Chii chinonzi Abacavir: Zvazvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Abacavir mushonga unopesana nemavhairasi unobatsira vanhu vanorarama neHIV kudzora mamiriro avo zvakanaka. Iwo wekirasi yemishonga inonzi nucleoside reverse transcriptase inhibitors, iyo inoshanda nekudzivirira HIV kubva pakuzvinyora mumuviri wako.

Mushonga uyu wave ibwe rekona rekurapa HIV kwemakore mazhinji, uchibatsira mamiriyoni evanhu kuchengetedza hutano hwavo uye kurarama hupenyu hwakazara. Kunzwisisa kuti abacavir inoshanda sei uye zvekutarisira zvinogona kukubatsira kuti unzwe wakavimbika nezvekufamba kwako kwekurapa.

Chii chinonzi Abacavir?

Abacavir mushonga unopesana nemavhairasi wakanyorwa zvakananga kurapa hutachiona hweHIV. Ndizvo zvinodaidzwa nachiremba kuti nucleoside reverse transcriptase inhibitor, kana NRTI muchidimbu.

Funga nezve abacavir semunhu anotevedzera mamorekuru anonyengera HIV. Iro vhairasi rinoedza kushandisa abacavir panzvimbo yezvivakwa zvakasikwa zvaanoda kuti azvibereke, asi abacavir inoita sechidimbu chakaremara chinogumisa maitiro ekukopa. Izvi zvinobatsira kudzivirira vhairasi kubva pakuwanda mumuviri wako.

Abacavir anenge achigara achinyorwa sechikamu chekurapa kwakabatanidzwa, zvinoreva kuti uchaitora pamwe chete nemimwe mishonga yeHIV. Iyi nzira, inonzi highly active antiretroviral therapy kana HAART, inonyanya kushanda kupfuura kushandisa mushonga mumwe chete.

Abacavir Inoshandiswa Kunei?

Abacavir inonyanya kushandiswa kurapa hutachiona hweHIV-1 muvanhu vakuru nevana vanorema angangoita 3 kilograms (anenge 6.6 pounds). Icho chikamu chakakosha chezvinodaidzwa nachiremba kuti antiretroviral therapy.

Chinangwa chikuru chekurapa abacavir ndechekucheka huwandu hweHIV muropa rako kusvika padanho risingaonekwe. Kana izvi zvikaitika, haugone kutapurira vhairasi kune vamwe kuburikidza nekudyidzana pabonde, uye immune system yako inogona kupora uye kuramba yakasimba.

Chiremba wako anganyora abacavir kana uchangobva kuongororwa uine HIV kana kana uchida kuchinja kubva kune rimwe mushonga weHIV nekuda kwemigumisiro kana kuramba. Zvinonyanya kubatsira vanhu vanoda imwe-zuva-rimwe kurapwa sarudzo, sezvo inowanzo sanganiswa nemimwe mishonga mumafomu emupiritsi rimwechete.

Abacavir Inoshanda Sei?

Abacavir inoshanda nekukanganisa kugona kweHIV kuzvigadzira mukati memaseru ako. Inoonekwa semushonga weHIV une simba repakati nepakati uyo unoita chikamu chakakosha chemazhinji ekurapa.

Kana HIV ikapinda mumaseru ako, inoshandisa enzyme inonzi reverse transcriptase kushandura genetic material yayo kuita DNA inogona kuiswa mujenetic code yeseru yako. Abacavir inotevedzera imwe yezvivakwa zvakasikwa zvinodiwa neiyi enzyme, asi kana enzyme ichiedza kushandisa abacavir, inonamira uye haigone kupedzisa maitiro ekukopa.

Iyi nzira yakafanana nekuedza kuvaka cheni ine chinongedzo chakatyoka. Hutachiona hahugone kupedzisa kugadzira makopi matsva eiyo pachayo, zvinoreva kuti mashoma matsva ehutachiona anogadzirwa. Nekufamba kwenguva, izvi zvinobatsira kuderedza huwandu hweHIV mumuviri wako uye zvinobvumira immune system yako kupora.

Ndinofanira Kutora Sei Abacavir?

Unogona kutora abacavir uine kana pasina chikafu, sezvo zvikafu zvisinganyanyi kukanganisa maitiro emuviri wako anotora mushonga. Vanhu vazhinji vanozviwana zviri nyore kutora nechikafu kubatsira kudzivirira chero dumbu rinogumbura.

Nguva yekutora mishonga yako yakakosha kuchengetedza mazinga akagadzikana emushonga muropa rako. Edza kutora abacavir panguva imwe chete zuva rega rega, ingave iri nekudya kwemangwanani, kudya kwemanheru, kana imwe tsika inowirirana inoshanda kwauri.

Medza mahwendefa ese nemvura yakazara. Kana iwe uchitora fomu remvura, shandisa chishandiso chekuyera chinouya nemushonga kuti uve nechokwadi chekuti unowana chiyero chaicho chakanyorwa. Usashandise zvipunu zvepamba, sezvo zvinogona kusiyana muhukuru uye zvinotungamira mukushandisa zvisizvo.

Kana uine dambudziko rekumedza mapiritsi, taura nachiremba wako kana muzvinabhuku wemishonga nezve dzimwe nzira. Mhinduro yemukanwa ingave sarudzo iri nani, kana kuti vangave vaine matipi ekuita kuti kutora piritsi kuve nyore.

Ndingatora Abacavir kwenguva yakareba sei?

Abacavir inowanzoita kurapwa kwenguva refu kwaunozofanira kutora chero bedzi ichiramba ichishanda mukudzora HIV yako. Vanhu vazhinji vanoiita zvachose sechikamu chekugadzirisa kwavo HIV kuri kuenderera mberi.

Kureba kwekurapa kunoenderana nekuti mushonga unoshanda sei kwauri uye kana iwe ukawana chero matambudziko emigumisiro. Chiremba wako achatarisa viral load yako uye CD4 count nguva dzose kuti ave nechokwadi chekuti abacavir iri kuita basa rayo nemazvo.

Zvakakosha kuti usambomira kutora abacavir kamwe kamwe kana kusvetuka madosi nguva dzose, sezvo izvi zvinogona kutungamirira kumishonga inodzivisa. Kana HIV ikava inodzivisa abacavir, mushonga unogona kusashanda kwauri, uye unogona kunge uine zvishoma zvekushandisa zviripo.

Kana iwe uchifunga kumisa kana kuchinja mushonga wako, gara uchikurukura izvi nemupi wako wehutano kutanga. Vanogona kukubatsira kuchinjira zvakachengeteka kune imwe nzira yekurapa kana zvichidikanwa.

Ndezvipi Zvakaipa zveAbacavir?

Semishonga yese, abacavir inogona kukonzera migumisiro, kunyangwe vanhu vazhinji vachiiita zvakanaka. Kunetseka kwakanyanya ndiko kuita allergic kunogona kuisa hupenyu panjodzi kunonzi hypersensitivity syndrome, iyo inokanganisa vanhu vanenge 5-8% vanotora abacavir.

Usati watanga abacavir, chiremba wako acharayira bvunzo yemajini inonzi HLA-B*5701 screening. Kana iwe ukaedzwa zvakanaka kune iyi genetic marker, une njodzi yakanyanya yekuvandudza iyo yakakomba allergic reaction, uye chiremba wako achasarudza imwe mishonga kwauri.

Common Side Effects

Mhedzisiro yakawanda kubva kuabacavir yakapfava uye inowanzoita nani sezvo muviri wako uchigadzirisa kumishonga mumavhiki mashoma ekutanga ekurapa.

• Kusvotwa uye dumbu kurwadza
• Kurwadza musoro
• Kuneta kana kufenda
• Dizziness
• Kutadza kurara
• Kushaya chido chekudya
• Manyoka

Zviratidzo izvi zvinowanzo manejwa uye zvinowanzoderera nekufamba kwenguva. Kutora abacavir nekudya kunogona kubatsira kuderedza kusvotwa, uye kugara uine mvura yakawanda kunogona kubatsira nekurwadza musoro nekuneta.

Mhedzisiro Yakakomba

Kunyange zvazviri zvisingawanzoitiki, dzimwe mhedzisiro dzinoda kutariswa kwechiremba nekukasira uye hadzifanirwe kufuratirwa.

Inonyanya kukosha i hypersensitivity syndrome, iyo inogona kukura mukati memavhiki matanhatu ekutanga ekurapa. Iyi mhinduro inogona kuuraya kana ukaramba uchitora abacavir mushure mekunge zviratidzo zvaitika.

• Fivha
• Meno emuviri
• Kuneta kwakanyanya
• Kusvotwa nekutsvuka
• Manyoka
• Kurwadza mudumbu
• Kuhuro kurwadza
• Kufema nekukurumidza
• Kukosora

Kana ukaona zviratidzo zviviri kana kupfuura izvi, rega kutora abacavir nekukasira uye taura nachiremba wako nekukasira. Usambofa wakadzokera kuabacavir kana wakambove nemhinduro ye hypersensitivity, sezvo mhinduro dzinotevera dzinogona kuve dzakanyanya.

Zvekufunga Kwenguva Refu

Vamwe vanhu vanotora abacavir kwenguva refu vanogona kuona shanduko mukuti muviri wavo unogadzirisa sei mafuta neshuga. Chiremba wako achakutarisa iwe kuti uone shanduko idzi kuburikidza nekuongororwa kweropa nguva dzose.

Kune zvakare njodzi shoma yakawedzera yematambudziko emoyo neabacavir, kunyanya muvanhu vatove vane njodzi yezvirwere zvepfungwa. Mupi wako wehutano achafunga nezvehutano hwako hwese hwemoyo kana achisarudza kana abacavir yakakunakira.

Ndiani Asingafaniri Kutora Abacavir?

Abacavir haikodzeri munhu wese, uye mamiriro akati wandei kana mamiriro anoita kuti zvisakwanise kana kuda matanho akakosha.

Chipingamupinyi chakakosha ndechokuva ne HLA-B*5701 genetic marker, iyo inowedzera zvakanyanya njodzi yako yekuwana allergic reaction inotyisa. Ichi ndicho chikonzero nei genetic testing yakakosha usati watanga abacavir.

Haufaniri kutora abacavir kana wakambove ne hypersensitivity reaction kwairi, kunyangwe reaction yacho yaiita seyakareruka. Kufumurwa kunotevera kunogona kuva kwakanyanya uye kungangove kunouraya.

Vanhu vane moderate kusvika severe liver disease vangangoda dose adjustments kana mamwe mishonga, sezvo abacavir ichigadziriswa nechiropa. Chiremba wako achaongorora basa rechiropa chako asati anyora abacavir.

Kana uine nhoroondo yechirwere chemoyo, chiremba wako achanyatsoongorora mabhenefiti nenjodzi, sezvo abacavir inogona kuwedzera zvishoma njodzi yemoyo mumwe vanhu.

Kuzvitakura kunoda kufunga kwakakosha. Kunyange abacavir ichigona kushandiswa panguva yekuzvitakura, chiremba wako achakurukura njodzi dzinogona kuitika nemabhenefiti newe kuti aone nzira yakanakisisa yekurapa iwe nemwana wako.

Mazita eAbacavir Brand

Abacavir inowanikwa pasi pemazita akati wandei emhando, zvichienderana nekuti yakanyorwa yega kana pamwe chete nemamwe mishonga yeHIV.

Zita remhando yeabacavir yega ndeye Ziagen. Iyi formulation ine abacavir chete uye inowanzo nyorwa kana uchida kuitora pamwe chete nemamwe mishonga yeHIV.

Kazhinji, abacavir inonyorwa mumhando dzakabatanidzwa. Epzicom inobatanidza abacavir ne lamivudine, nepo Trizivir iine abacavir, lamivudine, uye zidovudine mupiritsi rimwe chete.

Imwe yemibatanidzwa inozivikanwa ndeye Triumeq, iyo ine abacavir, lamivudine, uye dolutegravir. Iri piritsi rimwe chete pazuva rinowanzo nyorwa seyakazara HIV kurapwa regimen.

Abacavir Alternatives

Kana abacavir isina kukodzera kwauri, mishonga yakati wandei yeHIV inogona kupa mabhenefiti akafanana. Sarudzo inoenderana nemamiriro ako chaiwo, mamwe mishonga yaunotora, uye nhoroondo yako yekurapa.

Mamwe ma nucleoside reverse transcriptase inhibitors anosanganisira tenofovir, emtricitabine, uye lamivudine. Izvi zvinoshanda zvakafanana neabacavir asi zvine akasiyana side effect profiles uye dosing schedules.

Tenofovir-based combinations senge Descovy (tenofovir alafenamide plus emtricitabine) kana Truvada (tenofovir disoproxil fumarate plus emtricitabine) ndiyo imwe nzira dzakajairika dzisingade genetic testing.

Chiremba wako anogonawo kufunga integrase strand transfer inhibitors senge dolutegravir, bictegravir, kana raltegravir, izvo zvinoshanda nekudzivisa imwe nhanho muHIV's life cycle.

Imwe nzira yakanakisa kwauri inoenderana nezvinhu zvakaita sekushanda kwematsvo ako, hutano hwemapfupa, mamwe mamiriro ezvinhu ekurapa, uye zvinogona kudyidzana nemishonga yako.

Ko Abacavir Ari Nani Kudarika Tenofovir?

Ose ari maviri abacavir uye tenofovir mishonga inoshanda yeHIV, asi vane simba rakasiyana uye zvinofanirwa kufungwa izvo zvinoita kuti imwe ive yakakodzera kune vamwe vanhu.

Abacavir inoda genetic testing isati yashandiswa uye inotakura njodzi ye hypersensitivity syndrome, nepo tenofovir isina izvi zvinonetsa. Zvisinei, tenofovir inogona kukanganisa kushanda kwematsvo uye bone density nekufamba kwenguva, izvo abacavir kazhinji haaiti.

Panyaya yekushanda, ese ari maviri mishonga anoshanda zvakanyanya pakudzivisa HIV kana achishandiswa sechikamu chekubatanidza kurapa. Zvidzidzo zvinoratidza mitengo yakafanana yekudzivirira hutachiona pakati peabacavir-based uye tenofovir-based regimens.

Sarudzo pakati pavo inowanzouya kune zvikonzero zvemunhu. Kana iwe ukaedzwa uine HLA-B*5701, tenofovir inosarudzwa zvakajeka. Kana uine matambudziko ematsvo kana osteoporosis, abacavir inogona kunge iri sarudzo iri nani.

Chiremba wako achafunga nezve mufananidzo wako wese wekurapa, kusanganisira mamwe mishonga, kushanda kwematsvo, njodzi yemoyo, uye zvaunofarira iwe pachako paunenge uchisarudza mushonga wakanakira iwe.

Mibvunzo Inowanzo Bvunzwa Nezve Abacavir

Abacavir Yakachengeteka Kune Vanhu Vane Hepatitis B Here?

Abacavir inogona kushandiswa kune vanhu vane hepatitis B, asi inoda kunyatso tariswa. Kusiyana nemimwe mishonga yeHIV, abacavir haibati hepatitis B, saka unogona kuda mamwe mishonga yekugadzirisa zvese zvirwere.

Kana uine hepatitis B, chiremba wako achanyatso tarisa kushanda kwako kwechiropa uye anogona kunyora mishonga inobata HIV nehepatitis B panguva imwe chete, senge tenofovir-based combinations.

Kutanga kana kumisa abacavir muvanhu vane hepatitis B dzimwe nguva kunogona kukonzera kuti hepatitis B ive yakanyanya kushanda, saka chero shanduko kune yako kurapwa regimen inoda kunyatso manejwa nachiremba wako.

Ndoitei Kana Ndikatora Abacavir Yakawandisa Netsaona?

Kana netsaona ukatora abacavir yakawanda kupfuura yakanyorwa, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira. Kunyangwe pasina mushonga chaiwo weabacavir overdose, nyanzvi dzekurapa dzinogona kupa rutsigiro rwekutarisira uye kukutarisa iwe kuti uone matambudziko.

Usaedze "kugadzirisa" overdose nekusvetuka dose yako inotevera. Pane kudaro, tsvaga zano rekurapa nezvekuti ungaita sei nekuronga kwako kwenguva dzose.

Zviratidzo zveoverdose hazvina kutsanangurwa zvakanaka zveabacavir, asi unogona kusangana nemashandisirwo akawedzerwa emhedzisiro yakajairika senge kusvotwa, kurutsa, kana kuneta. Tsvaga kutariswa kwekurapa zvisinei nekuti unonzwa zviratidzo here.

Ndoitei Kana Ndikarasikirwa neDose yeAbacavir?

Kana ukakanganwa dose yeabacavir, itore nekukasira paunoyeuka, kunze kwekunge yava nguva yechikamu chako chinotevera chakatarwa. Muchiitiko ichocho, svetuka dose yakarasika uye uenderere mberi nehurongwa hwako hwenguva dzose.

Usambotora zvikamu zviviri panguva imwe chete kuti uzadze chikamu chawakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvinetso. Kana usina chokwadi nezvenguva, taura nemushonga wako kana mupi wehutano kuti uwane gwara.

Edza kuderedza zvikamu zvawakakanganwa nekugadzira zviyeuchidzo zvefoni, uchishandisa chirongwa chemishonga, kana kubatanidza nguva yako yemishonga kune tsika yezuva nezuva senge zvekudya. Kushandisa mishonga nguva dzose kunobatsira kuchengetedza mazinga anoshanda emushonga muropa rako.

Ndingamira Rini Kutora Abacavir?

Haufanire kumbomira kutora abacavir usati wataurirana nachiremba wako kutanga. Kumisa mishonga yeHIV kunogona kukonzera viral rebound, uko mazinga eHIV muropa rako anowedzera nekukurumidza uye anogona kuve asingashandi kurapwa.

Chiremba wako angangofunga kuchinja mishonga yako kana uine zvinetso zvinoramba zviripo, kana viral load yako ikava inozivikanwa pasinei nekurapwa, kana kana kuramba kwemishonga kukaitika. Chero shanduko dzichaitwa zvakanyatso rongwa kuti vachengetedze HIV inoshanda.

Kana uine matambudziko nezvinetso kana kutevedzera, taura nechikwata chako chehutano nezve nzira dzekuita kuti kurapwa kuve nyore pane kumira wega.

Ndinganwa Doro Here Ndichitora Abacavir?

Kunwa doro zvine mwero kunowanzoonekwa sekuchengeteka uchitora abacavir, asi kunwa zvakanyanya kunogona kuwedzera njodzi yako yematambudziko echiropa uye kunogona kukanganisa kugona kwemuviri wako kugadzirisa mushonga nemazvo.

Doro rinogonawo kuwedzera zvimwe zvinetso zveabacavir, senge kusvotwa uye dzungu. Kana ukasarudza kunwa, ita zvine mwero uye teerera kuti muviri wako unopindura sei.

Kana uine chirwere chechiropa kana nhoroondo yematambudziko edoro, taura nezvekushandisa doro nachiremba wako usati watanga abacavir. Vanogona kukurudzira kudzivisa doro zvachose kana kuongorora basa rechiropa chako zvakanyanya.