Chii chinonzi Bedaquiline: Zvayakashandiswa, Mishonga, Migumisiro Yakaipa nezvimwe

Bedaquiline mushonga unokosha weantibiotic wakagadzirirwa kurwisa mabhakitiriya eTB (TB) asingapinduri kurapwa kwakajairika. Mushonga uyu unoshanda zvakasiyana nemishonga yekare yeTB nekunangana nehurongwa hunogadzira simba mukati memabhakitiriya eTB, zvichivatsvaga simba.

Unogona kusangana nebedaquiline kana uri kubata ne multidrug-resistant tuberculosis (MDR-TB) kana extensively drug-resistant tuberculosis (XDR-TB). Aya ndiwo marudzi akakomba eTB akave achidzivirira kumishonga yakajairika yeTB, zvichiita kuti kurapwa kuve kwakaoma uye kuchida nzira dzakasimba, dzakanangana.

Chii chinonzi Bedaquiline chinoshandiswa?

Bedaquiline inorapa multidrug-resistant pulmonary tuberculosis muvanhu vakuru nevana vane makore mashanu zvichikwira. Izvi zvinoreva kuti inonangana nezvirwere zveTB mumapapu ako zvisina kupindura kumishonga miviri inoshanda zvakanyanya yeTB yakaita seisoniazid ne rifampin.

Chiremba wako achanyora bedaquiline sechikamu chekurapa kwakabatanidzwa, kwete ega. Mabhakitiriya eTB akangwara uye anogona kukudziridza kuramba nekukurumidza, saka kushandisa mishonga yakawanda pamwechete kunodzivirira mabhakitiriya kubva pakupfuura chero mushonga mumwe chete. Iyi nzira yakabatanidzwa inopa muviri wako mukana wakanakisa wekubvisa zvachose hutachiona.

Mushonga uyu wakachengeterwa zvakanyanya nyaya dzakakundikana dzimwe nzira dzekurapa kana dzisina kukodzera. Chikwata chako chehutano chichaedza mabhakitiriya ako eTB murabhoritari kuti vasimbise kuti kurapwa kwakajairika hakushande vasati vachikurudzira bedaquiline.

Bedaquiline inoshanda sei?

Bedaquiline inoshanda nekudzivisa ATP synthase, enzyme inodiwa nemabhakitiriya eTB kugadzira simba. Funga nezvazvo sekugura magetsi kufekitari - pasina simba, mabhakitiriya haagoni kurarama kana kubereka.

Izvi zvinoita kuti bedaquiline ive nesimba rakanyanya kurwisa mabhakitiriya eTB, asi haisi mushonga unoshanda husiku humwe. Mushonga unogara mumuviri wako kwenguva refu, uchiramba uchirwisa hutachiona kunyangwe pakati pemadosi. Kuvapo uku kwenguva refu mumuviri wako kunobatsira pakurapa hutachiona uye chimwe chinhu chichatariswa nachiremba wako nekuchenjerera.

Kusiyana nemimwe mishonga yeTB inouraya mabhakitiriya nekukurumidza, bedaquiline inoshanda zvishoma nezvishoma uye zvishoma nezvishoma. Iyi nzira zvishoma nezvishoma inogona kushanda zvakanyanya kurwisa mhando dzeTB dzakaoma, dzinodzivirira dzakadzidza kurarama mamwe marapirwo.

Ndingatora sei Bedaquiline?

Tora bedaquiline sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva nechikafu. Mushonga unonyanya kunyudzwa zviri nani kana uchitorwa nechikafu, saka usasvetuke kudya usati watora mushonga wako. Chero chikafu chitsika chichabatsira - haudi chimwe chinhu chakakosha.

Medza mahwendefa ese nemvura. Usapwanya, kutsenga, kana kuapwanya, sezvo izvi zvinogona kukanganisa nzira iyo mushonga unoburitswa mumuviri wako. Kana uine dambudziko rekumedza mahwendefa, taura nemupi wako wehutano nezveimwe nzira.

Edza kutora mushonga wako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako. Kugadzira chiyeuchidzo chezuva nezuva kunogona kukubatsira kuti urambe uchienderana, izvo zvakakosha pakurwisa TB inodzivirira zvinobudirira.

Chiremba wako anogona kunyorawo mimwe mishonga yeTB pamwe chete nebedaquiline. Tora zvese sezvakarairwa, kunyangwe ukatanga kunzwa zviri nani. Kumisa kurapwa nekukurumidza kunogona kubvumira mabhakitiriya eTB kudzoka uye kuve anoramba zvakanyanya.

Ndingatora Bedaquiline kwenguva yakareba sei?

Vanhu vazhinji vanotora bedaquiline kwemavhiki makumi maviri nemana (anenge mwedzi mitanhatu), asi nguva yako chaiyo yekurapa inoenderana nemamiriro ako chaiwo. Chiremba wako achafunga nezvezvinhu zvakaita sekuti uri kupindura sei kurapwa uye kuti uri kutora mimwe mishonga ipi.

Svondo mbiri dzekutanga dzakakosha zvikuru - uchatora bedaquiline zuva nezuva munguva iyi kuti ukurumidze kuvaka mazinga anoshanda mumuviri wako. Mushure meizvozvo, chiremba wako angachinja kuwanda zvichienderana nekuti uri sei.

Usamira kutora bedaquiline nekuti unonzwa zviri nani. Mabhakitiriya eTB anogona kuvanzika mumuviri wako uye kuita zvakare kana kurapwa kukamira nekukurumidza. Chikwata chako chehutano chichashandisa bvunzo dzakaita setsputum cultures uye chest X-rays kuti zviite kana zvakachengeteka kumira.

Vamwe vanhu vanoda nzira dzekurapa dzakareba, kunyanya kana TB yavo yakanyanya kuoma kana kana vaine mamwe mamiriro ehutano anokanganisa kupora. Chiremba wako achatarisa kufambira mberi kwako zvakanyanya uye achagadzirisa chirongwa chako chekurapa sezvinodiwa.

Ndezvipi Zvakaipa ZveBedaquiline?

Semishonga yese, bedaquiline inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anozviwana. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye uzive kuti ungataurirana riini nemupi wako wehutano.

Mhedzisiro yakajairika yaungacherechedza inosanganisira kusvotwa, kurwadziwa mumajoini, kurwadziwa nemusoro, uye shanduko mukunzwisisa kwako kuravira kana kunhuhwirira. Mhedzisiro iyi inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga mumavhiki mashoma ekutanga.

Heano mhedzisiro iyo vanhu vazhinji vanowana panguva yekurapa:

• Kusvotwa uye dumbu rinogumbuka
• Kurwadziwa mumajoini kana kurwadziwa kwemhasuru
• Kurwadziwa nemusoro
• Dizziness
• Shanduko mukuravira kana kunhuhwirira
• Kuneta kana kunzwa kuneta
• Rash yeganda

Izvi zvinowanzoitika zvinowanzoitika zvinowanzoitika uye hazvidi kumisa mushonga. Zvisinei, gara uchizivisa chikwata chako chehutano nezve chero zviratidzo zvauri kusangana nazvo kuti vakubatsire kuti unzwe wakasununguka.

Mhedzisiro yakakomba haina kujairika asi inoda kutariswa kwekurapa nekukurumidza. Izvi zvinosanganisira matambudziko emoyo, matambudziko akakomba echiropa, kana zviratidzo zvekuita allergic kwakanyanya.

Taura nachiremba wako nekukasira kana ukaona chero zviratidzo zvinonetsa izvi:

• Kurova kwemoyo kusingaite zvakanaka kana kurwadziwa muchipfuva
• Kurwadziwa kwakanyanya, kurutsa, kana kushaya chido chekudya
• Kusvava kweganda kana maziso (jaundice)
• Weti yakasviba kana zvimbuzi zvakachenuruka
• Kuneta kwakanyanya kana kushaya simba
• Kutadza kufema kana kumedza
• Meno akakomba kana hives

Chikwata chako chehutano chichakutarisa zvakanyanya panguva yekurapwa nekuedzwa kweropa nguva dzose uye kuongorora moyo. Izvi zvinobatsira kubata chero matambudziko angangoitika kare uye zvinovimbisa kuti kurapwa kwako kunoramba kuri kwakachengeteka uye kunobudirira.

Ndiani Asingafaniri Kutora Bedaquiline?

Bedaquiline haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakakukodzera. Vanhu vane mamiriro emoyo akati wandei kana avo vari kutora mishonga yakati wandei vangangoda dzimwe nzira dzekurapa.

Haufaniri kutora bedaquiline kana uine allergy inozivikanwa kumushonga kana chero zvinhu zvawo. Chiremba wako achavawo akangwarira nezvekumupa kana uine matambudziko emoyo akati wandei kana uri kutora mishonga inokanganisa mabasa emagetsi emoyo wako.

Mupi wako wehutano achada kuziva nezvemamiriro aya usati wanyora bedaquiline:

• Matambudziko emoyo (arrhythmias)
• Chirwere chechiropa kana ma enzymes echiropa akakwira
• Matambudziko eitsvo
• Potassium yakaderera, calcium, kana magnesium mazinga
• Nhoroondo yekurwisa kwemoyo kana kukundikana kwemoyo
• Nhoroondo yemhuri yerufu rwemoyo kamwe kamwe

Mishonga yakati wandei inogona kukanganisa bedaquiline nenzira ine njodzi, kunyanya iyo inokanganisa rhythm yemoyo kana basa rechiropa. Chiremba wako achaongorora mishonga yako yese iripo, kusanganisira zvinodhaka zvinotengeswa pasina mushonga uye zvinowedzera, usati watanga kurapwa.

Kana wakazvitakura kana kuti uri kuyamwisa, chiremba wako achanyatsoongorora zvakanakira nezvakaipira. Kunyange zvazvo kurapa TB kwakakosha kwauri nemwana wako, kushandiswa kwe bedaquiline panguva yekuzvitakura kunoda kunyatsoongororwa uye kufunga nezvezvimwe zvingashandiswa.

Mazita eBedaquiline Brand

Bedaquiline inowanikwa pasi pezita rekuti Sirturo munyika zhinji, kusanganisira United States. Iyi ndiyo nzira inowanzoitika yaunozoona ichirairwa uye ichinyorwa pamushonga.

Dzimwe nyika dzinogona kunge dziine mazita akasiyana emhando kana mhando dzakajairika dziripo. Murapi wako wemishonga anogona kukubatsira kuziva mushonga wako chaiwo uye kuona kuti uri kuwana fomu rakarurama.

Nguva dzose bvunza chiremba wako kana murapi wemishonga kana uine mibvunzo nezvekuonekwa kwemushonga wako kana kunyorwa. Zvakakosha kuti uve nechokwadi chekuti uri kutora chaizvo zvakarairwa.

Zvimwe Zvingashandiswa Panzvimbo peBedaquiline

Kana bedaquiline isina kukodzera kwauri, mimwe mishonga inogona kurapa TB inodzivisa mishonga yakawanda. Chiremba wako angangofunga nezvemishonga yakaita se linezolid, clofazimine, kana vamiririri vatsva vakaita sepretomanid, zvichienderana nerudzi rwako rweTB uye mamiriro ako ehutano.

Sarudzo yezvimwe zvingashandiswa zvinoenderana nezvinhu zvakati wandei, kusanganisira kuti mabhakitiriya ako eTB anodzivisa mishonga ipi, mamwe mamiriro ako ehutano, uye mikana yekudyidzana kwemishonga. Chikwata chako chehutano chichashanda pamwe chete nenyanzvi dzeTB kuti uwane musanganiswa wakanakisa wemamiriro ako ezvinhu.

Vamwe vanhu vangashandisa bedaquiline pamwe chete nezvimwe zvingashandiswa izvi pane seimwe nzira. Chinangwa chinogara chiri chekugadzira chirongwa chekurapa chinogona kuporesa TB yako uchideredza mhedzisiro yezvinhu uye matambudziko.

Sarudzo dzekurapa TB inodzivisa mishonga dzakaoma uye dzakasarudzika. Chiremba wako achafunga nezvemhedzisiro yelabhoreti inoratidza kuti mishonga ipi inoshanda kurwisa rudzi rwako rweTB, nhoroondo yako yekurapa, uye kuti unotsungirira sei mishonga yakasiyana.

Ko Bedaquiline iri Nani Kupfuura Mimwe Mishonga yeTB Here?

Bedaquiline haisi “iri nani” pane mamwe mishonga yeTB - inoshanda neimwe nzira. Nepo mishonga yekutanga yeTB yakaita seisoniazid ne rifampin ichishanda zvakanaka kune mazhinji eTB, bedaquiline inonyanya kurwisa mhando dzinodzivisa dzisingapinduri kumishonga yakajairika.

Kune TB inodzivisa mishonga yakawanda, bedaquiline yakaratidza zvakanakira zvakakosha muzvidzidzo zvekiriniki. Inogona kubatsira kuwana mitengo yepamusoro yekurapa uye inogona kubvumira nzira dzekurapa dzakapfupika kana dzichishandiswa sechikamu chekurapa kwakabatanidzwa.

Maitiro akasiyana emushonga anoita kuti ave akakosha kurwisa mabhakitiriya eTB akagadzira kuramba kune mamwe mishonga. Zvisinei, inowanzo chengeterwa kesi dzinodzivisa nekuda kwemutengo wayo, migumisiro inogona kuitika, uye kudiwa kwekutariswa kwakanyatsonaka.

Chiremba wako achasarudza mishonga yakakodzera zvichienderana nemhando yako yeTB, nhoroondo yako yezvokurapa, uye mamiriro ako ega. Kurapa

Kana ukatora bedaquiline yakawanda netsaona kupfuura yakarairwa, fonera chiremba wako kana nzvimbo yekudzora muchetura nekukasira. Usamirira kuti uone kana ukanzwa zviratidzo, nekuti bedaquiline overdose inogona kukonzera matambudziko akakomba emoyo.

Enda kuchipatara chekukurumidzira kana ukanzwa kurwadziwa muchipfuva, kurova kwemoyo kusingaite, dzungu rakanyanya, kana kufenda mushure mekutora mushonga wakawandisa. Uya nebhodhoro rako remushonga kuti vashandi vehutano vazive chaizvo zvawakatora uye zvakawanda sei.

Kuti udzivise overdose netsaona, chengeta bedaquiline mumudziyo wayo wekutanga uine mavara akajeka. Funga kushandisa chirongwa chemapiritsi kana kuseta zviyeuchidzo kuti zvikubatsire kuyeuka kana wakatotora dose yako yezuva nezuva.

Ndingaita Sei Kana Ndikakanganwa Dose yeBedaquiline?

Kana ukakanganwa dose ye bedaquiline, itore nekukasira paunoyeuka, asi chete kana iri mukati memaawa matanhatu enguva yako yakarongwa. Kana maawa anopfuura matanhatu apfuura, siya dose yakakanganwa uye tora dose yako inotevera panguva yakajairika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Izvi zvinogona kuwedzera njodzi yako yemigumisiro, kunyanya matambudziko emoyo. Pane kudaro, ramba uchienderera mberi nechirongwa chako chekushandisa.

Kana iwe uchikanganwa madosi kazhinji, taura nechiremba wako nezve nzira dzekukubatsira kuyeuka. Kushandisa nguva dzose kwakakosha kurwisa TB inodzivisa zvinobudirira uye kudzivirira mabhakitiriya kubva pakuwedzera kudzivisa.

Ndingamira Rini Kutora Bedaquiline?

Unogona kumira kutora bedaquiline chete kana chiremba wako akuudza kuti zvakachengeteka kuita kudaro. Sarudzo iyi inobva pamiedzo yelabhoritari, zvidzidzo zveimaging, uye mhinduro yako yekiriniki kumishonga, kwete chete pakuti unonzwa sei.

Vashandi vako vehutano vachatarisa tsika dzako dzesputum, X-rays yechipfuva, uye mamwe maedzo kuti vaone kana hutachiona hwako hweTB hwabatwa zvizere. Kumira nekukurumidza kunogona kubvumira mabhakitiriya kudzoka uye kuwedzera kudzivisa kurapwa.

Kunyange mushure mekurega kutora bedaquiline, unogona kuramba uchitora mamwe mishonga yeTB uye kuenda kumisangano yekutevera nguva dzose. Chiremba wako achada kuona kuti hutachiona hahudzoki uye kuti wapedza kurapwa zvizere.

Ndinganwe Doro Ndiri Kutora Bedaquiline Here?

Zvakanaka kudzivisa doro uchitora bedaquiline, nekuti zvese zvinogona kukanganisa chiropa chako nemoyo. Doro rinogona kuwedzera njodzi yako yematambudziko echiropa uye rinogona kukanganisa nzira iyo muviri wako unogadzirisa mishonga.

Kana ukasarudza kunwa dzimwe nguva, taura izvi nechiremba wako kutanga. Vanogona kukupa zano zvichienderana nemamiriro ako ehutano uye mamwe mishonga yaunotora.

Rangarira kuti chiropa chako chiri kushanda nesimba kugadzirisa bedaquiline nemamwe mishonga yeTB. Kuwedzera doro kumusanganiswa kunogona kuisa kushushikana kwakawanda pachirongwa ichi chakakosha uye zvinogona kukanganisa kushanda kwemishonga yako.