation kusimbisa rudzi rwe protein isingawanzoitiki
5. Bone marrow biopsy kuongorora masero ekenza zvakananga
6. Flow cytometry kuziva zviratidzo zvakakosha zvesero

Bone marrow biopsy kazhinji inoitirwa se outpatient procedure ine local anesthesia. Chiremba wako anotora sampuli diki yebone marrow kubva pabone rako rehip kuti aione pasi pe microscope.

Bvunzo dzakawedzerwa dzinogona kusanganisira CT scans kuongorora lymph nodes kana nhengo dzakakura, uye dzimwe nguva genetic testing yemasero ekenza kuti iite zvisarudzo zve kurapa. Chiremba wako anogonawo kuyedza kupfupika kweropa rako kana uine zviratidzo zve hyperviscosity syndrome.

Kurapa kweWaldenstrom Macroglobulinemia Chii?

Kurapa kweWM kunoenderana nezviratidzo zvako, mhinduro dzekuongororwa kweropa, uye hutano hwese. Vanhu vazhinji vane WM havadi kurapwa nekukurumidza uye vanogona kutarisirwa nekuongororwa kwenguva dzose, nzira inonzi "watch and wait."

Chiremba wako achakurudzira kurapwa kana ukawana zviratidzo, kana nhamba dzeropa dzako dzikadzikira zvakanyanya, kana mazinga ako eIgM akakwira zvakanyanya. Chinangwa ndechekudzora chirwere, kuderedza zviratidzo, uye kuchengetedza hupenyu hwako.

Sarudzo dzekurapa dzakajairika dzinosanganisira:

• Mishonga yechemotherapy senge bendamustine kana fludarabine
• Mishonga yakatarwa yekurapa senge ibrutinib kana rituximab
• Kusanganiswa kwe immunotherapy kunoshanda ne immune system yako
• Plasmapheresis kubvisa mapuroteni akawandisa muropa
• Stem cell transplantation muvarwere vaduku vakasarudzwa

Rituximab inowanzo shandiswa nekuti inonyanya kunangana nerudzi rwesero rinosanganisirwa muWM. Kazhinji inopiwa se infusion mukiriniki uye kazhinji inosanganiswa nemishonga yechemotherapy kuti iwane mhinduro dzakanaka.

Plasmapheresis ndiyo nzira inoshandisa ropa rako kubvisa protein yakawandisa yeIgM. Kazhinji inoshandiswa senzira yekukurumidza kuderedza kupfupika kweropa nepo mamwe kurapwa achitora chikamu.

Kurapa kazhinji kunopiwa mumaitiro ane nguva yekuzorora pakati kuti muviri wako ugone kupora. Vanhu vazhinji vanogona kuramba vachiita mabasa avo ezuva nezuva panguva yekurapa, kunyange zvazvo unganzwa uneta kupfuura kazhinji.

Nzira Yekudzora Waldenstrom Macroglobulinemia Kumba?

Kurarama neWM kunosanganisira kutarisira hutano hwako hwese uchigadzirisa chero zviratidzo zvaunogona kuva nazvo. Kugadzirisa kwakapusa kwemararamiro kunogona kukubatsira kunzwa zviri nani uye kuderedza njodzi yezvinetso.

Tarisisa kuchengetedza simba rako nekugara uchizorora uye kudya zvokudya zvine utano. Muviri wako unoda simba rakawanda kuti ubate nechirwere ichi, saka usazvipa mhosva yekuda kurara kupfuura kare.

Nhanho dzakakosha dzekuzvichengeta dzinosanganisira:

• Kudya zvokudya zvakakwana zvine michero, miriwo, uye mapuroteni
• Kuchengetedza mvura nekunova nemvura yakawanda
• Kuita zvemitambo nguva dzose, zvishoma nezvishoma sezvinobvumidzwa nesimba rako
• Kudzivisa mapoka panguva yechando nechirwere chemafuru
• Kugeza maoko kazhinji kudzivirira hutachiona
• Kutora mishonga yakanyorwa sezvakarayirwa

Tarisa zviratidzo zvako uye chengeta chero kuchinja. Vamwe vanhu vanoona zvichibatsira kuchengeta dhayari yakapusa yezvavanonzwa, izvo zvinogona kuva ruzivo runobatsira kune timu yako yehutano.

Rambai muchiziva nezvekuvharirwa, asi bvunza nachiremba wako kutanga sezvo mamwe majekiseni asingakurudzirwi panguva yekurapa. Immune system yako ingasapindura kumajekiseni zvakanaka sezvakajairwa, asi kudzivirirwa kwakati kwakanaka kupfuura kusina.

Usambotya kukumbira rubatsiro nemabasa ezuva nezuva kana uchinetseka kana usina kunaka. Kugamuchira rutsigiro kubva kumhuri neshamwari chikamu chakakosha chekuzvichengeta.

Ungagadzirira Sei Musangano Wako Wechemba?

Kuagadzirira misangano yako kunogona kukubatsira kuita zvakanyanya panguva yako netimu yako yehutano. Nyora mibvunzo yako nezvinetso zvako usati watanga kuti usakanganwa kukurukura nyaya dzakakosha.

Uyai ne rondedzero yakakwana yemishonga yese, mavhitamini, uye zvinowedzerwa zvamuri kutora, kusanganisira zvikamu uye kazhinji maunotora. Izvi zvinobatsira chiremba wako kudzivirira chero zvinogona kukuvadza zvinosangana.

Usati wasangana, gadzirira:

• Rondedzero yezviratidzo zvako zvese uye pavakatanga
• Nhoroondo yako yekurapa, kusanganisira mamwe mamiriro ekurapa
• Nhoroondo yemhuri yemarwere eropa kana kenza
• Mibvunzo nezvekuongororwa kwako, sarudzo dzekurapa, uye prognosis
• Shamwari yakavimbika kana nhengo yemhuri kuti iuve newe

Funga kukoka mumwe munhu kumisangano yako, kunyanya kana uchikurukura nezvesarudzo dzekurapa kana kuwana mhinduro dzebvunzo. Vanogona kukubatsira kuyeuka ruzivo rwakakosha uye kupa rutsigiro rwepfungwa.

Usatya kukumbira chiremba wako kuti atsanangure chero chinhu chisinganzwisisiki. Zvakajairika zvachose kuda kuti mazwi ekurapa atsanangurwe nemutauro wakapusa, uye vanachiremba vakanaka vanokoshesa varwere vanoda kunzwisisa mamiriro avo.

Chii Chinonyanya Kukosha Nezve Waldenstrom Macroglobulinemia?

WM mamiriro anogona kudzorwa anowanzo famba zvishoma nezvishoma, achikupa iwe netimu yako yehutano nguva yekuronga nzira yakanaka yemariro ako. Vanhu vazhinji vane WM vanorarama hupenyu hwakazara, hwakashanda kwemakore mazhinji.

Chinhu chakakosha chokurangarira ndechekuti WM inokanganisa munhu wese zvakasiyana. Vamwe vanhu vanoda kurapwa nekukurumidza, nepo vamwe vanogona kupfuura makore vasina kurapwa. Chiremba wako acashanda newe kuti aone nguva yakanaka uye nzira yemariro ako chaiwo.

Kurapa kwazvino kwakavandudza zvakanyanya mhinduro dzevanhu vane WM. Mishonga mitsva iri kugara ichigadzirwa, uye vanhu vazhinji vanowana nguva refu apo chirwere chavo chinodzorwa zvakanaka.

Tarisisa zvaunogona kudzora: kuchengetedza hutano, kutevera chirongwa chako chekurapa, kuchengetedza misangano yako, uye kuchengetedza kutaurirana kwakavhurika netimu yako yehutano. Nekutarisirwa kwakakodzera nekuongororwa, vanhu vazhinji vane WM vanogona kuramba vachifarira hupenyu hwavo nemabasa avanoda.

Mibvunzo Inowanzo Bvunzwa Nezve Waldenstrom Macroglobulinemia

Waldenstrom macroglobulinemia inogona kuwanikwa here?

Kunyangwe zviitiko zvizhinji zveWM zvichiitika zvisina chikonzero, anenge 20% yevanhu vane WM vane nhengo dzemhuri dzine chirwere chimwe chete kana marwere eropa ane hukama. Izvi zvinoratidza kuti genetics inogona kuita basa mune dzimwe mhuri, asi kuva ne nhengo yemhuri ine WM hazvirevi kuti iwe uchawana zvirokwazvo.

Kana uine nhoroondo yemhuri yeWM, kurukura izvi nachiremba wako. Vanogona kukurudzira kuongororwa kweropa kwakawanda kuti vatarisire zviratidzo zvekutanga, asi hapana bvunzo chaiyo yekuongorora WM muvanhu vasina zviratidzo.

Munhu anogona kurarama kwenguva yakareba sei neWaldenstrom macroglobulinemia?

WM kazhinji kenza inokura zvishoma nezvishoma, uye vanhu vazhinji vanorarama kwemakore mazhinji mushure mekuongororwa. Kupona kwenguva refu kazhinji kunoyerwa mumakore makumi mazhinji panzvimbo yemakore, kunyanya ne kurapwa kwazvino.

Tarisiro yako yakasarudzika inoenderana nezvinhu senge zera rako, hutano hwese, zviratidzo pakuongororwa, uye kuti unopindura sei kurapwa. Chiremba wako anogona kukupa ruzivo rwakakosha zvichienderana nemamiriro ako chaiwo.

Waldenstrom macroglobulinemia inogona kupora here?

Parizvino, hapana mushonga weWM, asi inofungwa sechinetso chinogona kurapwa zvikuru. Vanhu vazhinji vanowana remission kwenguva refu apo chirwere hachioneke kana kudzorwa kwemakore mazhinji.

Chinangwa chekurapa ndechekudzora zviratidzo, kudzivirira matambudziko, uye kuchengetedza hupenyu hwakanaka. Nekurapwa kwakakodzera, vanhu vazhinji vane WM vanogona kurarama hupenyu hwakajairika uye kuramba vachiita mabasa avo ezuva nezuva.

Chii chiri musiyano uripo pakati peWM ne multiple myeloma?

WM ne multiple myeloma zvese zviri marwere eropa anokanganisa plasma cells, asi zviri zvirwere zvakasiyana. WM inonyanya kugadzira IgM antibodies uye kazhinji haikanganisi mapfupa, nepo multiple myeloma kazhinji inogadzira mamwe antibodies uye inowanzo kukonzera kukuvara kwepfupa.

Kurapa kweizvi zvirwere kwakasiyana, ndosaka kuwana kuongororwa kwakakodzera kwakakosha. Chiremba wako achashandisa bvunzo dzakakosha kusiyanisa pakati pezvi zvirwere nezvimwe zvine hukama.

Ndichakwanisa kuramba ndichishanda neWaldenstrom macroglobulinemia here?

Vanhu vazhinji vane WM vanoramba vachishanda, kunyanya kana vasina zviratidzo kana zviratidzo zvavo zvakadzorwa zvakanaka ne kurapwa. Kukanganisa pahupenyu hwako hwebasa kunoenderana nezviratidzo zvako chaiwo, mhedzisiro yekurapa, uye rudzi rwebasa raunoita.

Vamwe vanhu vanoda kuita kugadzirisa, sekushanda kubva kumba panguva yekurapa kana kutora nguva yekuzorora yemisangano. Kurukura zvakasununguka nachiremba wako nezve mamiriro ako ebasa kuti vakubatsire kuronga nzira yakanaka yekuchengetedza basa rako uchigadzirisa hutano hwako.