Chii chinonzi Belimumab: Zvazvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe Zvakawanda

Belimumab mushonga unopiwa nachiremba unobatsira kudzikamisa immune system yako inoshanda zvakanyanya kana ikakanganisa muviri wako. Yakagadzirirwa kurapa mamiriro eautoimmune akadai se lupus, uko immune system yako inoda kutungamirirwa zvinyoro nyoro kuti irege kurwisa iwe.

Mishonga iyi inoshanda nekudzivisa protein inonzi BLyS (B-lymphocyte stimulator) iyo inoudza maseru eimmune kuti ashande zvakanyanya. Funga nezvazvo sekudzikisa vhoriyamu pane immune system yave ichiridza zvakanyanya.

Chii chinonzi Belimumab chinoshandiswa?

Belimumab inonyanya kushandiswa kurapa systemic lupus erythematosus (SLE), inozivikanwa se lupus. Chiremba wako angakupa mushonga uyu kana uine lupus inoshanda isina kupindura zvakanaka kumishonga yakajairika yakadai se antimalarials, corticosteroids, kana immunosuppressants.

Mishonga iyi inobvumidzwawo kurapa lupus nephritis, iyo inoitika kana lupus ikakanganisa itsvo dzako. Iyi imhando yakakomba ye lupus inoda kutarisirwa zvakanyanya kuchengetedza basa reitsvo dzako.

Mukuwedzera, belimumab inogona kubatsira ne systemic lupus erythematosus inoshanda muvana vane makore mashanu zvichikwira. Chiremba wako achanyatso kuyera mabhenefiti nenjodzi asati akurudzira vana vaduku.

Belimumab inoshanda sei?

Belimumab inoshanda nekunangana neB-maseru, ayo ari maseru eimmune anogadzira maantibodies. Mu lupus, aya B-maseru anova akanyanya kushanda uye anogadzira maantibodies anorwisa matishu ako ane hutano panzvimbo yekukudzivirira kubva kuzvirwere.

Mishonga iyi inovharisa BLyS, protein inoita semafuta eaya akanyanya kushanda B-maseru. Nekuderedza sosi iyi yemafuta, belimumab inobatsira kuderedza huwandu hweB-maseru ane matambudziko mumuviri wako, izvo zvinogona kuderedza zviratidzo zve lupus uye kuparara.

Izvi zvinoonekwa sekurapa kwakanangana pane kurapa kwakawanda kwe immunosuppressant, zvinoreva kuti zvakarurama zvakanyanya mukuti zvinokanganisa sei immune system yako. Zvisinei, ichiri mushonga une simba unoda kunyatso tariswa nechikwata chako chehutano.

Ndingatora sei Belimumab?

Belimumab inouya nenzira mbiri: intravenous (IV) infusion uye subcutaneous (pasi-peganda) jekiseni. Chiremba wako achasarudza kuti ndeipi nzira iri nani kwauri zvichienderana nemamiriro ako chaiwo uye zvaunoda muhupenyu.

Kune IV infusions, iwe uchagamuchira mushonga panzvimbo yehutano mumasvondo mana ega ega. Iyo infusion inowanzo tora anenge awa rimwe, uye iwe uchatariswa panguva uye mushure mekurapa kune chero mhinduro dzekukurumidza.

Kana iwe uchishandisa subcutaneous fomu, iwe ungangodaro uchiisa jekiseni kamwechete pavhiki kumba mushure mekuvhiyiwa kwakakodzera. Chikwata chako chehutano chichakudzidzisa nzira chaiyo yekujekiseni uye kukubatsira kuti unzwe wakasununguka nekuita.

Haufaniri kutora belimumab nechikafu, asi zvakakosha kuchengetedza purogiramu inoenderana. Vamwe vanhu vanozviwana zvichibatsira kumaka karenda ravo kana kumisa zviyeuchidzo zvefoni kuti vagare munzira.

Ndingatora Belimumab kwenguva yakareba sei?

Belimumab inowanzo kurapwa kwenguva refu kwaunoenderera mberi chero bedzi ichibatsira lupus yako uye uchizvitsungirira zvakanaka. Vanhu vazhinji vanozvitora kwemakore kuti vachengetedze kutonga kwezviratidzo zvavo uye kudzivirira kupenya.

Unogona kutanga kuona kuvandudzwa mushure memwedzi mishoma, kunyangwe zvingatora kusvika kumwedzi mitanhatu kuti uone mabhenefiti akazara. Kuvandudzwa uku zvishoma nezvishoma kunoitika nekuti belimumab inoshanda nekuderedza zvishoma nezvishoma maseru eimmune akawandisa pane kupa zororo rekukurumidza.

Chiremba wako achagara achiongorora kuti mushonga uri kushanda sei kuburikidza nemiedzo yeropa, kuongorora zviratidzo, uye kutarisa chero mativi. Vachakubatsira kusarudza kana zvakakodzera kuenderera mberi, kugadzirisa, kana kumisa kurapwa.

Ndezvipi Zvipingamupinyi zveBelimumab?

Sezvinongoita mishonga yese inokanganisa immune system yako, belimumab inogona kukonzera matambudziko, kunyangwe kwete munhu wese achiwana iwo. Kuziva zvekutarisa kunokubatsira kuti urambe wakachengeteka uye uwane rubatsiro nekukurumidza kana zvichidikanwa.

Matambudziko anowanzoitika aunogona kusangana nawo anosanganisira kusvotwa, manyoka, fivha, mhino dzakavharika, bronchitis, kushaya hope, uye kurwadziwa mumaoko ako kana makumbo. Zviratidzo izvi zvinowanzoita zvishoma uye zvinowanzoita nani muviri wako uchigadzirisa kumushonga.

Matambudziko akakomba asi asingawanzoitiki anogona kusanganisira:

• Kuwedzera njodzi yekutapukirwa nekuda kwe immune system suppression
• Severe allergic reactions, kunyanya panguva ye IV infusions
• Kushungurudzika kana shanduko dzemafungiro
• Zvirwere zvakakomba zvinogona kuda kupinda muchipatara

Nekuti belimumab inokanganisa immune system yako, iwe uchava nenjodzi yakakwirira yekutapukirwa. Izvi zvinoreva kuti unofanirwa kubata chiremba wako kana ukaona fivha, zviratidzo zvakaita sefuruwenza, kana chero zviratidzo zveutachiona.

Matambudziko asingawanzoitiki asi akakomba anosanganisira kushungurudzika kwakanyanya, pfungwa dzekuzvikuvadza, progressive multifocal leukoencephalopathy (PML), uye reactivation ye hepatitis B muvanhu vakambove nehutachiona uhu.

Ndiani Asingafaniri Kutora Belimumab?

Belimumab haisi yemunhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Hau faniri kutora mushonga uyu kana wakambove ne allergic reaction yakakomba ku belimumab kana chero zvinhu zvayo kare.

Vanhu vane zvirwere zvakakomba, zvinoshanda vanofanira kumirira kusvikira hutachiona hwapera zvizere vasati vatanga belimumab. Izvi zvinosanganisira zvirwere zvakakomba zvebhakitiriya, hutachiona, fungal, kana zvimwe zvirwere zvinogona kuwedzera ne immune suppression.

Chiremba wako achanyatso chenjerera kana uine:

• Nhoroondo yezvirwere zvisingaperi kana zvirwere zvinowanzoitika
• HIV, hepatitis B, kana hepatitis C
• Nhoroondo yekushungurudzika kana pfungwa dzekuzviuraya
• Kenza yakamboitika kana kurapwa kwekenza kuri kuitika
• Zvirongwa zvekutambira majekiseni mhenyu

Kana uri nepamuviri kana kuronga kuva nepamuviri, unozofanira kukurukura njodzi nemabhenefiti nachiremba wako. Belimumab inogona kuyambuka placenta uye inogona kukanganisa immune system yemwana wako ari kukura.

Mazita eBelimumab Brand

Belimumab inowanikwa pasi pezita remhando yeBenlysta. Iri ndiro zita rimwe chete remhando rinowanikwa parizvino remushonga uyu, rinogadzirwa neGSK (GlaxoSmithKline).

Kunyangwe iwe ukagamuchira IV kana subcutaneous fomu, ese ari maviri anotengeswa pasi pezita rimwe chete remhando yeBenlysta. Chinyorwa chako chichataura kuti ndeipi formulation nesimba raunoda.

Zvimwe Zvinhu zveBelimumab

Kana belimumab isina kukodzera iwe kana isingape kutonga kwakakwana kwe lupus yako, akati wandei ekurapa akasiyana anowanikwa. Chiremba wako angangofunga nezvemimwe mishonga yebiological senge rituximab, iyo zvakare inotarisa B-maseru asi inoshanda zvakasiyana.

Mishonga yechinyakare yekudzivirira immune inoramba iri sarudzo dzakakosha, kusanganisira methotrexate, mycophenolate, azathioprine, uye cyclophosphamide. Mishonga iyi ine marekodhi marefu uye inogona kukodzera mamiriro akati wandei.

Kurapa kutsva senge anifrolumab (Saphnelo) kunopa imwe nzira yakatarwa yekurapa lupus. Chiremba wako achafunga nezvezvinhu zvakaita sezviratidzo zvako zvakajeka, kurapwa kwakapfuura, uye hutano hwese pakusarudza sarudzo yakanakisa kwauri.

Dzimwe nguva, kurapa kwakabatanidzwa nemishonga inorwisa malaria senge hydroxychloroquine kana manejimendi akanyatsoitwa ecorticosteroid angave akakodzera kupfuura kuchinja kune imwe mishonga yebiological.

Belimumab Ari Nani Kupfuura Rituximab Here?

Kufananidza belimumab ne rituximab hakusi nyore nekuti vanoshanda zvakasiyana uye vanoshandiswa mumamiriro akasiyana. Vose vanonangana neB-masero, asi rituximab inopera masero aya zvakanyanya zvakakwana apo belimumab inoderedza kushanda kwavo zvishoma nezvishoma.

Belimumab ine data rakasimba rekuedzwa kwekiriniki kunyanya kurapa lupus, nekubvumidzwa kweFDA zvichibva pazvidzidzo zvakakura, zvakagadzirwa zvakanaka. Rituximab, kunyange ichishanda kune varwere vazhinji vane lupus, inoshandiswa "kunze kwechinyorwa" kune iyi mamiriro.

Sarudzo pakati pemishonga iyi inoenderana nemamiriro ako chaiwo, kusanganisira kuti lupus yako yakakomba sei, nhengo dzipi dziri kubatwa, uye wakaitei kumishonga yapfuura. Chiremba wako achafunga nezvezvinhu zvako zvega panzvimbo yekuzivisa imwe yakanaka "zvirinani."

Vamwe vanhu vanoita zvakanaka nekuswedera pedyo kwa belimumab, apo vamwe vanoda kuparadzwa kwakanyanya kweB-cell kwe rituximab. Mishonga yose miviri inoda kunyatso tariswa uye ine yavo yakasarudzika mhedzisiro.

Mibvunzo Inowanzo Bvunzwa Nezve Belimumab

Belimumab Yakachengeteka Kune Vanhu vane Chirwere cheItsvo Here?

Belimumab inobvumidzwa kurapa lupus nephritis, iyo inobatanidzwa neitsvo kubva ku lupus. Zvisinei, kana uine chirwere cheitsvo chakakomba kubva kune zvimwe zvikonzero, chiremba wako achada kunyatsoongorora kana belimumab yakakodzera kwauri.

Mishonga inonyanya kubviswa kuburikidza nemaitiro emuviri wako ekuparadza mapuroteni panzvimbo yekusefa itsvo, saka matambudziko eitsvo akapfava kusvika pakati nepakati kazhinji haadi kugadzirisa dose. Chiremba wako achatarisa basa reitsvo yako nguva dzose zvisinei.

Ndingaita Sei Kana Ndikashandisa Belimumab Yakawandisa Netsaona?

Kana ukabaya belimumab yakawanda subcutaneously kupfuura yakarairwa netsaona, taura nachiremba wako kana mupi wehutano nekukasira. Kunyange zvazvo pasina mushonga chaiwo wekuwandisa belimumab, vachada kukutarisa zvakanyanya kuti vatarise mhedzisiro.

Pamusoro pe IV infusions, overdose haina kuitika zvakanyanya sezvo vashandi vehutano vachipa mushonga. Zvisinei, kana uchifungidzira kuti kukanganisa kwakaitika panguva ye infusion yako, zivisa timu yako yehutano nekukasira kuti vakwanise kutora matanho akakodzera ekuongorora.

Ndingaita Sei Kana Ndikakanganwa Dose yeBelimumab?

Kana ukakanganwa jekiseni repasi peganda, tora nekukasira paunorangarira, wobva wadzokera kuchirongwa chako chevhiki nevhiki. Usawedzere madose kuti ugadzirise imwe yakakanganwa.

Pamusoro pe IV infusions, taura nemupi wako wehutano kuti urongezve nekukasira. Edza kuchengetedza nguva yemavhiki mana pakati pemadose, asi usanetseka kana uchida kugadzirisa nemazuva mashoma nekuda kwezvirongwa.

Ndingamira Rini Kutora Belimumab?

Usambomira kutora belimumab usina kutanga kukurukura nachiremba wako. Kumira kamwe kamwe kungaita kuti lupus flares kana kuwedzera kwezviratidzo zvako, sezvo mhedzisiro yekudzivirira yemushonga ichipera zvishoma nezvishoma.

Chiremba wako angangofunga kumisa belimumab kana wakwanisa kuwana remission yakagadzikana kwenguva yakareba, kana uri kusangana nemhedzisiro isingashiviriki, kana kana mushonga usingape rubatsiro rwakakwana. Vachakubatsira kuchinjira zvakachengeteka kune dzimwe kurapwa kana zvichidikanwa.

Ndingawana Majekiseni Ndiri Kutora Belimumab Here?

Unofanira kudzivisa majekiseni mhenyu uchitora belimumab, sezvo angangokonzera zvirwere muvanhu vane immune systems yakadzvanywa. Izvi zvinosanganisira majekiseni seMMR, varicella (chickenpox), uye majekiseni emhino eflu.

Majekiseni asina kushandiswa (semujekiseni weflu, majekiseni eCOVID-19, uye jekiseni renyumonia) anowanzo chengeteka uye anokurudzirwa. Zvisinei, angasashanda zvakanaka iwe uchitora belimumab, saka kurukura nguva uye zvaunotarisira nachiremba wako.