Chii chinonzi Amifostine: Zvayinoshandiswa, Madosi, Matambudziko, nezvimwe

Amifostine mushonga unodzivirira unobatsira kuchengetedza masero ane hutano kubva mukukuvadzwa panguva yekurapwa kwekenza. Inoshanda semurindi wemasero, ichipinda mukuderedza mhedzisiro inokuvadza yechemotherapy uye radiation pamatishu akajairika ichibvumira kurapwa uku kuramba kurwisa masero ekenza zvinobudirira.

Mushonga uyu wave chishandiso chinokosha mukuchengetwa kwekenza kwemakumi emakore, uchipa tariro kuvarwere vanoda kurapwa kwakanyanya asi vachida kuchengetedza nhengo dzavo dzine hutano. Kunzwisisa mashandiro anoita amifostine kunogona kukubatsira kuti unzwe wakavimbika pamusoro pezvisarudzo zvako zvekutsvaga kurapwa.

Chii chinonzi Amifostine?

Amifostine mushonga wecytoprotective, zvinoreva kuti inodzivirira masero ane hutano kubva mukukuvadzwa kwakashata. Mushonga unochinjwa kuita chimiro chinoshanda mukati memuviri wako chinova scavenger, ichibvisa mahara radicals anokuvadza akagadzirwa nekurapwa kwekenza.

Funga nezve amifostine sechidzitiro chinodzivirira masero akajairika asi chichisiya masero ekenza achiwanzotambura nekurapwa. Dziviriro iyi inosarudza inoitika nekuti masero ane hutano ane kuyerera kweropa kuri nani uye anogona kutora mushonga zvakanyanya kupfuura masero ekenza.

Mushonga uyu pakutanga wakagadzirwa neU.S. Army sedziviriro kubva mukuratidzwa kweradiation. Nhasi, oncologists vanoiisa kuti ibatsire varwere kutsungirira madosi epamusoro ekurapwa kwekenza kunoponesa hupenyu nemhedzisiro shoma.

Amifostine Inoshandiswa Kunei?

Amifostine inoshanda semubatsiri anodzivirira panguva yekurapwa kwekenza. Chiremba wako anogona kuikurudzira kuti ideredze kukuvadzwa kwematsvo kubva ku cisplatin chemotherapy kana kudzivirira muromo wakaoma panguva ye radiation therapy yekenza yemusoro nemutsipa.

Mushonga uyu unobatsira kudzivirira matambudziko ematsvo anokonzerwa ne cisplatin, ayo anogona kuva akakomba uye dzimwe nguva anogara. Paunogamuchira cisplatin yekenza senge ovarian, lung, kana testicular cancer, amifostine inogona kuderedza zvakanyanya njodzi yako yekukuvadzwa kwematsvo.

Kune varwere vane kenza yemusoro nemutsipa vari kugamuchira radiation, amifostine inobatsira kuchengetedza mate. Kuchengetedzwa uku kunogona kudzivirira muromo wakaoma unowanzoita kuti kudya, kutaura, uye kurara zvive zvakaoma mushure mekurapa ne radiation.

Vamwe vanachiremba vanoshandisawo amifostine kudzivirira mamwe mativi emishonga ane chekuita ne chemotherapy, kunyangwe kushandiswa uku kusingawanzoitika uye kunoenderana nemamiriro ako chaiwo.

Amifostine Inoshanda Sei?

Amifostine inoshanda nekuzova mudziviriri wecellular kana yapinda mumuviri wako. Mushonga unoputsika ne enzyme inonzi alkaline phosphatase, iyo inoshanda zvakanyanya mumatehwe ane hutano kupfuura mumasero ekenza.

Kuparara uku kunogadzira chinhu chinoshanda chinotora semwanda wemamorekuru, achitora mahara radicals ane chepfu ayo chemotherapy uye radiation inogadzira. Aya mahara radicals ndivo vanonyanya kukonzera kukuvadzwa kwenhengo kunoenderana nekurapa.

Runako rwe amifostine runovanda mukusarudza kwayo. Masero ane hutano ane ropa rakanaka anogona kutora uye kushandisa mushonga nemazvo, nepo masero ekenza ane kuyerera kweropa kushoma asingagoni. Izvi zvinoreva kuti nhengo dzako dzakajairika dzinowana dziviriro nepo masero ekenza achiramba achiwanzwa kurapwa.

Mushonga unoshanda nekukurumidza, nekudzivirirwa kwepamusoro kunoitika mukati memaminitsi gumi nemashanu kusvika makumi matatu mushure mekutarisirwa. Iyi nguva inobvumira timu yako yekurapa kuti iite zvakanaka nechirongwa chako chekurapa kenza.

Ndinofanira Kutora Sei Amifostine?

Amifostine inogara ichipiwa intravenously (kuburikidza neIV) muchipatara kana kiriniki. Hauzogoni kutora mushonga uyu kumba nekuti unoda kutariswa kwekurapa kwakanyatsonaka uye nguva chaiyo nekurapa kwako kenza.

Chikwata chako chekuchengetedza hutano chichakupa mushonga maminitsi makumi matatu usati watora chemotherapy yako kana kurapwa ne radiation. Iyi nguva inovimbisa kuti mhedzisiro yekudzivirira iri pamusoro payo paunogamuchira kurapwa kwako kenza.

Usati wapiwa amifostine, unofanirwa kunwa mvura yakawanda uye unogona kupiwa mishonga inodzivirira kusvotwa. Ropa rako richatariswa zvakanyanya nekuti mushonga uyu unogona kuita kuti ridzike kwenguva pfupi.

Kupinza kunowanzo tora maminitsi anenge gumi nemashanu. Uchagara munzvimbo yekurapwa kuti utarise kuti uone kuti unonzwa zvakanaka usati waenderera mberi nekurapwa kwako gomarara.

Ndingatora Amifostine Kwenguva Yakareba Sei?

Uchapihwa amifostine kwenguva yakareba sezvaunowana kurapwa kwegomarara kwairi kukudzivirira. Kana uri kuwana cisplatin chemotherapy, uchawana amifostine usati wapiwa dose yega yega ye cisplatin mukati mematreatment cycles ako.

Kune varwere ve radiation therapy, mushonga uyu unowanzo piwa zuva nezuva usati wapiwa radiation session yega yega. Radiation oncologist wako achasarudza chaiyo nguva zvichienderana nekurapwa kwako uye kuti unotsungirira sei mushonga.

Kureba kunoenderana zvachose nekurapwa kwako gomarara. Vamwe varwere vanoiwana kwemavhiki mashoma, asi vamwe vangaiisa kwemwedzi yakati wandei. Chikwata chako chekurapa chicharamba chichiongorora kana mabhenefiti achienderera mberi nekupfuura chero mhedzisiro.

Chiremba wako achamisa amifostine kana ukaona mhedzisiro yakakomba kana kana kurapwa kwako gomarara kuchichinja. Vachagara vachisa pamberi kuchengeteka kwako uye kubudirira kwekurapa pavanenge vachiita zvisarudzo izvi.

Ndezvipi Zvakaipa zveAmifostine?

Semishonga yakawanda, amifostine inogona kukonzera mhedzisiro, kunyangwe varwere vazhinji vachitsungirira zvakanaka. Mhedzisiro yakajairika inodzoreka uye yenguva pfupi, ichiitika kunyanya panguva kana nguva pfupi mushure mekuisa.

Heano mhedzisiro yaungasangana nayo, kutanga neayo akajairika:

• Kutemwa nemusoro nekutukwa (kunokanganisa vanenge 60% yevarwere)
• Kuderera kweropa panguva yekupinza mushonga
• Kuneta ne kusava nesimba
• Kutenderera kwemusoro kana kunzwa sekunge uchapera simba
• Kutsva kana kudziya pachiso chako nemutsipa
• Kuravira kwesimbi mumuromo mako
• Kuhotsira kana kuita zvirutsi
• Kuzara

Zvizhinji zvezvinhu izvi zviri nyoro uye zvinopera mukati memaawa mashoma. Chikwata chako chekuchengetwa kwehutano chichakutarisa zvakanyanya uye chinogona kupa mishonga yekubatsira kudzora kutemwa nemusoro nekutsigira ropa rako kana zvichidikanwa.

Vamwe varwere vanowana mhedzisiro isingawanzoitiki asi inonetesa inoda kutariswa kwekurapa nekukasira:

• Maitiro akakomba ekurwara neallergy ane matambudziko ekufema kana kuzvimba
• Kuderera kweropa kunotyisa kusingapinduri kurapwa
• Matambudziko akakomba eitsvo
• Kurova kwemoyo kusingaenderane
• Kutapukirwa (kusingawanzoitiki)

Mhedzisiro yakakomba iyi haina kujairika, asi chikwata chako chekurapa chakadzidziswa kuziva nekukurumidza nekuzvibata. Nzvimbo yekurapa inodzorwa inovimbisa kuti unogamuchira kutariswa nekukurumidza kana chero zviratidzo zvinonetsa zvikaitika.

Ndiani Asingafaniri Kutora Amifostine?

Amifostine haikodzeri munhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kwauri. Mamwe mamiriro ezvinhu ekurapa uye mamiriro anoita kuti mushonga uyu uve nenjodzi kushandisa.

Haufaniri kugamuchira amifostine kana uine chero chimwe chezvinhu izvi:

• Kuzivikanwa kweallergy kuamifostine kana zvikamu zvayo
• Kusadzorwa kweropa rakakwira
• Chirwere chemoyo chakakomba kana matambudziko emoyo achangobva kuitika
• Chirwere cheitsvo chakakomba
• Mhando dzakasiyana dzekenza dzinogona kuchengetedzwa nemushonga
• Kuzvitakura kana kuyamwisa

Chiremba wako achavawo akangwarira nezvekupa amifostine kana uine nhoroondo yekurohwa, matambudziko emoyo, kana kana uchitora mishonga inokanganisa ropa. Zera rega rega harisi chipingamupinyi, asi vanhu vakuru vangada kuongororwa zvakanyanya.

Mhando dzemamwe gomarara, kunyanya idzo dzine chekuita nemuongo kana maseru eropa, dzingasava vakwikwidzi veamifostine nekuti kudzivirira nzvimbo idzi kungavhiringidza kushanda kwemishonga.

Mazita eAmifostine Brand

Amifostine inowanikwa pasi pezita rekuti Ethyol muUnited States. Iyi ndiyo fomu inonyanya kunyorerwa yaunosangana nayo muzvipatara zvekurapa gomarara.

Shanduro ye generic inongonzi amifostine uye inoshanda zvakafanana nezita remhando. Inishuwarenzi yako inogona kusarudza imwe vhezheni pane imwe, asi ese ari maviri ane chinhu chimwe chete chinoshanda uye anopa mabhenefiti akafanana ekudzivirira.

Mamwe misika yepasi rose inogona kuva nemazita akasiyana emhando, asi mushonga wacho unoramba wakafanana. Chikwata chako chehutano chichaita shuwa kuti unogamuchira fomu yakakodzera zvisinei nezita remhando.

Zvimwe Zvinhu Zviri Kutsiva Amifostine

Parizvino, hapana zvakananga zvinotsiva amifostine zvinoshanda nenzira imwechete. Zvisinei, chiremba wako ane mamwe mazano ekudzivirira nhengo dzako panguva yekurapa gomarara.

Kuti udzivirire itsvo panguva yekurapa cisplatin, zvimwe zvinotsiva zvinosanganisira kushandisa carboplatin panzvimbo ye cisplatin, kunyangwe izvi zvingave zvisingashande kune mamwe magomarara. Hydration yakaoma uye mishonga yakaita se mannitol inogonawo kubatsira kuchengetedza basa reitsvo.

Kuti muromo wakaoma unokonzerwa nemwaranzi, zvimwe zvinotsiva zvinosanganisira intensity-modulated radiation therapy (IMRT) iyo inonyanya kutariswa gomarara uku ichichengetedza mate glands, kana mishonga yakaita se pilocarpine inogona kumutsa kugadzirwa kwemate mushure mekurapa.

Oncologist wako achakurukura izvi zvimwe zvingasarudzwa kana amifostine isina kukodzera iwe kana kana iwe ukaona mhedzisiro isingashiviriki. Sarudzo inoenderana nerudzi rwako rwegomarara, chirongwa chekurapa, uye hutano hwako hwese.

Ko Amifostine Ari Nani Pane Zvimwe Zvinhu Zvinodzivirira Mishonga?

Amifostine inomira seimwe chete mushonga wakabvumidzwa neFDA wakagadzirirwa kuchengetedza maseru ane hutano panguva yekurapa kenza. Hapana mumwe mushonga mumwe chete unopa mabhenefiti akafanana ekudzivirira kubva kune chemotherapy uye radiation damage.

Kana tichienzanisa nemamwe maitiro ekudzivirira, amifostine ine zvakanakira zvakasiyana. Inoshanda pamwero weseru kuti isagadzirise kukuvadzwa kusati kwaitika, pane kungorapa zviratidzo mushure. Iyi nzira yekutanga inowanzoita kuti pave nekudzivirira kuri nani pane kurapwa kunoita.

Zvisinei,

Kana ukawana matambudziko akakomba akadai sekufema zvakaoma, kurwadziwa muchipfuva, kana dzungu rakanyanya panguva yekupinza amifostine, zivisa timu yako yehutano nekukurumidza. Usamirira kana kuedza kuzvitsungirira.

Chikwata chako chekurapa chakadzidziswa kubata mamiriro aya nekukurumidza. Vanogona kumisa kupinza, kupa mishonga inotsigira, uye kuona kuti uri safe. Zvizhinji zvezvinhu zvakakomba zvinogadziriswa nekukurumidza kana kupinza kwamiswa.

Mushure mekuita kwakakomba, chiremba wako achatarisa zvakare kana amifostine ichiri yakakodzera kwauri. Vanogona kugadzirisa muyero, kuchinja chiyero chekupinza, kana kurudzira nzira dzekudzivirira dzimwe nzira dzekurapa ramangwana.

Ndingaramba ndichitora Amifostine Kana Ndikarasikirwa neDose Yakatarwa?

Sezvo amifostine ichipiwa munzvimbo yekurapa isati yatanga kurapwa kenza, madosi akarasika haawanzoitiki. Kana kurapwa kwako kenza kukamirwa kana kurongwa patsva, amifostine yako icharongwa patsva zvinoenderana.

Haufanire kunetseka nezvekugadzirisa madosi akarasika kana kuchengetedza chirongwa chakati wandei kunze kwemisangano yako yekurapa kenza. Mushonga unongoshanda kana ukapiwa nguva pfupi isati yatanga chemotherapy kana radiation.

Kana ukakanganwa musangano wekurapa kenza, taura nechikwata chako chekurapa kana chero kugadzirisa chirongwa chako chekurapa zvachose kuchidikanwa. Vanoona kuti chirongwa chako chemishonga yekudzivirira chinoenderana nechirongwa chako chekurapa kenza.

Ndingamira Rini Kutora Amifostine?

Uchamira kutora amifostine kana wapedza chemotherapy yako ye cisplatin kana nzira yekurapa radiation. Hapana chikonzero chekudzikisa mushonga zvishoma nezvishoma sezvo isiri chinhu chinova nechokuita nemuviri wako.

Chiremba wako anogonawo kumisa amifostine kana ukawana matambudziko asingatsungiririki kana chirongwa chako chekurapa kenza chikachinja. Vanoita chisarudzo ichi zvichibva pane zvaunoda kurapwa uye hupenyu hwako.

Vamwe varwere vanonetseka nezvekurasikirwa nekudzivirirwa kana amifostine yamiswa, asi yeukai kuti munongoda kudzivirirwa panguva yekurapwa kwekenza kuri kuitwa. Kana chemotherapy yako kana radiation yapera, nhengo dzako dzinogona kutanga maitiro adzo ekupora.

Amifostine Inokanganisa Kushanda Kwekurapa Kanza Here?

Tsvakurudzo yakawanda inoratidza kuti amifostine inodzivirira maseru ane hutano pasina kuderedza kushanda kwekurapa kenza. Chiito chemushonga chine sarudzo zvinoreva kuti maseru ekenza anoramba achiwanzwa apo nhengo dzako dzine hutano dzinowana dziviriro.

Miedzo yekiriniki yakaratidza kuti varwere vanogamuchira amifostine vane mhedzisiro yakafanana yekurapa kenza ichienzaniswa nevaya vasingaiwani. Uyu uchapupu unotsigira kushandiswa kwayo sechiyero chekudzivirira chisingakanganisi kutarisirwa kwako kenza.

Oncologist wako anongokurudzira amifostine chete kana vakavimba kuti haizokanganisi kurapwa kwako kenza. Kana paine chero kunetseka nezvekuderera kwekubudirira, vachaisa pamberi kurapwa kwako kenza pamusoro pekudzivirirwa kwenhengo.