Chii chinonzi Alendronate: Zvazvinoshandiswa, Madosi, Migumisiro, nezvimwe

Alendronate mushonga unosimbisa mapfupa unobatsira kudzivirira mapfupa kutyoka muvanhu vane osteoporosis kana kurasikirwa nemapfupa. Iwo wechikwata chemishonga inonzi bisphosphonates, iyo inoshanda nekumisa maitiro echisikigo anoparadza tishu yemapfupa. Izvi zvinopa muviri wako nguva yakawanda yekuvaka mapfupa matsva, akasimba, achibatsira kuderedza njodzi yako yekutyoka sezvaunokwegura.

Chii chinonzi Alendronate?

Alendronate mushonga unopiwa nachiremba wakagadzirirwa kurapa nekudzivirira osteoporosis, mamiriro apo mapfupa anova asina simba uye anotyoka. Funga nezvazvo sechidzitiro chekudzivirira mapfupa ako - inobatsira kuchengetedza density yemapfupa nekukanganisa maseru anowanzoita kuparadza tishu yemapfupa.

Mushonga uyu unouya muchimiro chepiritsi uye unotorwa nemuromo, kazhinji kamwe pavhiki kana kamwe pazuva zvichienderana nekukurudzirwa kwachiremba wako. Yave ichishandiswa zvakachengeteka kwemakumi emakore kubatsira mamiriyoni evanhu kuchengetedza mapfupa akasimba uye kuderedza njodzi yavo yekutyoka.

Alendronate inoonekwa seyekutanga-mutsara kurapwa kwe osteoporosis, zvinoreva kuti vanachiremba vanowanzoisarudza seyekutanga kurudziro yavo nekuda kwekubudirira kwayo kwakaratidzwa uye yakagadzwa zvakanaka kuchengeteka profile.

Chii chinonzi Alendronate chinoshandiswa?

Alendronate inorapa osteoporosis muvarume nevakadzi, kunyanya avo vari panjodzi huru yekutyoka kwemapfupa. Inobatsira zvakanyanya kuvakadzi vakapfuura menopause, sezvo shanduko yehomoni panguva ye menopause inogona kumhanyisa kurasikirwa kwemapfupa.

Chiremba wako angangokurudzira alendronate kana uine mamiriro akati wandei ane hukama nemapfupa anoda kutariswa:

• Osteoporosis ine nhoroondo yekutyoka
• Low bone density (osteopenia) iri kufambira mberi kuenda ku osteoporosis
• Steroid-induced osteoporosis kubva mukushandiswa kwenguva refu kwecorticosteroid
• Paget's disease, uko mapfupa anokura zvakanyanya uye asina simba
• Kudzivirira kurasikirwa kwemapfupa muvanhu vanotora mishonga inoderedza mapfupa

Mushonga uyu unokosha zvikuru kuvanhu vakambotyoka, sezvo uchideredza zvikuru mukana wekutyoka mune ramangwana. Unoshandiswawo kudzivirira vanhu vane zvinhu zvakawanda zvinokonzera osteoporosis.

Alendronate Inoshanda Sei?

Alendronate inoshanda nekudzivisa maseru akakosha anonzi osteoclasts ayo anowanzoita kuti mapfupa ekare aparadzwe. Uyu mushonga une simba rakati wandei unogadzira shanduko huru mumaitiro emapfupa ako echisikigo.

Mapfupa ako anogara achizvivakazve kuburikidza nekuyera kwemaparadziro nekuumbwa. Kana kuyera uku kukatsveyama kuenda kumaparadziro akawandisa, mapfupa anova asina simba uye anowanzo tyoka. Alendronate inodzorera kuyera nekuderedza rutivi rwemaparadziro ekuenzanisa.

Mushonga unotorwa mumapfupa ako uye unogara ikoko kwemwedzi kana makore, uchipa dziviriro inogara kwenguva refu. Ichi ndicho chikonzero nei mhedzisiro ichienderera mberi kunyangwe iwe ukamira kuutora, kunyangwe dziviriro ichiderera zvishoma nezvishoma nekufamba kwenguva.

Iwe unowanzoona kuvandudzwa mukukora kwemapfupa mukati memwedzi mitanhatu kusvika gumi nemaviri ekutanga kurapwa, nemabhenefiti akanyanya anowanzoitika mushure memakore maviri kusvika matatu ekushandisa nguva dzose.

Ndingatora Sei Alendronate?

Alendronate inoda nguva chaiyo uye kugadzirira kuti ishande nemazvo uye kudzivirira kutsamwa mudumbu. Unofanira kui tora mangwanani-ngwanani mudumbu risina chinhu nemvura yakazara yemapuro.

Heino nzira yechidimbu-ne-chidimbu chiremba wako angakurudzira:

1. Tora piritsi pakarepo paunomuka, usati wadyisa kana kunwa chero chinhu
2. Mumedze yose nemvura yakajeka ye6 kusvika 8 ounces (kwete mvura yemamineral, kofi, kana muto)
3. Gara wakamira (wakagara kana kumira) kwemaminitsi makumi matatu mushure mekuitora
4. Mirira angangoita maminitsi makumi matatu usati wadyisa, kunwa, kana kutora mamwe mishonga
5. Usavata pasi, kukotama, kana kurovedza muviri zvakanyanya panguva iyi yekumirira

Mirayiridzo iyi haisi kungoti mazano chete - akakosha kudzivirira mhedzisiro yakakomba uye kuona kuti mushonga unoshanda nemazvo. Kugara wakatwasuka kunobatsira kudzivirira piritsi kubva pakutsamwisa esophagus yako.

Kana iwe uchitora zvinowedzera calcium kana antacids, mirira angangoita maawa maviri mushure me dose yako ye alendronate, sezvo izvi zvinogona kukanganisa kunyudzwa.

Ndingatora Alendronate Kwenguva Yakareba Sei?

Vanhu vazhinji vanotora alendronate kwemakore matatu kusvika mashanu pakutanga, kunyangwe vamwe vachigona kuda kurapwa kwenguva refu zvichienderana nenjodzi yavo yekutyoka. Chiremba wako achagara achiongorora kana iwe uchifanira kuenderera mberi, kutora zororo, kana kuchinjira kune mumwe mushonga.

Mushure memakore mashanu ekurapa, vanhu vazhinji vanogona kutora zvinonzi "zororo remushonga" - zororo rakarongeka kubva kumushonga. Izvi zvinoitika nekuti alendronate inogara mumapfupa ako kwemakore, ichienderera mberi ichipa imwe dziviriro kunyangwe iwe ukamira kuitora.

Chiremba wako achafunga zvinhu zvakati wandei paanenge achisarudza nezve nguva yekurapa. Izvi zvinosanganisira zvaunotanga kuwanda kwemapfupa, maitiro ako akapindura kurapwa, zera rako, uye njodzi yako yekutyoka.

Vamwe vanhu vane njodzi yakanyanya yekutyoka vangangoda kuenderera mberi nekurapwa kwenguva yakareba kana kuchinjira kune imwe mhando yemushonga wemapfupa. Kuongororwa kwemapfupa nguva dzose uye kuongororwa kunobatsira kutungamira sarudzo idzi.

Ndezvipi Zvipingamupinyi zveAlendronate?

Vanhu vazhinji vanotsungirira alendronate zvakanaka, asi semishonga yese, inogona kukonzera mhedzisiro kubva pakureruka kusvika pakukomba. Mashoko akanaka ndewekuti mhedzisiro yakakomba haisi yakajairika kana mushonga uchitorwa nemazvo.

Mhedzisiro yakajairika yaungasangana nayo inowanzoita nyoro uye inowanzoita nani muviri wako paunojaira mushonga:

• Kusagadzikana mudumbu kana kusvotwa
• Heartburn kana acid reflux
• Kurwadziwa mudumbu
• Diareya kana kuvharika
• Kutemwa nemusoro
• Kurwadziwa kwemhasuru kana majoini

Zviratidzo izvi zvinowanzoitika mumavhiki mashoma ekutanga ekurapa uye kazhinji zvinopera zvega. Kutora mushonga sezvakarairwa kunoderedza zvakanyanya njodzi yemigumisiro ine chekuita nedumbu.

Kune mamwe mashoma asi akakomba migumisiro inoda kutariswa kwekurapa nekukurumidza, kunyangwe ichikanganisa vanhu vashoma pane 1 muna 1,000:

• Kurwadziwa kwakanyanya kwemashaya kana kuoma kuvhura muromo wako (osteonecrosis yemashaya)
• Kurwadziwa kwemukati kwemukati kana kurwadziwa kusingaperi
• Kupisa kwakanyanya kwemoyo kana kuoma kumedza
• Kurwadziwa kutsva kana kuwedzera kwemuchipfuwo
• Kurwadziwa kwakanyanya kwemhasuru, mapfupa, kana majoini akasiyana nekusagadzikana kwako kwakajairika

Kazhinji, vamwe vanhu vanogona kusangana nekutyoka kusingaite kwepfupa remukati mushure mekushandiswa kwenguva refu. Kutyoka uku kusingaite dzimwe nguva kunogona kuitika nekukuvara kushoma uye kunogona kutangirwa nekurwadziwa kwemukati kwemavhiki kana mwedzi.

Ndiani Asingafaniri Kutora Alendronate?

Alendronate haikodzeri munhu wese, uye mamwe mamiriro ehutano anoita kuti isachengeteke kana kushanda zvishoma. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wanyora mushonga uyu.

Haufaniri kutora alendronate kana uine chero mamiriro aya anoita kuti mushonga uyu uve nenjodzi:

• Matambudziko neesophagus yako, kusanganisira kuchecheuka kana kuoma kumedza
• Kusakwanisa kugara kana kumira wakatwasuka kwemaminitsi angangoita 30
• Mazinga epasi akaderera eropa calcium (hypocalcemia)
• Chirwere chakakomba cheitsvo
• Allergies inozivikanwa kune alendronate kana mishonga yakafanana

Mamwe mamiriro ehutano anoda kungwarira uye kuongororwa, kunyangwe asingakudzivise kutora alendronate. Chiremba wako achayerera mabhenefiti achipesana nenjodzi dzinogona kuitika kana uine matambudziko emudumbu, nyaya dzemazino, kana kushomeka kwevhitamini D.

Vakadzi vane pamuviri nevaya vanoyamwisa havafaniri kutora alendronate, nekuti zvinogona kukuvadza mwana ari kukura. Mushonga uyu unogona kugara mumapfupa kwemakore, saka vakadzi vari kuronga kuva nepamuviri vanofanira kukurukura nezve nguva yacho nachiremba wavo.

Mazita eAlendronate Brand

Alendronate inowanikwa pasi pemazita akawanda emhando, Fosamax ndiyo inonyanya kuzivikanwa. Iyo generic vhezheni ine chinhu chimwe chete chinoshanda uye inoshanda zvakanyanya sezvakaita mhando-mazita.

Mazita akajairika emhando anosanganisira Fosamax, Fosamax Plus D (iyo ine vhitamini D), uye Binosto (piritsi rinonyungudika mumvura). Pharmacy yako inogona kuve nemhando dzakasiyana, asi dzese dzine mushonga mumwe chete.

Sarudzo pakati pe generic uye mhando-mazita kazhinji inouya pasi pemutengo uye inishuwarenzi. Generic alendronate inowanzoita mari shoma uye inoshanda zvakafanana nemhando-mazita.

Zvimwe Zvinhu zveAlendronate

Kana alendronate isingashande zvakanaka kwauri kana kukonzera mhedzisiro inonetsa, mishonga yakati wandei inogona kubatsira kusimbisa mapfupa ako. Chiremba wako anogona kukubatsira kuwana sarudzo yakanakisa zvichienderana nezvido zvako uye mamiriro ehutano.

Mishonga mimwe ye bisphosphonate inoshanda zvakafanana ne alendronate asi inogona kuve nyore kutsungirira:

• Risedronate (Actonel) - inotorwa vhiki nevhiki kana mwedzi nemwedzi
• Ibandronate (Boniva) - inowanikwa semapiritsi emwedzi kana majekiseni emakota
• Zoledronic acid (Reclast) - inopiwa se infusion yegore negore

Zvimwe zvisiri zve-bisphosphonate zvinosanganisira denosumab (Prolia), iyo inopiwa sejojo mwedzi mitanhatu yega yega, uye teriparatide (Forteo), iyo inonyatso kurudzira kuumbwa kwemapfupa matsva pane kungodzivirira kurasikirwa kwemapfupa.

Kune vamwe vanhu, hormone replacement therapy, selective estrogen receptor modulators, kana calcitonin inogona kunge iri imwe nzira yakakodzera. Sarudzo yakanakisa inoenderana nezera rako, bonde, njodzi yekutyoka, uye zvimwe zvinhu zvehutano.

Ko Alendronate Zviri Nani Kudarika Risedronate?

Zvese alendronate ne risedronate mishonga inoshanda ye bisphosphonate inoshanda zvakafanana kudzivirira mapfupa uye kusimbisa mapfupa. Zvidzidzo zvinoratidza kuti zvakaenzana maererano nekushanda, zvese zvichideredza njodzi yekutyoka neanenge 30-50%.

Musiyano mukuru uri muzvirongwa zvekushandisa uye kuti vanhu vanotsungirira sei mushonga wega wega. Alendronate inowanzo torwa kamwe pavhiki, nepo risedronate inogona kutorwa pavhiki kana pamwedzi. Vamwe vanhu vanowana imwe iri nyore kutsungirira kune imwe maererano nemigumisiro yedumbu.

Risedronate inogona kunge iri nyoro zvishoma mudumbu kune vamwe vanhu, kunyangwe mishonga yese iri miviri inoda kutarisirwa kumwechete mudumbu risina chinhu nemvura yakawanda. Sarudzo inowanzoenderana nekupindura kwako wega uye zvaunofarira.

Chiremba wako achatarisa mamiriro ako ehutano, mamwe mishonga yaunotora, uye chero ruzivo rwekare ne bisphosphonates paachasarudza pakati pezvisarudzo izvi.

Mibvunzo Inowanzo Bvunzwa Nezve Alendronate

Ko Alendronate Yakachengeteka Kune Vanhu vane Chirwere cheItsvo?

Alendronate inogona kushandiswa nekuchenjerera kune vanhu vane matambudziko eitsvo, asi hazvikurudzirwe kune avo vane chirwere cheitsvo chakakomba. Chiremba wako achatarisa kushanda kweitsvo dzako nemiedzo yeropa vasati vanyora alendronate uye vanogona kuiongorora nguva nenguva panguva yekurapa.

Kana uine chirwere cheitsvo, chiremba wako angasarudza mushonga wakasiyana wepfupa kana kugadzirisa chirongwa chako chekurapa. Vanhu vane chirwere cheitsvo chakakomba havafaniri kutora alendronate sezvo ichigona kuvaka mumuviri uye zvinogona kukonzera matambudziko.

Ndingaita Sei Kana Ndikashandisa Alendronate Yakawandisa Netsaona?

Kana netsaona ukatora yakawanda kupfuura chiyero chako chakanyorwa, usavhunduka, asi taura nachiremba wako kana kutonga chepfu nekukasira. Usaedze kurutsa, sezvo izvi zvinogona kukonzera kuti mushonga ugumbure huro yako uye esophagus munzira yekudzoka kumusoro.

Inwa mukaka wakawanda kana mvura kuti zvikubatsire kunyungudutsa mushonga mudumbu rako. Gara wakamira uye dzivisa kurara pasi. Vanhu vazhinji vanotora mishonga yakawanda netsaona havawani matambudziko akakomba, asi kutsvaga mazano echiremba kwakakosha kuti uve nechokwadi chekuchengeteka kwako.

Ndingaita Sei Kana Ndakanganwa Kudya Mushonga weAlendronate?

Kana ukakanganwa kudya mushonga wako wevhiki uye ukuyeuka mukati mezuva rimwe kana maviri, tora mushonga wacho paunorangarira, uchitevera mirairo yese yenguva dzose. Wobva wadzokera kuchirongwa chako chenguva dzose vhiki rinotevera.

Kana mazuva akati wandei apfuura kubva pawakakanganwa kudya mushonga wako, usatore mushonga wacho zvachose uye tora mushonga wako unotevera pazuva raunogara uchiutora. Usatore mishonga miviri mukati mevhiki imwe chete kuti ugadzirise mushonga wakakanganwa, sezvo izvi zvichikwidza njodzi yako yekuwana mhedzisiro isingadiwi.

Ndingamira Rini Kudya Alendronate?

Usambomira kudya alendronate kamwechete usina kutanga wataurirana nachiremba wako. Vanhu vazhinji vanogona kutora zororo rakarongeka kubva kumushonga mushure memakore 3 kusvika ku5 ekurapa, asi sarudzo iyi inofanirwa kugara ichiitwa nemutungamiri wekurapa.

Chiremba wako achaongorora kuwanda kwemapfupa ako, njodzi yekutyoka, uye hutano hwako hwese usati warayira kana kuenderera mberi nekurapa, kutora zororo, kana kuchinja kune mumwe mushonga. Vamwe vanhu vangangoda kuenderera mberi nekurapa kwenguva refu zvichienderana nezvinhu zvavo zvinokonzera njodzi.

Ndingatora Alendronate nemimwe mishonga here?

Alendronate inogona kushanda nemimwe mishonga, saka zvakakosha kuti uudze chiremba wako nezvezvose zvauri kutora. Zvinhu zvinowedzera calcium, antacids, uye zvinowedzera iron zvinogona kukanganisa kunyudzwa kwealendronate kana zikatorwa pedyo pedyo.

Unofanira kumirira angangoita maawa maviri mushure mekutora alendronate usati watora calcium, antacids, kana mimwe mishonga. Mimwe mishonga yakaita semamwe maantibiotics kana anti-inflammatory drugs inogona kuwedzera njodzi yekutsamwa mudumbu kana yakasanganiswa nealendronate.