Chii chinonzi Brodalumab: Zvazvinoshandiswa, Mishonga, Mativi eMuviri uye Zvimwe

Brodalumab mushonga unopiwa nachiremba unobatsira kurapa psoriasis yakati wandei kusvika yakanyanya muvanhu vakuru. Imushonga webiologic unoshanda nekudzivisa mapuroteni akati wandei mumuviri wako wekudzivirira zvirwere anokonzera kuzvimba uye kukura nekukurumidza kwemasero eganda kunoonekwa mupsoriasis.

Mushonga uyu unouya sejojo yakazadzwa kare yaunozvipa iwe pasi peganda, kazhinji kamwe chete mumasvondo gumi nemaviri mushure menguva yekutanga yekuzadza. Chiremba wako achanyatsoongorora kana brodalumab yakakukodzera, sezvo ichida kuongororwa zvakakosha nekuda kwemamwe mativi akakomba asi asingawanzoitiki.

Chii chinonzi Brodalumab?

Brodalumab ndeyemukirasi yemishonga inonzi interleukin-17 receptor antagonists. Iyo yakatarwa biologic therapy inonyanya kudzivisa chiito cheinterleukin-17, puroteni inoita basa rakakosha mukukonzera zviratidzo zvepsoriasis.

Funga nezve interleukin-17 semutumwa anoudza muviri wako wekudzivirira zvirwere kuti ugadzire kuzvimba uye nekukurumidza kugadzirwa kwemasero eganda. Brodalumab inokanganisa meseji iyi, ichibatsira kudzikamisa mhinduro yakawandisa yekudzivirira zvirwere inokonzera mapuraki epsoriasis kuti aumbwe.

Mushonga uyu unogadzirwa semhinduro isina utachiona uye unouya mumajojo akazadzwa kare kana ma-auto-injectors. Izvi zvinoita kuti zvive nyore kwauri kuzvipa jojo kumba kana wangodzidziswa nemupi wako wehutano.

Brodalumab Inoshandiswa Kunei?

Brodalumab inobvumidzwa zvakanyanya kurapa psoriasis yakati wandei kusvika yakanyanya muvanhu vakuru vanokodzera systemic therapy kana phototherapy. Chiremba wako anowanzo funga nezvemushonga uyu kana kurapwa kwepamusoro kwakundikana kupa zororo rakakwana.

Psoriasis yePlaque ndiyo mhando inowanzoitika ye psoriasis, inoratidzwa nemavara akasimuka, matsvuku, ane makwapa paganda. Aya maplaque anogona kukwenya, kurwadza, uye kukanganisa zvakanyanya hupenyu hwako. Brodalumab inobatsira kuderedza saizi, ukobvu, uye kutsvuka kwemaplaque aya.

Mupi wako wehutano angangakurudzira brodalumab kana uine psoriasis inovhara chikamu chikuru chemuviri wako, kana kana mamiriro acho achikanganisa zvakanyanya mabasa ako ezuva nezuva, basa, kana hutano hwemanzwiro. Mushonga uyu wakachengeterwa nyaya idzo mabhenefiti anopfuura njodzi dzinogona kuitika.

Brodalumab Inoshanda Sei?

Brodalumab inoonekwa semushonga wakasimba, wakanangana uyo unoshanda nekudzivisa interleukin-17 receptor. Kana iyi receptor yakavharwa, inodzivirira inflammatory cascade inotungamira kune psoriasis zviratidzo.

Mu psoriasis, immune system yako inokanganisa masero eganda ane hutano, zvichikonzera kuti awande nekukurumidza kupfuura zvakajairika. Panzvimbo peiyo yakajairika mazuva makumi maviri nemasere kutenderera, masero eganda anogona kubereka mumazuva matatu kusvika mana chete, zvichitungamira mukuvaka kwemaplaque akakora, ane makwapa.

Nekudzivisa interleukin-17 signaling, brodalumab inobatsira kuderedza iyi yakakurumidza kugadzirwa kwemasero eganda. Inoderedzawo kuzvimba kunokonzera kutsvuka, kuzvimba, uye kusagadzikana kunobatanidzwa nemaplaque e psoriasis. Vanhu vazhinji vanotanga kuona kuvandudzwa mukati mevhiki 4-6 yekutanga kurapwa.

Ndinofanira Kutora Sei Brodalumab?

Brodalumab inopiwa sejojo subcutaneous, zvinoreva kuti inojekeswa munyama ine mafuta pasi peganda rako. Mupi wako wehutano achakudzidzisa maitiro ekugadzirira nekupa jojo iwe pachako.

Iyo yakajairika dosing schedule inotanga nemitatu yekutakura dosi ye210 mg imwe neimwe, inopiwa pavhiki 0, 1, uye 2. Mushure meiyi nguva yekutanga, iwe uchagamuchira dosi rekuchengetedza re210 mg mwedzi mitatu yega yega. Chiremba wako anogona kugadzirisa iyi purogiramu zvichienderana nekupindura kwako kurapwa.

Unogona kubaya brodalumab muchidya chako, ruoko rwepamusoro, kana dumbu, uchichinjisa nzvimbo dzekubaya kudzivirira kutsamwa. Mushonga unofanirwa kuchengetwa mufiriji uye kuunzwa kutembiricha yemumba usati wabaya. Usambofa wakazunza mushonga, sezvo izvi zvinogona kukuvadza mapuroteni.

Zvakanakisa kutora brodalumab panguva imwe chete yezuva rechirongwa chega chega. Haufaniri kuitora nechikafu, asi kuchengetedza chirongwa chine tsika kunobatsira kuona kushanda zvakanaka.

Ndingatora Brodalumab Kwenguva Yakareba Sei?

Kureba kwekurapa kwe brodalumab kunosiyana kubva kumunhu nemunhu uye kunoenderana nekuti unopindura sei kumushonga. Vanhu vazhinji vanoda kuramba vachirapwa kwenguva refu kuti vachengetedze ganda rakajeka, sezvo psoriasis iri mamiriro echirwere.

Chiremba wako achaongorora kufambira mberi kwako mwedzi mitatu yega yega kuti aone kana brodalumab ichiri kurapwa kwakakodzera kwauri. Kana ukawana kuvandudzwa kukuru, mupi wako wehutano anogona kukurukura kana kuenderera mberi, kugadzirisa chirongwa chekushandisa, kana kufunga nezvimwe zvingasarudzwa zvekutarisira.

Vamwe vanhu vanogona kukwanisa kuwedzera nguva pakati pejekiseni kana psoriasis yavo ichiramba ichidzora. Zvisinei, kumisa brodalumab zvachose kazhinji kunotungamirira kumashure kwezviratidzo zve psoriasis mukati memwedzi mishoma.

Ndezvipi Zvakaipa ZveBrodalumab?

Kufanana nemishonga yese, brodalumab inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoona. Kunzwisisa zvekutarisa kunokubatsira kuti unzwe wakagadzirira uye wakavimbika nezvekurapa kwako.

Mhedzisiro yakajairika inowanzoita nyoro uye inogoneka. Izvi zvinosanganisira kurwadziwa kwemajoini, kurwadziwa kwemusoro, kuneta, manyoka, kurwadziwa kwehuro, kusvotwa, kurwadziwa kwemhasuru, maitiro enzvimbo yekubaya, uye tinea infections (fungal skin infections senge athlete's foot).

Zvimwe zvakakomba asi zvisingawanzoitiki mhedzisiro zvinogona kuitika, uye zvakakosha kuziva izvi zvinogoneka:

• Njodzi yakawedzera yezvirwere, kusanganisira zvirwere zvebhakitiriya, zvevhairasi, uye zvefungi
• Chirwere chekuputika chematumbu, kusanganisira kutanga kutsva kana kuwedzera kwechirwere cheCrohn kana ulcerative colitis
• Kufunga kana maitiro ekuzviuraya (izvi hazviwanzoitiki asi zvinoda kutariswa kwechiremba nekukasira)
• Maitiro ekurwara, kubva pakurwara kweganda kusvika kune anaphylaxis yakakomba

Chiremba wako achakutarisisa zvakanyanya kuti uone matambudziko aya anogona kuitika. Mazhinji emigumisiro inogona kudzoreka nekutariswa kwechiremba kwakakodzera, uye mabhenefiti ekurapa anowanzo kukunda njodzi yevanhu vane psoriasis yakakomba.

Ndiani Asingafaniri Kutora Brodalumab?

Brodalumab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kwauri. Mamwe mamiriro ezvinhu ezvokurapa uye mamiriro anoita kuti mushonga uyu usakodzere kana kuti unoda matanho akakosha.

Haufaniri kutora brodalumab kana uine hutachiona hunoshanda, kusanganisira zvirwere zvebhakitiriya, zvevhairasi, kana zvefungi. Mushonga unodzvinyirira immune system yako, iyo inogona kuita kuti zvirwere zvive zvakanyanya kana kuoma kurapa.

Vanhu vane nhoroondo yechirwere chekuputika chematumbu vanofanira kushandisa brodalumab nekuchenjerera kukuru, sezvo inogona kuwedzera mamiriro aya. Saizvozvowo, kana uine nhoroondo yekufunga kuzviuraya kana kuora mwoyo, chiremba wako achada kuyera njodzi nemabhenefiti zvakanyatso.

Zvimwe zvinhu zvinosanganisira majekiseni achangobva kuitwa, pamuviri kana kuyamwisa, uye chero allergies inozivikanwa ku brodalumab kana zvigadzirwa zvayo. Mupi wako wehutano achadzokorora nhoroondo yako yezvokurapa yakazara asati anyora mushonga uyu.

Brodalumab Zita reBrand

Brodalumab inowanikwa pasi pezita rebrand Siliq muUnited States. Iyi ndiyo chete fomu ye brodalumab inowanikwa mumabhizinesi parizvino yakatenderwa neFDA.

Siliq inogadzirwa neBausch Health uye inouya mumajekiseni akazadzwa kare ane 210 mg ye brodalumab mu 1.5 mL yemhinduro. Mushonga uyu unoda mushonga uye unowanikwa kuburikidza nemakambani emishonga akakosha.

Nekuti brodalumab mushonga webiologic, parizvino hapana mhando dzakajairika dziripo. Dziviriro ye patent uye maitiro akaoma ekugadzira zvinoreva kuti Siliq inoramba iri iyo chete sarudzo ye brodalumab therapy.

Zvimwe Zvinhu Zviri Pedyo neBrodalumab

Mishonga yakati wandei yebiologic iripo yekurapa psoriasis yepakati nepakati, imwe neimwe iine zvainobatsira nezvazvinofunga. Chiremba wako anogona kukubatsira kunzwisisa kuti ndeipi sarudzo ingashanda zvakanyanya kune mamiriro ako chaiwo.

Zvimwe zvinodzivirira interleukin-17 zvinosanganisira secukinumab (Cosentyx) uye ixekizumab (Taltz), iyo inoshanda zvakafanana ne brodalumab asi iine madosi akasiyana uye maitiro emigumisiro. Mishonga iyi inogona kufungwa kana brodalumab isina kukodzera iwe.

TNF inhibitors senge adalimumab (Humira), etanercept (Enbrel), uye infliximab (Remicade) inomiririra imwe kirasi ye biologics ye psoriasis. Mishonga iyi inoshanda nekudzivirira tumor necrosis factor, imwe protein inopisa inobatanidzwa mu psoriasis.

Sarudzo itsva dzinosanganisira interleukin-23 inhibitors senge guselkumab (Tremfya), tildrakizumab (Ilumya), uye risankizumab (Skyrizi). Mishonga iyi inowanzoita kuti dosing isashande kazhinji uye inogona kuve nemaitiro akasiyana emigumisiro kana ichienzaniswa ne brodalumab.

Ko Brodalumab Ari Nani Kudarika Adalimumab?

Brodalumab neadalimumab zvese zvinobatsira kurapa psoriasis, asi zvinoshanda kuburikidza nemaitiro akasiyana uye zvine zvakanakira nezvazvinokanganisa. Sarudzo

Brodalumab inogona kupa kuvandudzika nekukurumidza, nevamwe vanhu vachiona mhedzisiro mukati mevhiki 2-4. Inopihwawo mushonga kazhinji mushure mekutanga, ichida majekiseni chete mumasvondo gumi nemaviri ega ega ekuchengetedza.

Adalimumab yanga iripo kwenguva refu uye ine data rakawanda rekuchengetedza kwenguva refu. Inobvumirwa kune mamiriro akawanda kupfuura psoriasis, kusanganisira rheumatoid arthritis uye inflammatory bowel disease. Zvisinei, inoda majekiseni anowanzoitika, kazhinji vhiki rega rega.

Sarudzo pakati pemishonga iyi inowanzoenderana nezvinhu zvakaita serisiko rako rezvirwere, nhoroondo ye inflammatory bowel disease, chido chejekiseni, uye maitiro ako kumishonga yapfuura. Chiremba wako wezvirwere zvepaganda achakubatsira kuyera zvinhu izvi kuti uite sarudzo yakanakisa yemamiriro ako ezvinhu.

Mibvunzo Inowanzo Bvunzwa Nezve Brodalumab

Brodalumab Yakachengeteka Kune Vanhu vane Chirwere cheShuga Here?

Brodalumab inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheshuga, asi kuongorora kwakawedzerwa kungadiwa. Chirwere cheshuga chinogona kuwedzera njodzi yako yezvirwere, uye brodalumab inokanganisawo kugona kwemuviri wako kurwisa zvirwere.

Chiremba wako achanyatso tarisa kutonga kweshuga yeropa rako uye achatarisa chero zviratidzo zvezvirwere, kunyanya fungal infections izvo zvinogona kuwanzana muvanhu vane chirwere cheshuga. Zvakakosha kuchengetedza kutonga kwakanaka kweshuga yeropa uye kutevera kuchengetedzwa kwenzvimbo yekujekiseni kuderedza njodzi yezvirwere.

Ndingaita Sei Kana Ndikashandisa Brodalumab Yakawandisa Netsaona?

Kana ukabaya brodalumab yakawanda netsaona kupfuura yakarairwa, taura nechiremba wako nekukasira. Kunyange zvazvo ruzivo rwekuwandisa rwakaganhurirwa, zvakakosha kuwana zano rekurapa nezvekuongorora kuwedzera kwemigumisiro.

Usayedze "kuyananisa" overdose nekusvetuka mushonga wako unotevera. Pane kudaro, tevera gwara rakaunzwa nachiremba wako pamusoro pekuti ungadzokera riini kune chirongwa chako chekushandisa mishonga. Chengeta zvakaitika uye riini kuti ubatsire mupi wako wehutano kuongorora mamiriro acho.

Ndingaita Sei Kana Ndikakanganwa Dose yeBrodalumab?

Kana ukakanganwa jekiseni rebrodalumab rakarongwa, zvipe jekiseni nekukasira paunorangarira, wobva wenderera mberi nechirongwa chako chekushandisa mishonga. Usaedze kubata nekutora mishonga miviri pedyo pedyo.

Kana wanonoka zvakanyanya nedose (kupfuura mavhiki mashoma), taura nemupi wako wehutano kuti uwane gwara. Vanogona kuda kugadzirisa chirongwa chako chekurapa kana kukutarisa zvakanyanya kuti uone zviratidzo zvepsoriasis zvinodzoka.

Ndingamira Rini Kutora Brodalumab?

Unofanirwa kungomira kutora brodalumab pasi pegwara remupi wako wehutano. Psoriasis chirwere chisingaperi, uye kumisa kurapwa kazhinji kunotungamira pakudzoka kwezviratidzo mukati memwedzi mishoma.

Chiremba wako angangofunga kumisa brodalumab kana ukaona mativi akakomba, kana mushonga usingashande zvakanaka, kana kana ukaita mamiriro anoita kuti kurapwa kuenderere mberi kusachengeteka. Usambomira kutora brodalumab kamwe kamwe pasina kutariswa kwechiremba.

Ndingafamba Here Ndichitora Brodalumab?

Unogona kufamba uchitora brodalumab, asi uchada kuronga pamberi kuti uchengete mishonga yako zvakanaka uye uchengetedze chirongwa chako chejekiseni. Brodalumab inofanira kutonhodzwa, saka uchada firiji yekufambisa.

Uya netsamba kubva kuchiremba wako ichitsanangura kudiwa kwako kwemishonga uye zvekupa jekiseni paunofamba nendege. Funga nezvekuisa nguva yekufamba kwako kutenderedza chirongwa chako chejekiseni, kana bvunza mupi wako wehutano nezvekugadzirisa mishonga yerwendo rwakareba.