Chii chinonzi Crizotinib: Zvazvinoshandiswa, Mishonga, Zvazvinokonzeresa uye Zvimwe

Crizotinib mushonga wekenza unotarisa uyo unobatsira kunonotsa kukura kwemarudzi akati wandei ekenza yemapapu. Inoshanda nekudzivisa mapuroteni chaiwo ayo maseru ekenza anoda kuti akure uye apararire mumuviri wako wese.

Mishonga iyi inomiririra kufambira mberi kukuru mukurapa kenza kwakagadzirirwa munhu. Chiremba wako anowanzo kuraira kuyedzwa kwemajini etumor yako asati arayira crizotinib kuti ave nechokwadi chekuti ndiyo yakakodzera kenza yako chaiyo.

Chii chinonzi Crizotinib?

Crizotinib mushonga wekenza wemuromo uyo uri muboka remishonga inonzi tyrosine kinase inhibitors. Inonyanya kutarisana nemaseru ekenza ichikonzera kukuvara kushoma kumasero ane hutano kana ichienzaniswa nechemotherapy yechinyakare.

Mishonga iyi inouya muchimiro chemakapsule uye inotorwa nemuromo kaviri pazuva. Yakambotanga kubvumidzwa neFDA muna 2011 uye kubvira ipapo yakabatsira zviuru zvevarwere vane marudzi akati wandei ekenza yemapapu kurarama hupenyu hurefu, hune hutano.

Funga nezve crizotinib sechishandiso chakarurama kwazvo chinogona kuziva uye kuvharira zviratidzo zvakajeka zvinoudza mamwe maseru ekenza kuti akure. Iyi nzira inotarisa kazhinji inoreva mashoma mativi emishonga kupfuura kurapwa kwakakura kwekenza.

Crizotinib Inoshandiswa Kunei?

Crizotinib inonyanya kushandiswa kurapa non-small cell lung cancer (NSCLC) iyo ine shanduko dzemajini chaiwo. Kenza yako inofanira kuyedzwa yakanaka yeALK gene rearrangements kana ROS1 gene rearrangements kuti mishonga iyi ive inoshanda.

Mishonga iyi inowanzo rayirwa kana kenza yapararira kune dzimwe nhengo dzemuviri wako kana kana kuvhiyiwa kusiri sarudzo. Inoonekwa seyekutanga-mutsara kurapwa, zvinoreva kuti inowanzo kuve mishonga yekutanga chiremba wako achayedza kune aya marudzi ekenza chaiwo.

Mune dzimwe nguva, crizotinib inogona kushandiswawo kune mamwe marudzi emakanser akaoma ayo ane ALK gene shanduko, senge inflammatory myofibroblastic tumors. Chiremba wako weoncologist achasarudza kana rudzi rwako rwekenza uye genetic makeup zvichikuita iwe munhu akakodzera kurapwa uku.

Crizotinib Inoshanda Sei?

Crizotinib inoshanda nekudzivisa mapuroteni asina kujairika ayo maseru ekenza anoshandisa kukura nekuzviparadzanisa. Kunyanya, inotarisa ALK uye ROS1 mapuroteni ayo akave akanyanya kushanda nekuda kweshanduko dze genetic mumasero ako ekenza.

Mishonga iyi inoonekwa seyakati wandei kurapwa kwekenza iyo yakatarwa kupfuura chemotherapy yechinyakare. Inokanganisa kugona kweseru rekenza kugamuchira zviratidzo zvekukura, zvichinyanya kuita kuti maseru ekenza asare nezvavanoda kuti vararame nekupararira.

Runako rwecrizotinib runovanda mukunyatsoita kwayo. Nepo chemotherapy yechinyakare ichikanganisa maseru ane hutano uye ane kenza, crizotinib inonyanya kutarisisa maseru ane zvisina kujairika zve genetic. Iyi nzira yakatarwa inowanzoita kuti pave nemigumisiro iri nani iine mashoma mativi akakomba.

Ndingatora Sei Crizotinib?

Tora crizotinib sezvakanyorwa nachiremba wako, kazhinji kaviri pazuva uine kana pasina chikafu. Medza makapisi ese nemvura yakazara, uye usapwanye, kutsenga, kana kuvhura.

Unogona kutora crizotinib nezvokudya kana ichikutsamwisa dumbu rako, kunyangwe chikafu chisiri kudikanwa kuti chinyatsoitwa. Varwere vazhinji vanowana kuti kuitora nechisvusvuro chakareruka kunobatsira kuderedza kusvotwa, iyo iri mhedzisiro yakajairika.

Edza kutora zvikamu zvako panguva imwe chete zuva rega rega, maawa gumi nemaviri akaparadzana. Izvi zvinobatsira kuchengetedza mazinga akagadzikana emushonga muropa rako. Kana uri kutora mamwe mishonga, kurukurai nguva nachiremba wako kuti mudzivise kupindirana kunogona kuitika.

Dzivisa grapefruit uye muto wegrapefruit paunenge uchitora crizotinib, sezvo zvinogona kuwedzera huwandu hwemushonga muropa rako uye zvinogona kukonzera mamwe mativi.

Ndingatora Crizotinib Kwenguva Yakareba Sei?

Varwere vazhinji vanoramba vachitora crizotinib chero bedzi ichidzora kenza yavo uye migumisiro yacho ichiramba ichigoneka. Izvi zvinogona kuva mwedzi kana makore, zvichienderana nekuti kenza yako inopindura sei kurapwa.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa nguva dzose uye bvunzo dzeropa, kazhinji mwedzi miviri mitatu pakutanga. Bvunzo idzi dzinobatsira kuona kana mushonga uri kushanda zvakanaka uye kana iwe uchifanira kuramba uchirapwa.

Vamwe varwere vangada kutora zororo kubva ku crizotinib kana migumisiro yacho yava yakanyanya, nepo vamwe vangazopedzisira vachichinjira kumimwe mishonga kana kenza yavo ikaita kuramba. Chirongwa chako chekurapa chichagadzirirwa zvinoenderana nekupindura kwako uye hutano hwako hwese.

Ndezvipi Zvakaipa ZveCrizotinib?

Semishonga yese yekenza, crizotinib inogona kukonzera migumisiro, kunyangwe kwete munhu wese achaiwana. Migumisiro yakawanda inogoneka uye inowanzoita nani muviri wako uchigadzirisa kumushonga.

Heano migumisiro yakajairika yaungasangana nayo:

• Kusvotwa uye kurutsa
• Dhiria kana kuvharika
• Kuneta uye kusava nesimba
• Kuzvimba mumakumbo, zvitsitsinho, kana kutenderedza maziso
• Kuchinja kwekuona, kusanganisira kuona kwakajeka kana kuona kupenya kwechiedza
• Dizziness kana lightheadedness
• Kuderera kwechido
• Meno ematehwe

Izvi zvakajairika migumisiro inowanzoita nyoro kusvika pakati nepakati uye inogona kugadziriswa nekuchengetwa kunotsigira kana kugadzirisa mishonga.

Migumisiro yakakomba inogona kuitika, kunyangwe isingawanzoitiki. Zvakakosha kuziva izvi kuitira kuti iwe ugone kutsvaga rubatsiro rwekurapa kana zvichidikanwa:

• Matambudziko echiropa (kushanduka yeganda kana maziso kuita yero, weti yakasviba, kuneta zvakanyanya)
• Kuzvimba kwemapapu (kukosora kutsva kana kuwedzera, kufema nekutambudzika, kurwadziwa muchipfuva)
• Matambudziko emoyo (kurwadziwa kwemoyo kusingaite zvakanaka, kurwadziwa muchipfuva, kufenda)
• Matambudziko akakomba eitsvo (kuchinja mukuyera weti, kuzvimba)
• Maitiro akakomba ekugumbuka (kufema nekutambudzika, rash yakakomba, kuzvimba kwechiso kana huro)

Bata chikwata chako chehutano nekukurumidza kana uine chero matambudziko aya akakomba. Vanogona kupa gwara uye kugadzirisa kurapwa kwako kana zvichidikanwa.

Ndiani Asingafaniri Kutora Crizotinib?

Crizotinib haina kukodzera munhu wese, uye mamwe mamiriro ezvinhu ehutano kana mamiriro anogona kuita kuti isachengeteke kwauri. Chiremba wako achanyatsoongorora hutano hwako hwese asati akurudzira mushonga uyu.

Haufaniri kutora crizotinib kana uine allergic kumushonga kana chero zvawo zvawo. Uye zvakare, vakadzi vane pamuviri vanofanira kudzivisa crizotinib sezvo ichikwanisa kukuvadza mwana ari kukura.

Vanhu vane mamwe mamiriro ehutano vanoda kungwarira zvakanyanya kana vangave vasiri vakwikwidzi vekurapwa kwecrizotinib:

• Chirwere chechiropa chakakomba kana kukanganiswa kwechiropa
• Chirwere cheitsvo chakakomba
• Matambudziko emoyo kana chirwere chemoyo chakakosha
• Chirwere chemapapu chinoshanda kana matambudziko ekufema
• Kuzvitakura kana kuyamwisa

Chiremba wako achafungawo nezvemimwe mishonga yako, sezvo crizotinib inogona kuita nemishonga yakawanda. Nguva dzose ipa runyorwa rwakakwana rwemishonga yese, zvinowedzera, uye zvigadzirwa zvechirimwa zvauri kutora.

Mazita eCrizotinib Brand

Crizotinib inotengeswa pasi pezita rekuti Xalkori muUnited States nemamwe mazhinji nyika. Iri ndiro zita rekutanga rakagadzirwa nePfizer, kambani yemishonga yakagadzira mushonga.

Unogonawo kuona crizotinib ichinzi nezita rayo re generic mumabhuku ezvokurapa kana uchikurukura nezvekurapa nechikwata chako chehutano. Mazita ese ari maviri anoreva mushonga mumwe chete une zvinhu zvakafanana zvinoshanda.

Mhando dze generic dze crizotinib dzinogona kuwanikwa mune ramangwana, asi parizvino, Xalkori ndiyo mhando yekutanga inowanikwa mumisika yakawanda.

Zvimwe Zvinotsiva Crizotinib

Mishonga yakati wandei inotsiva inowanikwa yekurapa kenza yemapapu ye ALK-positive uye ROS1-positive. Chiremba wako angatarisa izvi kana crizotinib isina kukodzera iwe kana kana kenza yako ichikura kuramba.

Kenza yemapapu ye ALK-positive, zvimwe zvinosanganisira alectinib (Alecensa), ceritinib (Zykadia), uye brigatinib (Alunbrig). Mishonga iyi mitsva dzimwe nguva inoshandiswa seyekutanga-mutsara kurapwa kana crizotinib ichirega kushanda.

Chemotherapy yechinyakare inoramba iri sarudzo, kunyangwe kurapwa kwakanangana se crizotinib kazhinji kunopa mhedzisiro iri nani ine mashoma mativi emhedzisiro kune varwere vane genetic markers chaiwo. Oncologist wako achabatsira kuona nzira yakanakisa yekurapa mamiriro ako chaiwo.

Crizotinib Ari Nani Pane Alectinib Here?

Crizotinib ne alectinib zvese zvinoshanda kurapa kenza yemapapu ye ALK-positive, asi zvidzidzo zvichangoburwa zvinoratidza kuti alectinib inogona kuva nezvimwe zvakanakira seyekutanga-mutsara kurapwa. Sarudzo pakati pavo inoenderana nemamiriro ako chaiwo uye nhoroondo yezvokurapa.

Alectinib inoita seinoshanda zvakanyanya pakudzivirira kenza kubva pakupararira kuuropi uye inogona kukonzera mashoma mativi emhedzisiro kune vamwe varwere. Zvisinei, crizotinib yakashandiswa kwenguva refu uye ine ruzivo rwakawanda rwechokwadi runotsigira kushanda kwayo.

Oncologist wako achatarisa zvinhu zvakaita sehutano hwako hwese, mamwe mamiriro ezvokurapa, mativi anogona kuitika, uye zvaunofarira pachako paunenge uchisarudza pakati pemishonga iyi. Zvese zviri zvesarudzo dzakanaka dzekurapa kenza yemapapu ye ALK-positive.

Mibvunzo Inowanzoitwa Pamusoro peCrizotinib

Crizotinib Yakachengeteka Here Kune Vanhu vane Chirwere chemoyo?

Crizotinib inogona kukanganisa rhythm yemoyo, saka vanhu vane matambudziko emoyo vanoda kunyatsoongororwa. Chiremba wako anogona kuraira electrocardiogram (EKG) usati watanga kurapwa uye nguva dzose panguva yekurapa.

Kana uine chirwere chemoyo, chiremba wako wecardiologist uye oncologist vachashanda pamwechete kuti vaone kana crizotinib yakachengeteka kwauri. Vanogona kugadzirisa mishonga yako yemoyo kana kukutarisa zvakanyanya, asi varwere vazhinji vane matambudziko emoyo vanogona kutora crizotinib zvakachengeteka.

Ndoitei Kana Ndikatora Crizotinib Yakawandisa Netsaona?

Kana netsaona ukatora crizotinib yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira. Usamirira kuti zviratidzo zviitike, sezvo kutariswa kwekurapa nekukurumidza kwakakosha.

Zviratidzo zvekuwandisa zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, manyoka, kana dzungu. Chengeta bhodhoro remushonga newe paunotsvaga kutarisirwa kwekurapa kuitira kuti vanopa hutano vazive chaizvo zvawakatora uye zvakawanda sei.

Ndoitei Kana Ndikakanganwa Dose yeCrizotinib?

Kana ukakanganwa dose uye kwapfuura maawa anopfuura matanhatu kusvika kune yako inotevera dose yakarongwa, tora dose yakakanganwa nekukasira paunoyeuka. Kana kwapfuura maawa asingasviki matanhatu kusvika kune yako inotevera dose, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chese.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Izvi zvinogona kuwedzera njodzi yako yemigumisiro isingapi mubatsiro wekuwedzera. Kana iwe uchikanganwa madosi kazhinji, funga kushandisa chirongwa chemushonga kana kumisa zviyeuchidzo zvefoni.

Ndingamira Rini Kutora Crizotinib?

Mira kutora crizotinib chete kana chiremba wako akuudza kuti zvakachengeteka kuita kudaro. Kunyangwe iwe uchinzwa zviri nani, mushonga unogona kunge uchiri kushanda kudzora kenza yako, uye kumira kamwe kamwe kunogona kubvumira kenza kukura zvakare.

Chiremba wako achashandisa ma scans enguva dzose uye bvunzo dzeropa kuti aongorore mhinduro yako kumushonga. Kana kenza ikawedzera kana kuti mativi emishonga akava asingadzoreki, chiremba wako achashanda newe kuti uchinjire kune imwe nzira yekurapa zvakachengeteka.

Ndingafamba here ndichitora Crizotinib?

Hongu, unogona kufamba uchiita crizotinib, asi zvinoda kuronga. Uya nemishonga yakawanda kana paine kunonoka, uye chengeta mishonga yako mubhegi rako rekutakura kana uchibhururuka kuti usarasikirwe nayo.

Zivisa timu yako yehutano nezve zvirongwa zvekufamba, kunyanya kana uchienda kune dzimwe nyika uko kutarisirwa kwekurapa kwakananga kungave kwakaoma kuwana. Vanogona kupa gwara rekugadzirisa mativi emishonga uchifamba uye kuona kuti une zvakakwana zvemishonga.