Chii chinonzi Bevacizumab: Zvazvinoshandiswa, Mishonga, Matambudziko, nezvimwe

Bevacizumab mushonga wekenza unotarisa unobatsira kunonotsa kukura kwebundu nekudzivisa kuumbwa kwemidzi yeropa. Kurapa uku kwakakosha kunoshanda nekugura ropa rinodiwa nematumbo kuti akure uye apararire mumuviri wako.

Seantibody ye monoclonal, bevacizumab inomiririra nzira yakarurama yekurapa kenza ichienzaniswa nechemotherapy yechinyakare. Chiremba wako weoncologist angakurudzira mushonga uyu sechikamu chechirongwa chako chekuchengetwa kwekenza, kazhinji pamwe chete nemamwe marapirwo kuti akupe mhedzisiro yakanaka.

Chii chinonzi Bevacizumab?

Bevacizumab ipuroteni yakagadzirwa murabhoritari inotevedzera maantibodies emuviri wako echisikigo emuviri. Inonyanya kutarisisa puroteni inonzi VEGF (vascular endothelial growth factor) iyo matumbo anoshandisa kugadzira midzi yeropa mitsva.

Funga nezve VEGF sechiratidzo chinoudza muviri wako kuti uvake migwagwa yeropa. Masero ekenza anotumira zviratidzo zvakawanda izvi kuti awane zvinovaka muviri zvaanoda kuti akure. Bevacizumab inodzivisa zviratidzo izvi, zvichidimburira chikafu chebundu.

Mushonga uyu ndewechikamu chinonzi angiogenesis inhibitors, zvinoreva kuti inodzivirira kuumbwa kwemidzi yeropa mitsva. Nekuita izvi, inogona kubatsira kunonotsa kukura kwekenza uye kuita kuti mamwe marapirwo ekenza ashande zvakanyanya.

Chii chinonzi Bevacizumab chinoshandiswa?

Bevacizumab inorapa mhando dzakawanda dzekenza yepamberi, kunyanya kana dzapararira kana kudzoka mushure mekurapwa kwekutanga. Chiremba wako anokuraira kana masero ekenza akagadzira network yavo yeropa.

Mhando dzekenza dzakajairika dzinorapwa nebevacizumab dzinosanganisira colorectal cancer, lung cancer, kidney cancer, uye mamwe matumbo ehuropi anonzi glioblastomas. Inoshandiswawo kune mamwe makenza e gynecologic senge ovarian uye cervical cancer.

Chiremba wako wezve oncology anowanzo sanganisa bevacizumab nemishonga yekurapa kenza panzvimbo yekushandisa yega. Iyi nzira yekusanganisa inowanzo shanda zviri nani pane chero kurapwa kwega, ichipa muviri wako nzira dzakawanda dzekurwisa kenza.

Mune dzimwe nguva, vanachiremba vanoshandisa bevacizumab kune mamiriro eziso senge wet age-related macular degeneration, kunyangwe izvi zvinoda imwe nzira uye chirongwa chekushandisa pane kurapwa kenza.

Bevacizumab Inoshanda Sei?

Bevacizumab inoshanda nekubatanidza mapuroteni eVEGF mumuviri wako, ichivadzivisa kubva pakunamira kune receptors pamaseru emidziyo yeropa. Izvi zvinovharisa chiratidzo chinowanzo udza muviri wako kuti ukure midziyo yeropa mitsva kune bundu.

Sezvo ichi chiri kurapwa kwakanangana, bevacizumab inoonekwa semushonga wepakati nepakati unoshanda zvakasiyana nekemotherapu yechinyakare. Panzvimbo yekuuraya maseru ekenza zvakananga, inovaomesa nenzara nekucheka ropa ravo.

Mishonga inotenderera mumuviri wako kwemavhiki akati wandei mushure mekuiswa kwega kwega. Munguva iyi, inoramba ichivharisa zviratidzo zveVEGF, ichibatsira kujairira network yemidziyo yeropa isina kurongeka iyo bundu rinogadzira.

Iyi nzira inogona kuita kuti bundu rive nyore kune mamwe marapirwo senge chemotherapy kana radiation, ndosaka vanachiremba vachishandisa bevacizumab sechikamu chekurapa kwakasiyana pane yega.

Ndinofanira Kutora Sei Bevacizumab?

Bevacizumab inopiwa chete kuburikidza ne intravenous (IV) infusion panzvimbo yekurapa kenza kana chipatara. Hauzokwanisi kutora mushonga uyu nemuromo kana kuuzvipinza iwe pachako kumba.

Kuiswa kwako kwekutanga kunowanzo tora maminitsi angangoita 90, zvichibvumira timu yako yezvokurapa kuti iongorore kuti muviri wako unopindura sei. Kana ukachigamuchira zvakanaka, kuisa kunotevera kunogona kupfupiswa kusvika kumaminitsi makumi matanhatu, uye pakupedzisira kusvika kumaminitsi makumi matatu.

Hapana chikonzero chekutsanya usati wapiwa mushonga, asi kudya chikafu chakareruka pamberi pezvo kunogona kukubatsira kuti unzwe wakasununguka panguva yekupinza mushonga. Uya nemvura nezvinhu zvekudya, sezvo uchagara kwenguva yakareba.

Mukoti wako achatarisa zviratidzo zvako zvakakosha nguva dzose uye achatarisa chero mhinduro dzekukurumidza. Mushonga uyu unosanganiswa nemvura yemunyu uye unopiwa zvishoma nezvishoma kuburikidza nemutsipa wako weIV kudzivirira mhedzisiro.

Ndingatora Bevacizumab Kwenguva Yakareba Sei?

Kureba kwemushonga webevacizumab kunosiyana zvakanyanya zvichienderana nerudzi rwako rwegomarara, nhanho, uye kuti unopindura sei kurapwa. Vanhu vazhinji vanogamuchira kupinza mushonga mazuva ese 2-3 kwemwedzi yakati wandei.

Chiremba wako weoncologist achatarisa gomarara rako kuburikidza nekuongorora nguva dzose uye bvunzo dzeropa kuti aone kana mushonga uri kushanda. Kana gomarara rako richipindura zvakanaka uye uchigona kushandisa mushonga, kurapwa kunogona kuenderera mberi kwemwedzi 6-12 kana kupfuura.

Vamwe varwere vanoenderera mberi nebevacizumab sekurapa kwekuchengetedza kunyangwe gomarara ravo richioneka serinodzorwa. Kurapa uku kunoenderera mberi kunobatsira kudzivirira gomarara kubva pakugadzira midziyo mitsva yeropa uye pamwe kukura zvakare.

Chiremba wako achakurukura kumisa kurapwa kana gomarara rako richifambira mberi pasinei nekurapwa, kana ukaita mhedzisiro yakakomba, kana kana uchida kuvhiyiwa kunoda nguva yekupora.

Ndezvipi Zvakaipa zveBevacizumab?

Kunzwisisa mhedzisiro inogona kuitika kunokubatsira kuti uzive zvekutarisira uye kuti ungabatana riini nechikwata chako chehutano. Vanhu vazhinji vanowana mhedzisiro yakati wandei, asi kazhinji vanogoneka nerutsigiro rwakakodzera uye kutariswa.

Mhedzisiro yakajairika iyo vanhu vazhinji vanowana inosanganisira high blood pressure, kuneta, uye kubuda ropa mumhino. Unogonawo kuona shanduko mukunzwa kwako kuravira, kusvotwa zvishoma, kana kuwedzera kupwanya kubva kumakomba madiki.

Heano mhedzisiro inonyanya kuziviswa:

• Kuvhiringidzika kweropa kunoda kugadziriswa kwemishonga
• Kuneta ne kusava nesimba zvinogona kuwedzera nekufamba kwenguva
• Kubuda ropa mumhino kana zvimwe zviitiko zvidiki zvekubuda ropa
• Mapuroteni mumweti wako akawanikwa kuburikidza nekuongorora nguva dzose
• Kuchinja kwekureruka kunokanganisa chido chako
• Kunyara zvishoma kusvika pakati nepakati
• Kuwanda kwekubuda ropa kana kupora kwemaronda kunonoka

Mhedzisiro yakakomba inoda kutariswa kwechimbichimbi, kunyangwe ichiitika kazhinji. Matambudziko aya anogona kuva anotyisa kana asina kutariswa nekukurumidza nechikwata chako chehutano.

Mhedzisiro isingawanzoitiki asi yakakomba inosanganisira:

• Kubuda ropa kwakanyanya mudumbu rako, mapapu, kana uropi
• Maviri eropa mumakumbo ako, mapapu, kana moyo
• Maburi kana misodzi mumadziro ako ematumbo (perforation)
• Dambudziko rakakomba rekukwira kweropa
• Matambudziko emoyo anosanganisira kutadza kwemoyo
• Kukuvadzwa kwetsvo nekurasikirwa kwemapuroteni
• Kusagadzikana kwakanyanya kwemuviri panguva yekuiswa

Chikwata chako chekurapa chinotarisa matambudziko aya akakomba kuburikidza nekuongororwa kweropa nguva dzose, kuongororwa kweropa, uye kuongororwa kwemuviri. Kuonekwa nekukurumidza uye kurapwa kwemhedzisiro kunogona kudzivirira matambudziko mazhinji kuti asaite njodzi.

Ndiani Asingafaniri Kutora Bevacizumab?

Mamwe mamiriro ezvinhu ekurapa uye mamiriro anoita kuti bevacizumab isachengeteke kana kuda matanho akakosha. Oncologist wako achanyatsoongorora nhoroondo yako yekurapa asati akurudzira kurapwa uku.

Haufaniri kugamuchira bevacizumab kana iwe uri nepamuviri kana kuronga kuva nepamuviri, sezvo ichigona kukonzera kukanganisa kukuru kuberekwa. Vakadzi vane makore ekubereka vachafanira kushandisa nzira yekudzivirira pamuviri inoshanda panguva yekurapwa uye kwemwedzi mitanhatu mushure meizvozvo.

Vanhu vane kuvhiyiwa kukuru kwemazuva ano kana maitiro ekurapa akarongeka havagone kugamuchira bevacizumab. Mushonga unokanganisa kupora kwemaronda, saka unozofanirwa kumisa kurapwa mazuva makumi maviri nemasere usati wavhiyiwa.

Mamwe mamiriro angatadzisa kushandiswa kwebevacizumab anosanganisira:

• Kukwira kweropa kusingadzoreki kunyangwe mushonga
• Nhoroondo ichangoburwa yezviitiko zvekubuda ropa zvakanyanya
• Zvirwere zvekukora ropa zvazvino
• Chirwere chemoyo chakanyanya kana kurwisa kwemoyo kuchangoburwa
• Zvirwere zviripo zvisingapinduri kurapwa
• Chirwere cheitsvo chakanyanya nekurasikirwa neprotein
• Sitroko ichangoburwa kana kubuda ropa muuropi

Chiremba wako achayerera mabhenefiti anogona kuwanikwa achipesana nenjodzi idzi dzemamiriro ako chaiwo. Dzimwe nguva kugadzirisa chirongwa chako chekurapa kana kuwedzera kuongorora kunogona kuita kuti bevacizumab ive yakachengeteka kune vanhu vane mamiriro akati.

Mazita eBevacizumab Brand

Bevacizumab inowanikwa pasi pemazita akati wandei emhando, neAvastin ndiyo yakanyanya kuzivikanwa yekutanga formulation. Iyi vhezheni yezita remhando yakashandiswa mukurapa kenza kwemakore mazhinji nerutsigiro rwakakura rwekutsvagisa rwekubudirira kwayo.

Mavhezheni eBiosimilar ebevacizumab aripo zvino, achipa mabhenefiti akafanana ekurapa pamitengo inogona kuderera. Izvi zvinosanganisira Mvasi, Zirabev, uye Alymsys, ese akatenderwa seakaenzana neyekutanga Avastin.

Inishuwarenzi yako inogona kukanganisa kuti chiremba wako anonyora chii, asi ese mavhezheni akatenderwa ane chinhu chimwe chete chinoshanda uye anoshanda zvakafanana mumuviri wako. Sarudzo pakati pemhando inowanzoenderana nekuwanikwa uye kufunga kwemitengo panzvimbo pemisiyano yekurapa.

Zvimwe Zvinhu zveBevacizumab

Mishonga yakati wandei inoshanda zvakafanana nebevacizumab nekunangana nekuumbwa kwemidzi yeropa, kunyangwe imwe neimwe iine hunhu hwakasiyana uye kushandiswa kwakatenderwa. Oncologist wako angangofunga izvi zvimwe zvinhu zvichibva pamhando yako chaiyo yekenza uye nhoroondo yekurapa.

Ramucirumab (Cyramza) imumwe mushonga unovharisa VEGF unoshandiswa zvakanyanya kurapa kenza yemudumbu nemapapu. Unoshanda nenzira yakasiyana zvishoma asi unoita zvakafanana mukudzivirira kukura kwetsinga dzeropa dzinopa bundu.

Zvimwe zvinodzivirira angiogenesis zvinosanganisira aflibercept (Zaltrap) yekenza yegwara guru remudumbu uye regorafenib (Stivarga) yekenza yegwara guru remudumbu rakaoma uye kenza yeropa. Mishonga iyi inopa sarudzo dzekutora nemuromo, iyo vamwe varwere vanosarudza pane kupiwa nemutsinga.

Kune mamwe marudzi ekenza, mishonga ye immunotherapy yakaita se pembrolizumab (Keytruda) kana nivolumab (Opdivo) inogona kufungwa panzvimbo pe kana pamwe chete ne bevacizumab, zvichienderana nemaitiro chaiwo ekenza yako uye biomarkers.

Bevacizumab iri nani pane mamwe mishonga yakafanana here?

Bevacizumab ndiyo yekutanga VEGF inhibitor yakatenderwa uye ine ruzivo rwakawanda rwekutsvagisa runotsigira kushandiswa kwayo mumhando dzakawanda dzekenza. Iyi rekodhi refu inobatsira vanachiremba kufanotaura kuti ungaita sei kumishonga.

Pakuenzanisa nezvimwe zvingasarudzwa zvitsva zvakaita se ramucirumab, bevacizumab inowanzoita misanganiswa yakawanda yekurapa inowanikwa uye mvumo yakakura yemhando dzakasiyana dzekenza. Zvisinei, sarudzo

Bevacizumab inogona kukanganisa hurongwa hwako hwemwoyo, saka vanhu vane matambudziko emwoyo vanoda kuongororwa zvakanyanya uye matanho ekudzivirira. Chiremba wako wemwoyo uye oncologist vachashanda pamwechete kuti vaone kana mabhenefiti achipfuura njodzi.

Kana uine chirwere chemwoyo chinyoro chinodzorwa zvakanaka, unogona kuramba uchikwanisa kugamuchira bevacizumab nekutarisa mwoyo kakawanda. Izvi zvinosanganisira ECGs dzenguva dzose, echocardiograms, uye manejimendi akanyatsoitwa eropa mukati mekurapa.

Vanhu vane kukundikana kwemwoyo kwakanyanya, kurwisa kwemwoyo kwemazuva ano, kana ropa rakakwira risingadzorwe kazhinji havagone kugamuchira bevacizumab zvakachengeteka. Mushonga unogona kuwedzera mamiriro aya uye kuwedzera njodzi yematambudziko akakomba emwoyo.

Ndoita Sei Kana Ndikagamuchira Bevacizumab Yakawandisa Netsaona?

Bevacizumab overdose haina kujairika nekuti inotungamirirwa nevashandi vehutano vakadzidziswa munzvimbo dzehutano dzakadzorwa. Mushonga unoverengwa zvakanyatsoenderana nehuremu hwako uye unopiwa zvishoma nezvishoma kuburikidza neIV infusion inotariswa.

Kana uchifungidzira kuti wagamuchira dose isiriyo, zivisa mukoti wako weinfusion kana chiremba nekukasira. Vanogona kuongorora marekodhi ako ekurapa uye kukutarisa zvakanyanya kune chero mhedzisiro isingajairiki.

Zviratidzo zvinogona kuratidza nyaya dzekushandisa zvinosanganisira kurwadziwa kwakanyanya kwemusoro, ropa rakakwira zvakanyanya, kubuda ropa kusingajairiki, kana kusvotwa kwakanyanya. Chikwata chako chehutano chinoziva maitiro ekugadzirisa mamiriro aya uye chichapa rutsigiro rwakakodzera.

Ndoita Sei Kana Ndikakanganwa Dose yeBevacizumab?

Taura nechikwata chako cheoncology nekukasira kana ukakanganwa infusion yebevacizumab yakarongwa. Vachakugadzirisa zvakare panguva yakakodzera yekutanga kuti vachengetedze kushanda kwako kwekurapa.

Chiremba wako anogona kuchinja zvishoma chirongwa chako chekurapa kuti chigadzirise mushonga wawakapotsa, asi usaedze "kuzadza" nekugamuchira mishonga iri pedyo. Nguva pakati pemishonga inorongwa zvakanyatsonaka kuti ienzanise kushanda pamwe nekuchengeteka.

Kupotsa mushonga mumwe chete kazhinji hakuna kukanganisa zvakanyanya mhedzisiro yako yekurapa, kunyanya kana ukatangazve chirongwa chako chesevhisi nekukurumidza. Oncologist wako achatarisa mhinduro yako uye anogona kukurudzira mamwe ma scans kuti ave nechokwadi chekuti kenza yako inoramba ichidzora.

Ndingamira Rini Kutora Bevacizumab?

Sarudzo yekumisa bevacizumab inoenderana nezvinhu zvakati wandei zvinosanganisira mhinduro yekenza yako kumishonga, mhedzisiro yaunowana, uye hutano hwako hwese. Oncologist wako achakutungamira sarudzo iyi zvichibva pakutarisa nguva dzose.

Unogona kumisa kurapwa kana kenza yako ichienderera mberi pasinei nemishonga, kana ukawana mhedzisiro yakakomba inodarika mabhenefiti, kana kana uchida kuvhiyiwa kunoda kupora kwakanaka kwemaronda.

Vamwe varwere vanomisa bevacizumab mushure mekupedza kosi yakarongwa yekurapa, nepo vamwe vachienderera mberi chero zvichibatsira kudzora kenza yavo uye vachizvitsungirira zvakanaka. Hapana "zuva rekupedzisira" rakatarwa kune vese.

Usambomira bevacizumab wega usina kuzvikurukura ne oncologist wako kutanga. Kumisa kamwe kamwe hakuzokonzeri zviratidzo zvinotyisa zvekubviswa, asi zvinogona kubvumira kenza yako kuti ienderere mberi nekukurumidza kupfuura zvaitarisirwa.

Ndinganwa Doro Ndichitora Bevacizumab Here?

Kunwa doro zvine mwero kazhinji kunogamuchirwa uchigamuchira bevacizumab, asi unofanira kukurukura tsika dzako dzekunwa ne oncologist wako. Doro rinogona kushamwaridzana nemimwe mishonga yaunotora uye rinogona kuwedzera mamwe mhedzisiro.

Sezvo bevacizumab inogona kukanganisa ropa rako uye kuwedzera njodzi yekubuda ropa, doro rinogona kuwedzera mhedzisiro iyi. Kana ukasarudza kunwa, zviise kune chimwe chinwiwa pazuva uye dzivisa doro pedyo nemazuva ako emishonga.

Chenjererai kuti doro rinokukanganisa sei panguva yekurapwa, sezvo mishonga yekenza inogona kuchinja kugona kwako. Vamwe varwere vanowana kuti vanonzwa migumisiro yedoro zvakanyanya kana vachisanganisa ne bevacizumab.