Chii chinonzi Bezlotoxumab: Zvazvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Bezlotoxumab mushonga wemuviri wakagadzirirwa kudzivirira hutachiona hweura hunotyisa kuti husadzokezve. Kana wanga uchitambura nehutachiona hweClostridioides difficile (C. diff), chiremba wako angakurudzira mushonga uyu kuti akubatsire kudzivirira kubva kune zviitiko zveramangwana.

Mushonga uyu unoshanda zvakasiyana nemishonga inorwisa mabhakitiriya yakajairika. Panzvimbo pokuuraya mabhakitiriya zvakananga, inobatsira muviri wako kuziva nekurwisa chepfu dzinoita kuti hutachiona hweC. diff huve nengozi. Funga nezvazvo sekupa muviri wako dziviriro yechisikigo kusimudzira kunobatsira kana vachizvida zvakanyanya.

Chii chinonzi Bezlotoxumab?

Bezlotoxumab imonoclonal antibody inonangana nechepfu B inogadzirwa neClostridioides difficile mabhakitiriya. Mushonga uyu unowanikwa semushonga weintravenous, zvinoreva kuti unopihwa zvakananga muropa rako kuburikidza nemitsi.

Mushonga uyu ndeweboka remishonga inonzi monoclonal antibodies. Aya mapuroteni akagadzirwa murabhoritari anotevedzera kugona kwemuviri wako kurwisa zvinhu zvinokuvadza. Bezlotoxumab inonyatso batanidza uye inodzima chepfu inokonzera zviratidzo zvakanyanya zveC. diff infections.

Kusiyana nemishonga inorwisa mabhakitiriya inouraya mabhakitiriya, bezlotoxumab inoshanda nekudzivisa mhedzisiro inokuvadza yechepfu yemabhakitiriya. Iyi nzira inobatsira kuderedza njodzi yekudzoka kwehutachiona ichibvumira mabhakitiriya ako eura akajairika kupora zvakanyanya.

Bezlotoxumab Inoshandiswa Kunei?

Bezlotoxumab inoshandiswa kuderedza mukana wekudzoka kwehutachiona hweClostridioides difficile muvanhu vakuru vari panjodzi huru yekudzoka. Chiremba wako anowanzo kurudzira mushonga uyu kana iwe uchigamuchira kurapwa nemishonga inorwisa mabhakitiriya yeC. diff uye uine zvimwe zvinhu zvine njodzi.

Mishonga iyi inobatsira zvikuru vanhu vakambove nezvirwere zvakawanda zveC. diff. Zvidzidzo zvinoratidza kuti vanenge 20-30% yevanhu vanopora kubva kune imwe chirwere cheC. diff vachazotambura chimwezve mukati memwedzi mishoma. Bezlotoxumab inogona kuderedza zvakanyanya njodzi iyi.

Mishonga iyi inofungwawo kuti inokodzera varwere vane makore anopfuura 65, vane masisitimu ekudzivirira muviri akakanganiswa, kana vane mamiriro ezvinhu akaipa ehutano. Zvinhu izvi zvinoita kuti zviite seC. diff infections ichadzoka uye inogona kuva yakakomba.

Bezlotoxumab Inoshanda Sei?

Bezlotoxumab inoshanda nekunangana nekudzivirira chepfu B, imwe yezvinhu zvikuru zvinokuvadza zvinogadzirwa neC. diff bacteria. Chepfu iyi ndiyo inokonzera kuzvimba uye kukuvadzwa kunoitika mumatumbu ako panguva yekutapukirwa.

Paunogamuchira bezlotoxumab, maantibodies aya akakosha anotenderera muropa rako uye anosungirira kumamorekuru echepfu B. Nekunamira kune chepfu, maantibodies anovadzivisa kukuvadza masero ako emumatumbu uye kukonzera zviratidzo zvine chekuita neC. diff infections.

Izvi zvinoonekwa sekurapa kwekudzivirira kwakasimba zvishoma. Kunyange zvisingaurayi mabhakitiriya zvakananga, inopa dziviriro yakakura kubva kune chepfu dzinokonzera kukuvadza kukuru. Mhedzisiro yacho inogona kugara kwemwedzi yakati wandei, ichipa muviri wako nguva yekudzosa chiyero chehutano hwebhakitiriya.

Ndingatora Sei Bezlotoxumab?

Bezlotoxumab inopiwa seimwechete intravenous infusion munzvimbo yekuchengetedza hutano senge chipatara kana nzvimbo yekupinza. Mishonga iyi inosanganiswa nemhinduro yesaline uye inopiwa zvishoma nezvishoma kwemaminitsi anenge 60 kuburikidza neIV line muruoko rwako.

Haufaniri kutsanya usati wagamuchira bezlotoxumab, uye hapana zvirambidzo zvakakosha zvekudya. Zvisinei, zvinobatsira kudya chikafu chakareruka pamberi kuti udzivise chero kusvotwa panguva yekupinza. Kugara uine mvura yakawanda nekunwa mvura yakawanda kunokurudzirwawo.

Mushonga uyu uchapiwa iwe uchiri kutora mishonga inorwisa mabhakitiriya eC. diff yako iripo. Chikwata chako chehutano chichakutarisa zvakanyanya panguva uye mushure mekurapa kuti chione chero maitiro. Vanhu vazhinji vanogona kuenda kumba pazuva rimwechete mushure menguva pfupi yekutarisa.

Ndingatora Bezlotoxumab Kwenguva Yakareba Sei?

Bezlotoxumab inopiwa semushonga wekamwe chete, kwete semushonga unopfuurira. Iwe uchagamuchira infusion imwe chete inopa dziviriro kwemwedzi yakati wandei mushure mekurapa kwako kweC. diff iripo.

Mhedzisiro yekudzivirira inowanzo gara kwemavhiki gumi nemaviri mushure me infusion. Munguva iyi, ma antibodies anoramba achishanda mumuviri wako, achibatsira kudzivirira chepfu B kubva pakukonzera imwe hutachiona kana iwe ukasangana neC. diff mabhakitiriya zvakare.

Chiremba wako achatarisa kupora kwako uye anogona kukurudzira mamwe matanho ekudzivirira kupfuura nguva yemavhiki gumi nemaviri. Zvisinei, vanhu vazhinji havadi madosi anoverengeka ebezlotoxumab kunze kwekunge vachikudziridza imwe hutachiona hweC. diff mune ramangwana.

Ndezvipi Zvakaipa ZveBezlotoxumab?

Vanhu vazhinji vanotsungirira bezlotoxumab zvakanaka, asi semushonga chero upi zvake, unogona kukonzera mhedzisiro. Maitiro anowanzoitika anowanzoita akapfava uye anoitika panguva kana nguva pfupi mushure me infusion.

Heano mhedzisiro yaungasangana nayo, uchifunga kuti vanhu vazhinji havana matambudziko zvachose:

• Kusvotwa uye kuneta - Izvi ndizvo zvinowanzozivikanwa mhedzisiro, zvichikanganisa vanenge 7-8% yevarwere
• Fivha uye kurwadziwa nemusoro - Inogona kuitika panguva kana mukati memaawa mashoma e infusion
• Dizziness - Kazhinji yakapfava uye yenguva pfupi
• Maitiro enzvimbo yekujekesa - Kutsvuka, kuzvimba, kana kusagadzikana uko IV yakaiswa

Mhedzisiro yakakomba asi isingawanzoitika inogona kusanganisira matambudziko emoyo, kunyanya kana uine chirwere chemoyo kare. Chikwata chako chekuchengetedza hutano chichatarisa kurova kwemoyo wako uye BP panguva yekupinza kuti ubate chero shanduko dzinonetesa pakutanga.

Allergic reactions ku bezlotoxumab hazviwanzoitiki asi zvinogoneka. Zviratidzo zvinogona kusanganisira kuoma kufema, kuzvimba kwechiso kana huro, kana kuoma kweganda. Ichi ndicho chikonzero nei uchizotariswa zvakanyanya panguva uye mushure mekurapa kwako.

Ndiani Asingafaniri Kutora Bezlotoxumab?

Bezlotoxumab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akurudzira kurapwa uku. Mushonga hauna kubvumidzwa kushandiswa muvana vari pasi pemakore gumi nemasere.

Vanhu vane mamiriro emoyo akati wandei vanogona kuda kufunga kwakakosha kana vangave vasiri vakwikwidzi vekurapa uku. Kana uine congestive heart failure kana nhoroondo yematambudziko akakomba emoyo, chiremba wako achayerera mabhenefiti achipesana nenjodzi dzinogona kuitika nekuchenjerera.

Unofanira kuudza chiremba wako nezve chero allergic reactions kumishonga, kunyanya mamwe monoclonal antibodies. Kunyange zvichiwanzowanikwa, vamwe vanhu vanogona kuva nemishonga kune zvikamu mu bezlotoxumab, zvichiita kuti kurapwa kusachengeteke.

Vakadzi vane pamuviri kana vanoyamwisa vanofanira kukurukura njodzi nemabhenefiti nemupi wavo wehutano. Kunyange zvazvo paine data shoma pakushandiswa kwe bezlotoxumab panguva yekuzvitakura, chiremba wako anogona kubatsira kuona kana mabhenefiti achipfuura chero njodzi dzinogona kuitika kwauri nemwana wako.

Bezlotoxumab Zita reBrand

Bezlotoxumab inowanikwa pasi pezita rebrand Zinplava. Iri ndiro zita rebrand chete riripo parizvino remushonga uyu muUnited States nemamwe mazana enyika.

Zinplava inogadzirwa neMerck uye yakabvumidzwa neFDA muna 2016. Parizvino hapana generic versions ye bezlotoxumab iripo, saka Zinplava ndiyo chete sarudzo kana chiremba wako akaraira kurapwa uku.

Inishuwarenzi yako inogona kusiyana pamishonga yemhando yakaita seZinplava. Zvakanaka kuti utarise nemupi wako weinishuwarenzi nezvekuvharwa uye chero zvinodiwa zvekutanga mvumo usati waronga kurapwa kwako.

Zvimwe Zvinhu Zvokutsiva Bezlotoxumab

Nepo bezlotoxumab iri rakasiyana mukuita kwayo kudzivirira C. diff kudzoka, kune dzimwe nzira dzinogona kufungwa nachiremba wako. Zvimwe zvinhu izvi zvinoshanda zvakasiyana asi zvinogonawo kubatsira kuderedza njodzi yekudzoka kwezvirwere.

Fecal microbiota transplantation (FMT) imwe nzira yekudzivirira C. diff kudzoka. Maitiro aya anosanganisira kuisa mabhakitiriya ane hutano kubva kumupi kuti abatsire kudzorera chiyero chako chemuviri. FMT inogona kushanda zvakanyanya asi inoda nzvimbo dzakakosha uye kuongororwa kwakanyatso.

Makosi eantibayoti akawedzerwa kana akaderedzwa anogona kurairwa panzvimbo yebezlotoxumab kana pamwe chete nayo. Vamwe vanachiremba vanoraira vancomycin kana fidaxomicin kwenguva yakareba kana mumadosi anoderera zvishoma nezvishoma kudzivirira kudzoka.

Probiotics uye shanduko dzekudya dzinogonawo kutamba basa rinotsigira, kunyangwe dzichiwanzoshandiswa pamwe chete nemamwe marapirwo pane senzira dzakazvimirira. Chiremba wako achabatsira kuona nzira yakanakisa zvichienderana nemamiriro ako chaiwo uye njodzi.

Bezlotoxumab Ari Nani Pane Vancomycin Here?

Bezlotoxumab nevancomycin zvinoshanda nenzira dzakasiyana zvachose, saka kuenzanisa zvakananga hakusi kufanana nekuenzanisa maapuro nemaapuro. Vancomycin mushonga unorapa zvirwere zveC. diff zviri kushanda, nepo bezlotoxumab ichidzivirira zvirwere zveramangwana kubva pakudzoka.

Vanhu vazhinji vanogamuchira bezlotoxumab vari kutorawo vancomycin kana imwe antibiotic kurapa hutachiona hwavo huripo. Mishonga miviri iyi inoshanda pamwe chete pane kukwikwidzana. Vancomycin inouraya mabhakitiriya eC. diff anokonzera zviratidzo zvako zviripo, nepo bezlotoxumab ichibatsira kudzivirira zviitiko zveramangwana.

Zvidzidzo zvinoratidza kuti vanhu vanogamuchira bezlotoxumab pamwe chete nekurapa kwemishonga inorwisa mabhakitiriya vane njodzi yakaderera ye10% yekudzoka kweC. diff infections kana ichienzaniswa nevaya vanogamuchira mishonga inorwisa mabhakitiriya chete. Izvi zvinoita kuti bezlotoxumab ive chinhu chinokosha kuwedzera kurapwa pane kutsiva mishonga inorwisa mabhakitiriya.

Chiremba wako achafunga nezvezvinhu zvakaita sezera rako, C. diff infections dzakapfuura, uye hutano hwako hwese paachasarudza kana achikurudzira bezlotoxumab pamwe chete nekurapa kwako nemishonga inorwisa mabhakitiriya. Nzira yekubatanidza inowanzoita kuti ive dziviriro yakanakisisa pakurwisa zvese zviripo uye zvirwere zveramangwana.

Mibvunzo Inowanzo Bvunzwa Nezve Bezlotoxumab

Q1. Bezlotoxumab Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Bezlotoxumab inoda kufungwa zvakanyanya muvanhu vane chirwere chemoyo, kunyanya avo vane kukundikana kwemoyo. Zvidzidzo zvekiriniki zvakaratidza njodzi yakakwira zvishoma yezvinhu zvine chekuita nemoyo muvarwere vane mamiriro emoyo aripo.

Chiremba wako achaongorora mamiriro ako chaiwo emoyo uye hutano hwazvino usati wakurudzira bezlotoxumab. Vanogona kuda kuongorora basa remoyo wako zvakanyanya panguva yekuiswa kana vangasarudza kuti njodzi dzinopfuura mabhenefiti mune yako chaiyo.

Kana iwe ukagamuchira bezlotoxumab uine chirwere chemoyo, ungangove uine kuongororwa kakawanda panguva uye mushure mekurapa. Izvi zvekuchenjerera zvakawedzerwa zvinobatsira kubata chero matambudziko angangoitika pakutanga uye inovimbisa kuchengeteka kwako mukati mekuita.

Q2. Ndoitei Kana Ndine Reaction Panguva yeBezlotoxumab Infusion?

Kana iwe ukawana chero zviratidzo zvinonetsa panguva yebezlotoxumab infusion yako, udza timu yako yehutano nekukasira. Zvinhu zvakajairika zvakaita senausea yakapfava kana kuneta zvinogona kutariswa nekuderedza kumhanya kwekuiswa kana kupa rutsigiro rwekutarisira.

Zviratidzo zvakakomba zvakaita sekufema zvakaoma, kurwadziwa muchipfuva, kana dzungu rakanyanya zvinoda kutariswa kwekurapa nekukasira. Chikwata chako chehutano chakadzidziswa kuziva nekukurumidza kurapa zviratidzo izvi, ndosaka kubaiwa jekiseni kuchigara kuchiitirwa munzvimbo yekurapa.

Zviratidzo zvakawanda zvinoitika panguva yekubaiwa jekiseni kana mukati memaawa mashoma mushure meizvozvo. Ichi ndicho chikonzero nei uchazvitariswa zvakanyanya panguva yekurapwa uye kwenguva pfupi mushure mekunge kubaiwa jekiseni kwapera. Usazeze kutaura kana usiri kunzwa zvakanaka chero nzira.

Q3. Ndoita Sei Kana Ndikakundikana Kugadzwa Kwangu kweBezlotoxumab?

Kana iwe ukakundikana kugadzwa kwako kwebezlotoxumab, taura nemupi wako wehutano nekukasira kuti ugadzirise zvakare. Sezvo ichi chiri kurapwa kamwe chete kunopiwa panguva yekurapa kwako antibiotic yeC. diff, nguva inogona kukosha kuti uwane kushanda zvakanyanya.

Chiremba wako anogona kuda kugadzirisa kubaiwa jekiseni nekukasira, kunyanya kana uchiri kutora maantibiotics eC. diff yako yazvino. Chinangwa ndechekukupa maantibodies ekudzivirira usati wapedza kurapwa kwako antibiotic.

Usanetseka kana uchida kugadzirisa - chikwata chako chehutano chinonzwisisa kuti kusangana kwenguva kunoitika. Vachashanda newe kuti vawane nguva yakanakisa iyo ichiri kupa dziviriro yakanakisa kubva pakudzoka kweC. diff.

Q4. Ndingamira Rini Kunetseka Nezve C. diff Recurrence Mushure meBezlotoxumab?

Bezlotoxumab inopa dziviriro yakasimba mumavhiki gumi nemaviri ekutanga mushure mekubaiwa kwako jekiseni. Panguva ino, maantibodies anoramba ari pamatanho avo epamusoro muhurongwa hwako, achipa dziviriro yakanyanya kubva kuC. diff toxins.

Mushure memavhiki gumi nemaviri, mhedzisiro yekudzivirira inoderera zvishoma nezvishoma, asi vanhu vazhinji vanoramba vaine dziviriro kwemwedzi yakati wandei. Njodzi yako yega yekudzoka inoenderana nezvinhu zvakaita sezera rako, immune system, uye kana uchida kutora maantibiotics kune mamwe mamiriro.

Zvakakosha kuramba uchitevera tsika dzakanaka dzekuchenesa uye kuudza vanopa hutano hwako nezve nhoroondo yako yeC. diff kana uchida mishonga inorwisa mabhakitiriya mune ramangwana. Kunyange zvazvo bezlotoxumab ichideredza zvakanyanya njodzi yako, kuramba wakangwarira nezvekudzivirira kunoramba kwakakosha kwenguva refu.

Mubvunzo 5. Ndingawana Bezlotoxumab Kanopfuura Kamwe Chete Here?

Hongu, unogona kugamuchira bezlotoxumab zvakare kana ukawana imwe C. diff infection mune ramangwana. Vamwe vanhu vangada kurapwa zvakare, kunyanya kana vaine njodzi dzinoenderera mberi kana masisitimu ekudzivirira muviri akakuvadzwa.

Chiremba wako achaongorora kana imwe dose yebezlotoxumab yakakodzera zvichienderana nemamiriro ako ega. Zvinhu zvakaita sekuti zvakatora nguva yakareba sei kubva pakupinza kwako kwekare uye njodzi dzako dzazvino dzichapesvedzera chisarudzo ichi.

Hapana muganho chaiwo wekuti unogona kugamuchira bezlotoxumab kangani, asi chisarudzo chega chega chekurapa chinofanira kuitwa nekuchenjerera nemupi wako wehutano. Vachafunga nezve mabhenefiti nenjodzi dzemamiriro ako chaiwo nguva imwe neimwe.