Chii chinonzi Afatinib: Zvazvinoshandiswa, Mishonga, Zvazvinokonzeresa uye Zvimwe

Afatinib mushonga wekenza unovharira mapuroteni akati wandei anobatsira masero ekenza kukura nekupararira. Imushonga unopiwa nachiremba unonyanya kushandiswa kurapa mamwe marudzi ekenza yemumapapu ane shanduko dzakasiyana dze genetic. Fungidzira sechishandiso chakarurama chinokanganisa kugona kwekenza kuwanda, panzvimbo yechemotherapy yakajairika inokanganisa masero ese anokurumidza kukamuka.

Chii chinonzi Afatinib?

Afatinib ndeyemukirasi yemishonga inonzi tyrosine kinase inhibitors. Inoshanda nekudzivisa mapuroteni akati wandei anonzi EGFR (epidermal growth factor receptor) anopa simba kukura kwemasero ekenza. Mushonga uyu wakagadzirirwa kunyanya kunangana nemasero ekenza ane shanduko mujeni reEGFR, zvichiita kuti ive nzira yekurapa yakagadzirirwa munhu.

Mishonga iyi inouya sepiritsi remuromo raunotora nemuromo, zvichiita kuti zvive nyore kupfuura kurapwa kwechemotherapy ye intravenous. Inogadzirwa seimwe nzira yekurapa, zvinoreva kuti yakagadzirirwa kurwisa zvinhu zvakakosha zvemasero ekenza uku ichikwanisa kukonzera kukuvara kushoma kumasero ane hutano kana ichienzaniswa nechemotherapy yechinyakare.

Chii chinonzi Afatinib chinoshandiswa?

Afatinib inonyanya kunyorerwa kurapa isiri-diki sero lung cancer (NSCLC) ine shanduko dzakasiyana dze genetic. Chiremba wako achayedza nyama yako yekenza kuti aone kana uine EGFR mutations dzinoita kuti afatinib ishande kune yako chaiyo kesi.

Mishonga iyi inowanzo shandiswa kana kenza yako yemumapapu yapararira kune dzimwe nhengo dzemuviri wako kana isingakwanise kubviswa nekuvhiyiwa. Inowanzo nyorerwa seyekutanga-mutsara wekurapa varwere vane tumor vane EGFR exon 19 deletions kana exon 21 substitution mutations.

Mune dzimwe nguva, vanachiremba vanogonawo kupa afatinib ye squamous cell carcinoma yemapapu, kunyanya kana dzimwe nzira dzekurapa dzisina kubudirira. Chiremba wako weoncologist achasarudza kana mushonga uyu wakakodzera zvichienderana nerudzi rwako rwekenza uye mhedzisiro yekuyedzwa kwemajini.

Afatinib Inoshanda Sei?

Afatinib inoshanda nekugara ichivharira mapuroteni eEGFR anotumira zviratidzo zvekukura kumasero ekenza. Kusiyana nedzimwe nzira dzekurapa dzakanangana, afatinib inosungirira zvisingadzoreki kumapuroteni aya, zvinoreva kuti kuvharika kunogara kwenguva refu uye kwakasimba.

Mushonga uyu unonyanya kuita kuti masero ekenza anzwe nzara yezviratidzo zvaanoda kuti akure nekukamura. Kana mapuroteni eEGFR akavharwa, masero ekenza anotambura kuti awande uye anogona kufa. Iyi nzira yakatarwa inogona kuderedza kana kumisa kufambira mberi kwekenza muvarwere vazhinji.

Sezvo iri kurapa kwakasimba kwakatarwa, afatinib inogona kubudirira asi inogonawo kukonzera migumisiro yakawanda kupfuura mamwe mishonga yekenza yemuromo. Kusungirirwa kusingadzoreki kunoita kuti ive yakanyanya kusimba pamhando dzakasiyana dzeEGFR mutations.

Ndinofanira Kutora Sei Afatinib?

Tora afatinib sezvinorayirwa nachiremba wako, kazhinji kamwe pazuva mudumbu risina chinhu. Unofanira kuitora angangoita awa rimwe usati wadyisa kana maawa matatu mushure mekudya kuti uve nechokwadi chekunyudzwa kwakakodzera.

Medza piritsi rose negirazi remvura izere. Usapwanye, kutsenga, kana kuputsa piritsi, sezvo izvi zvinogona kukanganisa mashandiro emushonga. Edza kuitora panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako.

Dzivisa kudya kwemaawa angangoita rimwe mushure mekutora afatinib. Zvokudya, kunyanya zvekudya zvine mafuta akawanda, zvinogona kuderedza zvakanyanya huwandu hwemushonga unotorwa nemuviri wako. Iyi nguva yakakosha kuti mushonga ushande nemazvo.

Kana uine dambudziko rekumedza mapiritsi, taura nechikwata chako chehutano nezve sarudzo. Usambofa wakanyungudutsa kana kupwanya mapiritsi eafatinib pasina mirairo chaiyo kubva kuna chiremba wako kana wezve mishonga.

Ndichatora Afatinib kwenguva yakareba sei?

Kazhinji, ucharamba uchitora afatinib kwenguva yakareba sekureba kwayo ichidzora kenza yako uye uchigona kutsungirira mhedzisiro yacho zvakanaka. Izvi zvinogona kutora mwedzi kana kunyange makore, zvichienderana nekuti kenza yako inopindura sei kurapwa.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa nguva dzose uye bvunzo dzeropa kuti aongorore kuti mushonga uri kushanda sei. Kana kenza yako ikamira kupindura afatinib kana kana mhedzisiro yacho ikava yakanyanya, oncologist wako anogona kuchinja chirongwa chako chekurapa.

Vamwe varwere vanotora afatinib kwenguva yakareba nekudzora kenza zvakanaka uye mhedzisiro inogoneka. Vamwe vangada kumira nekukurumidza nekuda kwekufambira mberi kwekenza kana mhedzisiro isingatsungiririki. Kureba kwekurapa kwako kuchave kwakanyanya kuenderana nemhinduro yako uye hutano hwese.

Ndezvipi Zvakaipa zveAfatinib?

Vanhu vazhinji vanotora afatinib vanowana dzimwe mhedzisiro, kunyangwe dzichisiyana muhukuru kubva kumunhu nemunhu. Mashoko akanaka ndewekuti mhedzisiro yakawanda inogona kutarisirwa nekuchengetedza rutsigiro uye kugadzirisa dosi.

Heano mhedzisiro yakajairika yaungawana paunenge uchitora afatinib:

• Manyoka (anoita kune vanhu vazhinji asi anowanzo manejwa)
• Meno eropa uye mapundu akafanana neacne pachiso nepamusoro pemuviri
• Ganda rakaoma, rakatsemuka, kana kupepuka
• Maronda emuromo kana maronda
• Matambudziko emumvuri anosanganisira hutachiona hwakapoteredza zvipikiri
• Kuderera kwechido uye kurasikirwa uremu
• Kuneta uye kusava nesimba
• Kusvotwa uye kurutsa

Izvi zvinowanzoitika zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga. Chikwata chako chehutano chinogona kupa mishonga uye nzira dzekubatsira manejimendi aya zviratidzo zvinobudirira.

Nepo zvisingawanzoitiki, vamwe varwere vanogona kusangana nemhedzisiro yakakomba inoda kutariswa kwekurapa nekukurumidza:

• Manyoka akakomba anotungamira kupera mvura mumuviri
• Kuita ganda zvakanyanya nemavanga kana kubva
• Kuzvimba kwemapapu kunokonzera kufema nekukosora
• Matambudziko echiropa anokonzera kuita yero yeganda kana maziso
• Matambudziko emoyo anokanganisa kugona kupomba
• Matambudziko akakomba emaziso anosanganisira kukuvadzwa kwekornea

Bata timu yako yehutano nekukurumidza kana uine chero matambudziko aya akakomba. Zvizhinji zvezvinhu zvinokonzera matambudziko zvinogadzirisika nerutsigiro rwakakodzera rwekurapa uye kugadzirisa dose.

Ndiani Asingafaniri Kutora Afatinib?

Afatinib haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kwauri. Vanhu vane mamwe mamiriro ehutano kana kutora mishonga yakatarwa vangangoda kudzivisa kurapwa uku.

Haufanire kutora afatinib kana uine allergic kwairi kana chero zvinhu zvayo. Chiremba wako achavawo akangwarira nezvekuiisa kana uine matambudziko akakomba eitsvo kana chiropa, sezvo nhengo idzi dzichibatsira kugadzirisa mushonga.

Vakadzi vane pamuviri havafaniri kutora afatinib sezvo ichigona kukuvadza mwana ari kukura. Kana uri pazera rekubereka, uchada kushandisa nzira yekudzivirira pamuviri inoshanda panguva yekurapa uye kwemavhiki maviri mushure mekumisa mushonga.

Vanhu vane mamwe mamiriro emoyo, chirwere chakakomba chemapapu, kana zvirwere zvinoshanda vangangoda mamwe marapirwo. Oncologist wako achaongorora nhoroondo yako yezvokurapa kuti aone kana afatinib yakakodzera mamiriro ako.

Afatinib Mazita eBrand

Afatinib inotengeswa pasi pezita rekuti Gilotrif muUnited States nemamwe mazhinji. Iyi ndiyo fomu inonyanya kunyorerwa yemushonga.

Zita re generic rekuti "afatinib" rinoreva chinhu chinoshanda, nepo Gilotrif iri zita remhando rinoshandiswa nemugadziri. Mazwi ese ari maviri anoreva mushonga mumwe chete, saka usavhiringike kana ukaona zita rimwe pazvinyorwa zvako kana marekodhi ekurapa.

Parizvino, Gilotrif ndiyo mhando huru iripo, kunyangwe izvi zvingachinja sezvo mapatent achipera uye mhando dzakajairika dzingavepo mune ramangwana.

Zvimwe Zvinhu Zvokutsiva Afatinib

Mamwe marapirwo akawanda akatarwa anowanikwa pakurapa kenza yepfupa yeEGFR-positive, imwe neimwe iine zvainobatsira nezvokufunga. Chiremba wako weoncologist achasarudza sarudzo yakanakisisa zvichienderana nekuchinja kwako kwemajini uye mamiriro ako ezvinhu ekurapa.

Erlotinib (Tarceva) uye gefitinib (Iressa) ndizvo zvimwe zvinodzora EGFR zvinoshanda zvakafanana neafatinib asi zvinogona kuva nezvimwe zvinokonzeresa. Mishonga iyi inogona kufungwa kana iwe usingakwanise kutsungirira afatinib kana kana kenza yako ikaita kuramba.

Osimertinib (Tagrisso) ndiyo imwe nzira itsva yekurapa yakatarwa iyo inonyanya kushanda kune mamwe maEGFR mutations uye inogona kukonzera mashoma mativi kupfuura afatinib. Chiremba wako angakurudzira izvi sezvimwe kana zvinotevera sarudzo yekurapa.

Mishonga yekare yekemotheraphy inoramba iri imwe nzira yakakosha, kunyanya kana nzira dzakatarwa dzisina kukodzera kenza yako. Mishonga yeImmunotherapy inogona zvakare kuva sarudzo zvichienderana nemamiriro ako chaiwo uye maitiro ekenza.

Afatinib Ari Nani Pane Erlotinib Here?

Zvese afatinib uye erlotinib zvinoshanda EGFR inhibitors, asi zvinoshanda zvishoma zvakasiyana uye zvinogona kunge zvakakodzera kune varwere vakasiyana. Sarudzo pakati pavo inoenderana nekuchinja kwako kwekenza uye maitiro ako ekutsungirira mativi.

Afatinib inodzivisa zvisingadzoreki mapuroteni eEGFR, nepo erlotinib's binding ichidzoreka. Izvi zvinoreva kuti afatinib inogona kuve yakanyanya simba asi inogona zvakare kukonzera mamwe mativi. Zvidzidzo zvinoratidza kuti afatinib inogona kunge iri nyore kune mamwe maEGFR mutations, kunyanya exon 19 deletions.

Panyaya yezvinhu zvinokonzeresa, erlotinib inogona kushandiswa zviri nani nevamwe varwere, zvichigona kuita kuti manyoka nematambudziko eganda ave mashoma. Zvisinei, mhinduro dzemunhu mumwe nemumwe dzinosiyana zvakanyanya, uye zvinoita zvakanaka kune mumwe munhu zvingasava zvakanaka kune mumwe.

Oncologist wako achatarisa zvinhu zvakaita semagene ako chaiwo, hutano hwako hwese, uye zvaunofarira iwe pachako paunenge uchisarudza pakati pemishonga iyi. Dzimwe nguva varwere vanogona kuyedza imwe vozochinjika kune imwe zvichienderana nekushanda kwayo uye kugona kutakurika.

Mibvunzo Inowanzo Bvunzwa Pamusoro peAfatinib

Afatinib Yakachengeteka Here Kune Vanhu vane Chirwere Chemoyo?

Afatinib inogona kukanganisa kushanda kwemoyo, saka vanhu vane zvirwere zvemoyo zviripo vanoda kutariswa zvakanyanya. Cardiologist wako uye oncologist vachashanda pamwechete kuti vaongorore kana mabhenefiti achipfuura njodzi yezvinhu zvako zvakakosha.

Kana uine chirwere chemoyo, chiremba wako anogona kuraira mamwe maedzo ekushanda kwemoyo usati watanga afatinib uye kukutarisa zvakanyanya panguva yekurapa. Vamwe varwere vane zvirwere zvemoyo zvishoma vanogona kutora afatinib zvakachengeteka nekutarisa kwakakodzera, nepo vamwe vachigona kuda mamwe marapirwo.

Ndoita Sei Kana Ndikatora Afatinib yakawanda netsaona?

Kana netsaona ukatora afatinib yakawanda kupfuura yakarairwa, taura nemupi wako wehutano kana nzvimbo yekudzora muchetura nekukasira. Kutora zvakanyanya kunogona kuwedzera njodzi yako yezvinhu zvakakomba zvakaita semanyoka akakomba, maitiro eganda, kana mamwe matambudziko.

Usamirira kuti uone kana zviratidzo zvichivapo, sezvo kupindira kwekutanga kwakakosha nekupfuura muyero wemishonga. Uya nebhodhoro remishonga newe kana uchida kutsvaga rubatsiro rwekurapa rwechimbichimbi, kuitira kuti vapi vehutano vazive chaizvo zvawakatora uye zvawakatora zvakadii.

Ndoita Sei Kana Ndikakanganwa Dose yeAfatinib?

Kana ukakanganwa mushonga uye zvapfuura maawa asingasviki 12 kubva panguva yako yenguva dzose, tora mushonga wakakanganwa paunorangarira. Kana zvapfuura maawa anopfuura 12, siya mushonga wakakanganwa uye tora mushonga wako unotevera panguva yakajairika.

Usambofa wakatora mishonga miviri panguva imwe chete kuti ugadzirise mushonga wakakanganwa, sezvo izvi zvingawedzera njodzi yako yemigumisiro. Kana uchikanganwa mishonga kakawanda, funga nezvekuisa zviyeuchidzo zvefoni kana kushandisa chirongwa chemishonga kuti zvikubatsire kuti urambe uri munzira.

Ndingamira Rini Kutora Afatinib?

Unofanirwa kungomira kutora afatinib pasi pekutungamirirwa nachiremba wako, kazhinji kana kenza yako isingachapinduri kumushonga kana kana uri kusangana nemigumisiro isingashiviriki. Kumira nekukurumidza kungabvumira kenza yako kukura nekukurumidza.

Oncologist wako achagara achiongorora kuti mushonga uri kushanda sei kuburikidza nekutarisa uye bvunzo dzeropa. Kana afatinib ikamira kushanda, chiremba wako achakurukura dzimwe nzira dzekurapa kuti arambe achibata kenza yako zvinobudirira.

Ndingatora Afatinib nemimwe mishonga here?

Afatinib inogona kushamwaridzana nemimwe mishonga, saka zvakakosha kuti uudze timu yako yehutano nezve zvese zvinodhaka, zvinowedzera, uye zvigadzirwa zvemiti zvauri kutora. Mimwe mishonga inogona kuwedzera kana kuderedza kushanda kweafatinib kana kuwedzera migumisiro.

Proton pump inhibitors (semuenzaniso omeprazole) inogona kuderedza kunyudzwa kweafatinib, saka chiremba wako angangoda kugadzirisa nguva kana zviyero. Nguva dzose tarisa nemupharmacist wako kana mupi wehutano usati watanga chero mishonga mitsva uchitora afatinib.