Chii chinonzi Atazanavir: Zvazvinoshandiswa, Mishonga, Migumisiro Yemuviri, nezvimwe

Atazanavir mushonga unopiwa nachiremba uyo uri muboka remishonga inonzi protease inhibitors, yakagadzirirwa kurapa hutachiona hweHIV. Mushonga uyu unoshanda nekudzivisa enzyme yakakosha inodiwa neHIV kuti iwedzere mumuviri wako, ichibatsira kuchengetedza hutachiona pasi pekutonga uye kuchengetedza immune system yako.

Kana iwe kana mumwe munhu waunoda akanyorerwa atazanavir, ungangodaro uri kutsvaga ruzivo rwakajeka, rwechokwadi nezvekuti unotarisira chii. Ngatifambei nezvose zvaunoda kuziva nezve mushonga uyu wakakosha weHIV nenzira inoita seinodzoreka uye inonyaradza.

Chii chinonzi Atazanavir?

Atazanavir mushonga weantiretroviral unobatsira kudzora hutachiona hweHIV nekukanganisa kugona kwehutachiona kuzvitsikirira. Funga nezvazvo sekumisa maitiro ekuwedzera kweHIV, izvo zvinopa immune system yako mukana wekuramba yakasimba uye ine hutano.

Mushonga uyu unogara uchishandiswa sechikamu chekurapa kwakabatanidzwa, zvinoreva kuti unotorwa pamwe chete nemimwe mishonga yeHIV kuti ugadzire nzira yakazara yekurapa. Chiremba wako haazombonyora atazanavir yega nekuti HIV inogona kukudziridza kuramba kumishonga imwe chete nekukurumidza.

Atazanavir inouya muchimiro chemakapsule uye inotorwa nemuromo, kazhinji kamwe pazuva. Inoonekwa seimwe nzira yekurapa yakagadzwa zvakanaka iyo yakabatsira vanhu vazhinji vane HIV kuchengetedza hutano hwavo uye hupenyu hwavo kwemakore.

Chii chinonzi Atazanavir chinoshandiswa?

Atazanavir inonyanya kushandiswa kurapa hutachiona hweHIV-1 muvanhu vakuru nevana vanorema angangoita makirogiramu makumi matatu nemashanu (anenge makirogiramu makumi matatu nemanomwe). Icho chikamu chakakosha chezvinodaidzwa nachiremba kuti highly active antiretroviral therapy, kana HAART, iyo inobatanidza mishonga yakawanda kuti idzivise hutachiona zvakanaka.

Chinangwa chikuru chekurapa neatazanavir ndechokuderedza huwandu hwehutachiona hwako, hunova huwandu hweHIV muropa rako, kusvika pamwero usingaonekwe. Kana huwandu hwehutachiona hwako husingaonekwe, zvinoreva kuti mushonga uri kushanda zvakanaka kudzora hutachiona, uye haugone kutapurira HIV kune vamwe kuburikidza nekudyidzana pabonde.

Chiremba wako angangakupa atazanavir sechikamu chekurapa kwako kwekutanga kweHIV, kana kuti vanogona kukuchinjira kwairi kubva kune mumwe mushonga kana kurapwa kwako kwazvino kusingashande sezvaitarisirwa. Sarudzo inoenderana nezvinhu zvakaita sehutano hwako hwazvino, mamwe mishonga yaunotora, uye kuti wakanaka sei kumishonga yapfuura.

Atazanavir Inoshanda Sei?

Atazanavir inoshanda nekunangana ne enzyme chaiyo inonzi HIV protease, iyo hutachiona hunoda kugadzira makopi matsva ehwoga. Nekuvharira enzyme iyi, atazanavir inodzivirira HIV kubva pakuunganidza zvinhu zvakakura, zvinotapukira zvinogona kupararira mumuviri wako.

Mushonga uyu unoonekwa seune simba zvishoma pakati pemishonga yeHIV, zvinoreva kuti inoshanda asi inoshanda zvakanyanya kana yakasanganiswa nemimwe mishonga inorwisa antiretroviral. Nzira yekusanganisa inovimbisa kuti kunyangwe HIV ichiedza kutsvaga nzira dzekupfuura mushonga mumwe, mamwe madhiragi ari muhurongwa hwako anogona kuramba achiidzora.

Zvinowanzo tora mavhiki akati wandei kuti uone mhedzisiro yakazara yeatazanavir muropa rako. Chiremba wako achatarisa huwandu hwehutachiona hwako uye kuverenga kweCD4 nguva dzose kuti ave nechokwadi chekuti mushonga uri kushanda nemazvo uye uchibatsira kusimbisa immune system yako nekufamba kwenguva.

Ndinofanira Kutora Sei Atazanavir?

Atazanavir inofanira kutorwa sezvinorayirwa nachiremba wako, kazhinji kamwe pazuva nechikafu. Kuitora nechikafu kana chikafu chikuru kunobatsira muviri wako kutora mushonga zvakanyanya uye kunoderedza mukana wekugumbuka mudumbu.

Nguva yekutora mushonga wako inokosha zvikuru neatazanavir. Edza kuutora panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana muropa rako. Vanhu vazhinji vanoona zvichibatsira kubatanidza mushonga wavo kune tsika yezuva nezuva, sekudya kwemangwanani kana kudya kwemanheru.

Mamedza makapisi ese nemvura kana chimwe chinwiwa. Usapwanye, kutsenga, kana kuvhura makapisi, sezvo izvi zvinogona kukanganisa nzira iyo mushonga unotorwa nayo uye unogona kuderedza kushanda kwavo.

Kana iwe uchitorawo mamwe mishonga, chiremba wako angakurudzira kutora atazanavir ne ritonavir, mumwe mushonga unobatsira kusimudzira kushanda kweatazanavir. Musanganiswa uyu unowanzo kurairwa pamwe chete kuti uve nechokwadi chekuwana mhedzisiro yekurapa yakanaka.

Ndingatora Atazanavir Kwenguva Yakareba Sei?

Atazanavir inowanzoita kurapwa kwenguva refu kwaunozofanira kuenderera mberi kwenguva yakareba sezvo ichidzora hutachiona hweHIV yako. Vanhu vazhinji vanoiita kwenguva isingagumi, sezvo kumisa kurapwa kweHIV kunogona kubvumira hutachiona kuti huwedzere nekukurumidza uye hunogona kukuvadza immune system yako.

Chiremba wako achatarisa nguva dzose kufambira mberi kwako kuburikidza nemiedzo yeropa inotarisa viral load yako uye CD4 count. Kana atazanavir ichienderera mberi nekushanda zvakanaka kwauri pasina kukonzera matambudziko, ungangoramba uchiitora kwemakore.

Zvisinei, pane nguva apo chiremba wako angakurudzira kuchinja kune mumwe mushonga. Izvi zvinogona kuitika kana iwe ukaita mhedzisiro inokanganisa hupenyu hwako, kana mushonga ukamira kushanda zvakanaka, kana kana nzira itsva dzekurapa dzikawanikwa dzinogona kushanda zviri nani kune mamiriro ako chaiwo.

Usambomira kutora atazanavir kamwe kamwe kana usina kutaura nachiremba wako kutanga. Kunyangwe iwe uchinzwa zvakanaka, mushonga uri kushanda kuseri kwemaziso kuti uchengetedze viral load yako yakadzvanywa, uye kuimisa kamwe kamwe kunogona kutungamira mukudzoka nekukurumidza mumazinga eHIV.

Ndezvipi Zvakaipa ZveAtazanavir?

Sezvinongoita mishonga yese, atazanavir inogona kukonzera matambudziko, kunyangwe vanhu vazhinji vachigara vachigara nayo zvakanaka. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye uzive kuti ungabatana riini nechikwata chako chehutano kuti uwane rubatsiro.

Matambudziko anowanzoitika anowanzoita akapfava uye anowanzoita nani sezvo muviri wako uchigadzirisa kumushonga mumavhiki mashoma ekutanga ekurapa.

Matambudziko anowanzoitika aunogona kusangana nawo anosanganisira:

• Kusvotwa kana kusagadzikana mudumbu, kunyanya mumavhiki mashoma ekutanga
• Kutemwa nemusoro kana dzungu rakapfava
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Kusviba kweganda kana maziso (jaundice), izvo zvinowanzoita zvakapfava uye zvinogadziriswa
• Kuchinja kwemafuta anoparadzirwa mumuviri wako nekufamba kwenguva
• Dhayareya kana shanduko mukufamba kwematumbo

Jaundice iyo dzimwe nguva inoonekwa neatazanavir haiwanzoita njodzi, asi inogona kuoneka uye kunetsa. Izvi zvinoitika nekuti atazanavir inogona kuwedzera zvishoma bilirubin mumuropa rako, izvo zvinokonzera ruvara rweyero.

Matambudziko asingawanzoitiki asi akakomba anoda kutariswa kwekurapa nekukasira anosanganisira:

• Kurwadziwa kwakanyanya mudumbu, izvo zvinogona kuratidza matambudziko e gallbladder kana itsvo
• Kubuda ropa kusinganzwisisike kana kupwanyika
• Zviratidzo zvematambudziko echiropa senge weti yakasviba, kusvotwa kwakanyanya, kana kuneta kusingaperi
• Matombo eitsvo kana kurwadziwa kwakanyanya kumusana
• Kurova kwemoyo kusingaite kana kurwadziwa muchipfuva
• Ganda rakanyanya kana rash

Matambudziko aya akakomba haawanzoitiki, asi zvakakosha kuziva zviratidzo zvekuyambira kuitira kuti uwane rubatsiro nekukurumidza kana zvichidikanwa. Chiremba wako achakutarisa nguva dzose nemiedzo yeropa kuti abate chero matambudziko angangove nekukurumidza.

Ndiani Asingafaniri Kutora Atazanavir?

Atazanavir haisi yakanakira munhu wese, uye chiremba wako achanyatso funga nezve nhoroondo yako yezvokurapa uye hutano hwako hwazvino usati wamupa mushonga uyu. Vamwe vanhu vanofanira kudzivisa mushonga uyu kana kuushandisa nekuchenjerera kwakanyanya.

Haufaniri kutora atazanavir kana uine allergic kwairi kana chero zvinhu zvayo. Zviratidzo zve allergic reaction zvinogona kusanganisira rash, itching, kuzvimba, dzungu rakanyanya, kana matambudziko ekufema.

Vanhu vanowanzoita vasina kutora atazanavir vanosanganisira avo vane:

• Chirwere chechiropa chakanyanya kana kutadza kwechiropa
• Zvimwe zvirwere zvemoyo
• Chirwere cheitsvo chakanyanya
• Maitiro akakomba ekurwara kune protease inhibitors

Kuchenjerera kwakakosha kunodiwa kana uine:

• Matambudziko echiropa akapfava kusvika pakati nepakati, kusanganisira hepatitis B kana C
• Mabwe eitsvo kana chirwere cheitsvo
• Diabetes kana shuga yeropa yakakwira
• Chirwere chemoyo kana matambudziko emoyo
• Zvirwere zvekubuda ropa senge hemophilia
• Chirwere chegallbladder

Kuzvitakura kunoda kufunga kwakakosha ne atazanavir. Kunyange zvazvo ichigona kushandiswa panguva yekuzvitakura kana mabhenefiti achipfuura njodzi, chiremba wako achada kukutarisa iwe nemwana wako zvakanyanya. Mushonga unogona kupinda mumukaka wemazamu, saka sarudzo dzekuyamwisa dzinofanira kukurukurwa nechikwata chako chehutano.

Atazanavir Mazita eBrand

Zita remhando ye atazanavir ndiReyataz, inogadzirwa neBristol-Myers Squibb. Iyi ndiyo vhezheni inonyanya kupihwa yemushonga uye iyo iwe ungangosangana nayo kumakemisi mazhinji.

Generic versions ye atazanavir inowanikwawo, iyo ine chinhu chimwe chete chinoshanda uye inoshanda zvakanyanya semhando-zita vhezheni. Inishuwarenzi yako inogona kufarira vhezheni yegeneric, iyo inogona kubatsira kuderedza mari yako yemuhomwe.

Zvisinei nekuti unowana Reyataz yezita kana atazanavir yechinyakare, mushonga unoshanda nenzira imwechete uye une kushanda kwakafanana. Murapi wako wemishonga anogona kukubatsira kunzwisisa kuti ndechipi chauri kuwana uye kupindura mibvunzo pamusoro pemisiyano.

Zvimwe Zvinotsiva Atazanavir

Kana atazanavir isingashande zvakanaka kwauri kana kukonzera matambudziko emigumisiro, mishonga yakati wandei yeHIV inogona kupa mabhenefiti akafanana. Chiremba wako achatarisa mamiriro ako chaiwo, kusanganisira maitiro ako ekuramba hutachiona uye mamwe mamiriro ehutano, paanenge achiongorora zvimwe zvinotsiva.

Zvimwe zvinodzivirira protease zvingafungwa zvinosanganisira:

• Darunavir (Prezista), iyo inowanzotsungirirwa zvakanaka uye inoshanda zvakanyanya
• Lopinavir/ritonavir (Kaletra), kunyangwe iyi musanganiswa une migumisiro yakawanda
• Fosamprenavir (Lexiva), imwe sarudzo yevanhu vane ruzivo rwekurapa

Zvimwe zvisiri zvinodzivirira protease zvinosanganisira:

• Integrase inhibitors senge dolutegravir (Tivicay) kana raltegravir (Isentress)
• Non-nucleoside reverse transcriptase inhibitors senge efavirenz (Sustiva)
• Entry inhibitors senge maraviroc (Selzentry) yemhando dzakasiyana dzehutachiona

Vanhu vazhinji nhasi vanotanga nemaitiro e-integrase inhibitor-based nekuti vanowanzoita migumisiro mishoma uye vanoshanda zvakanyanya. Zvisinei, atazanavir inoramba iri sarudzo inokosha, kunyanya kune vanhu vakagadzira kuramba kune mamwe makirasi emishonga.

Ko Atazanavir Ari Nani Pane Lopinavir?

Zvese atazanavir uye lopinavir zvinodzivirira protease zvinoshanda, asi vane zvakanakira zvakasiyana uye zvakashata zvinoita kuti imwe ive yakakodzera kupfuura imwe zvichienderana nemamiriro ako ega.

Atazanavir inowanzofarirwa nekuti inotorwa kamwe chete pazuva, izvo zvinoita kuti zvive nyore kutevedzera chirongwa chako chekurapa. Inowanzoitawo kuti pave nezvinetso zvishoma zvegastrointestinal zvakadai sedhiarrhea uye kusvotwa kana ichienzaniswa ne lopinavir.

Zvisinei, lopinavir (inowanzo kupiwa ne ritonavir seKaletra) inogona kufarirwa mune dzimwe nguva, sekunge munhu ane maitiro akasiyana ekuramba mushonga kana kana atazanavir asingashande zvakanaka. Lopinavir zvakare ine rekodhi refu rekushandiswa panguva yekuzvitakura.

Sarudzo pakati pemishonga iyi inoenderana nezvinhu zvakaita senhoroondo yako yekurapa yapfuura, mimwe mishonga yaunotora, zvaunofarira muhupenyu, uye kuti unotsungirira sei sarudzo imwe neimwe. Chiremba wako achakubatsira kuyera izvi kuti usarudze kurapwa kwakanakisa kwezvaunoda.

Mibvunzo Inowanzo Bvunzwa Nezve Atazanavir

Atazanavir Yakachengeteka Here Kune Vanhu vane Chirwere chechiropa?

Atazanavir inogona kushandiswa kune vanhu vane chirwere chechiropa chinyoro kusvika pakati nepakati, asi inoda kutariswa zvakanyanya uye dzimwe nguva kugadzirisa muyero. Chiremba wako achada kutarisa kushanda kwechiropa chako nguva dzose nemiedzo yeropa kuti ave nechokwadi chekuti mushonga hausi kukonzera kuwedzera kwechiropa.

Kana uine hepatitis B kana C pamwe chete neHIV, atazanavir inogona kuva sarudzo, asi timu yako yehutano ichakutarisa zvakanyanya kuti uone zviratidzo zvematambudziko echiropa. Vanhu vane chirwere chechiropa chakakomba kana kutadza kwechiropa havagone kutora atazanavir zvakachengeteka.

Ndingaita Sei Kana Ndikatora Atazanavir yakawandisa netsaona?

Kana netsaona ukatora atazanavir yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira, kunyangwe ukanzwa zvakanaka. Kutora zvakanyanya kunogona kuwedzera njodzi yako yezvinetso zvakakomba, kunyanya matambudziko emoyo.

Usayedze "kugadzirisa" nekutora zvakanyanya nekusvetuka mushonga wako unotevera. Pane kudaro, tevera mirairo yachiremba wako nezvekuti unotangazve riini chirongwa chako chekushandisa mishonga. Chengeta rekodhi rekuti overdose yakaitika riini kuitira kuti upe ruzivo urwu kuchikwata chako chehutano.

Ndingaita Sei Kana Ndakarasikirwa Nemushonga weAtazanavir?

Kana ukakarasikirwa nemushonga weatazanavir, utore paunorangarira, chero zvazviri mukati meawa gumi nembiri dzekushandisa mishonga yako yenguva dzose. Kana maawa anopfuura gumi nembiri apfuura, svetuka mushonga wakarasika uye tora mushonga wako unotevera panguva yakajairika.

Usambofa wakawedzera mishonga kuti ugadzirise yakarasika, sezvo izvi zvinogona kuwedzera njodzi yako yemigumisiro. Kana iwe uchikanganwa mishonga kazhinji, taura nachiremba wako nezve nzira dzekukubatsira kurangarira, senge varongi vemishonga kana zviyeuchidzo zvefoni.

Ndingamira Rini Kutora Atazanavir?

Unofanirwa kungomira kutora atazanavir pasi pekutungamirirwa nachiremba wako, kazhinji kana uchichinja kune imwe nzira yekurapa HIV. Usambofa wakamira kuitora wega, kunyangwe uchinzwa zvakanaka, sezvo izvi zvinogona kutungamira mukumhanya kwehutachiona uye kugadzirwa kwemishonga.

Chiremba wako anogona kukurudzira kumisa atazanavir kana iwe ukagadzira migumisiro yakakomba isingavandudzi, kana mushonga ukamira kushanda zvakanaka, kana iwe uchichinjira kune imwe itsva, yakasununguka sarudzo yekurapa. Chero shanduko kune yako HIV kurapwa inofanirwa kurongwa nekuchenjerera uye kuongororwa.

Ndingatora Atazanavir nemimwe mishonga here?

Atazanavir inogona kuita pamwe chete nemimwe mishonga yakawanda, saka zvakakosha kuti uudze chiremba wako nezve zvese zvauri kutora, kusanganisira mishonga yekurapa, mishonga isingatengwi, uye zvinowedzera. Dzimwe hukama hunogona kuva hwakakomba uye hunoda kugadzirisa dose kana dzimwe mishonga.

Mishonga inowanzoita kuti atazanavir ishande zvisina kufanira inosanganisira mamwe maantacid, proton pump inhibitors, mamwe maantibiotics, nemimwe mishonga yakawanda. Chiremba wako nemufesi wemishonga vachaongorora mishonga yako yese kuti vaone kuti inoshanda sei pamwe chete uye vangada kuchinja nguva kana zviyero zvekudzivirira kusangana kwemishonga.