Chii chinonzi Cabazitaxel: Zvazvinoshandiswa, Madosi, Zvazvinokonzeresa uye Zvimwe

Cabazitaxel mushonga une simba wechemotherapy unoshandiswa kurapa kenza yeprostate yakafambira mberi yakapararira kune dzimwe nhengo dzemuviri. Mushonga uyu unoiswa mutsinga yeropa unobva kuboka remishonga rinonzi taxanes, iyo inoshanda nekumisa masero ekenza kubva pakukamura nekukura.

Kana iwe kana mumwe munhu waunoda akanyorerwa cabazitaxel, ungangove uine mibvunzo yakawanda pamusoro pekurapa uku. Kunzwisisa kuti mushonga uyu unoshanda sei, zvekutarisira, uye maitiro ekugadzirisa zvazvinogona kukonzera zvinogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika panguva yerwendo rwako rwekenza.

Chii chinonzi Cabazitaxel?

Cabazitaxel mushonga wechemotherapy wakagadzirirwa kurwisa masero ekenza yeprostate akave asingadzivirirwi kune dzimwe nzira dzekurapa. Icho chibereko chesemi-synthetic chechinhu chechisikigo chinowanikwa mumakwati emuti weyew, wakagadziridzwa zvakanyatsonaka mumalaboratories kuti zviite zvinobudirira kurwisa masero ekenza akaoma.

Mushonga uyu unoonekwa sekurapa kwechipiri, zvinoreva kuti vanachiremba vanowanzo kunyora mushonga uyu mushure mekunge mamwe marapirwo emahormone amira kushanda. Cabazitaxel inokosha zvikuru nokuti inogona kurwisa masero ekenza kunyange kana akagadzira kusadzivirirwa kune docetaxel, mumwe mushonga wechemotherapy unowanzoitika.

Mushonga uyu unogara uchipiwa kuburikidza neIV infusion muchipatara kana nzvimbo yekurapa kenza yakakosha. Hauzombotori mushonga uyu kumba, sezvo uchida kunyatso tarisa uye kutarisirwa nehunyanzvi kuti uve nechokwadi chekuchengeteka kwako.

Chii chinonzi Cabazitaxel chinoshandiswa?

Cabazitaxel inonyanya kushandiswa kurapa metastatic castration-resistant prostate cancer (mCRPC). Izvi zvinoreva kuti kenza yakapararira kupfuura prostate gland uye haichapinduri kurapwa kunodzivirira mahomoni ayo anoderedza mazinga e testosterone.

Chiremba wako anowanzo kuraira cabazitaxel kana gomarara rako reprostate rakafambira mberi pasinei nekurapwa kwakamboitwa nechemotherapy yakavakirwa docetaxel. Inobvumirwa zvakananga varume vane gomarara rakaipa mushure mekuwana kurapwa kwehomoni uye kurapwa kwe docetaxel.

Mune dzimwe nguva, vanachiremba vanogona kufunga cabazitaxel seimwe nzira yekutanga chemotherapy, kunyanya kune varwere vasingakwanise kutsungirira docetaxel kana vane mamaki akakosha e genetic anoratidza kuti cabazitaxel inogona kushanda zvakanyanya. Oncologist wako achaongorora mamiriro ako ega ega kuti aone kana kurapwa uku kwakakunakira.

Cabazitaxel Inoshanda Sei?

Cabazitaxel inoshanda nekunangana nechimiro chemukati memaseru egomarara, kunyanya kukanganisa machubhu madiki anonzi microtubules anobatsira maseru kukamukana. Funga nezve microtubules izvi sechivakwa chinodiwa nemaseru kuti akamukane kuita maseru maviri matsva panguva yekubereka.

Kana cabazitaxel yapinda mumasero egomarara, inosungirirwa kune microtubules izvi uye inovadzivirira kubva pakuparara zvakanaka. Izvi zvinonyanya kuomesa maseru egomarara munzvimbo, zvichivadzivisa kukamukana uye pakupedzisira zvichikonzera kuti vafe.

Chinoita kuti cabazitaxel ishande zvakanyanya ndiko kukwanisa kwayo kuyambuka chipingamupinyi cheropa-uropi uye kupinda mumasero egomarara akagadzira kuramba kune mamwe madhiragi echemotherapy. Izvi zvinoonekwa semushonga wechemotherapy wakasimba zvine mwero, une simba kupfuura kurapwa kwehomoni asi wakagadzirirwa kuti utungamirirwe nerutsigiro rwakakodzera rwekurapa.

Ndinofanira Kutora Sei Cabazitaxel?

Cabazitaxel inogara ichipiwa se infusion ye intravenous kwenguva inenge awa imwe, kazhinji mumasvondo matatu ega ega. Uchapihwa kurapwa uku muchipatara, nzvimbo yegomarara, kana kiriniki yakakosha yekupinza uko nyanzvi dzehutano dzakadzidziswa dzinogona kukutarisa zvakanyanya.

Mberi kwekuiswa kwega kwega, uchagamuchira mishonga yekutanga yekubatsira kudzivirira mhinduro dzekurwara uye kuderedza kusvotwa. Izvi zvinowanzo sanganisira antihistamines, corticosteroids, uye mishonga yekurwisa kusvotwa inopiwa maminitsi makumi matatu usati watanga kurapwa kwako kwe cabazitaxel.

Haufaniri kutsanya usati warapwa, asi kudya chikafu chakareruka pamberi pezvo kunogona kubatsira kuderedza kusvotwa. Ramba wakanyatsogadzirwa nemvura nekunwa mvura yakawanda mumazuva anotungamira kune infusion yako. Chikwata chako chehutano chichapa mirairo chaiyo pamusoro pemishonga ipi neipi yaunofanira kudzivisa usati warapwa.

Panguva yekuiswa, vanamukoti vachaongorora zviratidzo zvako zvakakosha nguva dzose uye vachatarisa chero zviratidzo zvemhinduro dzekurwara. Nzvimbo ye IV ichatariswa zvakanyatsonaka kuti ive nechokwadi chekuti mushonga uri kuyerera zvakanaka uye haukonzere kutsamwa kumutsipa wako.

Ndingatora Cabazitaxel Kwenguva Yakareba Sei?

Kureba kwekurapwa kwe cabazitaxel kunosiyana zvakanyanya kubva kumunhu nemunhu, zvichienderana nekuti kenza inopindura sei uye kuti unotsungirira sei mushonga. Vanhu vazhinji vanogamuchira kurapwa kwemwedzi yakati wandei, kazhinji kubva ku6 kusvika ku10 cycles.

Oncologist wako achaongorora mhinduro yako mushure me2-3 cycles yega yega achishandisa bvunzo dzeropa, imaging scans, uye kuongororwa kwezviratidzo zvako. Kana kurapwa kuchishanda uye iwe uchigadzirisa zvakanaka mhedzisiro, unogona kuenderera mberi kwemamwe cycles.

Kurapa kunowanzoenderera mberi kusvika chimwe chezvinhu zvakati wandei zvaitika: kenza inorega kupindura kumushonga, mhedzisiro yave yakaoma kwazvo kugadzirisa, kana iwe nachiremba wako musarudza kuti mabhenefiti haachapfuuri njodzi. Vamwe varwere vanogona kugamuchira cabazitaxel kwegore kana kupfuura kana ichienderera mberi nekudzora kenza yavo zvinobudirira.

Ndezvipi Zvakaipa zveCabazitaxel?

Kufanana nemishonga yese ye chemotherapy, cabazitaxel inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anozviwana zvese. Kunzwisisa zvekutarisira kunogona kukubatsira kugadzirira uye kuziva kuti ungataurirana riini nechikwata chako chehutano.

Zvimwe zvinokonzera zvinowanzoitika zvaungasangana nazvo zvinosanganisira kuneta, kusvotwa, manyoka, uye kurasikirwa bvudzi kwenguva pfupi. Varwere vazhinji vanoonawo shanduko muchido chavo chekudya uye vanogona kuona kumwe kuoma kana kunzwa tsinga mumawoko avo netsoka.

Hezvino zvinowanzoziviswa zvinokonzera zvinokonzera izvo zvinokanganisa varwere vazhinji:

• Kunetwa uye kusava nesimba zvinogona kugara mazuva akati wandei mushure mekurapa
• Kusvotwa nekutsvuka, kazhinji kunogona kudzora nemishonga inorwisa kusvotwa
• Manyoka, izvo dzimwe nguva zvinogona kuva zvakanyanya uye zvinoda kutarisirwa kwekurapa
• Kurasikirwa bvudzi, kazhinji kutanga mushure mekurapa kwemavhiki mashoma
• Kuderera kwechido chekudya uye shanduko mukuravira
• Kuderera kwemasero eropa, kuwedzera njodzi yekutapukirwa
• Kuoma kana kunzwa tsinga mumawoko netsoka (peripheral neuropathy)
• Kurwadziwa kwemhasuru nemajoini

Izvi zvinokonzera zvinowanzoitika kwenguva pfupi uye zvinovandudzika pakati pemitambo yekurapa. Chikwata chako chehutano chichapa mishonga uye nzira dzekubatsira kudzora zviratidzo izvi zvinobudirira.

Kazhinji, vamwe varwere vanogona kuona zvakanyanya zvinokonzera zvinoda kutarisirwa kwekurapa nekukasira. Kunyange izvi zvichiitika muvanhu vashoma, zvakakosha kuziva nezvazvo.

Hezvino zvisingawanzoitiki asi zvakakomba zvinokonzera zvekutarisa:

• Zvakanyanya zvinokonzeresa allergic panguva kana nguva pfupi mushure mekuiswa
• Zvirwere zvakakomba nekuda kwehuwandu huri pasi hwemasero machena eropa
• Matambudziko eitsvo, kusanganisira shanduko mukuyerera weti kana kuzvimba
• Manyoka akakomba anotungamira mukushaya mvura mumuviri
• Kufema kwakaoma kana kukosora kusingaperi
• Kubuda ropa kusinganzwisisike kana kupwanya
• Kurwadziwa mudumbu kwakanyanya kana kutsvuka kusingaperi

Kana iwe ukaona chero chimwe chezviratidzo izvi zvakakomba, taura ne oncologist wako nekukasira kana kutsvaga rubatsiro rwekurapa rwekukurumidzira. Chikwata chako chehutano chichakutarisa zvakanyanya nemiedzo yeropa yenguva dzose kuti ubate chero matambudziko nekukurumidza.

Ndiani Asingafaniri Kutora Cabazitaxel?

Cabazitaxel haikodzeri munhu wese, uye chiremba wako achanyatsoongorora kana kurapwa uku kuri kwakachengeteka kwauri. Mamwe mamiriro ehutano kana mamiriro anogona kuita kuti cabazitaxel ive nenjodzi yakanyanya kana kushanda zvishoma.

Haufanire kugamuchira cabazitaxel kana uine allergy yakakomba kumushonga uyu kana chero zvinhu zvawo, kusanganisira polysorbate 80. Vanhu vane immune system yakakomba kana huwandu hweropa jena rakaderera zvakanyanya vanogonawo kuda kudzivirira kurapwa uku.

Chiremba wako achanyatso chenjerera nezvekunyora cabazitaxel kana uine chero mamiriro aya:

• Matambudziko akakomba echiropa kana ma enzymes echiropa akakwira
• Zvirwere zvinoshanda, zvisingadzorwe
• Kuvhiyiwa kukuru kwemazuva ano kana maronda anopora zvishoma
• Chirwere chakakomba cheitsvo
• Matambudziko emoyo kana kurwisa kwemoyo kwemazuva ano
• Nhoroondo yezvinhu zvakakomba zvinokonzerwa nemishonga ye taxane
• Hutano hwakashata hwese

Zera rega rega harikubvise pakugamuchira cabazitaxel, asi vanhu vakuru vanogona kuongororwa zvakanyanya nemigumisiro. Oncologist wako achayeresa mabhenefiti anogona kuitika pamusoro penjodzi zvichibva pahutano hwako hwega.

Mazita eCabazitaxel Brand

Cabazitaxel inowanikwa pasi pezita rekuti Jevtana, iro rinogadzirwa neSanofi. Iyi ndiyo yekutanga uye inonyanya kunyorerwa fomu ye cabazitaxel inowanikwa munyika zhinji.

Mhando dzemishonga ye cabazitaxel dzinogona kuwanikwa mune dzimwe nzvimbo, kunyangwe dzine chinhu chimwe chete chinoshanda uye dzinoshanda nenzira imwecheteyo seyemhando yezita. Kambani yako yemishonga nekambani yeinishuwarenzi ichabatsira kuona kuti ndeipi vhezheni yaunogamuchira.

Zvisinei nekuti ndeipi mhando yaunogamuchira, mushonga wacho pachake wakafanana maererano nekushanda uye migumisiro. Misiyano mikuru inogona kunge iri mukurongwa, chitarisiko, kana mutengo, asi mabhenefiti ekurapa anoramba akaita sezvavari.

Zvimwe Zvinhu Zvitsva zveCabazitaxel

Kana cabazitaxel isina kukodzera kwauri kana ikamira kushanda zvakanaka, dzimwe nzira dzakawanda dzekurapa dzinowanikwa kune gomarara repamberi re prostate. Chiremba wako weoncologist achakubatsira kuongorora dzimwe nzira idzi zvichienderana nemamiriro ako chaiwo.

Dzimwe nzira dzekurapa dzekemikari dzinosanganisira docetaxel, iyo inowanzoedzwa pamberi pe cabazitaxel, uye mitoxantrone, iyo inogona kufungwa nezvekudzora zviratidzo. Mhando itsva dzekurapa dzakatarisana senge enzalutamide, abiraterone, uye darolutamide dzinopa nzira dzakasiyana dzekushanda.

Dzimwe nzira dzimwe chiremba wako angangofunga dzinosanganisira:

• Radium-223, kurapwa kweradioactive kwemamota emapfupa
• Sipuleucel-T, kurapwa kweimmunotherapy
• Olaparib kana rucaparib kune varwere vane shanduko dzakasiyana dzejeni
• Lutetium-177 PSMA kune mamwe marudzi egomarara repamberi re prostate
• Miedzo yekiriniki ichiedza kurapwa kutsva kwejekerere

Nzira yakanakisa inoenderana nekurapwa kwako kwapfuura, mhedzisiro yekuyedzwa kwejeneti, hutano hwako hwese, uye zvaunofarira. Chikwata chako chehutano chichashanda newe kuti uwane danho rinotevera rakakodzera.

Ko Cabazitaxel Ari Nani Kudarika Docetaxel?

Cabazitaxel na docetaxel zvese zvinoshanda zvinodhaka zvekemikari zvegomarara re prostate, asi zvinowanzo shandiswa pamatanho akasiyana ekurapa. Docetaxel inowanzoita yekutanga sarudzo yekemikari, nepo cabazitaxel ichichengeterwa kana docetaxel ikamira kushanda.

Tsvagiridzo inoratidza kuti cabazitaxel inogona kushanda kunyangwe mushure mekunge docetaxel resistance yakura, ichiita kuti ive sarudzo yechipiri inokosha. Zvisinei, izvi hazvirevi kuti cabazitaxel iri "nani" pane docetaxel - vanoshanda zvinangwa zvakasiyana murwendo rwako rwekurapa.

Cabazitaxel inogona kukonzera mhedzisiro yakasiyana ne docetaxel, uye vamwe varwere vanotsungirira imwe iri nani pane imwe. Chiremba wako weoncologist achasarudza mushonga wakakodzera zvichienderana nenhoroondo yako yekurapa, mamiriro ako ehutano azvino, uye maitiro chaiwo egomarara.

Mibvunzo Inowanzoitwa Pamusoro peCabazitaxel

Cabazitaxel Yakachengeteka Here Kune Vanhu vane Chirwere cheShuga?

Cabazitaxel inogona kushandiswa zvakachengeteka kune vanhu vane chirwere cheshuga, asi mazinga eshuga yeropa rako anogona kuda kuongororwa zvakanyanya panguva yekurapa. Mishonga yaunogamuchira usati warapwa, kunyanya corticosteroids, inogona kukwidza mazinga eshuga yeropa kwenguva pfupi.

Shanda pedyo nevanachiremba vako veoncologist nevechirwere cheshuga kuti ugadzirise mishonga yako yechirwere cheshuga kana zvichidikanwa. Tarisa shuga yako yeropa kakawanda kupfuura zvakajairika, kunyanya pamazuva ekurapa uye kwemazuva akati wandei mushure.

Ndingaita Sei Kana Ndakanganwa Dose yeCabazitaxel?

Sezvo cabazitaxel ichipiwa munzvimbo yekurapa, hauzokanganwi dose kumba. Kana uchida kunonotsa kurapwa kwakarongeka nekuda kwekurwara, kuwanda kweropa kwakaderera, kana dzimwe nyaya dzehutano, taura neoncologist wako nekukurumidza sezvinobvira.

Vashandi vako vezvehutano vachasarudza kana zvakachengeteka kuronga kurapwa kwako zvakare. Dzimwe nguva kunonoka kunodiwa kuti muviri wako upore, uye izvi hazvizozoitisi kukuvadza mhedzisiro yekurapa kwako.

Ndingamira Rini Kutora Cabazitaxel?

Sarudzo yekumisa cabazitaxel inoenderana nezvinhu zvakati wandei, kusanganisira kuti kurapa kuri kudzora sei kenza yako uye kuti uri kubata sei nemigumisiro. Oncologist wako achagara achiongorora mhinduro yako achishandisa bvunzo dzeropa uye zvidzidzo zveimaging.

Unogona kumisa kurapwa kana kenza ichienderera mberi pasinei nekurapa, kana migumisiro ikava yakaoma kubata, kana iwe nachiremba wako mukasarudza kuti mabhenefiti haachapfuuri njodzi. Usambomira kurapwa usina kukurukura nevashandi vako vezvehutano kutanga.

Ndingashanda Here Ndichigamuchira Kurapa kweCabazitaxel?

Vanhu vazhinji vanogona kuramba vachishanda vachigamuchira cabazitaxel, kunyangwe iwe uchizoda kugadzirisa purogiramu yako kana mabasa ako. Kuneta kunowanzoitika uye kunogona kugara mazuva akati wandei mushure mekutenderera kwega kwega kwekurapa.

Fungai kuronga mazuva ebasa akareruka zvakananga mushure mekuiswa kwako, uye uve wakagadzirira kutora nguva yekuzorora kana ukaona hutachiona kana zvimwe zvinetso. Kurukura mamiriro ako ebasa nechikwata chako chekuchengetedza hutano kuti ugadzire chirongwa chechokwadi.

Cabazitaxel Ichakanganisa Kugona Kwangu Kuva neVana Here?

Cabazitaxel inogona kukanganisa kubereka muvarume uye inogona kukonzera kukuvadzwa kwemajini kune sperm. Kana uri kuronga kuva nevana mune ramangwana, kurukura sarudzo dzekuchengetedza kubereka nachiremba wako weoncologist usati watanga kurapwa.

Shandisa nzira yekudzivirira pamuviri inoshanda panguva yekurapwa uye kwemwedzi yakati wandei mushure, sezvinokurudzirwa nechikwata chako chekuchengetedza hutano. Mushonga unogona kuramba uri muhurongwa hwako kwenguva yakati wandei mushure meiyo dose yako yekupedzisira.