Chii chinonzi Abatacept: Zvazvinoshandiswa, Mishonga, Zvazvinokonzeresa uye Zvimwe

Abatacept mushonga unopiwa nachiremba unobatsira kudzikamisa immune system inoshanda zvakanyanya, kunyanya kune vanhu vane rheumatoid arthritis nezvimwe zvirwere zve autoimmune. Fungidzira sebhureki rinononoka re immune system yako painenge ichikanganisa kurwisa matishu ako ane hutano.

Mushonga uyu unouya nenzira mbiri: infusions ye intravenous (IV) inopiwa panzvimbo yekurapa, uye subcutaneous injections yaunogona kuzvipa iwe kumba. Zvose zvinoshanda nenzira imwechete asi zvinopa mazinga akasiyana ekureruka zvichienderana nemararamiro ako uye zvaunoda zvekushandisa mishonga.

Chii chinonzi Abatacept?

Abatacept mushonga we biologic uyo wekirasi inonzi selective costimulation modulators. Inoshanda nekudzivisa zviratidzo zvakasiyana pakati pemasero e immune anokonzera kuzvimba uye kukuvadza majoini.

Kusiyana nemamwe ma immunosuppressants akasimba, abatacept inotora nzira yakatarwa. Haisi kuvhara yese immune system yako asi inogadzirisa nzira dzakatarwa dzinobatsira kuzvirwere zve autoimmune. Izvi zvinoita kuti ive sarudzo yakanyanya kunaka asi ichiri kushanda.

Mushonga uyu unogadzirwa kubva kumapuroteni uye unofanirwa kuchengetwa mufiriji. Yakabvumidzwa neFDA kubvira 2005 uye yakabatsira mamiriyoni evanhu kudzora mamiriro avo e autoimmune zvakanyanya.

Chii chinonzi Abatacept chinoshandiswa?

Abatacept inonyanya kunyorerwa rheumatoid arthritis muvanhu vakuru nevana vane makore anopfuura 6. Inobvumidzwawo psoriatic arthritis uye juvenile idiopathic arthritis.

Chiremba wako angakurudzira abatacept kana dzimwe kurapwa dzisina kupa zororo rakakwana, kana semushonga wekutanga mune dzimwe nguva. Inobatsira kunyanya kune vanhu vanowana kuoma kwakanyanya mangwanani, kuzvimba majoini, uye kuneta kubva kumamiriro avo e autoimmune.

Vamwe vanachiremba vanoshandisawo abatacept kunze kwemutemo kune dzimwe nzvimbo dzekuzvirwisa dzakadai selupus kana mamwe marudzi e vasculitis. Zvisinei, izvi zvinoenderana nemamiriro ako chaiwo uye nhoroondo yako yezvokurapa.

Abatacept Inoshanda Sei?

Abatacept inoshanda nekudzivisa hukama chaihwo pakati pemasero ekudzivirira muviri anonzi T-cells nemasero anoratidza antigen. Kana masero aya achitaurirana zvisina kufanira, anokonzera kuzvimba kunokuvadza majoini ako uye matishu.

Mishonga inoshanda semutongi ane mutsa, achidzivirira hurukuro idzi dzinokuvadza pakati pemasero ekudzivirira muviri pasina kukwanisa zvachose kugonesa muviri wako kurwisa zvirwere. Iyi nzira yakatarwa ndiyo inokonzeresa kuti abatacept ionekwe semushonga wepakati-kati pane immunosuppressant inorema.

Unogona kutanga kuona kuvandudzwa mukati memwedzi miviri-3, kunyangwe vamwe vanhu vachiona mabhenefiti nekukurumidza. Mhedzisiro yakazara inowanzoitika pamusoro pemwedzi mitanhatu sezvo mushonga uchideredza zvishoma nezvishoma kuzvimba mumuviri wako wese.

Ndingatora Sei Abatacept?

Nzira yaunotora nayo abatacept inoenderana nefomu iro chiremba wako anoraira. IV infusions inopiwa panzvimbo yekurapa kwemaminitsi anenge makumi matatu, nepo subcutaneous injections inogona kuitwa kumba.

Kuti uwane kurapwa kweIV, iwe unowanzo gamuchira infusions pamavhiki maviri, mavhiki mana, wobva wapedza mavhiki mana mushure mekutanga kwako. Haufaniri kutsanya zvisati zvaitika, asi kugara uine mvura yakawanda kunogona kukubatsira kuti unzwe wakasununguka panguva ye infusion.

Kana iwe uchishandisa fomu re subcutaneous, iwe unozojoinjekita kamwechete pavhiki, kazhinji muchidya chako, dumbu, kana ruoko rwepamusoro. Chikwata chako chehutano chichakudzidzisa nzira chaiyo yekujekesa uye kutenderera kwenzvimbo dzekujekesa kudzivirira kutsamwa.

Mhando dzese dzinoshanda zvakaenzana, saka sarudzo inowanzoenderana nekuda kwako nyore kana chivimbo chekutariswa kwekurapa. Vamwe vanhu vanosarudza majekiseni epamba eweekly kuti vave vakasununguka, nepo vamwe vachida kushanya kwekiriniki kwemwedzi nemwedzi kuti vaenderere mberi nekuongorora.

Ndingatora Abatacept Kwenguva Yakareba Sei?

Abatacept kazhinji mushonga wenguva refu, zvinoreva kuti unogona kuramba uchiutora chero uchibatsira mamiriro ako uye usingakonzeri matambudziko makuru. Vanhu vazhinji vanoutora kwemakore kwete mwedzi.

Chiremba wako achatarisa mhinduro yako mwedzi mitatu mitatu kuti aongorore kana mushonga uyu uchiri kushanda nemazvo. Kana zviratidzo zvako zvichidzora zvakanaka uye usiri kusangana nematambudziko, kuramba kurapwa kazhinji kunopa mhedzisiro yakanaka.

Vamwe vanhu vanogona kuda kumira kwenguva pfupi kana vaine zvirwere zvakasiyana kana vachida kuvhiyiwa. Chiremba wako achakutungamira kuburikidza nekuzorora kwese kunodiwa uye kukubatsira kutangazve zvakachengeteka kana zvakakodzera.

Ndezvipi Zvakaipa ZveAbatacept?

Vanhu vazhinji vanotsungirira abatacept zvakanaka, asi semishonga yese, inogona kukonzera mhedzisiro. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakavimbika pamusoro pekurapa kwako.

Mhedzisiro yakajairika inowanzoita nyoro uye inogoneka. Izvi zviitiko zvemazuva ese zvinokanganisa vanhu vazhinji asi kazhinji hazvidi kumisa mushonga:

• Kutemwa nemusoro uye kuneta kudiki
• Zvirwere zvekufema zvepamusoro senge dzihwa
• Nausea kana dumbu rakashata
• Maitiro ekudzivirira jekiseni (kutsvuka, kuzvimba, kana kurwadziwa kudiki)
• Dizziness panguva kana mushure meIV infusions

Izvi zvinowanzoitika zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga mumavhiki mashoma kana mwedzi.

Mhedzisiro yakakomba haina kujairika asi inoda kutariswa kwekurapa nekukasira. Kunyange zvichishamisa, izvi zvinoda kuongororwa nekukurumidza:

• Zviratidzo zvechirwere chakakomba (fivha, kutonhora, kukosora kunoramba kuripo, kuneta kusinganzwisisike)
• Maitiro akakomba ekurwara (kufema kwakaoma, kuzvimba, rash yakakomba)
• Kubuda ropa kusinganzwisisike kana kupwanya
• Nausea inoramba iripo, kurutsa, kana kurwadziwa mudumbu
• Mavanga eganda matsva kana kuipa

Mashoko akanaka ndeekuti matambudziko akakomba anowanikwa muvanhu vashoma vanopfuura 5% vanotora abatacept, uye mazhinji anogona kubatwa zvakanaka kana akawanikwa nekukurumidza.

Ndiani Asingafaniri Kutora Abatacept?

Abatacept haisi yemunhu wese, uye mamiriro ehutano akati wandei anoita kuti isakodzere kana kuda matanho akakosha. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuraira.

Haufaniri kutora abatacept kana uine hutachiona hwakakomba hunoshanda, kusanganisira fivhiri, kana kana wakambove nemaitiro akakomba ekugumbuka kumushonga uyu. Vanhu vane mamwe marudzi ekenza vanogonawo kuda kuideredza kana kumirira kusvikira kurapwa kwavo kwapera.

Kungwarira kwakakosha kunodiwa kana uine nhoroondo yehutachiona hunodzoka, hepatitis B kana C, kana mamwe mamiriro emapapu. Chiremba wako anogona kuraira mamwe bvunzo uye kuongorora kana uine mamiriro aya asi uchiri kuda abatacept.

Vakadzi vane pamuviri kana vanoyamwisa vanofanira kukurukura njodzi nemabhenefiti zvakanyatsonaka nachiremba wavo, sezvo mhedzisiro pavacheche vari kukura isinganzwisiswe zvizere.

Mazita eAbatacept Brand

Abatacept inotengeswa pasi pezita rekuti Orencia mune ese ari maviri IV uye subcutaneous mafomu. Iri ndiro zita rinowanzoonekwa pamishonga uye magwaro einishuwarenzi.

Parizvino hapana mhando dzakajairika dze abatacept dziripo, sezvo iri mushonga wakaoma webiologic zvakaoma kutevedzera chaizvo. Zvisinei, mhando dzebiosimilar dzinogona kuwanikwa mune ramangwana.

Mamwe makambani einishuwarenzi anogona kuda mvumo yekutanga yeOrencia nekuda kwemutengo wayo, asi vanhu vazhinji vane rheumatoid arthritis vanogona kuwana kuvharwa kana zvichidikanwa zvekurapa zvagadzirwa.

Zvimwe Zvinhu Zvokutora Panzvimbo peAbatacept

Kana abatacept isingakodzere kwauri, mamwe mishonga ye biologic inoshanda zvakafanana nemamiriro eautoimmune. Izvi zvinosanganisira adalimumab (Humira), etanercept (Enbrel), uye rituximab (Rituxan).

Mishonga yechinyakare inogadzirisa zvirwere zve rheumatic (DMARDs) senge methotrexate kana sulfasalazine zvinowanzoedzwa kutanga kana kushandiswa pamwe chete nemishonga yebiological. Mishonga iyi ine nzira dzakasiyana dzekushanda uye mhedzisiro yezvinhu.

Chiremba wako achafunga nezvezvinhu zvakaita sehutano hwako chaihwo, mamwe matambudziko ehutano, zvaunofarira muhupenyu, uye inishuwarenzi paunenge uchisarudza imwe nzira yakanaka. Dzimwe nguva kuyedza mushonga wakasiyana kunogona kupa mhedzisiro iri nani kana mhedzisiro shoma.

Ko Abatacept Ari Nani Kudarika Methotrexate?

Abatacept uye methotrexate vanoshanda zvakasiyana uye vanowanzo shandiswa pamwe chete panzvimbo pezvimwe zvingasarudzwa. Methotrexate inowanzoita yekutanga-mutsara kurapwa kwe rheumatoid arthritis, nepo abatacept inowanzo wedzerwa kana methotrexate yega isina kukwana.

Methotrexate imishonga yekare, yakagadzwa zvakanaka inotorwa semapiritsi kana majekiseni uye inodhura zvishoma pane abatacept. Zvisinei, inogona kukonzera dumbu rakawanda uye inoda nguva dzose kuongororwa kweropa kwebasa rechiropa.

Abatacept inogona kunge iri nani kune vanhu vasingakwanise kutsungirira methotrexate kana vachida kumwe kutonga kuzvimba. Vanhu vazhinji vanotora mishonga yese pamwe chete kuti vawane mhedzisiro yakanaka, sezvo vachizadzisa mhedzisiro yavo.

Mibvunzo Inowanzo Bvunzwa Nezve Abatacept

Ko Abatacept Akachengeteka Kune Vanhu vane Chirwere cheShuga?

Hongu, abatacept inowanzo chengeteka kune vanhu vane chirwere cheshuga. Mushonga hauna zvakananga kukanganisa mazinga eshuga yeropa kana kukanganisa mishonga yeshuga.

Zvisinei, kuva nechirwere cheshuga kunogona kuwedzera njodzi yako yekutapukirwa, uye abatacept zvakare inowedzera zvishoma njodzi yekutapukirwa. Chiremba wako achakutarisa zvakanyanya uye anogona kukurudzira matanho ekuwedzera sekutarisa shuga yeropa kakawanda panguva yekurwara.

Ndoita Sei Kana Ndikashandisa Abatacept yakawandisa netsaona?

Kana ukabaya abatacept yakawanda kupfuura yakarairwa netsaona, fonera chiremba wako kana muzvinamutsa mushonga nekukasika. Kunyange zvazvo kuwandisa mishonga kusingawanzoitiki nemajekiseni akazadzwa kare, zvakakosha kuwana mazano ekurapa.

Usaedze "kugadzirisa" chiyero chakawedzerwa nekusvetuka jekiseni rako rinotevera rakarongeka. Chiremba wako achakupa zano pamusoro pe nzira yakachengeteka yekudzokera panzira nechirongwa chako chekushandisa mishonga nguva dzose.

Ndingaita Sei Kana Ndikakanganwa Dose yeAbatacept?

Kana ukakanganwa jekiseni repasi peganda, tora nekukasika paunorangarira, wobva wadzokera kuchirongwa chako chevhiki nevhiki. Usaite kaviri madosi kuti ugadzirise jekiseni raunenge wakanganwa.

Kune IV infusions, fonera hofisi yachiremba wako kuti urongezve nekukasika sezvinobvira. Vanogona kugadzirisa misangano yako mishoma inotevera kuti ikudzorere pachirongwa chakanaka chekurapa kwako.

Ndingamira Rini Kutora Abatacept?

Unofanira kungomira kutora abatacept pasi pekutariswa kwachiremba wako. Kumira kamwe kamwe kunogona kukonzera kupisa kwechirwere chako chemuviri mukati memavhiki kana mwedzi.

Chiremba wako angakurudzira kumira kana ukawana mhedzisiro yakakomba, kuwana kuregererwa kwenguva refu, kana uchida kuchinjira kumushonga wakasiyana. Vachagadzira chirongwa chekukutarisa zvakanyanya panguva yekuzorora kwekurapa.

Ndingawana Majekiseni Ndiri Kutora Abatacept?

Majekiseni mazhinji enguva dzose akachengeteka uchitora abatacept, asi unofanira kudzivisa majekiseni mhenyu se spray yemhino ye flu kana jekiseni re shingles. Chiremba wako achakurudzira jekiseni re flu rinobaiwa panzvimbo.

Zvakakosha chaizvo kuti urambe uchiziva nezve majekiseni uchitora abatacept, sezvo mushonga unogona kukuitisa kuti utapukirwe nezvimwe zvirwere. Ronga kuwana majekiseni ako paunenge uchinzwa zvakanaka uye usina hutachiona hunoshanda.