Chii chinonzi Crisaborole: Zvazvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Crisaborole mushonga unozodzwa paganda unobatsira kurapa eczema (atopic dermatitis) yakapfava kusvika pakati nepakati nekuderedza kuzvimba nekukwenya. Kirimu iyi yakapfava, isiri ye-steroidal inoshanda zvakasiyana nemishonga yechinyakare ye steroid, zvichiita kuti ive sarudzo inokosha yevanhu vanoda kutarisirwa kwenguva refu ye eczema vasina zvimwe zvinonetsa zvinouya nekushandiswa kwenguva refu kwe steroid.

Chii chinonzi Crisaborole?

Crisaborole i phosphodiesterase-4 (PDE-4) inhibitor inouya se ointment inozodzwa paganda. Yakagadzirirwa kunyatsorapa eczema nekunangana nekuita kwekuputika kunokonzera matanda matsvuku, anokwenya, uye akatsamwisa ganda rinoratidza mamiriro aya.

Kusiyana ne topical steroids, crisaborole haidzivisi immune system yako zvakanyanya. Pane kudaro, inoshanda zvakanyanya nekudzivisa ma enzymes akasiyana anobatsira mukuzvimba muganda rako. Iyi nzira yakatarwa inoita kuti ive inobatsira kunzvimbo dzakaita se chiso nemutsipa, uko kushandiswa kwenguva refu kwe steroid kungakonzera kutetepa kana dzimwe shanduko dzeganda.

Mishonga iyi yakatenderwa neFDA muna 2016 uye yakave sarudzo yakakosha yekurapa vana nevakuru vane eczema. Inowanikwa chete nemishonga uye inowanzo kurudzirwa kana dzimwe mishonga isina kupa zororo rakakwana kana kana uchida sarudzo isiri ye-steroidal yekutarisira kwakawanda.

Crisaborole Inoshandiswa Kunei?

Crisaborole inonyanya kushandiswa kurapa mild kusvika pakati nepakati atopic dermatitis, inozivikanwa se eczema. Iyi mamiriro eganda echronic anokonzera matanda eganda kuti azvimbe, akwenye, atsvuke, uye dzimwe nguva akatsemuka kana kuoma.

Chiremba wako angakurudzira crisaborole kana uine zviratidzo zvakajairika zve eczema zvakaita sekukwenya kunoramba kuripo, mavara matsvuku kana mashava paganda, zvidonhwe zvidiki zvakakwidzwa zvinogona kubuda mvura kana zvakwenywa, kana ganda rakakora, rakatsemuka, kana rine makwapa.

Mushonga uyu unobatsira zvikuru pakurapa eczema panzvimbo dzako dzine hanya, kusanganisira chiso chako, maziso, mutsipa, uye makwinya eganda.

Mishonga iyi inokoshawo pakurapa kwenguva refu. Nekuti haitore njodzi dzakafanana nekushandiswa kwenguva refu kwemishonga ye steroid, vanachiremba vazhinji vanoikurudzira kune vanhu vanoda kurapwa kwenguva refu kudzivirira eczema flare-ups. Inogona kushandiswa zvakachengeteka kwenguva yakareba pasina kunetseka kweganda kuonda kana mamwe mativi emishonga ye steroid.

Crisaborole Inoshanda Sei?

Crisaborole inoshanda nekudzivisa enzyme inonzi phosphodiesterase-4 (PDE-4) mumaseru ako eganda. Iyi enzyme inowanzoita kuti chinhu chinonzi cyclic adenosine monophosphate (cAMP), icho chinobatsira kudzora kuzvimba.

Kana PDE-4 yakavharwa, mazinga e cAMP anowedzera mumaseru ako eganda. Mazinga epamusoro e cAMP anobatsira kuderedza kugadzirwa kwezvinhu zvinopisa zvinokonzera kutsvuka, kuzvimba, uye kukwenya kunobatanidzwa ne eczema. Funga nezvazvo sekudzima vhoriyamu pane mhinduro yekuzvimba kweganda rako pane kuivhara zvachose.

Maitiro aya anoita kuti crisaborole ive mishonga inopesana nekuzvimba. Haisi simba rekukurumidza semishonga yepamusoro-soro ye steroid, asi inopa zororo rakagadzikana, rinoramba riripo pasina mukana wekuti ganda rionde kana mamwe matambudziko ane chekuita ne steroid. Mushonga uyu unowanzo kutanga kushanda mukati memazuva mashoma kusvika vhiki rekushandisa nguva dzose, nemabhenefiti akazara anowanzoonekwa mushure memavhiki 2-4 ekushandisa nguva dzose.

Ndingashandisa Sei Crisaborole?

Shandisa crisaborole sezvinorayirwa nachiremba wako, kazhinji kaviri pazuva kunzvimbo dzeganda dzakakanganiswa. Unogona kuishandisa uine kana usina chikafu, sezvo iri mushonga wepamusoro usingaite hukama nezvaunodya.

Tangira nekushambidza maoko ako zvakanyatsonaka usati waisa. Chenesa ganda rakakanganiswa zvinyoro-nyoro nesipo nemvura, wobva wariomesa. Isa rukoko rutete rwekirimu kunzvimbo dzakakanganiswa uye nyatsorukwiza kusvikira rwanyangarika. Mushonga unofanirwa kuiswa paganda rako, kwete mucous membranes senge mukati memuromo wako kana mhino.

Mushure mekuisa crisaborole, shamba maoko ako zvakare kunze kwekunge uri kurapa maoko ako pachako. Haufaniri kuvhara nzvimbo dzakabatwa nemabhandeji kana kupfeka kunze kwekunge chiremba wako achikurudzira zvakananga. Unogona kuisa moisturizer pamusoro pemushonga kana zvichidikanwa, asi mirira maminitsi mashoma kuti crisaborole inyudzike kutanga.

Dzivisa kuisa mushonga mumaziso ako, muromo, kana mukati memhino dzako. Kana izvi zvikaitika netsaona, sukurudza nzvimbo yacho zvakanyatsonaka nemvura. Unogona kushambira kana kushowera zvakajairika uchishandisa crisaborole, asi edza kuisa mushonga paganda rakachena, rakaoma kuti unyudzike zvakanaka.

Ndingatora Crisaborole Kwenguva Yakareba Sei?

Kureba kwekushandiswa kwecrisaborole kunosiyana zvichienderana nekupindura kwako kwega uye kuoma kweeczema yako. Vanhu vazhinji vanotanga kuona kuvandudzwa mukati mevhiki yekutanga yekushandisa, nemabhenefiti akakosha anowanzoonekwa mushure memavhiki 2-4 ekushandisa nguva dzose.

Kune acute flare-ups, unogona kushandisa crisaborole kwemavhiki akati wandei kusvikira zviratidzo zvako zvichidzorwa zvakanaka. Kana eczema yako yavandudzwa, chiremba wako anogona kukurudzira kuenderera mberi nemushonga sekurapa kwekuchengetedza kudzivirira flare-ups yeramangwana. Iri ndiro rimwe remabhenefiti e crisaborole - inogona kushandiswa zvakachengeteka kwenguva yakareba pasina matambudziko ane hukama nekushandiswa kwenguva refu kwe steroid.

Vamwe vanhu vanoshandisa crisaborole kwemwedzi kana kunyange makore sechikamu chechirongwa chavo chekurapa eczema. Chiremba wako achatarisa kufambira mberi kwako uye anogona kuchinja chirongwa chako chekurapa zvichienderana nekuti ganda rako rinoita sei uye kana uine chero mhedzisiro. Usamira kushandisa mushonga kamwechete usina kubvunza chiremba wako, sezvo izvi zvinogona kukonzera kudzoka kwezviratidzo zvako.

Ndezvipi Zviri Zvakaipa zveCrisaborole?

Vanhu vazhinji vanoshivirira crisaborole zvakanaka, asi semishonga yese, inogona kukonzera mhedzisiro. Mashoko akanaka ndewekuti mhedzisiro yakakomba haisi yakajairika, uye maitiro mazhinji akapfava uye enguva pfupi.

Mhedzisiro yakajairika inokanganisa kusvika ku10% yevanhu inosanganisira:

• Kunanzva kana kunzwa kunopisa panzvimbo yekushandisa (kazhinji kupfava uye kwenguva pfupi)
• Kutsamwa kweganda kana kutsvuka kwaunoshandisa mushonga
• Kukwenya panzvimbo yekushandisa (iyo ingaite seinopesana nekuti mushonga unorapa kukwenya)
• Kurwadziwa kweganda kana kunyorova
• Allergic contact dermatitis (ganda rinoita kumushonga pachako)

Izvi zvinowanzoitika kana iwe ukatanga kushandisa mushonga uye kazhinji zvinovandudzika sezvo ganda rako rinogadzirisa kurapwa. Kunanzva kana kunzwa kunopisa kunowanzoonekwa zvakanyanya panguva yekutanga kushandiswa uye kunowanzoita kuderedza nekushandiswa kwakawanda.

Mhedzisiro isingawanzoitiki asi inonyanya kukosha inosanganisira:

• Maitiro akakomba ekuita allergic (rash, hives, kuoma kufema, kuzvimba kwechiso, miromo, kana huro)
• Zviratidzo zvehutachiona hweganda (kuwedzera kutsvuka, kudziya, pus, kana fivha)
• Kuwedzera kwezviratidzo zvako zve eczema
• Kuchinja kweganda kusinganzwisisike kana kusviba

Kana iwe uine chero maitiro akakomba kana kana mhedzisiro yakapfava isingavandudzike mushure mevhiki rekushandisa, taura nechiremba wako. Vanogona kubatsira kuona kana iwe uchifanira kuenderera mberi nemushonga kana kuyedza imwe nzira yekurapa.

Ndiani Asingafaniri Kutora Crisaborole?

Crisaborole haikodzeri munhu wese, uye vamwe vanhu vanofanira kudzivisa kushandisa mushonga uyu. Chiremba wako achatarisa nhoroondo yako yezvokurapa uye hutano hwako hwazvino usati wanyora mushonga uyu.

Haufaniri kushandisa crisaborole kana uine allergy kwairi kana kune chero zvinhu zvayo. Zviratidzo zvekuita allergy zvinosanganisira rash yakakomba, hives, kuoma kufema, kana kuzvimba kwechiso chako, miromo, rurimi, kana huro. Kana wakambove neallergy kune mishonga yakafanana yekuzora kare, ita shuwa kuti unoudza chiremba wako.

Vanhu vane mamwe mamiriro eganda vanofanira kushandisa crisaborole nekuchenjerera:

• Zvirwere zveganda zviri kushanda (bacterial, viral, kana fungal) panzvimbo yekurapa
• Maronda akavhurika kana ganda rakakuvadzwa zvakanyanya
• Mamiriro eganda kunze kwe eczema anogona kuwedzerwa nemushonga
• Nhoroondo yezvakaipa zvakanyanya zveallergy kumishonga yekuzora

Zvimwe zvinhu zvinoshanda kuvakadzi vane pamuviri uye vanoyamwisa. Kunyange zvazvo zvidzidzo zvisina kuratidza mhedzisiro inokuvadza kuvana vasati vazvarwa, crisaborole inofanira kushandiswa chete panguva yekuzvitakura kana mabhenefiti anogona kukunda njodzi. Kana uri kuyamwisa, dzivisa kushandisa mushonga kunzvimbo dzemuviri wako uko mwana wako angasangana nawo, senge chipfuva kana nzvimbo yezamu.

Vana vari pasi pemakore maviri havafaniri kushandisa crisaborole kunze kwekunge zvichikurudzirwa zvakananga nachiremba wevana. Kuchengeteka uye kushanda muvana vadiki zvikuru hazvina kumiswa zvizere.

Mazita eCrisaborole Brand

Crisaborole inowanikwa pasi pezita rekuti Eucrisa muUnited States. Iri ndiro zita rekutanga remhando iyo mushonga unotengeswa uye unonyorerwa.

Eucrisa inogadzirwa nePfizer uye inouya semushonga we2% wekuzora. Mushonga unowanikwa mumachubhu emhando dzakasiyana, kazhinji 60 gramu kana 100 gramu, zvichienderana nemushonga wako uye zvaunoda kurapwa.

Parizvino, hapana mhando dzakajairika dze crisaborole dziripo muUnited States. Izvi zvinoreva kuti Eucrisa ndiyo chete mhando inowanikwa, izvo zvinogona kuita kuti mushonga uyu udhure kupfuura dzimwe nzira dzakajairika. Zvisinei, hurongwa hwakawanda hwe inishuwarenzi hunobhadhara crisaborole, uye mugadziri anopa zvirongwa zvekubatsira varwere kubatsira kuderedza mari yevanhu vanokodzera.

Zvimwe Zvinhu Zvokutsiva Crisaborole

Kana crisaborole isina kukodzera kwauri kana isingapi rubatsiro rwakakwana, pane dzimwe nzira dzakawanda dzekurapa dzinowanikwa pakurapa eczema. Chiremba wako anogona kukubatsira kuti uongorore sarudzo idzi zvichienderana nezvido zvako zvakakosha uye nhoroondo yako yezvokurapa.

Topical corticosteroids ichiri iyo inonyanya kurairwa. Izvi zvinosanganisira sarudzo dzakapfava dzakaita se hydrocortisone yenzvimbo dzakapfava, steroid dzepakati-simba dzakaita se triamcinolone yenzvimbo dzemuviri, uye sarudzo dzakasimba dzakaita se clobetasol yekupisa kwakanyanya. Kunyange zvazvo zvichibudirira, mishonga iyi inoda kutariswa zvakanyanya pakushandiswa kwenguva refu kudzivirira migumisiro yakaita sekuonda kweganda.

Dzimwe nzira dzisiri dze-steroidal dzinosanganisira:

• Topical calcineurin inhibitors (tacrolimus, pimecrolimus) - inonyanya kubatsira pakurapa kumeso nemutsipa
• Topical JAK inhibitors yakaita se ruxolitinib - sarudzo itsva ye eczema yakapfava kusvika pakati nepakati
• Barrier repair creams uye prescription moisturizers
• Antihistamines yekubatsira kubvisa kukwenya

Ye eczema yakakomba isingapinduri kumishonga yepamusoro, sarudzo dzakarongeka dzinogona kufungwa. Izvi zvinosanganisira mishonga yemuromo yakaita se dupilumab injections, methotrexate, kana cyclosporine, kunyange izvi zvinowanzo chengeterwa nyaya dzakanyanya nekuda kwemigumisiro yavo inogona kukonzera.

Ko Crisaborole Ari Nani Pane Tacrolimus?

Zvese crisaborole uye tacrolimus zvinoshanda zvisiri zve steroid kurapa eczema, asi zvinoshanda zvakasiyana uye zvine zvakanakira zvakasiyana. Sarudzo pakati pavo inoenderana nemamiriro ako chaiwo, kunzwa kweganda, uye zvinangwa zvekurapa.

Crisaborole inowanzoita nyoro uye inokonzera kushoma kupisa kana kurwadza pakushandisa ichienzaniswa ne tacrolimus. Izvi zvinoita kuti ive sarudzo iri nani kune vanhu vane ganda rinonyanya kunzwa kana avo vasina kukwanisa kutsungirira tacrolimus nekuda kwekutsamwa kwekutanga. Crisaborole zvakare haina yambiro yeFDA yebhokisi dema iyo tacrolimus ine maererano nenjodzi yekenza inogona kuitika nekushandiswa kwenguva refu.

Zvisinei, tacrolimus inowanzoonekwa seyakasimba uye inogona kushanda zvakanyanya kune yakati wandei kusvika kune yakanyanya eczema. Yave iripo kwenguva refu uye ine tsvakurudzo yakawanda inotsigira kushandiswa kwayo. Tacrolimus zvakare inowanzoita nekukurumidza kupfuura crisaborole, nevamwe vanhu vachiona kuvandudzwa mukati memazuva panzvimbo pemavhiki.

Kune facial eczema, mishonga yese iri miviri isarudzo yakanaka sezvo isingakonzeri kuonda kweganda senge steroids. Chiremba wako angatanga ne crisaborole kana uine ganda rinonzwa kana kunetseka pamusoro pekutsungirira, wobva wafunga tacrolimus kana uchida simba rekurwisa-kuzvimba. Vamwe vanhu vanoshandisa mishonga yese iri miviri panguva dzakasiyana kana nzvimbo dzakasiyana dzemuviri sechikamu chechirongwa chavo chekurapa.

Mibvunzo Inowanzo Bvunzwa Nezve Crisaborole

Crisaborole Yakachengeteka Here Kune Chirwere cheShuga?

Hongu, crisaborole inowanzo chengeteka kune vanhu vane chirwere cheshuga. Sezvo iri mushonga we topical unoshanda munzvimbo yeganda, haikanganisi mazinga e shuga yeropa kana kukanganisa mishonga yechirwere cheshuga.

Asi, vanhu vane chirwere cheshuga vanofanira kungwarira zvakanyanya nezvekuchengetwa kweganda nekuti vanowanzoita zvirwere zvepaganda uye kupora kwemaronda kunononoka. Kana uine chirwere cheshuga uye ukaona chero zviratidzo zvechirwere cheganda uchishandisa crisaborole, zvakadai sekutsvedza kwakawedzera, kupisa, pus, kana fivha, taura nachiremba wako nekukurumidza. Murapi wako wehutano angada kutarisa ganda rako zvakanyanya panguva yekurapa kuti ave nechokwadi chekupora kwakakodzera.

Ndoita Sei Kana Ndikashandisa Crisaborole Yakawandisa Netsaona?

Kushandisa crisaborole yakawandisa dzimwe nguva hazisi kuzokonzera matambudziko akakomba nekuti mushonga wepamusoro. Zvisinei, kushandisa huwandu hwakawandisa kunogona kuwedzera njodzi yako yemigumisiro yakadai sekutsamwa kweganda, kupisa, kana maitiro ekuita allergic.

Kana netsaona ukashandisa zvakanyanya, pukuta zvinyoro nyoro zvakawandisa nejira rakachena, rakanyorova. Usakwenya kana kukwiza zvakasimba, sezvo izvi zvinogona kuwedzera kutsamwisa ganda rako. Tarisa nzvimbo yakarapiwa kuti uone kuwedzera kutsvuka, kupisa, kana zvimwe zviratidzo zvekutsamwa mumahora mashoma anotevera.

Kana ukaona kupisa kwakanyanya, rash yakapararira, kana zviratidzo zvekuita allergic mushure mekutora crisaborole yakawandisa, geza nzvimbo yacho zvakakwana nesipo yakapfava nemvura uye taura nemupi wako wehutano. Munguva yemberi, yeuka kuti rukoko rutete rwakakwana - mushonga wakawanda haurevi mhedzisiro iri nani.

Ndoita Sei Kana Ndikakanganwa Dose yeCrisaborole?

Kana ukakanganwa dose ye crisaborole, isa pakarepo paunorangarira. Zvisinei, kana yava nguva yechikamu chako chinotevera, tsika dose yakakanganwa uye uenderere mberi nechirongwa chako chekushandisa nguva dzose.

Usashandisa mushonga wakawedzerwa kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yemigumisiro. Kuenderana kwakakosha ne crisaborole, saka edza kuiisa panguva imwechete zuva rega rega kuti uchengetedze mazinga akagadzikana paganda rako.

Kana uchikanganwa zvikamu zvakawanda, funga nezvekuisa zviyeuchidzo zvefoni kana kushandisa mushonga sechikamu chetsika yako yezuva nezuva, sekutevera kukwesha mazino ako mangwanani nemanheru. Kukanganwa zvikamu zvimwe chete hakuzokukuvadzi, asi kushandiswa kwakawanda kunogona kuderedza kushanda kwemushonga mukudzora eczema yako.

Ndingamira Rini Kutora Crisaborole?

Unogona kumira kushandisa crisaborole kana zviratidzo zvako zve eczema zvanyangarika uye zvakaramba zvakagadzikana kwenguva yakatarwa nachiremba wako. Zvisinei, usamira mushonga kamwechete usina kutanga kubvunza chiremba wako.

Vanachiremba vazhinji vanokurudzira kuderedza zvishoma nezvishoma kuwanda kwekushandiswa pane kumira kamwechete. Semuenzaniso, unogona kubva kaviri pazuva kuenda kamwe pazuva, wobva waenda kune rimwe zuva, usati wamira zvachose. Iyi nzira inobatsira kudzivirira kupararira kwemashoko uye inokutendera kuti utarise kuti ganda rako rinopindura sei.

Vamwe vanhu vanoda kuenderera mberi ne crisaborole se long-term maintenance therapy kudzivirira eczema flare-ups. Sezvo yakachengeteka kushandiswa kwenguva yakareba, chiremba wako angakurudzira kurapwa kuri kuenderera mberi kana uine chronic eczema inowanzo dzoka kana kurapwa kwamira. Sarudzo yekupfuurira kana kumira inofanira kugara ichiitwa mukubvunzana nachiremba wako zvichibva pamhinduro yako yega yega nezvido.

Ndingashandisa Crisaborole nemimwe mishonga yeEczema here?

Hongu, crisaborole inogona kushandiswa pamwe chete nemamwe marapirwo e eczema, asi iwe unofanirwa kugara uchitarisa nachiremba wako usati wasanganisa mishonga. Mupi wako wehutano anogona kubatsira kugadzira chirongwa chakazara chekurapa chinowedzera mabhenefiti uchideredza kusangana kunogona kuitika.

Crisaborole inoshanda zvakanaka nemoisturizers uye barrier repair creams, izvo zvinhu zvakakosha zve eczema management. Isa crisaborole kutanga, mirira maminetsi mashoma kuti itore, wobva waisa moisturizer yako. Unogona zvakare kuishandisa ne oral antihistamines kuti uwane imwe rubatsiro rwekurwadziwa.

Kana uchishandisa mamwe marapirwo ekuzora, chiremba wako angakurudzira kuti uazore panguva dzakasiyana dzezuva kana kuachinjana kuti udzivise kusangana kunogona kuitika. Dzimwe nzira dzokushandisa mishonga yakasiyana, sekushandisa crisaborole pamwe chete nemishonga yekuzora ye steroid, zvingarairwa kana paine matambudziko akakomba, asi izvi zvinoda kutarisirwa kwakanyatsoitwa nachiremba kuti ave nechokwadi chekuchengeteka nekushanda zvakanaka.