Chii chinonzi Belinostat: Zvazvinoshandiswa, Madosi, Migumisiro Yakaipa nezvimwe

Belinostat mushonga wekenza unovavarira kubatsira kurapa mhando dzekenza yeropa nekudzivisa mapuroteni chaiwo anodiwa nemaseru ekenza kuti akure. Mushonga uyu unoiswa mutsinga yeropa unobva kuboka rinonzi histone deacetylase inhibitors, iro rinoshanda nekukanganisa kugona kweseru rekenza kuwanda nekurarama.

Uchagamuchira mushonga uyu kuburikidza neIV infusion panzvimbo yekurapa kenza, uko chikwata chako chehutano chinogona kukutarisa zvakanyanya. Kunyange zvazvo belinostat chiri chishandiso chine simba mukurwisa kenza, kunzwisisa mashandiro ainoita uye zvekutarisira zvinogona kukubatsira kuti unzwe wakagadzirira rwendo rwako rwekurapa.

Chii chinonzi Belinostat?

Belinostat mushonga wekenza unotariswa nemishonga unovavarira maenzayemu chaiwo mukati memaseru ekenza kubatsira kumisa kukura kwawo. Mushonga uyu unoshanda nekudzivisa histone deacetylases, ayo ari mapuroteni anobatsira maseru ekenza kurarama uye kuwanda zvisingadzoreki.

Mushonga uyu unouya seupfu hunosanganiswa nemvura yakachena uye hunopiwa kuburikidza neIV line zvakananga muropa rako. Iyo FDA yakabvumira belinostat zvakananga kurapa peripheral T-cell lymphoma, mhando isingawanzoitiki asi ine hasha yekenza yeropa inokanganisa immune system yako.

Oncologist wako achasarudza kana belinostat yakakodzera mamiriro ako chaiwo zvichienderana nerudzi rwako rwekenza, hutano hwako hwese, uye maitiro ako kumamwe marapirwo.

Chii chinonzi Belinostat chinoshandiswa?

Belinostat inonyanya kushandiswa kurapa peripheral T-cell lymphoma (PTCL) muvarwere vakatoedza kamwe chete kurapwa kumwe kusina kushanda zvakanaka. PTCL iboka remakenza eropa ane hasha anokura kana mamwe maseru machena eropa anonzi T-cells ave nekenza.

Chiremba wako angakurudzira belinostat kana lymphoma yako yakadzoka mushure mekumira kana kana isina kupindura zvakakwana kurapwa kwemakemikari apfuura. Mushonga uyu unowanzo fungwa kana mamwe marapirwo akajairika asina kubudirira.

Dzimwe nguva, vanachiremba vanogona kushandisa belinostat sechikamu chekudzidza tsvagiridzo dzemamwe marudzi ekenza, asi kushandiswa kwayo kukuru kwakabvumirwa kunoramba kuri yerudzi urwu rwe lymphoma.

Belinostat Inoshanda Sei?

Belinostat inoshanda nekunangana nema enzymes anonzi histone deacetylases (HDACs) ayo maseru ekenza anovimba nawo kuti ararame uye awande. Funga nezvema enzymes aya semaswitch emamorekuru ayo maseru ekenza anoshandisa kuvhura nekudzima mamwe majini.

Kana belinostat ikavhara ma enzymes aya, inokanganisa kugona kweseru rekenza kudzora kukura kwayo uye nzira dzekurarama. Kukanganisa uku kunokonzera kuti maseru ekenza amire kupatsanurwa uye pakupedzisira afe, ukuwo zvichikonzera kukuvara kushoma kumasero ane hutano.

Mushonga uyu unoonekwa seune simba zvine mwero, zvinoreva kuti unogona kushanda zvakanaka kune mhando dzekenza dzine hasha asi dzinogonawo kukonzera migumisiro yakakosha. Chikwata chako chekuchengetedza hutano chichanyatsoenzanisa mabhenefiti pamwe nenjodzi dzinogona kuitika zvichienderana nemamiriro ako ega.

Ndingatora Sei Belinostat?

Uchagamuchira belinostat se infusion ye intravenous kwemaminitsi makumi matatu pamazuva 1 kusvika ku5 eimwe neimwe yezuva rekurapa remazuva makumi maviri nerimwe. Mushonga unofanirwa kupihwa panzvimbo yekurapa kenza uko nyanzvi dzehutano dzakadzidziswa dzinogona kuugadzirira nekupa zvakachengeteka.

Pamberi peimwe neimwe infusion, chikwata chako chekuchengetedza hutano chichaongorora kuverenga kweropa rako uye hutano hwese kuti uve nechokwadi chekuti muviri wako wakagadzirira kurapwa. Haufaniri kutora belinostat nechikafu sezvo ichienda zvakananga murwizi rwako rweropa, asi kugara uine mvura zvakanaka usati watanga uye mushure mekurapa kunogona kubatsira muviri wako kugadzirisa mushonga.

Mukoti wako achaisa mutsetse weIV muruoko rwako kana kupinda muchiteshi chako kana uine chimwe. Munguva yekuiswa, iwe uchatariswa kune chero maitiro ekukasira, uye iwe unogona kazhinji kuverenga, kushandisa zvishandiso zvemagetsi, kana kuzorora zvakanaka.

Ndingatora Belinostat kwenguva yakareba sei?

Kureba kwekurapa kwe belinostat kunosiyana zvakanyanya kubva kumunhu nemunhu, zvichienderana nekuti kenza yako inopindura sei uye kuti muviri wako unotsungirira sei mushonga. Vanhu vazhinji vanogamuchira matenderedzwa akawanda, netenderedzwa rega rega richigara mazuva makumi maviri nerimwe.

Oncologist wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa kweropa nguva dzose, imaging scans, uye kuongororwa kwemuviri kuti uone kana kurapwa kuchishanda nemazvo. Kana kenza yako ichipindura zvakanaka uye iwe uchitsungirira mushonga zvine musoro, unogona kuramba kurapwa kwemwedzi yakati wandei.

Kurapa kunowanzoenderera mberi kusvikira kenza yako yamira kupindura mushonga, mhedzisiro yacho yave yakanyanya kuoma kudzora, kana kenza yako yapinda mukuregererwa. Chikwata chako chehutano chichakurukura zvisarudzo izvi newe mukati merwendo rwako rwekurapa.

Ndezvipi Zvakaipa zveBelinostat?

Kufanana nemishonga yakawanda yekenza, belinostat inogona kukonzera mhedzisiro iyo inobva pakureruka kusvika kune yakakomba. Kunzwisisa zvekutarisira kunogona kukubatsira kugadzirira uye kuziva nguva yekubata chikwata chako chehutano.

Mhedzisiro yakajairika yaungasangana nayo inosanganisira kuneta, kusvotwa, fivha, uye kuderedzwa kwechido. Vanhu vazhinji vanogadzirawo huwandu hweropa hwakaderera, izvo zvinogona kuwedzera njodzi yako yekutapukirwa, kubuda ropa, kana anemia.

Mhedzisiro Yakajairika

Mhedzisiro iyi inoonekwa muvanhu vazhinji vachitora belinostat uye kazhinji inodzoreka nekuchengetedzwa kwakakodzera uye kutariswa:

• Kuneta uye kushaya simba zvinogona kuramba zviripo pakati pemitsetse yekurapa
• Kusvotwa nekutsvuka, izvo zvinowanzo kutariswa nemishonga inorwisa kusvotwa
• Fivha nekutonhora, kunyanya mumazuva anotevera kurapwa
• Kuderera kwechido uye shanduko mukuravira
• Dhayareya kana kuvharika
• Kufema kwekufema panguva yekurovedza muviri
• Kutemwa nemusoro nekutinhira
• Meno emuviri kana kukwenya

Chikwata chako chehutano chichapa mishonga uye nzira dzekubatsira kutarisira zviratidzo izvi uye kuchengetedza hupenyu hwako panguva yekurapa.

Mhedzisiro Yakakomba

Nepo isingawanzoitiki, dzimwe mhedzisiro dzinoda kutariswa kwekurapa nekukurumidza uye kutariswa zvakanyanya panguva yekurapwa kwako:

• Kudonha kwakanyanya mumaseru eropa (neutropenia, thrombocytopenia, anemia)
• Zvirwere zvakakomba nekuda kwehutachiona hwakaderera
• Kubuda ropa kwakakosha kana kupwanya
• Matambudziko echiropa, kusanganisira kuwedzera kwechiropa enzymes
• Kusagadzikana kwemoyo kana mamwe matambudziko emoyo
• Kupindura kwakanyanya kune allergy panguva kana mushure mekuisa
• Tumor lysis syndrome, uko maseru ekenza anotyoka nekukurumidza

Chikwata chako chekurapa chichatarisa matambudziko aya kuburikidza nekuongororwa kweropa nguva dzose uye kuongorora, uye vachagadzirisa chirongwa chako chekurapa kana zvichidikanwa.

Mhedzisiro isingawanzoitiki asi Yakakomba

Muzviitiko zvisingawanzoitiki, belinostat inogona kukonzera matambudziko akakomba anoda kupindira kwekurapa nekukurumidza:

• Kukuvadzwa kwakanyanya kwechiropa kana kutadza kwechiropa
• Zvirwere zvinotyisa hupenyu kana sepsis
• Matambudziko akakomba emoyo kana kutadza kwemoyo
• Kenza yechipiri inogona kukura makore gare gare
• Maitiro akakomba eganda kana kukuvadzwa kwetishu

Nepo matambudziko aya asina kujairika, chikwata chako chehutano chicharamba chichichenjerera zviratidzo zvekutanga uye chichatora matanho akakodzera kana akaitika.

Ndiani Asingafaniri Kutora Belinostat?

Belinostat haikodzere munhu wese, uye chiremba wako achanyatsoongorora kana mushonga uyu wakachengeteka kune mamiriro ako chaiwo. Mamwe mamiriro ehutano kana mamiriro anogona kuita kuti kurapwa uku kuve kwakanyanya njodzi.

Haufanire kugamuchira belinostat kana uchiziva kuti une allergy kumushonga kana chero zvawo. Uye zvakare, kana uine chirwere chechiropa chakakomba, chiremba wako anogona kudzivisa kurapwa uku sezvo belinostat inogona kukanganisa basa rechiropa.

Vanhu vane matambudziko emoyo akakomba, zvirwere zvakakomba zviripo, kana huwandu hweropa hwakaderera zvakanyanya vangave vasiri vakakodzera kurapwa nebelinostat. Oncologist wako achayerera izvi zvinhu pamwe chete nemabhenefiti anogona kuwanikwa ekurapa.

Zvekufunga Zvakakosha

Mamwe mapoka evanhu anoda kuongororwa nekuchenjerera kwakanyanya uye kuongororwa kana kurapwa nebelinostat kuchifungwa:

• Vakadzi vane pamuviri kana vanoyamwisa (belinostat inogona kukuvadza vana vari kukura)
• Vanhu vane matambudziko echiropa aripo kana hepatitis
• Varwere vane matambudziko emoyo kana chirwere chemoyo
• Avo vane matambudziko eitsvo kana basa reitsvo rakaderedzwa
• Vanhu vanotora zvinoderedza ropa kana vane matambudziko ekubuda ropa
• Varwere vane immune systems yakakanganiswa kubva kune zvimwe zvikonzero

Vashandi vehutano vako vachanyatsoongorora nhoroondo yako yekurapa uye mamiriro ako ehutano aripo vasati vakurudzira kurapwa nebelinostat.

Mazita eBelinostat Brand

Belinostat inowanikwa pasi pezita rekuti Beleodaq muUnited States. Iyi ndiyo chete fomu yebelinostat iripo yekutengeserana parizvino yakatenderwa neFDA.

Beleodaq inouya seupfu hwakaomeswa hunogadziriswa nevashandi vehutano nemvura yakachena vasati vashandisa. Mushonga uyu unogadzirwa neAcrotech Biopharma uye unowanikwa chete kuburikidza nemakemisi chaiwo uye nzvimbo dzekurapa kenza.

Haukwanowana mhando dzakajairika dze belinostat parizvino, sezvo mushonga uyu uchiri pasi pekudzivirirwa kwepatent. Izvi zvinoreva kuti Beleodaq ndiyo chete sarudzo iripo yekurapa belinostat parizvino.

Zvimwe Zvingashandiswa Panzvimbo peBelinostat

Kana belinostat isina kukodzera iwe kana ikamira kushanda nemazvo, chiremba wako weoncologist ane dzimwe nzira dzekurapa lymphoma yeperipheral T-cell. Idzi dzimwe nzira dzinoshanda nemaitiro akasiyana uye dzinogona kukodzera mamiriro ako chaiwo.

Zvimwe zvinodzivirira HDAC zvakaita se romidepsin (Istodax) zvinoshanda zvakafanana ne belinostat uye zvinogona kufungwa kana usingakwanise kutora belinostat. Uye zvakare, mamwe marapirwo matsva akatarisirwa uye sarudzo dzekurapa immunotherapies dziri kuwanikwa kune T-cell lymphomas.

Maitiro ekare ekurapa chemotherapy, kutamiswa kwemasero emuti, kana kutora chikamu mumiedzo yekiriniki yekurapa kwekuongorora zvinogona zvakare kuve sarudzo zvichienderana nehutano hwako hwese uye nhoroondo yekurapa.

Ko Belinostat Ari Nani Kudarika Romidepsin?

Zvese belinostat ne romidepsin zvinodzivirira HDAC zvinoshandiswa kurapa peripheral T-cell lymphoma, asi hazvifanirwe kunge zviri nani kana zvakashata kune mumwe nemumwe. Mushonga wega wega une mabhenefiti awo uye maitiro emhedzisiro anogona kuita kuti mumwe akodzere mamiriro ako chaiwo.

Belinostat inopiwa se infusion pfupi kwemaminitsi makumi matatu kwemazuva mashanu akateedzana, nepo romidepsin ichida infusions refu pamazuva akatarwa emutambo. Vamwe vanhu vanotsungirira mushonga mumwe zviri nani kune mumwe maererano nemhedzisiro.

Chiremba wako weoncologist achafunga nezvezvinhu zvakaita sehutano hwako hwese, kurapwa kwakapfuura, mikana yekudyidzana kwemishonga, uye zvaunofarira pachako paunenge uchisarudza pakati pesarudzo idzi. Sarudzo

Belinostat inoda kufungwa zvakanyanya muvanhu vane matambudziko aripo echiropa nekuti mushonga uyu unogona kukanganisa kushanda kwechiropa. Chiremba wako achada kuongorora kuoma kwechirwere chako chechiropa uye kuyera mabhenefiti anogona kuwanikwa pamwe nenjodzi.

Kana uine matambudziko echiropa ari nyore, chiremba wako angangofunga nezve belinostat asi nekutarisa kazhinji bvunzo dzako dzekushanda kwechiropa. Zvisinei, kana uine chirwere chechiropa chakakomba kana hepatitis inoshanda, belinostat ingasava yakachengeteka kwauri.

Vashandi vehutano vako vachaita bvunzo dzekushanda kwechiropa vasati vatanga kurapwa uye vachavatarisa nguva dzose mukati mekurapwa kwako kuti vave nechokwadi chekuti chiropa chako chiri kubata mushonga zvakachengeteka.

Ndoita Sei Kana Ndikagamuchira Belinostat Yakawandisa Netsaona?

Sezvo belinostat ichipiwa nenyanzvi dzehutano munzvimbo yekurapa inodzorwa, overdoses netsaona hazviwanzoitiki. Zvisinei, kana uchifungidzira kuti wagamuchira mushonga wakawandisa, zivisa mukoti wako kana chiremba wako nekukasira.

Hapana mushonga chaiwo wekudzorera overdose ye belinostat, saka kurapwa kwaizotarisa pakugadzirisa chero zviratidzo zvinomuka. Chikwata chako chekurapa chaizokutarisa zvakanyanya kuti uone zviratidzo zvekuwedzera mhedzisiro, kunyanya kudonha muhuwandu hwemasero eropa kana matambudziko echiropa.

Nzvimbo yekutonga inodzorwa uye kuverenga kwakanyatsoita kunobatsira kudzivirira mamiriro ekuwedzeredza, asi chikwata chako chehutano chakagadzirira kupindura nekukurumidza kana chero zvikanganiso zvekushandisa zvikaitika.

Ndoita Sei Kana Ndikarasikirwa neDosi yeBelinostat?

Kana ukakanganwa infusion ye belinostat yakarongwa, taura nechikwata chako cheoncology nekukasira kuti urongezve. Usaedze kutsiva madosi akarasika nekupeta kana kuchinja hurongwa hwako pasina gwara rekurapa.

Chiremba wako achasarudza nzira yakanakisa yekuenderera mberi zvichienderana nezvawakarasikirwa nedosi uye kwauri mumutambo wako wekurapa. Dzimwe nguva, vanogona kugadzirisa hurongwa hwako hwemutambo kana kugadzirisa chirongwa chako chekushandisa.

Kusavapo kwemishonga kunogona kukanganisa kushanda kwemushonga wako, saka zvakakosha kuchengeta zvese zvako zvakarongeka uye kutaura nechikwata chako kana uine dambudziko rekuenda kumishonga.

Ndingamira Rini Kutora Belinostat?

Unofanira kungomira kurapwa nebelinostat pasi pekutungamirirwa nachiremba wako weoncologist. Sarudzo yekumisa kurapwa inoenderana nezvinhu zvakati wandei, kusanganisira kuti kenza yako iri kupindura sei, matambudziko auri kusangana nawo, uye hutano hwako hwese.

Chiremba wako angakurudzira kumisa belinostat kana kenza yako ikapinda mukuregererwa, kana matambudziko acho akava akanyanya kuoma kubata, kana kana mushonga ukamira kushanda kurwisa kenza yako.

Usambomira kurapwa nebelinostat wega, kunyangwe uchinzwa zviri nani kana uchisangana nematambudziko. Chiremba wako weoncologist anoda kuongorora mamiriro ako akazara uye anogona kuda kukuchinjisa kune dzimwe nzira dzekurapa kana kutarisirwa kunotsigira.

Ndingatora Mimwe Mishonga Ndiri paBelinostat?

Unogona kutora mimwe mishonga uchigamuchira belinostat, asi chikwata chako chehutano chinoda kuongorora zvese zvauri kutora kudzivirira kusangana kunogona kuva nenjodzi. Mimwe mishonga inogona kuwedzera matambudziko ebelinostat kana kukanganisa kushanda kwayo.

Gara uchizivisa chiremba wako weoncologist nezve mishonga yese yakanyorwa, mishonga inotengeswa pasina gwaro, mavitamini, uye zvinowedzerwa zvauri kutora. Vachasarudza zvakachengeteka kuenderera mberi uye zvingangoda kugadziriswa kana kumiswa.

Mufemisi wako wemishonga nechikwata cheoncology vachashanda pamwe chete kuti vaone kuti mishonga yako yese inoenderana uye kuti uri kuwana kurapwa kwakachengeteka, kunoshanda zvakanyanya.