Chii chinonzi Alemtuzumab: Zvinoshandiswa, Mishonga, Migumisiro Yemuviri uye Zvimwe

Alemtuzumab mushonga unopiwa nechiremba unopiwa kuburikidza neIV unobatsira kurapa mamwe marudzi ekenza yeropa uye multiple sclerosis. Inoshanda nekunangana nemaseru akati wandei ekudzivirira muviri anokonzera matambudziko mumamiriro ezvinhu aya, zvichipa muviri wako wekudzivirira muviri reset inotariswa zvakanyanya.

Mushonga uyu ndewechikamu chinonzi monoclonal antibodies, izvo zvakagadzirwa murabhoritari mapuroteni akagadzirirwa kutsvaga uye kubatanidza kune zvakanangana mumuviri wako. Funga nezvazvo sechishandiso chakarurama icho chikwata chako chekurapa chinoshandisa kana dzimwe nzira dzekurapa dzisina kushanda sezvaitarisirwa.

Chii chinonzi Alemtuzumab chinoshandiswa?

Alemtuzumab inorapa mamiriro maviri makuru: chronic lymphocytic leukemia (CLL) uye relapsing forms of multiple sclerosis (MS). Chiremba wako achakurudzira mushonga uyu kana uchida nzira yakatarisana yekugadzirisa mamiriro ako.

Kune chronic lymphocytic leukemia, alemtuzumab inobatsira kana iyi kenza yeropa isina kupindura zvakanaka kune dzimwe nzira dzekurapa chemotherapy. Inonyanya kunangana nemaseru eB-cancerous anowedzera nekukurumidza muropa rako uye lymph nodes.

Mu multiple sclerosis, alemtuzumab inoshanda zvakasiyana nekunangana nemaseru ekudzivirira muviri anokanganisa kutambura nehurongwa hwako hwetsinga. Izvi zvinobatsira kuderedza kakawanda uye kuoma kweMS relapses, zvichipa muviri wako mukana wekupora uye kugadzikana.

Alemtuzumab inoshanda sei?

Alemtuzumab inofungidzirwa semushonga une simba unoshanda nekubatanidza kune puroteni inonzi CD52 inowanikwa pamaseru akati wandei ekudzivirira muviri. Kana yabatanidzwa, inoratidza muviri wako kuti uparadze maseru aya, izvo zvinobatsira kumisazve maitiro ako ekudzivirira muviri.

Iyi nzira ine simba uye yakazara. Mushonga haungodzvinyiriri muviri wako wekudzivirira muviri kwenguva pfupi - unonyatso pedza mhando dzakasiyana dzemaseru ekudzivirira muviri zvachose. Muviri wako unobva zvishoma nezvishoma unovakazve maseru aya nekufamba kwenguva, kazhinji uine chiyero chiri nani uye chiitiko chisingakuvadzi.

Kuvakazve kunogona kutora mwedzi kana makore, ndosaka alemtuzumab ichida kunyatsotarisirwa. Chikwata chako chekurapa chichakutarisa zvakanyanya sezvo immune system yako ichipora uye ichizvigadzirisa.

Ndingatora Sei Alemtuzumab?

Uchagamuchira alemtuzumab kuburikidza neIV infusion kuchipatara kana kiriniki yakakosha, kwete kumba. Mushonga unogara uchipiwa nenyanzvi dzehutano dzakadzidziswa dzinogona kukutarisa zvakanyanya panguva uye mushure mekurapa.

Pamberi peimwe neimwe infusion, iwe unowanzo gamuchira pre-medications kubatsira kudzivirira maitiro. Izvi zvinowanzo sanganisira antihistamines, acetaminophen, uye dzimwe nguva corticosteroids. Chikwata chako chehutano chichatanga izvi maminitsi makumi matatu usati watanga infusion yako yealemtuzumab.

Infusion pachayo inowanzo tora maawa mana edosi yako yekutanga, nedosi dzinotevera dzinogona kutora nguva shoma. Iwe uchatariswa mukati mekuita, nezviratidzo zvako zvakakosha zvichiongororwa nguva dzose uye vashandi vezvokurapa vari pedyo kuti vatarise chero zvinonetsa nekukurumidza.

Vanhu vazhinji vanofanira kugara vachiona kwemaawa mashoma mushure mekupera kweinfusion. Izvi zvinobvumira chikwata chako chekurapa kuti chive nechokwadi chekuti uri kunzwa zvakanaka uye usina kukudziridza chero maitiro akareba usati waenda kumba.

Ndingatora Alemtuzumab Kwenguva Yakareba Sei?

Chirongwa chekurapa chealemtuzumab chinoenderana nemamiriro ako chaiwo uye kuti unopindura sei zvakanaka. Kune multiple sclerosis, iwe unowanzo gamuchira nzira mbiri dzekurapa dzakaparadzaniswa gore rimwe chete.

Nzira imwe neimwe yekurapa ine infusions yezuva nezuva kwemazuva akati wandei akatevedzana. Kune MS, izvi zvinowanzoita mazuva mashanu ekurapa mukosi yekutanga, ichiteverwa nemazuva matatu ekurapa mukosi yechipiri gore gare gare.

Kune chronic lymphocytic leukemia, chirongwa chinogona kunge chakasiyana uye zvinoenderana nekuti kenza yako inopindura sei. Oncologist yako ichasarudza nguva chaiyo zvichienderana nekuverenga kweropa rako, maitiro auri kutora kurapa, uye kana leukemia iri kuvandudza.

Vamwe vanhu vangada makosi ekuwedzera kupfuura chirongwa chakajairika, asi chisarudzo ichi chinogara chichiitwa nekuchenjerera nechikwata chako chekurapa zvichibva mukupindura kwako pachako uye chero mhedzisiro yaunowana.

Ndezvipi Zvakaipa zveAlemtuzumab?

Alemtuzumab inogona kukonzera mhedzisiro yakasiyana, kubva kumhinduro dzakapfava panguva yekuiswa kusvika kumatambudziko akakomba anokura nekufamba kwenguva. Kunzwisisa izvi kunokubatsira kuti uzive zvekutarisa uye kuti ungataurirana riini nechikwata chako chehutano.

Mhedzisiro yakajairika inoitika panguva kana nguva pfupi mushure mekuiswa kwako uye inowanzo manejwa nemishonga yekutanga uye kuongorora kwepedyo:

• Mhinduro dzekuiswa dzakadai sefivha, kutonhora, uye kusvotwa
• Kutsvuka kweganda kana mburwa
• Kurwadziwa nemusoro uye kuneta
• Kuderera kweropa kana kurova kwemoyo nekukurumidza
• Kufema kwemhepo kana kusimba pachipfuva

Mhinduro idzi dzine chekuita nekuiswa dzinowanzoita nani nekufamba kwenguva uye kutarisirwa kunotsigira. Chikwata chako chekurapa chakagadzirirwa zvakanaka kuti chizvigadzirise kana zvikaitika.

Mhedzisiro yakakomba inogona kukura masvondo kusvika kumwedzi mushure mekurapa, kunyanya nekuti alemtuzumab inokanganisa zvakanyanya immune system yako. Izvi zvinoda kuenderera mberi kwekuongorora uye kutariswa nekukurumidza:

• Zvirwere zvakakomba nekuda kwekusadzivirirwa kwakaderera
• Matambudziko eautoimmune thyroid
• Matambudziko ekubuda ropa kubva pakuverenga kwepakati kwepakati
• Matambudziko eitsvo kubva kumhinduro dzeautoimmune
• Kusagadzikana kwemoyo

Mukuwedzera, kune mamwe mhedzisiro isingawanzoitiki asi yakakomba zvikuru iyo chikwata chako chekurapa chichatarisa zvakanyatsonaka. Izvi zvinosanganisira mamiriro eautoimmune akakomba anokanganisa ropa rako, itsvo, kana zvimwe zvikamu, pamwe chete nemamwe marudzi ekenza anogona kukura nekuda kwekudzivirirwa kwemuviri.

Chikwata chako chehutano chichapa zvirongwa zvakadzama zvekuongorora uye kukudzidzisa chaizvo zviratidzo zvekutarisa kumba. Uku kuchenjerera kunoenderera mberi chikamu chakakosha chekurapa kwealemtuzumab.

Ndiani Asingafaniri Kutora Alemtuzumab?

Alemtuzumab haikwanisi kumunhu wese, uye chiremba wako achanyatsoongorora kana zvakakunakira. Zvimwe zvirwere zvekurapa uye mamiriro anoita kuti mushonga uyu uve nenjodzi yakanyanya kushandisa zvakachengeteka.

Haufanire kugamuchira alemtuzumab kana uine zvirwere zvinoshanda, kusanganisira HIV, hepatitis B kana C, kana tuberculosis. Mhedzisiro yemushonga pamasoja ako ekudzivirira muviri inogona kuita kuti zvirwere izvi zvinyanye kuipa uye zvinogona kuisa hupenyu panjodzi.

Vanhu vane mamwe mamiriro eautoimmune kunze kweMS vangave vasiri vakakodzera alemtuzumab. Chiremba wako achayerera kana mabhenefiti achikunda njodzi kana uine mamiriro akadai sechirwere chakakomba cheautoimmune thyroid kana zvimwe zvirwere zvemasoja ekudzivirira muviri.

Kuzvitakura nekuyamwisa zvakare zvinhu zvakakosha. Alemtuzumab inogona kukuvadza mwana ari kukura, saka uchada nzira yekudzivirira pamuviri yakavimbika panguva yekurapa uye kwemwedzi yakati wandei mushure. Kana uri kuronga kuva nepamuviri, kurukura nguva zvakanyatsonaka nechikwata chako chehutano.

Chiremba wako achafungawo nezvehutano hwako hwese, mamwe mishonga yaunotora, uye chero nhoroondo yekupindura kwakanyanya kumishonga usati waraira kurapwa kwealemtuzumab.

Mazita eAlemtuzumab Brand

Alemtuzumab inowanikwa pasi pemazita emhando Lemtrada naCampath, kunyangwe kuwanikwa kuchisiyana nenyika uye chiratidzo chekurapa. Lemtrada inonyanya kushandiswa kurapa multiple sclerosis, nepo Campath yaishandiswa zvakanyanya leukemia.

Mune dzimwe nzvimbo, Campath inogona kunge isisipo, asi alemtuzumab pachayo inoramba ichiwanikwa kuburikidza nemamwe mafomu. Chikwata chako chehutano chichaita shuwa kuti unogamuchira vhezheni yakakodzera yechimiro chako.

Zvisinei nezita remhando, chinhu chinoshanda uye mhedzisiro zvinoramba zvakafanana. Chikwata chako chekurapa chichabata zvese zvakadzama nezvekuti ndeipi fomu yaunogamuchira.

Zvimwe Zvinhu zveAlemtuzumab

Pane dzimwe nzira dzakawanda dzekurapa multiple sclerosis uye chronic lymphocytic leukemia, asi chiremba wako achasarudza zvinoenderana nemamiriro ako chaiwo uye kuti dzimwe nzira dzekurapa dzakashanda sei kwauri.

Pamusoro pe multiple sclerosis, dzimwe nzira dzinosanganisira dzimwe nzira dzekuchinja chirwere dzakadai se natalizumab, rituximab, kana mishonga mitsva yemuromo yakadai se fingolimod kana dimethyl fumarate. Imwe neimwe ine mabhenefiti akasiyana uye njodzi iyo nyanzvi yako yetsinga dzinotaura newe.

Mu chronic lymphocytic leukemia, dzimwe nzira dzinogona kusanganisira mamwe monoclonal antibodies akadai se rituximab, chemotherapy combinations, kana nzira itsva dzinotarwa dzakadai se ibrutinib kana venetoclax. Chiremba wako weoncologist achafunga nezvezvinhu zvakaita sehutano hwako hwese, genetics ye leukemia yako, uye kurapwa kwakapfuura.

Sarudzo yenzira imwe inonyanya kuenderana nemamiriro ako ega, kusanganisira kuti mamiriro ako akakomba sei, zera rako uye hutano hwese, uye kuti ndedzipi nzira dzekurapa dzawakatoedza.

Alemtuzumab Ari Nani Kudarika Dzimwe Kurapa kweMS?

Alemtuzumab inowanzoita zvakanyanya kupfuura dzimwe nzira dzekurapa MS mukuderedza relapses uye kunonotsa kufambira mberi kwekusagona, asi inotakurawo njodzi dzakakomba. Izvi zvinoita kuti zvive zvakakosha kune vanhu vane aggressive MS vasina kupindura zvakanaka kune dzimwe mishonga.

Pakuenzanisa neinterferons kana glatiramer acetate, alemtuzumab inowanzoita mhedzisiro yakasimba uye inogara kwenguva refu. Vanhu vazhinji vanowana kuderedzwa kukuru mukuita kweMS kwemakore mushure mekurapa, izvo zvinogona kuchinja hupenyu kune avo vane chirwere chinoshanda.

Zvisinei, kuwedzera kushanda kunouya nezvinodiwa zvakanyanya zvekuongorora uye zvinogona kuita zvakanyanya kukomba. Nyanzvi yako yetsinga dzinokubatsira kuyera kana mabhenefiti anoruramisa njodzi mumamiriro ako chaiwo.

Sarudzo iyi inowanzovimba nezvinhu zvakaita sekuti MS yako iri kushanda zvakadii, kuti wakanzwa sei kune dzimwe nzira dzekurapa, zera rako, uye kugona kwako pachako kutarisana nenjodzi vachienzanisa nekubatsirwa kunogona kuwanikwa.

Mibvunzo Inowanzoitwa Pamusoro peAlemtuzumab

Alemtuzumab Yakachengeteka Here Kune Vanhu Vane Matambudziko Emoyo?

Alemtuzumab inoda kuongororwa zvakanyatso kana uine matambudziko emoyo, sezvo inogona kukanganisa rhythm yemoyo wako uye ropa rinofamba mumuviri panguva yekupinza. Chiremba wako wemoyo uye timu iri kukupa alemtuzumab vachashanda pamwechete kuti vaone kana zvakachengeteka kwauri.

Kana ukagamuchira alemtuzumab uine matambudziko emoyo, unozoda kuongororwa zvakanyanya panguva yekupinza uye pamwe kuongororwa kwe rhythm yemoyo mushure meizvozvo. Vanhu vazhinji vane matambudziko emoyo akagadzikana vanogona kuramba vachigamuchira kurapwa uku zvakachengeteka nekuchenjerera kwakakodzera.

Ndingaita Sei Kana Ndikakanganwa Dose yeAlemtuzumab Yakatarwa?

Taura nechikwata chako chehutano nekukasira kana ukakanganwa kupinza kwe alemtuzumab kwakatarwa. Sezvo mushonga uyu uchipiwa mumakosi akanyatsoitwa nguva, kukanganwa madhizi kunogona kukanganisa kuti kurapwa kwako kunoshanda sei.

Chikwata chako chekurapa chichazotara dose yako zvakare nekukasira uye chinogona kuchinja zvishoma chirongwa chako chekurapa. Usaedze "kubata" nekutora mushonga wakawanda - gara uchitevera gwara rechikwata chako chehutano pamusoro pekutara zvakare.

Ndingaita Sei Kana Ndine Zvinhu Zvakaipa Zvikuru kubva kuAlemtuzumab?

Tsvaga rubatsiro rwekurapa nekukasira kana ukawana zviratidzo zvehutachiona hwakakomba (fivha, kutonhora, kuneta kusinganzwisisike), kubuda ropa kusinganzwisisike kana kupwanya, kana zviratidzo zvematambudziko ethyroid (kurova kwemoyo nekukurumidza, shanduko dzisina kutsanangurwa dzehuremu, kuneta zvakanyanya).

Chikwata chako chehutano chichakupa mirairo yakadzama pamusoro pezviratidzo zvinoda kutariswa nekukasira vachienzanisa neavo vanogona kumirira kusvikira kugadzwa kwako kunotevera. Chengeta mirairo iyi ichiwanikwa nyore nguva dzose.

Ndingamira Rini Kuongorora Mushure meKurapa kweAlemtuzumab?

Kutarisa kunoenderera mberi kwemakore angangoita 4 mushure mekurapa kwako kwekupedzisira kwealemtuzumab, uye zvimwe zvinhu zvinogona kuda kutariswa kweupenyu hwese. Kutarisa uku kwakawedzerwa kwakakosha nekuti matambudziko akakomba anogona kukura mwedzi kana kunyange makore mushure mekurapa.

Chikwata chako chekuchengetedza hutano chichapa chirongwa chaiwo chekutarisa chinosanganisira bvunzo dzeropa dzenguva dzose, kuongororwa kwebasa rethyroid, uye mamwe maongororo. Kutevera chirongwa ichi zvakavimbika kwakakosha pakubata chero matambudziko nekukurumidza kana achigona kurapwa zvakanyanya.

Ndingagamuchira Majekiseni Ndichitora Alemtuzumab Here?

Majekiseni mhenyu haana kuchengeteka apo immune system yako iri kupora kubva kualemtuzumab, kazhinji kwemwedzi angangoita 6 mushure mekurapa. Zvisinei, unogona kukwanisa kugamuchira mamwe majekiseni asina basa nekubvumidzwa kwachiremba wako.

Chikwata chako chekuchengetedza hutano chichapa gwara chaiwo pamusoro pemajekiseni api akachengeteka uye rini. Zvakakosha kukurukura chero zvinodiwa zvejekiseni, kusanganisira majekiseni ekufamba, nguva refu usati waronga majekiseni ako.