Chii chinonzi Calaspargase Pegol: Zvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe Zvinhu

Calaspargase pegol mushonga wakanangana nekenza unoshandiswa kurapa acute lymphoblastic leukemia (ALL), rudzi rwekenza yeropa inokanganisa maseru machena eropa. Mushonga uyu unoshanda nekuparadza protein inokosha inodiwa nemaseru ekenza kuti ararame, zvichivatsamwisa apo vachisiya maseru ane hutano asina kukanganiswa zvakanyanya. Inopiwa kuburikidza neIV muchipatara kana kiriniki, uye chikwata chako chehutano chichakutarisa zvakanyanya panguva yekurapa.

Chii chinonzi Calaspargase Pegol?

Calaspargase pegol mushonga weenzyme unonangana nemaseru ekenza nenzira yakanyanya. Iyo vhezheni yakagadziridzwa yeenzyme inowanikwa zvakasikwa inonzi asparaginase, iyo yakawedzerwa kuti ishande kwenguva refu mumuviri wako uye kukonzera kushungurudzika kushoma pane shanduro dzekare.

Mushonga uyu ndeweboka remishonga inonzi antineoplastic enzymes. Funga nezvayo sechishandiso chakakosha chinobvisa chimwe chinhu chinodiwa nemaseru ekenza zvakanyanya kuti akure uye awande. Mazhinji maseru ane hutano mumuviri wako anogona kugadzira yavo yekupa iyi chivakwa chakakosha, asi mazhinji maseru ekenza yeropa haagoni.

Nzira iyi yakatarwa inoita kuti calaspargase pegol inyanye kubudirira kurwisa acute lymphoblastic leukemia apo ichinyanya kunyoro pamatishu ako ane hutano zvichienzaniswa nemamwe marapirwo ekenza.

Chii chinonzi Calaspargase Pegol chinoshandiswa?

Calaspargase pegol inonyanya kushandiswa kurapa acute lymphoblastic leukemia muvana nevakuru. Chiremba wako anowanzo kunyora sechikamu chechirongwa chekurapa chinosanganisira mamwe mishonga yekenza.

Mushonga uyu unokosha zvikuru kuvashandi vakagadzira allergic reactions kune dzimwe nzira dzeasparaginase. Iyo pegylated fomu (iyo "pegol" chikamu chezita) inobatsira kuderedza mukana wezvikuru allergic reactions apo vachichengetedza kushanda zvakanaka pamaseru ekenza.

Chiremba wako wezvirwere zvegomarara angakurudzirawo calaspargase pegol kana uri kurapwa ALL yakadzoka mushure mekurapwa kwapfuura. Inowanzo shandiswa panguva dzakasiyana dzekurapa, kusanganisira induction therapy (iyo yekutanga intensive treatment phase) uye consolidation therapy (follow-up treatment yekuchengetedza remission).

Calaspargase Pegol Inoshanda Sei?

Calaspargase pegol inoshanda nekuderedza asparagine, amino acid iyo maseru e leukemia anoda kuti ararame nekukura. Mushonga uyu unoonekwa sekurapa gomarara rine simba repakati nepakati rinonangana nemaseru egomarara zvakananga.

Izvi ndizvo zvinoitika mumuviri wako: Maseru akajairika anogona kugadzira asparagine yawo kana achiida, asi mazhinji maseru e leukemia akarasikirwa nekwaniso iyi. Kana calaspargase pegol ikaputsa asparagine inotenderera muropa rako, maseru egomarara anonyanya kupera nzara nekuti haagone kugadzira zvawo.

Iyo

Musati muiswa mushonga uyu, hamufaniri kutsanya, asi zvinobatsira kudya chikafu chakareruka kudzivirira kunzwa kusvotwa mudumbu risina chinhu. Chengetai muviri wenyu uine mvura yakakwana nekunwa mvura yakawanda mumazuva ari pamberi pekurapwa kwenyu, kunze kwekunge chiremba wenyu akakupa zvirambidzo zvakakosha zvemvura.

Vashandi venyu vezvokurapa vangakupa mishonga yekutanga musati muiswa mushonga uyu kubatsira kudzivirira mhinduro dzekurwara. Izvi zvinogona kusanganisira antihistamines kana corticosteroids, zvichienderana nezvinhu zvako zvaunotarisira uye nhoroondo yako yezvokurapa.

Ndingatora Calaspargase Pegol kwenguva yakareba sei?

Kureba kwekurapwa kwecalaspargase pegol kunoenderana nechirongwa chako chekurapa uye kuti unopindura sei kurapa. Vanhu vazhinji vanoiwana kwemwedzi yakati wandei sechikamu chechirongwa chavo chekurapa leukemia.

Kazhinji, muchagamuchira zvikamu mumasvondo maviri kana matatu panguva yekurapa. Chiremba wako weoncologist achasarudza nguva chaiyo zvichienderana nechirongwa chako chekurapa, icho chingasanganisira kurapa kwekutanga kunotora mazuva 28-42, zvichiteverwa nematanho ekusimbisa anogona kutora mwedzi yakati wandei.

Chiremba wako achatarisa nguva dzose huwandu hweropa rako uye hutano hwako hwese kuti aone kuti ungawedzera, kushandura, kana kumisa mishonga rini. Vamwe varwere vangada kuchinjira kune dzimwe nzira dzekurapa kana vakawana matambudziko akakosha kana kana kenza yavo isingapinduri sezvaitarisirwa.

Rangarirai kuti kumisa kurapwa kwekenza nekukurumidza kunogona kuva nenjodzi, saka zvakakosha kutevera gwara rechiremba wako kunyangwe uchinzwa zviri nani. Vashandi venyu vezvokurapa vachakuzivisa kana zvakachengeteka kupedzisa nzira yako yekurapa.

Ndezvipi Zvakaipa ZveCalaspargase Pegol?

Semishonga yese yekenza, calaspargase pegol inogona kukonzera matambudziko, kunyangwe vanhu vazhinji vachiiwana zvakanaka. Chikwata chako chehutano chichakutarisa zvakanyanya uye kubatsira kubata chero matambudziko anovapo.

Ngatitange nemigumisiro yakajairika yaungasangana nayo, iyo inowanzoitika mukati memazuva mashoma ekutanga kusvika kumavhiki ekurapa:

• Kuwedzera kweiyo enzymes yeropa (inoonekwa kuburikidza nemiedzo yeropa)
• Kusvotwa uye kuderedzwa kwechido
• Kuneta uye kusava nesimba
• Kutemwa nemusoro
• Fivha
• Kurwadziwa kwemhasuru kana majoini
• Dhayareya kana kuvharika

Mazhinji emigumisiro iyi yakajairika inogona kutariswa nekuchengetedza rutsigiro uye mishonga. Chikwata chako chekurapa chine ruzivo rwekubatsira varwere kuburikidza nematambudziko aya.

Zvino, ngatitaurirei nezve mimwe migumisiro yakakomba inoda kutariswa kwekurapa nekukasira, kunyangwe ichiitika kazhinji:

• Maitiro akakomba ekuita allergic (kuoma kufema, kuzvimba, rash yakakomba)
• Pancreatitis (kurwadziwa kwakanyanya mudumbu, kunyanya mushure mekudya)
• Matambudziko ekuita ropa (kubuda ropa kusinganzwisisike kana kuita ropa)
• Matambudziko akakomba echiropa (kushanduka kweganda kana maziso kuita yero, weti yakasviba)
• Mazinga epamusoro eshuga yeropa

Kune zvakare mamwe mashoma asi akakomba migumisiro iyo chikwata chako chekurapa chichatarisa zvakanyanya:

• Kutapukirwa kana dzimwe shanduko dzeuropi
• Zvirwere zvakakomba nekuda kwehuwandu hwehuwandu hweropa chena
• Matambudziko eitsvo
• Shanduko dzakakomba dzemafungiro kana kuvhiringidzika

Chikwata chako chehutano chichaita bvunzo dzeropa nguva dzose kuti chitarise matambudziko aya anogona kuitika. Kana iwe ukasangana nezviratidzo zvinonetsa pakati pekushanya, usazeza kubata chikwata chako chekurapa nekukasira.

Ndiani Asingafaniri Kutora Calaspargase Pegol?

Calaspargase pegol haina kukodzera munhu wese, uye oncologist yako ichanyatsoongorora kana iri sarudzo chaiyo yemamiriro ako chaiwo. Mamwe mamiriro ekurapa uye mamiriro anogona kuita kuti mushonga uyu uve nenjodzi.

Hamufaniri kugamuchira calaspargase pegol kana muchiziva kuti mune allergy yakakomba kumushonga uyu kana mamwe mafomu e asparaginase. Chiremba wenyu achavawo akanyatso chenjerera kana muine nhoroondo yezvinetso zvakakomba zve allergy kumishonga yakafanana.

Mamwe mamiriro ezvinhu ekurapa anoda kungwarira kwakanyanya kana anogona kukutadzisa kugamuchira kurapwa uku:

• Pancreatitis inoshanda kana nhoroondo ye pancreatitis yakakomba
• Chirwere chechiropa chakakomba
• Zvirwere zvekubuda ropa zviri kushanda
• Diabetes isingadzorwi
• Nhoroondo ichangoburwa yegwamba reropa

Kuzvitakura nekuyamwisa zvinodawo kufunga kwakakosha. Mushonga uyu unogona kukuvadza mwana asati aberekwa, saka chiremba wenyu achakurukura nzira dzekudzivirira kubata pamuviri dzinoshanda kana muri pazera rekubereka. Kana wakazvitakura kana kuronga kuzvitakura, chiremba wako weoncologist achanyatso kuyera njodzi nemabhenefiti.

Zera rega rega harikubvise pakurapwa, asi vanhu vakuru vangada kunyatso tariswa nekuda kwekuwedzera kunzwisiswa kune mhedzisiro. Chikwata chako chekurapa chichagadzirisa chirongwa chako chekutarisira zvinoenderana.

Zita reBrand reCalaspargase Pegol

Calaspargase pegol inotengeswa pasi pezita rebrand Asparlas muUnited States. Zita rebrand iri rinobatsira kusiyanisa kubva kune mamwe mafomu emishonga yeasparaginase inoshanda zvakafanana asi iine mafomu akasiyana.

Kambani yako yeinishuwarenzi uye pharmacy ichaziva zvese zita re generic (calaspargase pegol) uye zita rebrand (Asparlas). Mushonga wakafanana zvisinei nekuti nderipi zita rinoshandiswa pamushonga wako kana marekodhi ekurapa.

Sezvo uyu uri mushonga wekenza wakakosha, unowanikwa chete kuburikidza nemafarmacy emuchipatara uye nzvimbo dzekurapa kenza. Chikwata chako cheoncology chichabatana kuwana nekugadzirira mushonga wekudururwa kwako.

Zvimwe Zvinhu zveCalaspargase Pegol

Kana calaspargase pegol isina kukodzera kwauri kana ikamira kushanda zvakanaka, chiremba wako weoncologist ane mamwe mishonga yeasparaginase iripo. Imwe neimwe ine mabhenefiti ayo uye zvipingamupinyi zvinogona kuitika.

Zvimwe zvakakosha zvinosanganisira native E. coli asparaginase uye pegaspargase (PEG-asparaginase). Native asparaginase inoshanda nekukurumidza asi inoda kuiswa kazhinji, kazhinji mazuva mashoma oga oga. Zvisinei, ine njodzi yakakwirira yekugadzirisa allergic zvichienzaniswa ne calaspargase pegol.

Pegaspargase imwe fomu ye pegylated ye asparaginase iyo yave iripo kwenguva refu kupfuura calaspargase pegol. Inopiwa kazhinji kashoma kupfuura native asparaginase asi inogona kukonzera allergic reactions kupfuura calaspargase pegol mune vamwe varwere.

Kune varwere vasingakwanise kutsungirira chero fomu ye asparaginase, chiremba wako weoncologist angangofunga nzira dzimwe dzekurapa. Izvi zvinogona kusanganisira misanganiswa yakasiyana yemishonga ye chemotherapy, kunyangwe sarudzo dzakatarwa dzichitsamira pamamiriro ako ega uye mhando ye leukemia yaunorwisa.

Ko Calaspargase Pegol Zviri Nani Kupfuura Pegaspargase?

Calaspargase pegol uye pegaspargase zvose mishonga inoshanda pakurapa acute lymphoblastic leukemia, asi calaspargase pegol inopa zvimwe zvakanakira varwere vazhinji. Sarudzo pakati pavo inotsamira pamaitiro ako ekurapa ega uye njodzi.

Calaspargase pegol kazhinji inokonzera allergic reactions shoma pane pegaspargase, izvo zvakakosha kana wakambove ne allergic reactions kune mamwe mishonga ye asparaginase munguva yakapfuura. Iyi njodzi yakaderedzwa ye allergy inogona kukubatsira kupedzisa nzira yako yekurapa yakazara pasina kukanganiswa.

Mishonga yose iri miviri inoshanda kwenguva yakafanana mumuviri wako, saka kazhinji inopiwa pamagadzirirwo akafanana. Kushanda zvakanaka kurwisa masero e leukemia kwakafanana pakati pemishonga miviri, zvinoreva kuti zvese zvinogona kuve sarudzo dzakanaka pakurapa kenza yako.

Chiremba wako wezve oncology achatarisa mamiriro ako chaiwo, kusanganisira chero maitiro ekurwara kare, hutano hwako hwese, uye inishuwarenzi yako paachisarudza pakati pemishonga iyi. Imwe neimwe inogona kuva sarudzo yakanaka yechirongwa chako chekurapa.

Mibvunzo Inowanzo Bvunzwa Pamusoro peCalaspargase Pegol

Q1. Calaspargase Pegol Yakachengeteka Here Kune Chirwere cheShuga?

Calaspargase pegol inogona kukanganisa mazinga eshuga yeropa, saka varwere vane chirwere cheshuga vanoda kuongororwa zvakanyanya panguva yekurapa. Mushonga uyu unogona kukonzera kuti shuga yeropa ikwire, dzimwe nguva zvakanyanya, izvo zvinoda kutarisirwa zvakanyanya.

Kana uine chirwere cheshuga, timu yako yezvokurapa ichatarisa mazinga eshuga yeropa rako kakawanda uye inogona kuda kugadzirisa mishonga yako yechirwere cheshuga. Vamwe varwere vanoda kutanga insulin kwenguva pfupi, kunyangwe vasiri kuida zvakajairika.

Izvi hazvirevi kuti haugone kugamuchira calaspargase pegol kana uine chirwere cheshuga. Chiremba wako wezve oncology uye endocrinologist (kana uine mumwe) vachashanda pamwechete kuti vachengetedze shuga yako yeropa ichidzorwa paunogamuchira kurapwa uku kwakakosha kwekenza.

Q2. Ndingaita Sei Kana Ndikashandisa Zvakawandisa Calaspargase Pegol Netsaona?

Sezvo calaspargase pegol inongopiwa muzvipatara nevashandi vehutano vakadzidziswa, overdose netsaona haina kumbobvira yaitika. Timu yako yezvokurapa inonyatsoverenga uye kugadzirira dose imwe neimwe zvakananga kwauri.

Kana uine hanya yekugamuchira mishonga yakawandisa panguva yekuiswa kwako, usazeza kubvunza mukoti wako kana chiremba nezve dose. Vanogona kukuratidza kuti vanoverenga sei uye vanosimbisa huwandu hwakakodzera huremu hwako hwemuviri uye chirongwa chekurapa.

Mushonga uyu unopiwa zvishoma nezvishoma kwenguva imwe kusvika kumaawa maviri, izvo zvinobvumira timu yako yezvokurapa kukutarisa nguva dzose uye kumisa infusion nekukasira kana chero matambudziko akaitika.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose yeCalaspargase Pegol?

Kana ukakundikana kutora mushonga wecalaspargase pegol sezvakatarwa, taura nechikwata chako cheoncology nekukasira kuti urongezve. Kukundikana kutora mishonga yekenza kunogona kukanganisa kushanda kwemushonga wako, saka zvakakosha kuti udzokere pachirongwa nekukurumidza sezvinobvira.

Chikwata chako chekurapa chichasarudza nzira yakanakisa yekugadzirisa chirongwa chako chekurapa. Dzimwe nguva vanogona kukurongeza mukati memazuva mashoma, nepo dzimwe nguva zvingada kugadzirisa chirongwa chako chose chekurapa.

Usaedze "kubata" nekutora mishonga iri pedyo pedyo kupfuura yakarairwa. Oncologist wako anofanira kuchengetedza nzvimbo yakakodzera pakati pemishonga kuti ave nechokwadi chekuchengeteka nekushanda.

Q4. Ndingamira Rini Kutora Calaspargase Pegol?

Unofanira kungomira calaspargase pegol kana oncologist wako achiona kuti zvakachengeteka uye zvakakodzera kuita kudaro. Sarudzo iyi inobva pamhinduro yako kumushonga, mhedzisiro yebvunzo yeropa, uye chirongwa chose chekurapa.

Vamwe varwere vanopedzisa nzira yavo yakarongwa yekurapa uye vanogona kumisa mushonga sezvakatarwa. Vamwe vangada kumira nekukurumidza nekuda kwemigumisiro kana kana kenza yavo isingapinduri sezvaitarisirwa.

Usambomira mushonga uyu wega, kunyangwe uchinzwa zviri nani. Kumisa kurapwa kwekenza nekukurumidza kunogona kubvumira maseru eukemia kuti adzokezve uye ave akaoma kurapa gare gare.

Q5. Ndingawana Majekiseni Ndiri Kutora Calaspargase Pegol?

Majekiseni mazhinji emararamiro anofanira kudziviswa paunenge uchitora calaspargase pegol, sezvo immune system yako inogona kunetsekana nekuda kwekurapwa kwekenza. Izvi zvinosanganisira majekiseni akaita sejekiseni remhino reflu, MMR, uye jekiseni rema shingles.

Zvisinei, mamwe majekiseni akaurayiwa kana asina kushandiswa anogona kurairwa, senge flu shot kana pneumonia vaccine. Oncologist wako achashanda pamwe chete nachiremba wako wekutanga kuti asarudze majekiseni api akachengeteka uye anobatsira kwauri.

Nguva dzose taura nechikwata chako chezvokurapa usati wapiwa majekiseni. Vanogona kupa mazano chaiwo zvichienderana nekuti uri muchikamu chipi chekurapwa uye mamiriro ako emuviri ekudzivirira zvirwere.